A Brief Discussion on the Development of the Silk-Weaving Industry Along the “Southern Silk Road” in Yunnan

Ancient Yunnan was one of the most significant regions along China’s ancient“Southern Silk Road.”During the Nanzhao period(738–902)of the late Tang Dynasty,Yunnan’s silk-weaving industry underwent a qualitative leap as skilled silk craftsmen from the Bashu area migrated to Yunnan and introduced mulberry planting,silkworm breeding,and advanced silk-weaving techniques from Sichuan to the region.Consequently,people in Yunnan gradually acquired expertise in brocade weaving and embroidery.Many even mastered complex silk-weaving techniques.The development and progress of the silk-weaving industry in the ancient Yunnan region were intricately linked to the economic function and value of silk as both a commodity and currency along the“Southern Silk Road.”The local government in ancient Yunnan was greatly motivated by the economic interests brought by the development of silk-related industries and recognized the significance of developing the local silk industry.They even initiated a campaign to capture skilled silk craftsmen from Sichuan,aiming to foster the growth of the silk-weaving industry in Yunnan.After years of dedicated efforts from the local government in ancient Yunnan,the region emerged as a significant hub for silk production along China’s ancient“Southern Silk Road.”Despite the devastation caused by the wars in other parts of the country,Yunnan’s silk industry continued to thrive and provide ample silk products to sustain trade along this renowned route.In the contemporary era,amidst the decline of the silk-weaving industry in eastern China,Yunnan has proposed an industrial development strategy known as“relocating the silk-weaving industry from east to west.”This involves introducing advanced silk production techniques from the eastern regions into Yunnan to enhance and enrich its local silk industry,thereby establishing it as a traditional national sector and securing a competitive position within the global silk market.The historical experience of Yunnan’s silk industry demonstrated that economic development opportunities can only be seized through proactive endeavors rather than passive anticipation.The modern Yunnan silk industry,which upholds its historical traditions,continues to actively engage in international high-end technical cooperation,thus ensuring the enduring vitality of the ancient“Southern Silk Road.”

Research on the Communication and Development of Heilongjiang Cultural and Creative Industry under the Background of“Belt and Road”

This paper focuses on the research on the dissemination and development of cultural and creative industries in Heilongjiang Province under the background of“Belt and Road.”Firstly,the paper analyzes the main characteristics of cultural and creative industries in Heilongjiang Province and then puts forward the leading advantages of the government to promote the development of cultural and creative industries.The government gives full play to its regional advantages and creates Longjiang cultural products,while also accelerating regional industrial cooperation and innovative cultural communication forms.In-depth discussion is made on integrating scientific and technological means of the times and strengthening the cultivation of innovative talents.The government optimizes the communication and development path of the Heilongjiang cultural entrepreneurship industry and brings positive influence to the stable development of the Heilongjiang region in the future.

On the Road To Development

Uganda’s President Yoweri Museveni has lamented that his country’s bad roads get easily damaged by heavy rains,while also expressing his confidence in the new roads recently built by Chinese construction companies.

New aspects of a small GTPase RAB35 in brain development and function

In eukaryotic cells,organelles in the secretory,lysosomal,and endocytic pathways actively exchange biological materials with each other through intracellular membrane trafficking,which is the process of transporting the cargo of proteins,lipids,and other molecules to appropriate compartments via transport vesicles or intermediates.These processes are strictly regulated by various small GTPases such as the RAS-like in rat brain(RAB)protein family,which is the largest subfamily of the RAS superfamily.Dysfunction of membrane trafficking affects tissue homeostasis and leads to a wide range of diseases,including neurological disorders and neurodegenerative diseases.Therefore,it is important to understand the physiological and pathological roles of RAB proteins in brain function.RAB35,a member of the RAB family,is an evolutionarily conserved protein in metazoans.A wide range of studies using cultured mammalian cells and model organisms have revealed that RAB35 mediates various processes such as cytokinesis,endocytic recycling,actin bundling,and cell migration.RAB35 is also involved in neurite outgrowth and turnover of synaptic vesicles.We generated brain-specific Rab35 knockout mice to study the physiological roles of RAB35 in brain development and function.These mice exhibited defects in anxiety-related behaviors and spatial memory.Strikingly,RAB35 is required for the precise positioning of pyramidal neurons during hippocampal development,and thereby for normal hippocampal lamination.In contrast,layer formation in the cerebral cortex occurred superficially,even in the absence of RAB35,suggesting a predominant role for RAB35 in hippocampal development rather than in cerebral cortex development.Recent studies have suggested an association between RAB35 and neurodegenerative diseases,including Parkinson's disease and Alzheimer's disease.In this review,we provide an overview of the current understanding of subcellular functions of RAB35.We also provide insights into the physiological role of RAB35 in mammalian brain development and function,and discuss the involvement of RAB35 dysfunction in neurodegenerative diseases.

