Diagnostic Accuracy of Computerized Bowel Sound Analysis with Non-Invasive Devices for Irritable Bowel Syndrome:A Systematic Review and Meta-Analysis

Objective To assess the diagnostic accuracy of bowel sound analysis for irritable bowel syndrome(IBS)with a systematic review and meta-analysis.Methods We searched MEDLINE,Embase,the Cochrane Library,Web of Science,and IEEE Xplore databases until September 2023.Cross-sectional and case-control studies on diagnostic accuracy of bowel sound analysis for IBS were identified.We estimated the pooled sensitivity,specificity,positive likelihood ratio,negative likeli-hood ratio,and diagnostic odds ratio with a 95% confidence interval(CI),and plotted a summary receiver operat-ing characteristic curve and evaluated the area under the curve.Results Four studies were included.The pooled diagnostic sensitivity,specificity,positive likelihood ratio,nega-tive likelihood ratio,and diagnostic odds ratio were 0.94(95%CI,0.87‒0.97),0.89(95%CI,0.81‒0.94),8.43(95%CI,4.81‒14.78),0.07(95%CI,0.03‒0.15),and 118.86(95%CI,44.18‒319.75),respectively,with an area under the curve of 0.97(95%CI,0.95‒0.98).Conclusions Computerized bowel sound analysis is a promising tool for IBS.However,limited high-quality data make the results'validity and applicability questionable.There is a need for more diagnostic test accuracy studies and better wearable devices for monitoring and analysis of IBS.

Urea breath test for Helicobacter pylori infection in adult dyspeptic patients: A meta-analysis of diagnostic test accuracy

BACKGROUND Helicobacter pylori(H.pylori)infection has been well-established as a significant risk factor for several gastrointestinal disorders.The urea breath test(UBT)has emerged as a leading non-invasive method for detecting H.pylori.Despite numerous studies confirming its substantial accuracy,the reliability of UBT results is often compromised by inherent limitations.These findings underscore the need for a rigorous statistical synthesis to clarify and reconcile the diagnostic accuracy of the UBT for the diagnosis of H.pylori infection.AIM To determine and compare the diagnostic accuracy of 13C-UBT and 14C-UBT for H.pylori infection in adult patients with dyspepsia.METHODS We conducted an independent search of the PubMed/MEDLINE,EMBASE,and Cochrane Central databases until April 2022.Our search included diagnostic accuracy studies that evaluated at least one of the index tests(^(13)C-UBT or ^(14)C-UBT)against a reference standard.We used the QUADAS-2 tool to assess the methodo-logical quality of the studies.We utilized the bivariate random-effects model to calculate sensitivity,specificity,positive and negative test likelihood ratios(LR+and LR-),as well as the diagnostic odds ratio(DOR),and their 95%confidence intervals.We conducted subgroup analyses based on urea dosing,time after urea administration,and assessment technique.To investigate a possible threshold effect,we conducted Spearman correlation analysis,and we generated summary receiver operating characteristic(SROC)curves to assess heterogeneity.Finally,we visually inspected a funnel plot and used Egger’s test to evaluate publication bias.endorsing both as reliable diagnostic tools in clinical practice.CONCLUSION In summary,our study has demonstrated that ^(13)C-UBT has been found to outperform the ^(14)C-UBT,making it the preferred diagnostic approach.Additionally,our results emphasize the significance of carefully considering urea dosage,assessment timing,and measurement techniques for both tests to enhance diagnostic precision.Nevertheless,it is crucial for researchers and clinicians to evaluate the strengths and limitations of our findings before implementing them in practice.

