Application of Feature, Event, and Process Methods to Leakage Scenario Development for Offshore CO_(2) Geological Storage

Offshore carbon dioxide(CO_(2)) geological storage(OCGS) represents a significant strategy for addressing climate change by curtailing greenhouse gas emissions. Nonetheless, the risk of CO_(2) leakage poses a substantial concern associated with this technology. This study introduces an innovative approach for establishing OCGS leakage scenarios, involving four pivotal stages, namely, interactive matrix establishment, risk matrix evaluation, cause–effect analysis, and scenario development, which has been implemented in the Pearl River Estuary Basin in China. The initial phase encompassed the establishment of an interaction matrix for OCGS systems based on features, events, and processes. Subsequent risk matrix evaluation and cause–effect analysis identified key system components, specifically CO_(2) injection and faults/features. Building upon this analysis, two leakage risk scenarios were successfully developed, accompanied by the corresponding mitigation measures. In addition, this study introduces the application of scenario development to risk assessment, including scenario numerical simulation and quantitative assessment. Overall, this research positively contributes to the sustainable development and safe operation of OCGS projects and holds potential for further refinement and broader application to diverse geographical environments and project requirements. This comprehensive study provides valuable insights into the establishment of OCGS leakage scenarios and demonstrates their practical application to risk assessment, laying the foundation for promoting the sustainable development and safe operation of ocean CO_(2) geological storage projects while proposing possibilities for future improvements and broader applications to different contexts.

Matrix metalloproteinases in neural development:a phylogenetically diverse perspective

The matrix metalloproteinases（MMPs） are a family of zinc-dependent endopeptidases originally characterized as secreted proteases responsible for degrading extracellular matrix proteins.Their canonical role in matrix remodelling is of significant importance in neural development and regeneration,but emerging roles for MMPs,especially in signal transduction pathways,are also of obvious importance in a neural context.Misregulation of MMP activity is a hallmark of many neuropathologies,and members of every branch of the MMP family have been implicated in aspects of neural development and disease.However,while extraordinary research efforts have been made to elucidate the molecular mechanisms involving MMPs,methodological constraints and complexities of the research models have impeded progress.Here we discuss the current state of our understanding of the roles of MMPs in neural development using recent examples and advocate a phylogenetically diverse approach to MMP research as a means to both circumvent the challenges associated with specific model organisms,and to provide a broader evolutionary context from which to synthesize an understanding of the underlying biology.

Development of quality function development matrix to measure the quality management performance of contractor

Quality function development (QFD) matrix was introduced as a tool to measure the quality management performance of contractors. Engineering quality, quality management system components, and their relationship were defined. An integrated engineering quality system was decomposed into seven factors and the quality management system was composed of eight factors. Importance weights of all factors and their relationship point were acquired by questionnaires and interviews. Then, QFD matrix was formulated and the calculating process was proposed. This model was verified on a case study. The result shows that it is useful for contractor in benchmarking themselves and invaluable for owners in the process of deciding contractor.

Analyzing the role of extracellular matrix during nervous system development to advance new regenerative strategies

Regeneration in the central nervous system （CNS） is limited, and CNS damage often leads to cognitive impairment or permanent functional motor and sensory loss. Impaired regenerative capacity is multifactorial and includes inflammation, loss of the blood-brain barrier, and alteration in the extracellular matrix （ECM）. One of the main problems is the formation of a glial scar and the production of inhibitory ECM, such as proteoglycans, that generates a physical and mechanical barrier, impeding axonal regrowth （Figure 1A）.

Three Types of Spatial Function Zoning in Key Ecological Function Areas Based on Ecological and Economic Coordinated Development: A Case Study of Tacheng Basin, China

Three types of spatial function zoning is an effective measure for regional environmental protection and orderly development.For ecological and economic coordinated development, spatial function zones should be divided scientifically to clear its direction of development and protection. Therefore, based on ecological constraints, a beneficial discussion would be about the key ecological function areas adopting the concept of ecological protection restriction and supporting socioeconomic development for spatial function zoning. In this paper, the researchers, taking Tacheng Basin, Xinjiang of China as an example, choose township as basic research unit and set up an evaluation index system from three aspects, namely, ecological protection suitability, agricultural production suitability, and urban development suitability, which are analyzed by using spatial analysis functions and exclusive matrix method. The results showed that: 1) This paper formed a set of multilevel evaluation index systems for three types of spatial function zoning of the key ecological function areas based on a novel perspective by scientifically dividing Tacheng Basin into ecological space, agricultural space, and urban space,which realized the integration and scientific orientation for spatial function at the township scale. 2) Under the guidance of three types of spatial pattern, the functional orientation and suggestions of development and protection was clearly defined for ecological protection zones,ecological economic zones, agricultural production zones, and urban development zones. 3) A new idea of space governance is provided to promote the coordinated and sustainable development between ecology and economy, which can break the traditional mode of thinking about regional economic development, and offers a scientific basis and reference for macro decision-making.