Comparison of the Development of CDMO at Home and Abroad and Its Enlightment to China

Objective To analyze the development status of contract development manufacturing organization(CDMO)at home and abroad,and to make some suggestions for the development of CDMO in China.Methods The relevant literature was searched and reviewed,and the development status of CDMOs in the United States,France,Japan and China was compared from the aspects of market scale,development process,development focus,advantages and disadvantages,and policy support.Then,some suggestions for the development of CDMO enterprises in China were summarized.Results and Conclusion Through the comparison of CDMO development at home and abroad,it can be seen that China started CDMO late,there were many technical barriers and its globalization layout were not sufficient.However,the development trend was good and it focused on the field of chemical drugs and biological drugs to constantly develop innovative drugs.China needs to continuously improve its own technical capabilities to carry out innovative research.Therefore,cost reduction and efficiency increase will be the key elements for the development of CDMOs,and they are expected to have a rapid and comprehensive development in the future.

Establishment of human cerebral organoid systems to model early neural development and assess the central neurotoxicity of environmental toxins

Human brain development is a complex process,and animal models often have significant limitations.To address this,researchers have developed pluripotent stem cell-derived three-dimensional structures,known as brain-like organoids,to more accurately model early human brain development and disease.To enable more consistent and intuitive reproduction of early brain development,in this study,we incorporated forebrain organoid culture technology into the traditional unguided method of brain organoid culture.This involved embedding organoids in matrigel for only 7 days during the rapid expansion phase of the neural epithelium and then removing them from the matrigel for further cultivation,resulting in a new type of human brain organoid system.This cerebral organoid system replicated the temporospatial characteristics of early human brain development,including neuroepithelium derivation,neural progenitor cell production and maintenance,neuron differentiation and migration,and cortical layer patterning and formation,providing more consistent and reproducible organoids for developmental modeling and toxicology testing.As a proof of concept,we applied the heavy metal cadmium to this newly improved organoid system to test whether it could be used to evaluate the neurotoxicity of environmental toxins.Brain organoids exposed to cadmium for 7 or 14 days manifested severe damage and abnormalities in their neurodevelopmental patterns,including bursts of cortical cell death and premature differentiation.Cadmium exposure caused progressive depletion of neural progenitor cells and loss of organoid integrity,accompanied by compensatory cell proliferation at ectopic locations.The convenience,flexibility,and controllability of this newly developed organoid platform make it a powerful and affordable alternative to animal models for use in neurodevelopmental,neurological,and neurotoxicological studies.

Postnatal development of rat retina:a continuous observation and comparison between the organotypic retinal explant model and in vivo development

The organotypic retinal explant culture has been established for more than a decade and offers a range of unique advantages compared with in vivo experiments and cell cultures.However,the lack of systematic and continuous comparison between in vivo retinal development and the organotypic retinal explant culture makes this model controversial in postnatal retinal development studies.Thus,we aimed to verify the feasibility of using this model for postnatal retinal development studies by comparing it with the in vivo retina.In this study,we showed that postnatal retinal explants undergo normal development,and exhibit a consistent structure and timeline with retinas in vivo.Initially,we used SOX2 and PAX6 immunostaining to identify retinal progenitor cells.We then examined cell proliferation and migration by immunostaining with Ki-67 and doublecortin,respectively.Ki-67-and doublecortin-positive cells decreased in both in vivo and explants during postnatal retinogenesis,and exhibited a high degree of similarity in abundance and distribution between groups.Additionally,we used Ceh-10 homeodomain-containing homolog,glutamate-ammonia ligase(glutamine synthetase),neuronal nuclei,and ionized calcium-binding adapter molecule 1 immunostaining to examine the emergence of bipolar cells,Müller glia,mature neurons,and microglia,respectively.The timing and spatial patterns of the emergence of these cell types were remarkably consistent between in vivo and explant retinas.Our study showed that the organotypic retinal explant culture model had a high degree of consistency with the progression of in vivo early postnatal retina development.The findings confirm the accuracy and credibility of this model and support its use for long-term,systematic,and continuous observation.

