Viruses and autism: A Bi-mutual cause and effect

Autism spectrum disorder(ASD)is a group of heterogeneous,multi-factorial,neurodevelopmental disorders resulting from genetic and environmental factors interplay.Infection is a significant trigger of autism,especially during the critical developmental period.There is a strong interplay between the viral infection as a trigger and a result of ASD.We aim to highlight the mutual relationship between autism and viruses.We performed a thorough literature review and included 158 research in this review.Most of the literature agreed on the possible effects of the viral infection during the critical period of development on the risk of developing autism,especially for specific viral infections such as Rubella,Cytomegalovirus,Herpes Simplex virus,Varicella Zoster Virus,Influenza virus,Zika virus,and severe acute respiratory syndrome coronavirus 2.Viral infection directly infects the brain,triggers immune activation,induces epigenetic changes,and raises the risks of having a child with autism.At the same time,there is some evidence of increased risk of infection,including viral infections in children with autism,due to lots of factors.There is an increased risk of developing autism with a specific viral infection during the early developmental period and an increased risk of viral infections in children with autism.In addition,children with autism are at increased risk of infection,including viruses.Every effort should be made to prevent maternal and early-life infections and reduce the risk of autism.Immune modulation of children with autism should be considered to reduce the risk of infection.

Transcriptome analysis to identify candidate genes related to chlorogenic acid biosynthesis during development of Korla fragrant pear in Xinjiang

Korla fragrant pear(KFP)with special fragrance is a unique cultivar in Xinjiang,China.In order to explore the biosynthesis molecular mechanism of chlorogenic acid(CGA)in KFP,the samples at different development periods were collected for transcriptome analysis.High performance liquid chromatography analysis showed that CGA contents of KFP at 88,118 and 163 days after full bloom were(20.96±1.84),(12.01±0.91)and(7.16±0.41)mg/100 g,respectively,and decreased with the fruit development.Pears from these typical 3 periods were selected for de novo transcriptome assemble and 68059 unigenes were assembled from 444037960 clean reads.One‘phenylpropanoid biosynthesis’pathway including 57 unigenes,11 PALs,1 PTAL,64CLs,9 C4Hs,25 HCTs and 5 C3’Hs related to CGA biosynthesis was determined.It was found that the expression levels of 11 differentially expressed genes including 1 PAL,2 C4Hs,34CLs and 5 HCTs were consistent with the change of CGA content.Quantitative polymerase chain reaction analysis further showed that 8 unigenes involved in CGA biosynthesis were consistent with the RNA-seq data.These findings will provide a comprehensive understanding and valuable information on the genetic engineering and molecular breeding in KFP.

Agronomic Traits of Transgenic Soybean Overexpressing TaDREB3

Dongnong50 was overexpressing TaDREB3, a stress-tolerance gene, and transgenic progenies with TaDREB3 showing stable heredity characters were obtained in this study. The seeds of T4 generation were sowed on saline land of which salt concentration was 0.19% and pH was 8.43, and agronomic traits including growth period, plant height, numbers of main nodes, branching numbers, pods per plant, numbers of seeds per plant, and weight of 100-seed were collected and comparing to control plants Dongnong50 were made. The impacts of TaDREB3 gene on agronomic traits of soybeans under high concentration of salt were discussed. The results showed that the growth period was not altered in transgenic line with TaDREB3 under high concentration of saline and alkali, the extremely significant or significant increase in the numbers of main nodes, pods per plant and in branching numbers and other agronomic traits in transgenic lines in comparing with non-transgenic lines was an indicator of their resistance to saline-alkali stress

Effects of Low Temperature Treatment on Bolting of Radish(Raphanus sativus L.)

[Objectives]This study was conducted to screen out a vernalization method of radish that is more suitable for breeding and hybrid production.[Methods]Eight radish inbred lines with different bolting tolerance were used as the research objects for the experiment.The following three treatments were done:(1)treating at 4℃in the dark with heat preservation for 1,2,3,4,and 5 weeks,respectively~([1]),(2)treating at 4℃in the dark with heat preservation for 3 weeks after 24 h incubation in light at 20℃,and(3)treating under light at a low temperature of 6.5℃for three weeks after cultivating under light at 20℃to 4 true leaves.The effects of low temperature treatment on the bolting and flowering time of different varieties of radish treated at different developmental stages were analyzed.[Results]When comparing these three methods,the low-temperature treatment of wet seeds had a better effect on early bolting of radish and is simpler and more feasible.The effect of treating four-leaf seedlings at 6.5℃was the worst;most radish inbred lines could shorten bolting time when treated at 4℃for one week;and within a certain range,the longer the 4℃treatment time,the better the vernalization effect.Different radish inbred lines had different performances to low temperature treatment.[Conclusions]This study provides a scientific basis for the theoretical research on vernalization of radish.