Advancing healthcare through laboratory on a chip technology:Transforming microorganism identification and diagnostics

In a recent case report in the World Journal of Clinical Cases,emphasized the crucial role of rapidly and accurately identifying pathogens to optimize patient treatment outcomes.Laboratory-on-a-chip(LOC)technology has emerged as a transformative tool in health care,offering rapid,sensitive,and specific identification of microorganisms.This editorial provides a comprehensive overview of LOC technology,highlighting its principles,advantages,applications,challenges,and future directions.Success studies from the field have demonstrated the practical benefits of LOC devices in clinical diagnostics,epidemiology,and food safety.Comparative studies have underscored the superiority of LOC technology over traditional methods,showcasing improvements in speed,accuracy,and portability.The future integration of LOC with biosensors,artificial intelligence,and data analytics promises further innovation and expansion.This call to action emphasizes the importance of continued research,investment,and adoption to realize the full potential of LOC technology in improving healthcare outcomes worldwide.

Diagnostic efficacy of virtual organ computer-assisted analysis in measuring the volume ratio of subchorionic hematoma with serum progesterone

BACKGROUND Subchorionic hematoma(SCH)is a common complication in early pregnancy characterized by the accumulation of blood between the uterine wall and the chorionic membrane.SCH can lead to adverse pregnancy outcomes such as miscarriage,preterm birth,and other complications.Early detection and accurate assessment of SCH are crucial for appropriate management and improved pregnancy outcomes.AIM To evaluate the diagnostic efficacy of virtual organ computer-assisted analysis(VOCAL)in measuring the volume ratio of SCH to gestational sac(GS)combined with serum progesterone on early pregnancy outcomes in patients with SCH.METHODS A total of 153 patients with SCH in their first-trimester pregnancies between 6 and 11 wk were enrolled.All patients were followed up until a gestational age of 20 wk.The parameters of transvaginal two-dimensional ultrasound,including the circumference of SCH(Cs),surface area of SCH(Ss),circumference of GS(Cg),and surface area of GS(Sg),and the parameters of VOCAL with transvaginal three-dimensional ultrasound,including the three-dimensional volume of SCH(3DVs)and GS(3DVg),were recorded.The size of the SCH and its ratio to the GS size(Cs/Cg,Ss/Sg,3DVs/3DVg)were recorded and compared.RESULTS Compared with those in the normal pregnancy group,the adverse pregnancy group had higher Cs/Cg,Ss/Sg,and 3DVs/3DVg ratios(P<0.05).When 3DVs/3DVg was 0.220,the highest predictive performance predicted adverse pregnancy outcomes,resulting in an AUC of 0.767,and the sensitivity,specificity were 70.2%,75%respectively.VOCAL measuring 3DVs/3DVg combined with serum progesterone gave a diagnostic AUC of 0.824 for early pregnancy outcome in SCH patients,with a high sensitivity of 82.1%and a specificity of 72.1%,which showed a significant difference between AUC.CONCLUSION VOCAL-measured 3DVs/3DVg effectively quantifies the severity of SCH,while combined serum progesterone better predicts adverse pregnancy outcomes.

Research status and prospects of the fractal analysis of metal material surfaces and interfaces

As a mathematical analysis method,fractal analysis can be used to quantitatively describe irregular shapes with self-similar or self-affine properties.Fractal analysis has been used to characterize the shapes of metal materials at various scales and dimensions.Conventional methods make it difficult to quantitatively describe the relationship between the regular characteristics and properties of metal material surfaces and interfaces.However,fractal analysis can be used to quantitatively describe the shape characteristics of metal materials and to establish the quantitative relationships between the shape characteristics and various properties of metal materials.From the perspective of two-dimensional planes and three-dimensional curved surfaces,this paper reviews the current research status of the fractal analysis of metal precipitate interfaces,metal grain boundary interfaces,metal-deposited film surfaces,metal fracture surfaces,metal machined surfaces,and metal wear surfaces.The relationship between the fractal dimensions and properties of metal material surfaces and interfaces is summarized.Starting from three perspectives of fractal analysis,namely,research scope,image acquisition methods,and calculation methods,this paper identifies the direction of research on fractal analysis of metal material surfaces and interfaces that need to be developed.It is believed that revealing the deep influence mechanism between the fractal dimensions and properties of metal material surfaces and interfaces will be the key research direction of the fractal analysis of metal materials in the future.

