Research on the Countermeasures for the Development of Biopharmaceutical Industrial Parks in China

Objective To systematically analyze the current development status of biopharmaceutical industrial park in China,sort out the problems and put forward some countermeasures and suggestions.Methods Relevant literature was searched and reviewed to find out the problems faced by the development of biopharmaceutical industrial parks in China.Results and Conclusion Biopharmaceutical industrial parks are developing rapidly due to their unique industrial clustering advantages,but there are problems such as lack of overall planning at the top level,insufficient government support,imperfect talent support services and weak innovation capacity of the parks.It is recommended to promote the rapid development of biopharmaceutical industrial parks and biopharmaceutical enterprises by strengthening top-level design,increasing government support,focusing on talent introduction,and enhancing the innovative strength of the parks.

An Analysis of Liberia’s Vulnerability to Climate Change in the Context of Least Developed Countries (LDCs): A Review

Climate change is an alarming global challenge, particularly affecting the least developed countries (LDCs) including Liberia. These countries, located in regions prone to unpredictable temperature and precipitation changes, are facing significant challenges, particularly in climate-sensitive sectors such as mining and agriculture. LDCs need more resilience to adverse climate shocks but have limited capacity for adaptation compared to other developed and developing nations. This paper examines Liberia’s susceptibility to climate change as a least developed country, focusing on its exposure, sensitivity, and adaptive capacity. It provides an overview of LDCs and outlines the global distribution of carbon dioxide emissions. The paper also evaluates specific challenges that amplify Liberia’s vulnerability and constrain sustainable adaptation, providing insight into climate change’s existing and potential effects. The paper emphasizes the urgency of addressing climate impacts on Liberia and calls for concerted local and international efforts for effective and sustainable mitigation efforts. It provides recommendations for policy decisions and calls for further research on climate change mitigation and adaptation.

Developability assessment of the therapeutic antibodies studies: are they druggable?

In recent years,with the continuous development of biotechnology and medical science and technology,therapeutic antibodies,as new biologics,have shown great potential and have become a research hotspot in the fields of oncology,autoimmune diseases,cardiovascular and neuroscience.Therapeutic antibodies refer to drugs or therapeutic methods for the treatment of diseases with specificity,high affinity and high efficiency antibody molecules prepared by biotechnological means.In this paper,we will systematically review the types of therapeutic antibodies,research progress,problems in research and development,mechanisms of action,and challenges faced in clinical applications.

Analytic Hierarchy Process for Technological Risks in the Process of Innovative Drug Development in China

Objective To identify the critical risks in the process of innovative drug research and development,and to provide reference for improving the efficiency of innovative drug development and risk control in China.Methods Expert investigation and analytic hierarchy process were used to determine the weights of different risks.Results and Conclusion The research and analysis results showed that the risks at different stages of development had different effects on the success rate of drug development,among which the risk at the drug discovery stage influenced the most.In the drug discovery stage,inappropriate target selection had the greatest impact on the success rate of drug development.The lack of appropriate cell tissue or animal models had the greatest impact on the success rate of drug development from the discovery of a compound to the application for clinical trials.The difference in changes between nonclinical and clinical studies had the greatest impact on the success rate of drug development from early clinical studies to pivotal clinical studies.Incorrect dose selection had the greatest impact on the success rate of drug development from pivotal clinical studies to marketing authorization applications.The biggest impact from the marketing authorization application to the approval stage was inadequate communication with regulators.After investigating the weight of risk factors in the process of innovative drug development based on scientific methods,a new perspective for the risk control of new drug development and improving the research and development efficiency is provided.

Development Tendency in Main Fields of Reading Researches

The last few decades have witnessed the publication of a considerable amount of empirical evidence supporting what Krashen has called "the power of reading"(Krashen,1993).There is a widespread approval that reading itself leads to better reading,better vocabulary,better writing,and better control of grammar in both first and second languages.In this article,the following research areas will be discussed,which can be mainly divided into the following 20 categories.

Action Research——the Way to Enhancing Teacher Professional Development

This paper introduces the notion of action research in its international academic context. Action research is potentially beneficial to both pre-service teachers and in-service teachers in their professional development and it should play an important role in the curriculum renewal of English teaching methodology in China.