Structure, expression, and developmental function of early divergent forms of metalloproteinases in Hydra

Metalloproteinases have a critical role in a broad spectrum of cellular processes ranging from the break-down of extracellulax matrix to the processing of signal transduction-related proteins. These hydrolyticfunctions underlie a variety of mechanisms related to developmental processes as well as disease states.Structural analysis of metalloproteinases from both invertebrate and vertebrate species indicates that theseenzymes are highly conserved and arose early during metazoan evolution. In this regard, studies from vari-ous laboratories have reported that a number of classes of metalloproteinases are found in hydra, a memberof Cnidaria, the second oldest of existing animal phyla. These studies demonstrate that the hydra genomecontains at least three classes of metalloproteinases to include members of the 1) astacin class, 2) matrix met-alloproteinase class, and 3) neprilysin class. Functional studies indicate that these metalloproteinases playdiverse and important roles in hydra morphogenesis and cell differentiation as well as specialized functionsin adult polyps. This article will review the structure, expression, and function of these metalloproteinasesin hydra.

Study on DSM-based task planning of product cooperative development

The results of analyzing the managerial characteristics and complexity of product cooperative development suggest that task planning is an important aspect for process management of product cooperative development and the method for planning tasks should be able to model the dependency between tasks and iterations during the development process. In this paper, a DSM-based method and its corresponding optimization algorithms are developed. At first the coupled task sets and uncoupled task sets are identified, and the tasks are then optimized by the corresponding algorithms. The optimal tasks plan will reduce the development time and cost. Considering the practical requirements in real world, a Multilayer DSM is proposed, and its information communication techniques between DSM and traversing principle are described in details.

Role of activin receptor-like kinase 1 in vascular development and cerebrovascular diseases

Activin receptor-like kinase 1(ALK1)is a transmembrane serine/threonine receptor kinase of the transforming growth factor beta(TGFβ)receptor superfamily.ALK1 is specifically expressed in vascular endothelial cells,and its dynamic changes are closely related to the proliferation of endothelial cells,the recruitment of pericytes to blood vessels,and functional differentiation during embryonic vascular development.The pathophysiology of many cerebrovascular diseases is today understood as a disorder of endothelial cell function and an imbalance in the proportion of vascular cells.Indeed,mutations in ALK1 and its co-receptor endoglin are major genetic risk factors for vascular arteriovenous malformation.Many studies have shown that ALK1 is closely related to the development of cerebral aneurysms,arteriovenous malformations,and cerebral atherosclerosis.In this review,we describe the various roles of ALK1 in the regulation of angiogenesis and in the maintenance of cerebral vascular homeostasis,and we discuss its relationship to functional dysregulation in cerebrovascular diseases.This review should provide new perspectives for basic research on cerebrovascular diseases and offer more effective targets and strategies for clinical diagnosis,treatment,and prevention.

Structure,expression,and developmental function of early divergent forms of metalloproteinases in Hydra

Metalloproteinases have a critical role in a broad spectrum of cellular processesranging from the break-down of extracellular matrix to the processing of signaltransduction-related proteins.These hydrolytic functions underlie a variety of mechanisms related to developmental processes as well as disease states.Structural analysis of metalloproteinases from both invertebrate and vertebrate species indicates that these enzymes are highly conserved and arose early during metazoan evolution.In this regard,studies from vari-ous laboratories have reported that a number of classes of metalloproteinases are found in hydra,a member of Cnidaria,the second oldest of existing animal phyla.These studies demonstrate that the hydra genome contains at least three classes of metalloproteinases to include members of the 1)astacin class,2)matrix met-alloproteinase class,and 3)neprilysin class.Functional studies indicate that these metalloproteinases play diverse and important roles in hydra morphogenesis and cell differentiation as well as specialized functions in adult polyps.This article will review the structure,expression,and function of these metalloproteinases in hydra.