Storage time affects the level and diagnostic efficacy of plasma biomarkers for neurodegenerative diseases

Several promising plasma biomarker proteins,such as amyloid-β(Aβ),tau,neurofilament light chain,and glial fibrillary acidic protein,are widely used for the diagnosis of neurodegenerative diseases.However,little is known about the long-term stability of these biomarker proteins in plasma samples stored at-80°C.We aimed to explore how storage time would affect the diagnostic accuracy of these biomarkers using a large cohort.Plasma samples from 229 cognitively unimpaired individuals,encompassing healthy controls and those experiencing subjective cognitive decline,as well as 99 patients with cognitive impairment,comprising those with mild cognitive impairment and dementia,were acquired from the Sino Longitudinal Study on Cognitive Decline project.These samples were stored at-80°C for up to 6 years before being used in this study.Our results showed that plasma levels of Aβ42,Aβ40,neurofilament light chain,and glial fibrillary acidic protein were not significantly correlated with sample storage time.However,the level of total tau showed a negative correlation with sample storage time.Notably,in individuals without cognitive impairment,plasma levels of total protein and tau phosphorylated protein threonine 181(p-tau181)also showed a negative correlation with sample storage time.This was not observed in individuals with cognitive impairment.Consequently,we speculate that the diagnostic accuracy of plasma p-tau181 and the p-tau181 to total tau ratio may be influenced by sample storage time.Therefore,caution is advised when using these plasma biomarkers for the identification of neurodegenerative diseases,such as Alzheimer's disease.Furthermore,in cohort studies,it is important to consider the impact of storage time on the overall results.

Multilevel analysis of the central-peripheral-target organ pathway:contributing to recovery after peripheral nerve injury

Peripheral nerve injury is a common neurological condition that often leads to severe functional limitations and disabilities.Research on the pathogenesis of peripheral nerve injury has focused on pathological changes at individual injury sites,neglecting multilevel pathological analysis of the overall nervous system and target organs.This has led to restrictions on current therapeutic approaches.In this paper,we first summarize the potential mechanisms of peripheral nerve injury from a holistic perspective,covering the central nervous system,peripheral nervous system,and target organs.After peripheral nerve injury,the cortical plasticity of the brain is altered due to damage to and regeneration of peripheral nerves;changes such as neuronal apoptosis and axonal demyelination occur in the spinal cord.The nerve will undergo axonal regeneration,activation of Schwann cells,inflammatory response,and vascular system regeneration at the injury site.Corresponding damage to target organs can occur,including skeletal muscle atrophy and sensory receptor disruption.We then provide a brief review of the research advances in therapeutic approaches to peripheral nerve injury.The main current treatments are conducted passively and include physical factor rehabilitation,pharmacological treatments,cell-based therapies,and physical exercise.However,most treatments only partially address the problem and cannot complete the systematic recovery of the entire central nervous system-peripheral nervous system-target organ pathway.Therefore,we should further explore multilevel treatment options that produce effective,long-lasting results,perhaps requiring a combination of passive(traditional)and active(novel)treatment methods to stimulate rehabilitation at the central-peripheral-target organ levels to achieve better functional recovery.

Molecular Genetic Diagnostics of Prader-Willi Syndrome:a Validation of Linkage Analysis for the Chinese Population

Prader-Willi Syndrome （PWS） is a genetic disorder that is difficult to detect, particularly at an early age. PWS is caused by disruption of normal, epigenetically controlled gene function in the chromosome 15q11-q13 region. Clinical symptoms are difficult to diagnose in infants and only become clearer at later ages as the patients develop hyperphagia and morbid obesity. Molecular genetic tests are able to definitively diagnose PWS and allow early diagnosis of the syndrome. High resolution cytogenetic testing, methylation-specific PCR （MS-PCR）, and linkage analysis are routinely used to diagnose PWS. To establish a linkage analysis method for Chinese patients, this study identified a useful set of STR markers in the typical PWS deletion and adjacent area, for linkage analysis in two Chinese families with PWS offspring. Using this method, the authors confn＇rned that one patient had a paternal deletion in chromosome 15q 11-q 13 and the other patient had maternal uniparental heterodisomy of chromosome 15. MS -PCR and high resolution chromosome G-banding also confirmed this diagnosis. This linkage analysis method can detect both deletion and uniparental disomy, thus providing valuable information for genetic counseling and the opportunity to analyze the relationship between the genotype and phenotype of PWS.

