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Establishment of a Predictive Diagnostic Model for Acute Mycoplasma Pneumoniae Infection in Elderly Patients with Community-acquired Pneumonia 被引量:6
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作者 XiAO Hong Li XIN De Li +6 位作者 WANG Yan CUI Li Jian LIU Xiao Ya LIU Song SONG Li Hong LIU Chun Ling YIN Cheng Hong 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 2017年第7期540-544,共5页
We established a diagnostic model to predict acute Mycoplasma pneumoniae (M. pneumonia) infection in elderly Community-acquired pneumonia (CAP) patients. We divided 456 patients into acute and non-acute M. pneumon... We established a diagnostic model to predict acute Mycoplasma pneumoniae (M. pneumonia) infection in elderly Community-acquired pneumonia (CAP) patients. We divided 456 patients into acute and non-acute M. pneumoniae infection groups. Binary logistic regression and receiver operating characteristic (ROC) curves were used to establish a predictive model. The following independent factors were identified: age 〉 70 years; serum cTNT level 〉 0.0S ng/mL; lobar consolidation; mediastinal lymphadenopathy; and antibody titer in the acute phase 〉 1:40. The area under the ROC curve of the model was 0.923 and a score of 2 7 score predicted acute M. pneumoniae infection in elderly patients with CAP. The predictive model developed in this study has high diagnostic accuracy for the identification of elderly acute M. pneumoniae infection. 展开更多
关键词 in AS of were Establishment of a Predictive diagnostic model for Acute Mycoplasma Pneumoniae Infection in Elderly Patients with Community-acquired Pneumonia for with
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The calculation of the circulation in South China Sea by a diagnostic model 被引量:4
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作者 ZHOU Weidong YANG Yang DONG Danpeng 《Acta Oceanologica Sinica》 SCIE CAS CSCD 2008年第z1期31-45,共15页
A high resolved two-dimensional linear global diagnostic model combining with the dynamical calculation is used to calculate velocity field in the South China Sea(SCS). The study of model results shows that eddy diffu... A high resolved two-dimensional linear global diagnostic model combining with the dynamical calculation is used to calculate velocity field in the South China Sea(SCS). The study of model results shows that eddy diffusion does not change basic structure of circulation in the SCS and does not change the direction of invasive water, but changes the value of transport considerably especially in straits. The velocity field is not changed whether the wind stress is considered or not. This result shows the circulation is largely determined by a density field which well records most of the important contribution of the wind stress effect. Potential vorticity is calculated to testify the dynamics of the model results. The result shows that a good conservation of the nonlinear PV. This indicates most effects of the important nonlinear processes are well recorded in density and the nonlinear term is negligible so that the simplified model is reliable. The model results show the water exchanges between the SCS and open ocean or surrounding seas. Cold deep water invades through Luzon Strait and Warm shallow water is pushed out mainly through Karimata Straits. The model results also reveal the structure of the circulation in the SCS basin. In two circulations of upper and middle layers, a cyclonic one in the north and an anti-cyclonic one in the south, reflect the climatologic average of the circulation driven by monsoon. In the deep or bottom layer, these two circulations reflect the topography of the basin. Above the middle layer, invasive water enters westward in the north but the way of invasion of Kuroshio is not clear. Below the deep layer, a current goes down south near the east basin ,and invasive water enters in the basin from the west Pacific. 展开更多
关键词 diagnostic model South China Sea potential vorticity CIRCULATION
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A new diagnostic model of primary open angle glaucoma based on FD-OCT parameters 被引量:1
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作者 Ya-Jie Zheng Ying-Zi Pan +4 位作者 Xue-Ying Li Yuan Fang Mei Li Rong-Hua Qia Yu Cai 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2018年第6期951-957,共7页