Financial development during COVID‑19 pandemic:the role of coronavirus testing and functional labs

The outbreak of the SARS-CoV-2 virus in early 2020,known as COVID-19,spread to more than 200 countries and negatively affected the global economic output.Financial activities were primarily depressed,and investors were reluctant to start new financial investments while ongoing projects further declined due to the global lockdown to curb the disease.This study analyzes the money supply reaction to the COVID-19 pandemic using a cross-sectional panel of 115 countries.The study used robust least square regression and innovation accounting techniques to get sound parameter estimates.The results show that COVID-19 infected cases are the main contributing factor that obstructs financial activities and decrease money supply.In contrast,an increasing number of recovered cases and COVID-19 testing capabilities gave investors confidence to increase stock trade across countries.The overall forecast trend shows that COVID-19 infected cases and recovered cases followed the U-shaped trend,while COVID-19 critical cases and reported deaths showed a decreasing trend.Finally,the money supply and testing capacity show a positive trend over a period.The study concludes that financial development can be expanded by increasing the testing capacity and functional labs to identify suspected coronavirus cases globally.

Research and Implementation of Task Management Model in Product Development Process Management

The implementation of product development process management (PDPM) is an effective means of developing products with higher quality in shorter lead time. It is argued in this paper that product, data, person and activity are basic factors in PDPM With detailed analysis of these basic factors and their relations in product developmed process, all product development activities are considered as tasks and the management of product development process is regarded as the management of task execution A task decomposition based product development model is proposed with methods of constructing task relation matrix from layer model and constraint model resulted from task decomposition. An algorithm for constructing directed task graph is given and is used in the management of tasks. Finally, the usage and limitation of the proposed PDPM model is given with further work proposed.

基于Delphi法的三级医院手术室护理信息化建设发展的SWOT分析及对策研究

采用SWOT分析法探索医院手术室护理信息化建设持续发展策略,明确三级医院手术室当前信息化建设发展的优势和劣势因素,以及持续发展过程所带来的机会和威胁等,根据SWOT分析矩阵形成持续发展的具体策略。三级医院建设发展应以持续创新理念为指导,提升手术室护理服务质量,注重多学科之间团队协作,通过有效数据资料提取分析,以提升手术运营效率和患者安全为重点,实现信息化建设高质量发展。

Matrix VB插件在VB编程中的应用

介绍了利用 Matrix VB插件实现从 VB中调用 MATL AB函数的具体方法 ,利用该方法 ,可大大提高VB程序的计算和绘图能力 ,增强用户开发人机界面友好的计算程序的能力 ,举出了一个利用 Matrix VB开发的射弹侵彻混凝土深度计算系统 ,可方便地绘出射弹侵彻过程中各种参数的变化关系。

Matrix metalloproteinase 2 degrades collagen I to regulate ovarian development by association with an insulin-like peptide

The ovary generally undergoes tissue remodeling during larval to pupal transition,which includes membrane degeneration and ovariole growth.At the same time,the hormones produced by insects significantly change during metamorphosis.However,the regulatory mechanism for ovarian development and hormones is not fully understood in insects.Herein,we found that matrix metalloproteinase 2(MMP2)was highly expressed in the ovarian capsules and ovarioles,and the development was abnormal after knocking out MMP2 in Bombyx mori.The process of abnormal degradation of collagen I due to MMP2 deletion,which resulted in abnormal development of ovarioles and eggs,was analyzed in detail.The proteomics of ovaries in the MMP2-knock out and wild type strains showed a critically significant difference in the expression of a protein,insulin-like peptide(ILP).Additional analysis revealed significant alteration of ILP during ovarian development,and abnormal expression of ILP significantly affected ovarian development in vivo and MMP2 expression in vitro and in vivo.These results showed that MMP2 regulation of ovarian tissue remodeling is closely related to ILP expression.Our study provides new insights into the regulatory mechanism of MMP2 and ovarian development in B.mori.

基于AHP和Matrix的开发园区用地评判与产业挂钩对策——兼以滁州市域13个省级及以上开发区实证

中国开发园区建设正处于快速推进阶段,但同时存在空间开发秩序混乱,土地利用粗放、土地生态环境降低等问题,制约园区扩区升级及未来产业发展。在此,综合运用AHP、多因子加权分析法及Matrix互斥矩阵等模型算法,以滁州市域13个省级及以上开发园区为实证,分维评价各开发园的适宜性与集约性,综合评价并划分为挖潜开发型、限制开发型、拓展开发型、重点开发型、过渡开发型等5种开发类型,分区提出土地利用空间开发策略及产业布局发展对策,为开发园区未来制定土地利用与产业发展政策提供参考。