Diagnostic Analysis on A Hail Storm Occurred in Dalian Area

By using regular meteorological data and Doppler radar data,causes for a hail storm over northern area of Dalian on Oct.13,2009 were analyzed from several aspects,including synoptic background,T-LnP charts and the characteristics of radar reflectivity factor evolution.The results showed that the hail storm occurred in downstream of 500 hPa trough.The 500 hPa cold trough turned zonally and triggered the formation of shear line on lower level.Before the hail event,instability energy and moisture supply were observed.The shear line on lower level intensified the atmospheric instability,promoted the release of potential energy,caused the hail event.The cooperation of upper and lower level jet streams provided favorable dynamic condition for strong convection development.The Doppler radar analysis showed that strong convection was comprised of multiple convection cells,which demonstrated 'L' and 'V' shapes during mature stage,with peak intensity of 50-60 dBz.

Differential Diagnostic Value of Texture Feature Analysis of Magnetic Resonance T2 Weighted Imaging between Glioblastoma and Primary Central Neural System Lymphoma

Objective To investigate the difference in tumor conventional imaging findings and texture features on T2 weighted images between glioblastoma and primary central neural system(CNS) lymphoma. Methods The pre-operative MRI data of 81 patients with glioblastoma and 28 patients with primary CNS lymphoma admitted to the Chinese PLA General Hospital and Hainan Hospital of Chinese PLA General Hospital were retrospectively collected. All patients underwent plain MR imaging and enhanced T1 weighted imaging to visualize imaging features of lesions. Texture analysis of T2 weighted imaging(T2 WI) was performed by use of GLCM texture plugin of ImageJ software, and the texture parameters including Angular Second Moment(ASM), Contrast, Correlation, Inverse Difference Moment(IDM), and Entropy were measured. Independent sample t-test and Mann-Whitney U test were performed for the between-group comparisons, regression model was established by Binary Logistic regression analysis, and receiver operating characteristic(ROC) curve was plotted to compare the diagnostic efficacy. Results The conventional imaging features including cystic and necrosis changes(P = 0.000), ‘Rosette' changes(P = 0.000) and ‘incision sign'(P = 0.000), except ‘flame-like edema'(P = 0.635), presented significantly statistical difference between glioblastoma and primary CNS lymphoma. The texture features, ASM, Contrast, Correlation, IDM and Entropy, showed significant differences between glioblastoma and primary CNS lympoma(P = 0.006,0.000, 0.002, 0.000, and 0.015 respectively). The area under the ROC curve was 0.671, 0.752, 0.695, 0.720 and 0.646 respectively, and the area under the ROC curve was 0.917 for the combined texture variables(Contrast, cystic and necrosis, ‘Rosette' changes, and ‘incision sign') in the model of Logistic regression. Binary Logistic regression analysis demonstrated that cystic and necrosis changes, ‘Rosette' changes and ‘incision sign' and texture Contrast could be considered as the specific texture variables for the differential diagnosis of glioblastoma and primary CNS lymphoma. Conclusion The texture features of T2 WI and conventional imaging findings may be used to distinguish glioblastoma from primary CNS lymphoma.