Spatiotemporal Patterns of Road Network and Road Development Pri-ority in Three Parallel Rivers Region in Yunnan,China:An Evaluation Based on Modified Kernel Distance Estimate

Road network is a critical component of public infrastructure,and the supporting system of social and economic development.Based on a modified kernel density estimate(KDE)algorithm,this study evaluated the road service capacity provided by a road network composed of multi-level roads(i.e.national,provincial,county and rural roads),by taking account of the differences of effect extent and intensity for roads of different levels.Summarized at town scale,the population burden and the annual rural economic income of unit road service capacity were used as the surrogates of social and economic demands for road service.This method was applied to the road network of the Three Parallel River Region,the northwestern Yunnan Province,China to evaluate the development of road network in this region.In results,the total road length of this region in 2005 was 3.70×104km,and the length ratio between national,provincial,county and rural roads was 1∶2∶8∶47.From 1989 to 2005,the regional road service capacity increased by 13.1%,of which the contributions from the national,provincial,county and rural roads were 11.1%,19.4%,22.6%,and 67.8%,respectively,revealing the effect of′All Village Accessible′policy of road development in the mountainous regions in the last decade.The spatial patterns of population burden and economic requirement of unit road service suggested that the areas farther away from the national and provincial roads have higher road development priority(RDP).Based on the modified KDE model and the framework of RDP evaluation,this study provided a useful approach for developing an optimal plan of road development at regional scale.

The Belt and Road Initiative and the 2030 Agenda for Sustainable Development:seeking linkages for global environmental governance

Global environmental cooperation serves as an important part in the Chinese ideal of building a Community with a Shared Future for all Human Beings. The report of 19 th CPC National Congress indicates that China is committed to proactive mitigation under the Paris Agreement and further participating in global environmental governance under the 2030 Agenda for Sustainable Development, and both of which are largely integrated to the Belt and Road Initiative(BRI). BRI are also closely linked with South-South environmental and climate cooperation proposed by China from previous UN summits. Based on shared ideas, intersected agendas, and compatible governance approaches, BRI and the 2030 Agenda for Sustainable Development grow increasingly relevant and they might form synergies based on increasingly interactive relations. In sum,seeking and intensifying the linkages between BRI and 2030 sustainable development goals(SDGs) could address global environmental governance deficits and enhance cooperation among nations.

The road map for green development of Western China

China has made some remarkable achievements in sustainable development,but the constant deterioration of the overall trend of the environment has not yet been effectively curbed.To achieve the goal of sustainable development,we must first ensure coordination and coherence of national development goals in different areas and adhere to green development road.To achieve the objectives related to green development,and to clarify the direction of green development in the next 20years,a road map is needed to guide and coordinate the process.This paper describes the concept of the green development road map,introduces a green development road map for the western region,and further elaborates it The road map clarifies the objectives and guiding principles of green development in the western region,points the areas that deserve more concern and institutional innovation,and builds a green development monitoring and evaluation(M&E)framework.Finally,the paper provides corresponding policy recommendations based on the established road map.

Gradient effect of road transportation on economic development in different geomorphic regions

The economic benefits of transport infrastructure investment have been widely accepted.However,the varying influence of road transport development across vertical space has rarely been discussed.Taking Sichuan province in China as case study area where the landform is diverse and complex,administrative counties were categorized into 4 main types:plain counties,hill counties,mountain counties,and plateau counties.Using statistical data during 2006-2014,theperformanceofeconomic development and transport construction level in the four types of counties are discussed.Subsequently,the heterogeneous effect of each grade road on economy was calculated by local regression model(GWR).The results indicate that plain counties largely surpassed the other geomorphic counties in economic development level,while the gradient gap among them was on the decline.Similarly,distribution of transport infrastructure presented a decreasing trend from the low plain counties to high plateau counties.Regional imbalances were mainly reflected in the County road and Village road.Regarding the changes of regional gaps,National&Provincial roads and County roads were constantly expanding,whereas the disparity of Village road was slowly narrowing over time.Particularly noteworthy was the non-stationary economic influence of traffic factors across vertical gradients.On average,National&Provincial roads generated higher benefits in the high elevation regions than the lowlands.In contrast,County road and Village road were found to be more effective in promoting economic development in plains.With regard to local estimates of traffic factors,coefficients in mountain counties exhibited larger fluctuation ranges than other geomorphic units.The conclusions provide a basis for government decisionmaking in a more reasonable construction arrangement of road facilities and sustainable economic development.

