Cytokinesis-blocked micronucleus assay was applied as a biological dosimeter to detect abnormalities in human peripheral lymphocytes of thirteen students exposed to formaldehyde (FA) during a 12-week (10 h per week) a...Cytokinesis-blocked micronucleus assay was applied as a biological dosimeter to detect abnormalities in human peripheral lymphocytes of thirteen students exposed to formaldehyde (FA) during a 12-week (10 h per week) anatomy class. Breathing-zone air samples colleeted during dissection procedures showed a mean concentration of 2. 37 ppm (3. 17mg/m3 ). Ten students from the same school but without FA exposure served as controls. Chromosome aberrations (CA) and sister chromatid exchanges (SCE) were detected in both groups. The micronuclei (MN) rate (6. 38 ± 2. 50‰ ) and CA rate (5. 92 ±2. 40‰ ) in the FA-exposed group showed a significant increase (P< 0. 01 ) when compared with those of the controls (3. 15 ±1. 46‰and 3. 40 ± 1. 57 % respectively). A correlation between MN and CA in individuals was observed. SCE in the exmpd group were also increased (P< 0. 05), but not so greatly as MN or CA. The results indicated that FA might damage the chromosomes of human lymphocytes.展开更多
Stochastic resonance (SR) has been proved to be an effective approach to extract weak signals overwhelmed in noise. However, the detection effect of current SR models is still unsatisfactory. Here, a coupled tri-sta...Stochastic resonance (SR) has been proved to be an effective approach to extract weak signals overwhelmed in noise. However, the detection effect of current SR models is still unsatisfactory. Here, a coupled tri-stable stochastic resonance (CTSSR) model is proposed to further increase the output signal-to-noise ratio (SNR) and improve the detection effect of SR. The effects of parameters a, b, c, and r in the proposed resonance system on the SNR are studied, by which we determine a set of parameters that is relatively optimal to implement a comparison with other classical SR models. Numerical experiment results indicate that this proposed model performs better in weak signal detection applications than the classical ones with merits of higher output SNR and better anti-noise capability.展开更多
Determining effective traditional Chinese medicine (TCM) treatments for specific disease conditions or particular patient groups is a difficult issue that necessitates investigation because of the complicated person...Determining effective traditional Chinese medicine (TCM) treatments for specific disease conditions or particular patient groups is a difficult issue that necessitates investigation because of the complicated personalized manifestations in real-world patients and the individualized combination therapies prescribed in clinical settings. In this study, a multistage analysis method that integrates propensity case matching, complex network analysis, and herb set enrichment analysis was proposed to identify effective herb prescriptions for particular diseases (e.g., insomnia). First, propensity case matching was applied to match clinical cases. Then, core network extraction and herb set enrichment were combined to detect core effective herb prescriptions. Effectiveness-based mutual information was used to detect strong herb symptom relationships. This method was applied on a TCM clinical data set with 955 patients collected from well-designed observational studies. Results revealed that groups of herb prescriptions with higher effectiveness rates (76.9% vs. 42.8% for matched samples; 94.2% vs. 84.9% for all samples) compared with the original prescriptions were found. Particular patient groups with symptom manifestations were also identified to help investigate the indications of the effective herb prescriptions.展开更多
Using a strong nonlinear saturation absorption effect is one technique for breaking through the diffraction limit. In this technique, formation of a dynamic and reversible optical pinhole channel and transient superre...Using a strong nonlinear saturation absorption effect is one technique for breaking through the diffraction limit. In this technique, formation of a dynamic and reversible optical pinhole channel and transient superresolution is critical. In this work, a pump–probe transient detection and observation–experimental setup is constructed to explore the formation process directly. A Ge2Sb2Te5 thin film with strong nonlinear saturation absorption is investigated. The dynamic evolution of the optical pinhole channel is detected and imaged, and the transient superresolution spot is directly captured experimentally. Results verify that the superresolution effect originates from the generation of an optical pinhole channel and that the formation of the optical pinhole channel is dynamic and reversible. A good method is provided for direct detection and observation of the transient process of the superresolution effect of nonlinear thin films.展开更多
A math model that can describe the effect of stimulated Raman scattering (SRS) on pilot-tone detection technique is proposed.Through numerical simulation,it is shown that the effect of SRS could produce ghost-tones.Th...A math model that can describe the effect of stimulated Raman scattering (SRS) on pilot-tone detection technique is proposed.Through numerical simulation,it is shown that the effect of SRS could produce ghost-tones.The power of ghost-tones was larger for the channels separated further from the real-tone. The power ratio between real-tone and ghost-tones increases linearly with the increase of transmission length when propagation distance longer than 300 km.展开更多
Highly sensitive, selective, and stable hydrogen peroxide (H2O2) detection using nanozyme-based catalysts are desirable for practical applications. Herein, vertical α-FeOOH nanowires were successfully grown on the ...Highly sensitive, selective, and stable hydrogen peroxide (H2O2) detection using nanozyme-based catalysts are desirable for practical applications. Herein, vertical α-FeOOH nanowires were successfully grown on the surface of carbon fiber paper (CFP) via a low-temperature hydrothermal procedure. The formation of vertical α-FeOOH nanowires is ascribed to the structure-directing role of sodium dodecyl sulfate. The resulting free-standing electrode with one-dimensional (1D) nanowires offers oriented channels for fast charge transfer, excellent electrical contact between the electrocatalyst and the current collector, and good mechanical stability and reproducibility. Thus, it can serve as an efficient electrocatalyst for the reduction and sensitive detection of H2O2. The relation of the oxidation current of H202 with the concentration is linear from 0.05 to 0.5 mM with a sensitivity of -0.194 mA/(mM.cm2) and a low detection limit of 18μM. Furthermore, the portability in the geometric tailor and easy device fabrication allow extending the general applicability of this free-standing electrode to chemical and biological sensors.展开更多
文摘Cytokinesis-blocked micronucleus assay was applied as a biological dosimeter to detect abnormalities in human peripheral lymphocytes of thirteen students exposed to formaldehyde (FA) during a 12-week (10 h per week) anatomy class. Breathing-zone air samples colleeted during dissection procedures showed a mean concentration of 2. 37 ppm (3. 17mg/m3 ). Ten students from the same school but without FA exposure served as controls. Chromosome aberrations (CA) and sister chromatid exchanges (SCE) were detected in both groups. The micronuclei (MN) rate (6. 38 ± 2. 50‰ ) and CA rate (5. 92 ±2. 40‰ ) in the FA-exposed group showed a significant increase (P< 0. 01 ) when compared with those of the controls (3. 15 ±1. 46‰and 3. 40 ± 1. 57 % respectively). A correlation between MN and CA in individuals was observed. SCE in the exmpd group were also increased (P< 0. 05), but not so greatly as MN or CA. The results indicated that FA might damage the chromosomes of human lymphocytes.