Diagnostic model construction and example analysis of habitat degradation in enclosed bay: II. spatiotemporal variations in habitat degradation in Sansha Bay

The process of habitat degradation varies in habitat type and driving force which shows certain spatial and temporal heterogeneity on regional scales. In the present study, a new diagnostic model for enclosed bay habitat degradation was established, with which the spatial and temporal variation patterns of habitat degradation during 1991–2012 in Sansha Bay, Fujian, China was investigated. The results show that anthropogenic disturbance is the major controlling factor for the habitat degradation in large temporal heterogeneity in the bay. On the other hand, the habitat degradation experienced signifi cant spatial variations among six sub-bays. Under the joint action of temporal and spatial heterogeneity, the degradation trend in growing scale shows a more signifi cant correlation with the distribution of local leading industries along shorelines. Therefore, we quantifi ed the main characters of habitat degradation in Sansha Bay, and have understood the relationship between the status of habitats spatio-temporal variation value and the main controlling factor leading to the changes. However, a defi ciency of this research is the lack of or inaccessible to the detailed data, which shall be better solved in the future study for accessing more data from more sources.

THE DIAGNOSTIC ANALYSIS OF THE TRACK AND PRECIPITATION OF TYPHOON “RANANIM” AFTER LANDFALL

Over the past few years, landfall and track,intensity, sustaining mechanisms of tropical cyclones （hereafter TCs） and associated weather changes have become heated topics of research, From the viewpoints of energy transformation, moisture transfer, midlatitude baroclinic frontal zones and ambient wind fields, Chen et al.Le et al.and Zeng et al.studied the sustaining mechanism of TCs that have made landfall. Li et al.also pointed out that the intensification of TCs during transition was associated with the disturbance and downward transportation of high-level potential vortexes, low-level frontal zones and low-pressure circulation around TCs, after explaining the difference in TCs transition following the theory of wet potential vortexes. With large-scale diagnostic study of two types of TCs that unexpectedly weaken or enhance just before landfall in southern China, Hu et al.noted that enhancing TCs were usually to the southwest or south of the subtropical high with low levels featured by well-defined southwesterly inflow inside TCs and sufficient supply of water vapor. Liang et al.not only analyzed the changes in convective cloud bands, precipitation, track and temperature and humidity structure in the course of TC Vongfang landfall, but the effect of cold air and Southwest Monsoon on its intensity in particular. As also shown in numerical experiments conducted both at home and abroad and relevant studies,saturated humidity and large-sized bodies of water are favorable for the maintenance and enhancement of landfall TCs circulation. All of the above research achievements not only help broaden the understanding of the patterns by which TCs behave but are positive in improving the forecast of the track, winds and rains after landfall. It is.however, not much addressed in the field or evounon of landfall TCs when they are with special underlying surface and circulation background. TC Rananim （0414） was the most serious typhoon that ever affected Zhejiang province after landfall in the 48 years from 1956 to 2004, which was also the storm that caused heavy rains in the most widespread area in Jiangxi province in the past 20 years. There are two points about Rananim that stand out from the other storms. The first was the sudden westward turning of its track and the second the significant enhancement of precipitation after moving above the Boyang Lake.What kind of mechanism caused such remarkable change in the storm？ With 6-hourly 1×1°NECP global reanalysis data, real-time upper-level observations and TCs location reports by the Central Observatory, the above two points and possible causes are studied in terms large-scale circulation background, underlying surface, cold air and diagnosis of physical quantity fields. New understanding has been made about the behavioral pattern of landfall TCs and related results will offer effective help in operational forecast.

Diagnostic Analysis of Rainstorm and Backward Trajectory Simulation of Water Vapor in Jilin Province in July,2010

[Objective] The research aimed to analyze the rainstorm process and backward trajectory simulation of water vapor condition in Jilin Province in July,2010.[Method] Based on the actual situation data of routine weather chart,NCEP (2.5°×2.5°) reanalysis data per 6 h and GBL data of NOAA,the rainstorm process was carried out the diagnostic analysis of physical quantity in Jilin Province in July,2010.Moreover,HYSPLIT backward trajectory mode was used to simulate the water vapor source.[Result] The coexistence of upper-level divergence and low-level convergence generated the ascending motion,which was the dynamic condition of rainstorm appearance.The unstable energy induced by the low-level shear promoted the generation of heavy rainstorm.The water vapor source of precipitation process was divided into the water vapor in the southern sea area,northern high-altitude water vapor transportation and local water vapor source.[Conclusion] The research provided some reference basis for the forecast and analysis of rainstorm.

