Redox balance is fundamentally important for physiological homeostasis. Pathological factors that disturb this dedicated balance may result in oxidative stress, leading to the development or aggravation of a variety o...Redox balance is fundamentally important for physiological homeostasis. Pathological factors that disturb this dedicated balance may result in oxidative stress, leading to the development or aggravation of a variety of diseases, including diabetes mellitus, cardiovascular diseases, metabolic syndrome as well as inflammation, aging and cancer. Thus, the capacity of endogenous free radical clearance can be of patho-physiological importance; in this regard, the major reactive oxygen species defense machinery, the nuclear factor (erythroid-derived 2)-like 2 (Nrf2) system needs to be precisely modulated in response to pathological alterations. While oxidative stress is among the early events that lead to the development of insulin resistance, the activation of Nrf2 scavenging capacity leads to insulin sensitization. Furthermore, Nrf2 is evidently involved in regulating lipid metabolism. Here we summarize recent findings that link the Nrf2 system to metabolic homeostasis and insulin action and present our view that Nrf2 may serve as a novel drug target for diabetes and its complications.展开更多
Objective.To identify the A3243G mutation of mi tochondrial(mt )DNA in patients with latent autoimmu ne diabetes mellitus in adults(LADA)of Han nationality in the northeast a rea of China.Methods.Seventy-nine diabetic...Objective.To identify the A3243G mutation of mi tochondrial(mt )DNA in patients with latent autoimmu ne diabetes mellitus in adults(LADA)of Han nationality in the northeast a rea of China.Methods.Seventy-nine diabetics of Han natio nality,whose families have resided in the northeast area of China for more than 3generations,we re divided into 3groups:Group 1(22cases of type 2diabetes with mater-nal inheritance history),Group 2(34cases of LADA),Group 3(23cases of type 1diabetes in adolesc ents).The A3243G of mt DNA was detected in th ese 79subjects with the method of PCR-RFLP.Results.None of the 79diabetics studied was p ositively identified for the A3243G mutation of mt DNA.Conclusion.The A3243G mutation of mt DNA might not be related to the onset of LADA in dia betic popula-tion of Han nationality in northeast area of China and there might not be close relationship between A3243G mut a-tion of mt DNA and autoimmunity.展开更多
目的:探讨胰岛素、血糖、C肽(C-peptide,CP)联合检测对糖尿病合并肝脏损害的早期诊断价值.方法:将滨州医学院附属医院收治的61例糖尿病合并肝脏损害患者作为研究组,同时选取55例糖尿病肝功能正常患者和50例健康人群分别作为对照组和正常...目的:探讨胰岛素、血糖、C肽(C-peptide,CP)联合检测对糖尿病合并肝脏损害的早期诊断价值.方法:将滨州医学院附属医院收治的61例糖尿病合并肝脏损害患者作为研究组,同时选取55例糖尿病肝功能正常患者和50例健康人群分别作为对照组和正常组;比较3组血糖、胰岛素和CP水平.结果:研究组和对照组空腹血糖、餐后血糖水平均显著高于正常组(t=2.317,2.918,P<0.0 5),其中研究组空腹血糖(f a s t i n g blood-glucose,FBG)、餐后2 h血糖(2 hour postprandial blood glucose,2 h PBG)水平又显著高于对照组(t=3.084,4.431,P<0.05);研究组和对照组空腹胰岛素(fasting insulin,FINS)、餐后胰岛素(2 hour postprandial fasting insulin,P2INS)、空腹CP(fasting C peptide,CP)、餐后CP(2 hour postprandial fasting C peptide,P2CP)、胰岛素抵抗指数(insulin resistance index,HOMA-IR)水平均显著高于正常组(t=2.276,3.426,5.317,3.342,P<0.05);其中研究组各指标水平又显著高于对照组,两组间相比差异具有统计学意义(t=6.436,3.341,2.195,3.341,3.426,5.317,3.342,P<0.05).糖尿病合并肝脏损伤患者血糖水平与胰岛素、CP相关性呈正相关关系(r=0.589,0.724,P<0.05);3项联合检测能够显著提高诊断的敏感性和特异性分别为87.1%和94.8%,较单项检测显著提高.结论:胰岛素、血糖、CP联合检测可以作为糖尿病合并肝脏损害的早期诊断指标之一.展开更多