Study of the development road map of China’s renewable energy

Renewable energy (RE) has been attached high attention around the world due to its carbon-free and indigenous production in a sustainable way. China enjoys plenty of renewable energy resources, particularly the wind, solar, hydro- and biomass energy, which could be a sound basis for a large-scale exploitation. This report examines the current status of RE technology and industry, analyzes the challenges of promoting RE in China. In order to pave the way for a long-term development of RE, this paper outlines the basic principles and priorities for individual RE technology. In line with these, the paper puts forward the RE targets and further describes the RE road map by 2020, 2030 and extend to 2050, taking consideration of China’s RE resources, industrial basis and energy demand etc. At last, this paper provides some recommendations to ensure the achievements of the RE targets.

Development and characterization of formulation of dust-suppressant used for stope road in open-pit mines

The components of dust-suppressant were determined based on the analysis on characteristics and mechanisms of road dust raising in open-pit mines. The components were initially selected from moisture agent, coagulation agent and surfactant. The optimal formulation was determined based on orthogonal test and using the water loss rate as the evaluation index. The performances of moisture releasing and adsorption, wind resistance of optimal formulation in the natural environment were tested. The results show that the formula obtained in experiments provide a good performance of moisture absorption and water retention, and it also had a good dust preventing and controlling performance due to its high surface strength and consolidation under dry conditions. It has good application prospects considering the wide variety of sources for materials and the simple preparation process.

Evaluation of the sustainable development level of countries along the Belt and Road and its impact factors:Empirical analysis based on the Super-efficiency slacks-based measure and Tobit measure models

Sustainable development is an important component of the Belt and Road Initiative(BRI)and is of great significance for evaluating the levels of sustainable development of countries along this route(henceforth,BRI countries).Therefore,this study aims to identify the factors that influence the levels of sustainable development of BRI countries in a reasonable and objective manner.Eventually,this study employs the super efficiency slacks-based measure(Super-SBM)model,which considers unexpected outputs to measure the level of sustainable development of BRI countries.The dynamic change and composition of the sustainable development level of these countries are calculated using the global Malmquist-Luenberger index.Furthermore,the Tobit model is used to identify the factors influencing the level of sustainable development of BRI countries in general and in various categories.The empirical results suggest the following points.(a)The overall level of sustainable development of BRI countries is low,whereas those of high-income and middle-and high-income countries are relatively high.(b)The overall sustainable development levels of BRI countries declined to a certain extent in 2008 owing to the effect of the financial crisis,.However,the sustainable development level of other countries,barring low-income countries,has gradually increased since 2011.(c)Since 2008,technological progress has replaced technical efficiency as the main driving force behind the improvement of the sustainable development level of BRI countries.(d)A U-shaped relationship is observed between the economic and sustainable development levels of these countries.(e)The level of science and technology and the proportion of renewable energy consumption can promote the sustainable development of these countries.Moreover,a negative correlation exists between the level of opening to the outside world and that of sustainable development of countries that mainly export resource-based products and are dominated by labor-intensive export industries.Barring low-income countries,the energy structure plays an effective role in improving the level of sustainable development.Finally,the study presents suggestions for China in the process of coping with the sustainable development of relevant countries during its promotion of the BRI.

The"Belt and Road"Initiative:A Chinese Concept for Global Development

China＇s ＂Belt and Road＂ initiative is emerging as the Western-dominated world order is declining. Capitalism has intensified the rich-poor divide and power politics have led to great upheavals. Western values have caused a ＂value dislocation＂ for non-Western countries. The world is calling for new development concepts. The ＂Belt and Road＂ initiative has emerged as an answer. It embodies China＇s ideas on global development. First, it works for the ＂common prosperity＂ of every country, which will ease contradictions between the South and the North. Second, it emphasizes geo-economie integration that will heal the fragmentation of Eurasia. Third, it advocates linkages between people and inclusiveness to create a new kind of civilization. However, many difficulties and challenges lie ahead for the implementation of the ＂Belt and Road＂ initiative.