DIAGNOSTIC ANALYSIS ON THE DISTRIBUTION OF RAINFALL ASSOCIATED WITH TYPHOON"MOLAVE"(0906)

This work examines the mechanism of rainfall associated with typhoon Molave(0906)in Guangdong province and Guangxi Zhuang Autonamous Region with rainfall observations,radar mosaics from China National Meteorological Center and the final analysis data of National Center of Environmental Prediction(FNL/NCEP,USA).The result shows that the mechanism is different for the rainfall in the these areas.The rainfall in eastern Guangdong is mainly associated with a convective line to the front-right of the typhoon.The convective line is about 200 km away from the typhoon center.The rainfall in western Guangdong and Guangxi appear ahead of or to the left of the typhoon and is very close to the typhoon center.Both rainfall moves forward with the typhoon anticlockwise.It was also found that the rainfall occurred in the boundary between unstable and low-level convergent areas and closer to the convergent area.The unstable area is located in the downstream of rainfall and ahead of the convective line.It is an important factor to the development and convection.Strong frontogenesis is observed in the backward or upstream convective area of rainfall and is thus an important lifting condition for the formation of rainfall.When the low-level convergent area moves to the unstable area ahead of it,the unstable energy is left behind and as a result the convection is strengthened.

Diagnostic Analysis on a Regional Rainstorm Weather in North-central Henan Province

[Objective] The research aimed to analyze a regional rainstorm weather process in north-central Henan Province. [Method] Based on the conventional meteorological observation data and the rainfall data of Henan Meteorological Station, the diagnostic analysis of atmospheric thermodynamics and dynamics on a rainstorm weather process in north-central Henan Province on July 19, 2010 was carried out. The characteristics of physical quantity field and the evolution of weather situation in north-central Henan Province when the rainstorm happened were studied. [Result] Western Pacific subtropical high strengthened to extend westward. The dynamic uplifting of low vortex at the middle and low layers, the strong water vapor transportation of southwest low-level jet caused the regional rainstorm weather process in north-central Henan Province. The diagnostic results of physical quantity showed that the deep, thick wet layer and the sustained water vapor convergence provided the abundant water vapor for rainstorm generation. The positive vorticity advection center developed and spread from northwest to southeast, which was favorable for the development of vertical movement. The structure maintenance of positive vorticity at the middle and low layers, negative vorticity at the middle and high levels provided the power condition for the regional rainstorm generation. The pumping effect of convergence at the middle and low layers, divergence at the high layer was favorable for the strengthening of vertical ascending motion at the low layer. The uplifting effect of dew point front at the middle and low layers triggered the release of unstable energy. The confrontation of warm and cold air was one of the important reasons for the regional rainstorm. TBB characteristic analysis showed that TBB was from -60 to -50 ℃ in north-central Henan Province in the whole strong precipitation time, and the moving speed was equivalent to that of southwest vortex. The low-value belt of TBB corresponded with the rainstorm occurrence zone in Henan, and the minimum-value center of TBB was basically consistent with the strongest center of precipitation. [Conclusion] The research provided the scientific basis for the short-term forecast of rainstorm.

Application of Automatic Diagnostic Analysis on Atmospheric Horizontal Inversion Area and Freezing Rain Falling Area

The automatic diagnostic analysis on atmospheric horizontal inversion area is realized through changing the single atmospheric inversion into horizontal one based on the sounding data in Micaps system;the basic conceptual model INCLUDING atmospheric horizontal inversion area,ground 0 ℃ line,high altitude wet area,extreme point 0 ℃ line in inversion layer is buillt after the research on relationship between atmospheric horizontal inversion area and freezing rain falling area;automatic diagnostic analysis on freezing rain falling area is developed based on the conceptual model,the method is in accord well with the actual situation (freezing rain disaster weather occurred in most part of the south in beginning of 2008) and fitting rate reaches 94.4%,quantitative correlation coefficient between the area of freezing rain falling area and stations reporting freezing rain is 0.839.