Progress in Research and Development of Refractory Oxide-Nonoxide Composites

Some of the progress made in our laboratories in collaboration with industry in research and development work on high performance oxide-nonoxide composites for metallurgical applications has been reviewed. （1） SiAlON bonded corundum composites for blast furnace usage have been produced by reduction-nitridation sinte-ring at high temperature, using bauxite instead of alu-mina in the matrix. （2） Low carbon Al2O3 - SiAlON slide plate materials successfully used in high quality steel continuous casting have been developed in which most or all of the graphite in Al2O3 - C brick is replaced by bauxite-based β-SiAlON. （3） A1/Si metal bonded A12 03 - C material characterized by low carbon content, low firing temperature and in-situ formation of carbides and nitrides at high temperature during service are found to possess very high hot strength and very good thermal shock resistance and have also been successfully used as slide plates in ladles and tundishes for high quality steel casting.

Research and development of deepwater offshore linepipe of Baosteel UOE SAWL X70 of heavy wall thickness and large diameter

Baoshan Iron ＆ Steel Co.,Ltd., （referred to as Baosteel） in China first succeeded in developing the U-ing-O- ing-Expanding （UOE） longitudinal submerged arc welded pipes （SAWLs） offshore linepipe of a maximum thickness/ outside diameter （T/D） 0.042 in 2011. Described in this paper is the research and development of the X70 UOE SAWL pipes by the company. The result shows that the said X70 linepipe has been in compliance with relevant requirements as specified in Specifications DNV-OS-F101 ,and has been successfully used in the South China Sea deepwater gas pipeline project.

Progress and Problems of Development Research and Application of Sand Barriers

Due to the restrictions on the conditions for afforestation and sand control,the development research,and application of sand barriers have accelerated in recent years,but some problems that cannot be ignored have emerged in practice. In this paper,the functions of wind prevention,sand blocking and fixation,improving soil physical and chemical properties and increasing plant diversity of sand barriers,accretion coefficient and capacity between sand barriers,and mobile sand barriers were analyzed firstly,and then several issues that should be noted in the development and application of sand barriers were proposed. The results show that sand barriers can fix sand on the spot and maintain the stability of sand surface. As an auxiliary measure before afforestation on a mobile sand surface,they are practical and feasible. The biggest drawback of sand barriers is that they are easy to be saturated. Although they can increase plant diversity and surface roughness,they lose the function of blocking sand flow after being saturated,and their function of in-situ sand fixation also rapidly decreases with the degradation of sand barriers. Mobile sand barriers overcome the disadvantage of sand barriers being easy to be saturated to some extent,but the cost greatly increases. In terms of desertification prevention and control by plants,plants are used as sand barriers to study their functions of sand blocking and sand fixation in many researches and practices,but the more important ecological functions of adjusting temperature on sand surface and achieving surface thermodynamic equilibrium of plants are ignored.

Overview of Research and Development for Anticancer Drugs

Anticancer drugs research and development have been the largest market area in the pharmaceutical industry in terms of the number of project, clinical trials and spending. In the last 10 - 30 years, targeting therapy for cancers has been developed and achieved enormous clinical effectiveness by transforming some previously deadly malignancies into chronically manageable conditions, but cure problem still remains. This mini review outlined the current status of anticancer drugs development and hinted the opinions of how to further increase the accuracy and efficacy of discovery for cancer treatment.

China’s environmental scientific research and technology development:review and envisage

The topic was concentrated on environmental technology development in China within the context of China's economic acceleration and reform. Firstly, cleaner technology should be adopted where possible in industrial production; secondly, eco agricultural technological system, especially biological technology, should be developed in agricultural production; thirdly, end of pipe solution should focus on waste utilization or recycling technology where appropriate clean technology does not exist; lastly but not the least, existing technologies to minimize eco environmental deterioration such as soil erosion, salinization, desertification and deforestation should also be extended and developed. The mentioned ways of environmental technology development can only be realized on the condition that a resource conservation based production system and life style could be established and appropriate policy secured.