Alternatives of Strategic Environmental Assessment for Road Traffic Development Planning——Case of Changchun City,China

On analyzing the achievement of the goal in the modem urban road traffic development planning, the alternative of Strategic Environmental Assessment for urban traffic planning should include the basic scheme, the extended scheme and the environmental protection scheme. This study from different perspectives designed the alternatives for Changchun＇s county-level road and urban road system planning, and used the method of System Dynamics to simulate, optimize and analyze those alternatives. Thereafter, some methods including the correlation function method were used to comprehensively assess and rank those alternatives for recommending two best alternatives with the consideration to the indicators, such as the total emission amount of CO, the total emission amount of nitrogen oxides, the noise value, the road construction cost, the fossil oil consumption and the traffic capacity. The result showed that the study would provide substantial supports for decision-makers to make more scientific decisions and promote the sustainable urban traffic in Changchun City.

A Review of the DCP-DN Pavement Design Method for Low Volume Sealed Roads: Development and Applications

Widespread implementation of the DCP-DN design method for low volume roads has been promoted internationally over the past decade or so. The method has progressed from a simple determination of the in situ CBR investigation based on DCP-CBR correlations with respective cover requirements to a more sophisticated method using the DCP penetration data directly and omitting any need to use correlations with the CBR. This paper summarises the development of the method, and some of its advantages and compares the design structures with other recognised and widely implemented designs.

A causation mechanism for coal bursts during roadway development based on the major horizontal stress in coal:Very specific structural geology causing a localised loss of effective coal confinement and Newton’s second law

In 2017,one of the international authorities on coal bursts,Mark Christopher,published a paper entitled"Coal bursts that occur during development:A rock mechanics enigma",in which several relevant technical issues were identified.This paper outlines what is considered to be a credible,first-principles,mechanistic explanation for these three current development coal burst conundrums by reference to early published coal testing work examining the significance of a lack of"constraint"to coal stability and an understanding of how very specific structural geology and other geological features can logically cause this to occur in situ,albeit on a statistically very rare basis.This basic model is examined by reference to published information pertaining to the development coal-burst that occurred at the Austar Coal Mine in New South Wales,Australia,in 2014 and from the Sunnyside District in Utah,the United States.The"cause and effect"model for development of coal bursts presented also offers a meaningful explanation for the statistical improbability for what are nonetheless potentially highly-destructive events,being able to explain the statistical rarity being just as important to the credibility of the model as explaining the local conditions associated with burst events.The model could also form the basis for a robust,riskbased approach utilising a"hierarchy of controls",to the operational management of the development coal burst threat.Specifically,the use of pre-mining predictions for likely burst-prone and non-burstprone areas,the use of the mine layout to avoid or at least minimise mining within burst-prone areas if appropriate,and finally the development of an operational Trigger Action Response Plan(TARP)that reduces the likelihood of inadvertent roadway development into a burst-prone area without suitable safety controls already being in place.

Opportunities of Inner Mongolia's economic development under the background of the “Silk Road Economic Belt”

"The Silk Road Economic Belt" is a great strategic thought, through which China deepens allround reform and opening up, especially in the major move of opening up to the west. Inner Mongolia autonomous region owns the superior geographical position and was closely related to the Silk Road in ancient times. In the new stage, Inner Mongolia autonomous region should seize the opportunity of the development strategy, and strive to develop economic construction under the background of the belt of Prairie Silk Road, and play an important role in the economic belt of the "Prairie Silk Road".

Public Finance Sources and Road Network Development in a Transition Country--Hungary （1990-2018）

This article reviews the history of the Hungarian public road network in the thirty years that has passed since the change of the political and economic regime up to the present from the aspect of financing. In the context of the neighboring countries that today are also members of the European Union, this writing outlines the growth-public finance course that this country, formerly belonging to the Soviet type planned economy mechanism, followed during the past nearly three decades after breaking away from that system. It provides insight into the specific public finance positions determined by the macroeconomic course since 1990 and the opportunities offered by this course for infrastructural developments. In connection with the above, the article outlines the main characteristic features of the social expectations, the financing solutions that could be linked to the various governmental concepts regarding road matters, focusing primarily on motorway development. It shall touch upon the respective starting points and life cycles of those concepts and the role of the EU supports in the developing of the domestic public road system. In light of expenditures, it is illustrating the development by some servicing indicators.