基金Supported by An operating grant from Canadian Institutes of Health Research,No.89887 to Jin TRa NSFC grant,No.81072300 to Jin TR and Yu ZWa NSFC grant,No.30730079 to Ling WH in part
文摘Redox balance is fundamentally important for physiological homeostasis. Pathological factors that disturb this dedicated balance may result in oxidative stress, leading to the development or aggravation of a variety of diseases, including diabetes mellitus, cardiovascular diseases, metabolic syndrome as well as inflammation, aging and cancer. Thus, the capacity of endogenous free radical clearance can be of patho-physiological importance; in this regard, the major reactive oxygen species defense machinery, the nuclear factor (erythroid-derived 2)-like 2 (Nrf2) system needs to be precisely modulated in response to pathological alterations. While oxidative stress is among the early events that lead to the development of insulin resistance, the activation of Nrf2 scavenging capacity leads to insulin sensitization. Furthermore, Nrf2 is evidently involved in regulating lipid metabolism. Here we summarize recent findings that link the Nrf2 system to metabolic homeostasis and insulin action and present our view that Nrf2 may serve as a novel drug target for diabetes and its complications.
文摘Objective.To identify the A3243G mutation of mi tochondrial(mt )DNA in patients with latent autoimmu ne diabetes mellitus in adults(LADA)of Han nationality in the northeast a rea of China.Methods.Seventy-nine diabetics of Han natio nality,whose families have resided in the northeast area of China for more than 3generations,we re divided into 3groups:Group 1(22cases of type 2diabetes with mater-nal inheritance history),Group 2(34cases of LADA),Group 3(23cases of type 1diabetes in adolesc ents).The A3243G of mt DNA was detected in th ese 79subjects with the method of PCR-RFLP.Results.None of the 79diabetics studied was p ositively identified for the A3243G mutation of mt DNA.Conclusion.The A3243G mutation of mt DNA might not be related to the onset of LADA in dia betic popula-tion of Han nationality in northeast area of China and there might not be close relationship between A3243G mut a-tion of mt DNA and autoimmunity.
文摘目的:探讨胰岛素、血糖、C肽(C-peptide,CP)联合检测对糖尿病合并肝脏损害的早期诊断价值.方法:将滨州医学院附属医院收治的61例糖尿病合并肝脏损害患者作为研究组,同时选取55例糖尿病肝功能正常患者和50例健康人群分别作为对照组和正常组;比较3组血糖、胰岛素和CP水平.结果:研究组和对照组空腹血糖、餐后血糖水平均显著高于正常组(t=2.317,2.918,P<0.0 5),其中研究组空腹血糖(f a s t i n g blood-glucose,FBG)、餐后2 h血糖(2 hour postprandial blood glucose,2 h PBG)水平又显著高于对照组(t=3.084,4.431,P<0.05);研究组和对照组空腹胰岛素(fasting insulin,FINS)、餐后胰岛素(2 hour postprandial fasting insulin,P2INS)、空腹CP(fasting C peptide,CP)、餐后CP(2 hour postprandial fasting C peptide,P2CP)、胰岛素抵抗指数(insulin resistance index,HOMA-IR)水平均显著高于正常组(t=2.276,3.426,5.317,3.342,P<0.05);其中研究组各指标水平又显著高于对照组,两组间相比差异具有统计学意义(t=6.436,3.341,2.195,3.341,3.426,5.317,3.342,P<0.05).糖尿病合并肝脏损伤患者血糖水平与胰岛素、CP相关性呈正相关关系(r=0.589,0.724,P<0.05);3项联合检测能够显著提高诊断的敏感性和特异性分别为87.1%和94.8%,较单项检测显著提高.结论:胰岛素、血糖、CP联合检测可以作为糖尿病合并肝脏损害的早期诊断指标之一.