Immunodiagnostic efficacy of detection of Schistosoma japonicum human infections in China:a meta analysis

Objective:To assess the diagnostic efficacy of the currently most widely used indirect hemagglutination assay(IHA) and enzyme-linked immunosorbent assay(ELISA) for detection of Schistosoma japonicum human infections.Methods:A comprehensive search was undertaken from China National Knowledge Infrastructure,Wanfang Database.VIP Database,PubMed. Cochrane Library,Science Citation Index Expanded.Proquest,and the inclusion and exclusion criteria were strictly settled.The funnel plot was used to assess the publication bias.Cochran’s Q test was employed to measure the homogeneity between studies,a summary receiver operating characteristic(SROC) curve was used to compare the diagnostic accuracy between the IHA and ELISA qualitatively by means of the Weighted Least Square method,the Ordinary Least Square method and the Robust regression method,and the diagnostic odds ratio(DOR) was drawn to compare the accuracy quantitatively.Results:Out of 785 publications,19 papers were eventually selected for analysis.Literature finality assessment indicated that minor publication bias existed in studies pertaining IHA test,but no bias was found in literatures regarding ELISA test.The heterogeneity test showed a heterogeneity between studies was present(χ~2 =466.07 and 34.67. both P values【0.0001).The areas under the SROC curves of IHA were all higher than that of ELISA test using the three methods(Weighted Least Square method:0.766 vs.0.695.Ordinary Least Square method:0.826 vs.0.741.Robust regression:0.815 vs.0.715).The TPR* values for IHA and EUSA were 0.710.0.759.0.749.and 0.650.0.686 and 0.666.respectively,and OR values were 5.997.9.937.8.893.and 3.432.4.784 and 3.959.respectively.The DOR of IHA was 9.41(95% CI:4.88-18.18).and 4.78(95%CI:3.21-7.13) for ELISA.Conclusions:All above results revealed that the diagnostic performance of IHA is better than that of ELISA.However,taking into account their unsatisfactory diagnostic value in areas with low infection intensity,a search for a better diagnostic test that can be applied in field situations in China should be given high priority.

Diagnostic Analysis of a Snowfall Weather in Beijing,Tianjin and Hebei in 2010

[ Objective] The research aimed to analyze a local snowstorm weather process which happened in Beijing, Tianjin and Hebei during I - 4 January, 2010. [ Method] Based on routine meteorological observation data and NCEP/NCAR 2.5° ×2.5° grid data （four times every day）, a lo- cal snowstorm weather process which happened in Beijing, Tianjin and Hebei during 1 -4 January, 2010 was carried out diagnostic analysis by using composite analysis method. [Result] Circumfluence on the ground and strong cold advection in the rear of upper trough were the main weath- er system of the snowfall. The deep thick wet layer and strong water vapor convergence provided sufficient water vapor for snowfall. The divergence field of low-level convergence and high^level divergence, dynamic coupling effect of vorticity provided favorable dynamic condition upwardly for the occurrence of strong snowfall. The steep dense area of Oso, low temperature at the ground layer and inversion temperature at the high layer provided certain energy condition for the development of snowfall weather. [ Conclusion] The research provided theoretical basis for snowfall forecast in future.

Diagnostic value of interleukin-8 in colorectal cancer:A case-control study and meta-analysis

AIM: To assess the diagnostic value of serum interleukin-8 (IL-8) in the detection of colorectal cancer (CRC).

Structural Design and Force Analysis for Equatorial Diagnostic Port Plug of ITER

The structural design of equatorial diagnostic port plug for international thermonuclear experimental reactor （ITER） was discussed in this paper. The induced electromagnetic （EM） loads of port plug and blanket shielding module （BSM） were presented. The finite element analysis （FEA） and numerical calculation of the system were performed under the maximum loads. According to the American Society of Mechanical Engineers （ASME） criteria, the EM stress is far below the admissible failure boundary, which indicates that the system can resist the cooperative action of EM loads and device deadweight. The analysis could provide technical data and references for further analysis and optimized design of the system.