AIM: To build a clinical diagnostic model of primary open angle glaucoma (POAG) using the normal probability chart of frequency-domain optical coherence tomography (FD-OCT). METHODS: This is a cross-sectional ... AIM: To build a clinical diagnostic model of primary open angle glaucoma (POAG) using the normal probability chart of frequency-domain optical coherence tomography (FD-OCT). METHODS: This is a cross-sectional study. Total 133 eyes from 133 healthy subjects and 99 eyes from 99 early POAG patients were included in the study. The retinal nerve fibre layer (RNFL) thickness parameters of optic nerve head (ONH) and RNFL3.45 scan were measured in one randomly selected eye of each subject using RTVue-100 FD-OCT. Then, we used these parameters to establish the diagnostic models. Four different diagnostic models based on two different area partition strategies on ONH and RNFL3.45 parameters, including ONH traditional area partition model (ONH-T), ONH new area partition model (ONH-N), RNFL3.45 traditional area partition model (RNFL3.45-T) and RNFL3.45 new area partition model (RNFL3.45-N), were built and tested by cross-validation. RESULTS: The new area partition models had higher area under the receiver operating characteristic (AROC; ONH-N: 0.990; RNFL3.45-N: 0.939) than corresponding traditional area partition models (ONH-T: 0.979; RNFL3.45-T: 0.881). There was no statistical difference among AROC of ONH-T, ONH-N, and RNFL3.45-N. Nevertheless, ONH-N was the simplest model. CONCLUSION: The new area partition models had higher diagnostic accuracy than corresponding traditional area partition models, which can improve the diagnostic ability of early POAG. In particular, the simplest ONH-N diagnostic model may be convenient for clinical application. 展开更多
关键词 primary open angle glaucoma opticalcoherence tomography ethnic-specific database diagnostic model
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Creating Knowledge-Based Diagnostic Models by Mining Textual Diagnostic Reports of SPECT Scans
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作者 Chuangui Cao Chengcheng Han Qiang Lin 《Journal of Computer and Communications》 2021年第5期10-19,共10页
Mining rich semantic information hidden in heterogeneous information network is one of the important tasks of data mining. Generally, a nuclear medicine text consists of the description of disease (<i>i.e.</i... Mining rich semantic information hidden in heterogeneous information network is one of the important tasks of data mining. Generally, a nuclear medicine text consists of the description of disease (<i>i.e.</i>, lesions) and diagnostic results. However, how to construct a computer-aided diagnostic model with a large number of medical texts is a challenging task. To automatically diagnose diseases with SPECT imaging, in this work, we create a knowledge-based diagnostic model by exploring the association between a disease and its properties. Firstly, an overview of nuclear medicine and data mining is presented. Second, the method of preprocessing textual nuclear medicine diagnostic reports is proposed. Last, the created diagnostic modes based on random forest and SVM are proposed. Experimental evaluation conducted real-world data of diagnostic reports of SPECT imaging demonstrates that our diagnostic models are workable and effective to automatically identify diseases with textual diagnostic reports. 展开更多
关键词 Text Classification Nuclear Medicine SPECT Imaging diagnostic model Random Forest SVM
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A Clinical Analysis of 293 FUO Patients, A Diagnostic Model Discriminating infectious Diseases from Non-infectious Diseases
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作者 Qing Zhou Xu-wen Xu +3 位作者 De-ming Tan Yu-tao Xie Yun-zhu Long Meng-hou Lu 《国际感染病学(电子版)》 CAS 2014年第2期54-63,共10页
Objective A diagnostic model was established to discriminate infectious diseases from non-infectious diseases. Methods The clinical data of patients with fever of unknown origin(FUO) hospitalized in Xiangya Hospital C... Objective A diagnostic model was established to discriminate infectious diseases from non-infectious diseases. Methods The clinical data of patients with fever of unknown origin(FUO) hospitalized in Xiangya Hospital Central South University, from January, 2006 to April, 2011 were retrospectively analyzed. Patients enrolled were divided into two groups. The first group was used to develop a diagnostic model: independent variables were recorded and considered in a logistic regression analysis to identify infectious and non-infectious diseases(αin = 0.05, αout = 0.10). The second group was used to evaluate the diagnostic model and make ROC analysis.Results The diagnostic rate of 143 patients in the first group was 87.4%, the diagnosis included infectious disease(52.4%), connective tissue diseases(16.8%), neoplastic disease(16.1%) and miscellaneous(2.1%). The diagnostic rate of 168 patients in the second group was 88.4%, and the diagnosis was similar to the first group. Logistic regression analysis showed that decreased white blood cell count(WBC < 4.0×109/L), higher lactate dehydrogenase level(LDH > 320 U/L) and lymphadenectasis were independent risk factors associated with non-infectious diseases. The odds ratios were 14.74, 5.84 and 5.11(P ≤ 0.01), respectively. In ROC analysis, the sensitivity and specificity of the positive predictive values was 62.1% and 89.1%, respectively, while that of negative predicting values were 75% and 81.7%, respectively(AUC = 0.76, P = 0.00).Conclusions The combination of WBC < 4.0×109/L, LDH > 320 U/L and lymphadenectasis may be useful in discriminating infectious diseases from non-infectious diseases in patients hospitalized as FUO. 展开更多
关键词 Fever of unknown origin diagnostic model White blood cell Lactate dehydrogenase LYMPHADENECTASIS