基金Project supported by the National Natural Science Foundation of China(Grant Nos.61071025 and 61502538)
文摘Stochastic resonance (SR) has been proved to be an effective approach to extract weak signals overwhelmed in noise. However, the detection effect of current SR models is still unsatisfactory. Here, a coupled tri-stable stochastic resonance (CTSSR) model is proposed to further increase the output signal-to-noise ratio (SNR) and improve the detection effect of SR. The effects of parameters a, b, c, and r in the proposed resonance system on the SNR are studied, by which we determine a set of parameters that is relatively optimal to implement a comparison with other classical SR models. Numerical experiment results indicate that this proposed model performs better in weak signal detection applications than the classical ones with merits of higher output SNR and better anti-noise capability.
文摘Determining effective traditional Chinese medicine (TCM) treatments for specific disease conditions or particular patient groups is a difficult issue that necessitates investigation because of the complicated personalized manifestations in real-world patients and the individualized combination therapies prescribed in clinical settings. In this study, a multistage analysis method that integrates propensity case matching, complex network analysis, and herb set enrichment analysis was proposed to identify effective herb prescriptions for particular diseases (e.g., insomnia). First, propensity case matching was applied to match clinical cases. Then, core network extraction and herb set enrichment were combined to detect core effective herb prescriptions. Effectiveness-based mutual information was used to detect strong herb symptom relationships. This method was applied on a TCM clinical data set with 955 patients collected from well-designed observational studies. Results revealed that groups of herb prescriptions with higher effectiveness rates (76.9% vs. 42.8% for matched samples; 94.2% vs. 84.9% for all samples) compared with the original prescriptions were found. Particular patient groups with symptom manifestations were also identified to help investigate the indications of the effective herb prescriptions.
基金partially supported by National Natural Science Foundation of China (Nos. 51172253 and 61137002)
文摘Using a strong nonlinear saturation absorption effect is one technique for breaking through the diffraction limit. In this technique, formation of a dynamic and reversible optical pinhole channel and transient superresolution is critical. In this work, a pump–probe transient detection and observation–experimental setup is constructed to explore the formation process directly. A Ge2Sb2Te5 thin film with strong nonlinear saturation absorption is investigated. The dynamic evolution of the optical pinhole channel is detected and imaged, and the transient superresolution spot is directly captured experimentally. Results verify that the superresolution effect originates from the generation of an optical pinhole channel and that the formation of the optical pinhole channel is dynamic and reversible. A good method is provided for direct detection and observation of the transient process of the superresolution effect of nonlinear thin films.
基金This work was supported by the National Natural Science Foundation of China under Grant No. 90104003.
文摘A math model that can describe the effect of stimulated Raman scattering (SRS) on pilot-tone detection technique is proposed.Through numerical simulation,it is shown that the effect of SRS could produce ghost-tones.The power of ghost-tones was larger for the channels separated further from the real-tone. The power ratio between real-tone and ghost-tones increases linearly with the increase of transmission length when propagation distance longer than 300 km.
基金We gratefully acknowledge the support of this research by the Key Program Projects of the National Natural Science Foundation of China (No. 21031001), the National Natural Science Foundation of China (Nos. 21371053 and 21573062), the Cultivation Fund of the Key Scientific and Technical Innovation Project, Program for Innovative Research Team in University (No. IRT-1237), Application Technology Research and Development Projects in Harbin (No. 2013AE4BW051), International Science & Technology Cooperation Program of China (No. 2014DFR41110), and the Foundation of HeilongjJLang Province of China (No. QC2013C009).
文摘Highly sensitive, selective, and stable hydrogen peroxide (H2O2) detection using nanozyme-based catalysts are desirable for practical applications. Herein, vertical α-FeOOH nanowires were successfully grown on the surface of carbon fiber paper (CFP) via a low-temperature hydrothermal procedure. The formation of vertical α-FeOOH nanowires is ascribed to the structure-directing role of sodium dodecyl sulfate. The resulting free-standing electrode with one-dimensional (1D) nanowires offers oriented channels for fast charge transfer, excellent electrical contact between the electrocatalyst and the current collector, and good mechanical stability and reproducibility. Thus, it can serve as an efficient electrocatalyst for the reduction and sensitive detection of H2O2. The relation of the oxidation current of H202 with the concentration is linear from 0.05 to 0.5 mM with a sensitivity of -0.194 mA/(mM.cm2) and a low detection limit of 18μM. Furthermore, the portability in the geometric tailor and easy device fabrication allow extending the general applicability of this free-standing electrode to chemical and biological sensors.