A STUDY ON ENVIRONMENTAL EVOLUTION OF BEIJING-TIANJIN-TANGSHAN REGION FROM JIN DYNASTY TO THE REPUBLIC OF CHINA (A.D. 1153-1949)

Studies of the law and characteristics of population and land-use development of the Bejing-Tianjin-Tangshen region from 1153-1949 indicated that the land development process in the region is closely related with population change of the corresponding period In Jin Dynasty, population increased rapidly, in Yuan and Ming dynasties, population increased with a sustainability while from Qing Dynasty to the founding of the Republic, population increased substatially.Wasteland reclamation and cereals cultivation by garrison and farmers appeared in Jin Dyasty and reached climax in Ming Dynasty. Correlation analysis of poulation increase and cultivated area showed that they follow a linear equation which means that population increase and cultivated area expansion were at a similar rate.

Western China Development During 13th Five-Year Plan Period:Poverty Alleviation and Green Development

The 12th Annual Conference of the Consortium for Western China Development Studies July,2017Gui-An New District,CHINABackground Since its establishment in 2004,the Consortium for Western China Development Studies(CWCDS)has organized nine conferences on vari-

China's Biotechnology Development Program during the Tenth Five-Year Plan Period (2001-2005)

Bioengineering TechnoIogy(Ⅰ)1. Crop molecular marker-assisted selection and pyramiding breeding technology2. Super hybrid

Development of China's Food Industry——Focal Points For China's Food Industry Development During the Ninth Five-Year Plan Period

1.Products of the basic rawmaterials industry Products of the basic raw materialsindustry should improve product quality,make great efforts to realize diversification,serialization and specialization in productvariety,develop new varieties,and expandproduction so as to adapt to the demands forthe development of the food industry. Cereals:Develop high quality riceand wheat flour on a grade and class basis;develop special rice and wheat flour suitablefor the needs of processing various kinds offood;actively utilize coarse cereals such ascorn to open up various kinds of

CHINA'S NON-FERROUS METALS INDUSTRY——Its Development Policies and Goals During the Ninth Five-year Plan Period

The China Non-ferrous MetalsIndustry Corporation has putforward ten development policiesfor the Ninth Five-year Plan period,according to the central government’sinstruction to change the way of economicgrowth,and raise the integral quality andbenefit of the national economy:

Establishment of an internationally recognized platform for the communication of pharmaceutical researches supported by the National New Drug Innovation Programs ——Experiences and goals of the Journal of Chinese Pharmaceutical Sciences

The initiation of the National New Drug Innovation Key Technology Program marked a strategic shift of new drug discovery in China, which will greatly enhance the new drug discovery research activities. It presents a valuable opportunity for the growth and quality advancement of pharmaceutical science journals. As the only comprehensive English journal of the Chinese Pharmaceutical Association, In the new situation, Journal of Chinese Pharmaceutical Sciences （JCPS） plays a critical role in the communication of new discoveries in pharmaceutical researches to the scientific community. To fulfill the roles as an internationally recognized platform for the communication of the new drug discoveries supported by the National New Drug Innovation Programs, the JCPS editorial office will take advantage of its English language specialty, emphasize quality and digital access, and promote the advancement of the journal.

Analyses and architectural typology of preserved traditional mosques in the old city of Herat in Afghanistan:the case of Quzzat Quarter

The study aims to analyse the architectural typology and determine the period of construction for the preserved traditional mosques of the Quzzat Quarter in the Old City of Herat(known as the Pearl of Khorasan).Twenty-nine mosques are located in the area,three of which are modern and 26 are traditional.Twelve out of the 26 traditional mosques still exist and have preserved their traditional landscape.Using analogy to analyse water cisterns and mosques,we determine when each mosque was developed and establish the period of development for each structure.Further analyses are carried out on the edifces’architectural details.Architectural analyses and mosque typologies suggest that fve buildings were built before the Timurid dynasty;two were built during the Timurid dynasty(1370−1507 CE);and one was built after the Timurid dynasty.Two mosques incorporating elements from diferent periods are counted as exceptions,and the remaining two are considered to have been built during transitional periods.

The Period of Strategic Opportunities for China’s Development after the U.S. Eastward Shift of Its Strategic Focus

The period of strategic opportunities for China’s development, in terms of international environment, means the environment, opportunities, conditions and the time limits provided by the period of strategic opportunities. Since the U.S. eastward shift of its strategic focus, the changing China-U.S. relations and major powers games will exert tremendous impacts on the period of strategic opportunities and lead to three new characteristics featuring a more complicated and changeable strategic posture, controllable crisis management and universal values.