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Genetic algorithm-optimized backpropagation neural network establishes a diagnostic prediction model for diabetic nephropathy:Combined machine learning and experimental validation in mice 被引量:1
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作者 WEI LIANG ZONGWEI ZHANG +5 位作者 KEJU YANG HONGTU HU QIANG LUO ANKANG YANG LI CHANG YUANYUAN ZENG 《BIOCELL》 SCIE 2023年第6期1253-1263,共11页
Background:Diabetic nephropathy(DN)is the most common complication of type 2 diabetes mellitus and the main cause of end-stage renal disease worldwide.Diagnostic biomarkers may allow early diagnosis and treatment of D... Background:Diabetic nephropathy(DN)is the most common complication of type 2 diabetes mellitus and the main cause of end-stage renal disease worldwide.Diagnostic biomarkers may allow early diagnosis and treatment of DN to reduce the prevalence and delay the development of DN.Kidney biopsy is the gold standard for diagnosing DN;however,its invasive character is its primary limitation.The machine learning approach provides a non-invasive and specific criterion for diagnosing DN,although traditional machine learning algorithms need to be improved to enhance diagnostic performance.Methods:We applied high-throughput RNA sequencing to obtain the genes related to DN tubular tissues and normal tubular tissues of mice.Then machine learning algorithms,random forest,LASSO logistic regression,and principal component analysis were used to identify key genes(CES1G,CYP4A14,NDUFA4,ABCC4,ACE).Then,the genetic algorithm-optimized backpropagation neural network(GA-BPNN)was used to improve the DN diagnostic model.Results:The AUC value of the GA-BPNN model in the training dataset was 0.83,and the AUC value of the model in the validation dataset was 0.81,while the AUC values of the SVM model in the training dataset and external validation dataset were 0.756 and 0.650,respectively.Thus,this GA-BPNN gave better values than the traditional SVM model.This diagnosis model may aim for personalized diagnosis and treatment of patients with DN.Immunohistochemical staining further confirmed that the tissue and cell expression of NADH dehydrogenase(ubiquinone)1 alpha subcomplex,4-like 2(NDUFA4L2)in tubular tissue in DN mice were decreased.Conclusion:The GA-BPNN model has better accuracy than the traditional SVM model and may provide an effective tool for diagnosing DN. 展开更多
关键词 Diabetic nephropathy Renal tubule Machine learning diagnostic model Genetic algorithm
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Fecal microbial biomarkers combined with multi-target stool DNA test improve diagnostic accuracy for colorectal cancer 被引量:2
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作者 Jin-Qing Fan Wang-Fang Zhao +4 位作者 Qi-Wen Lu Fu-Rong Zha Le-Bin Lv Guo-Liang Ye Han-Lu Gao 《World Journal of Gastrointestinal Oncology》 SCIE 2023年第8期1424-1435,共12页
BACKGROUND Colorectal cancer(CRC)is a major global health burden.The current diagnostic tests have shortcomings of being invasive and low accuracy.AIM To explore the combination of intestinal microbiome composition an... BACKGROUND Colorectal cancer(CRC)is a major global health burden.The current diagnostic tests have shortcomings of being invasive and low accuracy.AIM To explore the combination of intestinal microbiome composition and multi-target stool DNA(MT-sDNA)test in the diagnosis of CRC.METHODS We assessed the performance of the MT-sDNA test based on a hospital clinical trial.The intestinal microbiota was tested using 16S rRNA gene sequencing.This case-control study enrolled 54 CRC patients and 51 healthy controls.We identified biomarkers of bacterial structure,analyzed the relationship between different tumor markers and the relative abundance of related flora components,and distinguished CRC patients from healthy subjects by the linear discriminant analysis effect size,redundancy analysis,and random forest analysis.RESULTS MT-sDNA was associated with Bacteroides.MT-sDNA and carcinoembryonic antigen(CEA)were positively correlated with the existence of Parabacteroides,and alpha-fetoprotein(AFP)was positively associated with Faecalibacterium and Megamonas.In the random forest model,the existence of Streptococcus,Escherichia,Chitinophaga,Parasutterella,Lachnospira,and Romboutsia can distinguish CRC from health controls.The diagnostic accuracy of MT-sDNA combined with the six genera and CEA in the diagnosis of CRC was 97.1%,with a sensitivity and specificity of 98.1%and 92.3%,respectively.CONCLUSION There is a positive correlation of MT-sDNA,CEA,and AFP with intestinal microbiome.Eight biomarkers including six genera of gut microbiota,MT-sDNA,and CEA showed a prominent sensitivity and specificity for CRC prediction,which could be used as a non-invasive method for improving the diagnostic accuracy for this malignancy. 展开更多
关键词 Gut microbiome Colorectal cancer diagnostic model Multi-target stool DNA test Tumor biomarker
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Study on short-range numerical forecasting of ocean current in the East China Sea—II.Three-dimensional diagnostic model and its application in the Bohai Sea