Extracellular matrix and biomimetic engineering microenvironment for neuronal differentiation

Extracellular matrix(ECM)influences cell differentiation through its structural and biochemical properties.In nervous system,neuronal behavior is influenced by these ECMs structures which are present in a meshwork,fibrous,or tubular forms encompassing specific molecular compositions.In addition to contact guidance,ECM composition and structures also exert its effect on neuronal differentiation.This short report reviewed the native ECM structure and composition in central nervous system and peripheral nervous system,and their impact on neural regeneration and neuronal differentiation.Using topographies,stem cells have been differentiated to neurons.Further,focussing on engineered biomimicking topographies,we highlighted the role of anisotropic topographies in stem cell differentiation to neurons and its recent temporal application for efficient neuronal differentiation.

Three-dimensional aspects of formulation excipients in drug discovery:a critical assessment on orphan excipients,matrix effects and drug interactions

Formulation/pharmaceutical excipients play a major role in formulating drug candidates,with the objectives of ease of administration,targeted delivery and complete availability.Many excipients used in pharmaceutical formulations are orphanized in preclinical drug discovery.These orphan excipients could enhance formulatability of highly lipophilic compounds.Additionally,they are safe in preclinical species when used below the LD50 values.However,when the excipients are used in formulating compounds with diverse physico-chemical properties,they pose challenges by modulating study results through their bioanalytical matrix effects.Excipients invariably present in study samples and not in the calibration curve standards cause over-/under-estimation of exposures.Thus,the mechanism by which excipients cause matrix effects and strategies to nullify these effects needs to be revisited.Furthermore,formulation excipients cause drug interactions by moderating the pathways of drug metabolizing enzymes and drug transport proteins.Although it is not possible to get rid of excipient driven interactions,it is always advised to be aware of these interactions and apply the knowledge to draw meaningful conclusions from study results.In this review,we will comprehensively discuss a)orphan excipients that have wider applications in preclinical formulations,b)bioanalytical matrix effects and possible approaches to mitigating these effects,and c)excipient driven drug interactions and strategies to alleviate the impacts of drug interactions.

远距离风电分频送出方式及大功率变频装置的研发

分频输电作为一种新型输电方式,在风电远距离送出场景下极具优势。为了给远距离风电经分频输电系统送出场景下的关键变频设备——模块化多电平矩阵式换流器(modular multilevel matrix converter,M3C)在工程上的实机研制与生产运行提供参考,首先介绍了分频输电的特性、风电经分频输电送出的系统方案与拓扑以及分频输电系统的关键变频设备。在此基础上,研制了分频输电系统中工/分频能量变换的关键设备——35 kV/3 MVA M3C变频器,并进行了性能试验。试验结果表明:分频变频器工程样机满载情况下的效率、模块电压不均衡度、电压/电流谐波畸变率、分频侧频率调节偏差以及功率阶跃响应时间等关键性能指标均符合设计要求。最后对分频输电系统的发展前景以及效益进行了分析,同时也指出了目前分频输电系统发展所面临的技术挑战。

柠条复配基质对设施茄子生长发育的影响

以设施茄子为试材,将柠条发酵料、草炭、蛭石、珍珠岩按照一定比例配制复配基质,采用不同基质栽培条件下设施茄子生长比较分析法,研究不同基质的理化性质对设施茄子的生长指标、生理指标的影响,筛选最佳的柠条复配基质配比,以期为植物废弃资源开发提供参考依据。结果表明:当发酵料与蛭石比例为3∶1、2∶2或1∶3时不利于植物的生长,综合表现最差;当发酵料与珍珠岩比例为1∶3或3∶1时,不利于株高、茎粗叶片数的增加,比例为2∶2植物的干物质积累量和抗性较差。当发酵料与草炭的比例为1∶3或3∶1时最有利于茄子株高、茎粗、叶片数、地上和地下部分干鲜质量的积累,茄子的叶绿素和根系活力也较高,抗性为最强。

桥梁工程中的纤维增强树脂基复合材料应用进展

为满足恶劣环境条件下现代化桥梁工程高质量建造所需材料的力学性能、耐腐蚀性及耐疲劳性等要求,基于纤维增强树脂基复合材料的优异性能,从公路桥、观赏桥、梁式桥以及超大跨度悬索桥等不同工况要求下的桥梁建设出发,总结了纤维增强树脂基复合材料的发展与应用现状。指出纤维增强树脂基复合材料在桥梁工程应用中仍存在应力损失、受风力影响大及回收处理难等弊端,并提出了主要的解决思路。