Prospect Conceiving of Joint Research and Development of Shale Gas and Coalbed Methane in China

Inspired by successful development of shale gas in USA and influenced by hydrocarbon resources shortage currently, China has strengthened shale gas research and accelerated its exploration process. In order to enrich coalbed methane (CBM) and shale gas geological theory and promote their development process, this paper compared shale gas with CBM in accumulation, distribution, reservoir and production. It expatiated on the background and significance of the combined research and development, and analyzed the geological foundation and future prospects. Our investigation demonstrated that there are many sets of coal-bearing strata in Shanxi formation of Permian system in Ordos in North China, Longtan formation of Upper Permian and Xujiahe formation of Upper Triassic in Southern Yangtze region, Xishanyao formation of Middle Jurassic in Turpan-Hami Basin and Junggar Basin in Northwest China, and Shahezi formation of Cretaceous in Songliao Basin in northeast China. In these regions, shales which are interbeded with coal seams have the characters of big thickness, continuous distribution, high content of organic matter, good parent material and high maturity, accord with the basic geological conditions to format shale gas and CBM reservoir and composite gas reservoir, thus form appropriate regions and layers to carry out joint research and exploration with good prospects for development.

Virtual reality research and development in NTU

In 1981,Nanyang Technological Institute was established in Singapore to train engineers and accountants to keep up with the fast-growing economy of the country.In 1991,the institute was upgraded to Nanyang Technological University(NTU).NTU holds the rank for world's top young university for six consecutive years according to the Quacquarelli Symonds(QS)world university ranking.Virtual Reality(VR)research began in NTU in the late 1990s.NTU's colleges,schools,institutes,and centers have contributed toward the excellence of VR research.This article briefly describes the VR research directions and activities in NTU.

Development of Fundamental Research of SiC_w / Al Composites in HIT Part Ⅱ: Mechanical Behaviour of Squeeze-cast SiC_w / Al Composites

Studies on the mechanical behaviour of squeeze-cast SiCw / Al composites have been revjewed. The results show that SiCw / Al composites exhibit improved mechan ical properties and cyclic hard ening. The reasons leading to the above results are discussed. Localized deformation near SiC whiskers plays an important role in the initiation of microcracks in the composites, and the fracture of the composites is caused by the abrupt linking of microcracks

The development and research of art innovation in artistic practice

＂Innovation＂ is the natural law of art creation, art works, and art development, is a major issue of art theory, aesthetic theory and art practice. This paper focus on the theme of artistic innovation, analyzes the meaning of art innovative, delves into the type and the level of value of art innovation, and proposes some Reflections on artistic innovation.

Research on the Origin and Development of Gas Volleyball under the Background of National Fitness

Since the promulgation of the Outline of the National Fitness Program,vigorously developing mass sports and fitness activities has always been its top priority.Promoting and developing a variety of mass sports and fitness activities and improving the physical quality of the people throughout the country is the goal of achieving the national fitness program.Gas volleyball is a mass sports that integrates fitness,leisure and entertainment.It is not limited by age,gender,physical condition and technical level.It is a combination of ornamental,entertaining,competitive and fitness.Innovative sports programs are a sport that is popular among the masses.This paper analyzes the origin and development of gas volleyball through literature and mathematical statistics,promotes the popularization and development of gas volleyball,and makes more people love and participate in this sport.It is of great significance to develop social culture and improve the physical fitness of the whole people.

Current Status of Material Research and Development in CISRI

The full name of CISRI is Central Iron&Steel Research Institute under the Ministry of Metallurgical Industry in China.It is the largest institute of metallurgical process research in China(the word"large"here refers to various fields,large personnel and many research projects).It includes ironmaking,steel-making,cold and hot processing of steel,metallic product,ferroalloy,refractory,automatic metallurgy control,design

Review of Research on the Development of Tourism Resources in Ecological Economic Zone of Poyang Lake

Based on analyzing and summarizing the previous research results,the existing problems in the researches of tourism resources development in the ecological economic zone of Poyang Lake were analyzed. And then the research trend in the future was pointed out.

Research and Development of New Broadband Wireless Access System

Broadband Wireless Access (BWA) has become one of the major evolution trends in the fields of broadband access and mobile communications. However,some difficulties emerged during the application and industrialization of the BWA system,which calls for typical service models,key technology innovations and backbone support from broadband Internet. This article introduces a Broadband Wireless Multimedia (BWM) access system. It aims to build a new-type "triple play" BWA network by integrating terrestrial digital TV system and the BWA system,and by taking broadband Internet as its core network platform. A primary research shows that the new BWA system is an effective solution to the existing difficulties of BWA system. Moreover,it is quite competitive in service provision,service coverage,frequency planning,terminal power consumption and cost for network construction.