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作者 Zhao Jinping and Shi Maochong 《Acta Oceanologica Sinica》 SCIE CAS CSCD 1994年第2期173-188,共16页
In this paper,a tbree-dimensional (3-D) baroclinic diagnostic model for short-range numerical forecast is proposed to calculate the monthly averaged flow field in the Bohai Sea. By using the model and monthly averaged... In this paper,a tbree-dimensional (3-D) baroclinic diagnostic model for short-range numerical forecast is proposed to calculate the monthly averaged flow field in the Bohai Sea. By using the model and monthly averaged tempeature and salinity date, monthly barotropic and baroclinic flow field are calculated,and 2-D and 3-D characteristics of flow are described and demonstrated. On the basis of the analysis of the modelling results and the observed temperature,salinity and wind data,the monthly and seasonal characteristics and generation mechanism of circulation in the Bohai Sea are also discussed. It is pointed out in this paper that in spring and autumn,the monthly averaged flow fields are not representative, for the wind direction varies in a wide range and the averaged wind field is much weaker than the instantaneous one. These results show the reliability of the model for describing the monthly characteristics in numerical forecast of ocean current. 展开更多
关键词 diagnostic model monthly averaged flow field the Bohai Sea CIRCULATION three-dimensional characteristics
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Diagnostic of capacitively coupled radio frequency plasma from electrical discharge characteristics:comparison with optical emission spectroscopy and fluid model simulation 被引量:3
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作者 何湘 刘冲 +6 位作者 张亚春 陈建平 陈玉东 曾小军 陈秉岩 庞佳鑫 王一兵 《Plasma Science and Technology》 SCIE EI CAS CSCD 2018年第2期26-33,共8页
The capacitively coupled radio frequency(CCRF)plasma has been widely used in various fields.In some cases,it requires us to estimate the range of key plasma parameters simpler and quicker in order to understand the ... The capacitively coupled radio frequency(CCRF)plasma has been widely used in various fields.In some cases,it requires us to estimate the range of key plasma parameters simpler and quicker in order to understand the behavior in plasma.In this paper,a glass vacuum chamber and a pair of plate electrodes were designed and fabricated,using 13.56 MHz radio frequency(RF)discharge technology to ionize the working gas of Ar.This discharge was mathematically described with equivalent circuit model.The discharge voltage and current of the plasma were measured atdifferent pressures and different powers.Based on the capacitively coupled homogeneous discharge model,the equivalent circuit and the analytical formula were established.The plasma density and temperature were calculated by using the equivalent impedance principle and energy balance equation.The experimental results show that when RF discharge power is 50–300 W and pressure is 25–250 Pa,the average electron temperature is about 1.7–2.1 e V and the average electron density is about 0.5?×10^17–3.6?×10^17m^-3.Agreement was found when the results were compared to those given by optical emission spectroscopy and COMSOL simulation. 展开更多
关键词 plasma diagnostic equivalent circuit model optical emission spectrometry COMSOL simulation
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Current Problems of the Diagnostics and Treatment of Sepsis and Burn Injuries: The Modified Pathogenetic Concept
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作者 Olga Kovalenko Lesia Ostapiuk Anatoliy Voloshinovskii 《International Journal of Clinical Medicine》 CAS 2023年第1期20-33,共14页
Background: The deep understanding of pathogenesis is a key moment in the formation of the modern strategy of modern medicine. We conducted the thorough analysis of the microscopic processes occurring in the bodies of... Background: The deep understanding of pathogenesis is a key moment in the formation of the modern strategy of modern medicine. We conducted the thorough analysis of the microscopic processes occurring in the bodies of patients with purulent-septic complications. The modified pathogenetic concept of the diagnostic and treatment model of diseases with septic complications is presented. The obtained information about the mechanisms of origin and development of these diseases is fundamentally important for finding the modern effective methods of treating patients. The aim of the research is to modify treatment tactics for patients with sepsis and burn injuries based on the modified pathogenetic concept using modern diagnostics, i.e. the method of fluorescence spectroscopy (MFS) and biomarkers. Materials and Methods: The proposed modified pathogenetic concept of the diagnostic and treatment model of diseases with purulent-septic complications along with standard methods was used successfully for effective treatment of 15 patients with sepsis and 25 with burn injuries. Results: 3 main scenarios of behaviour of spectral-fluorescence characteristics of patients with sepsis are illustrated. Spectral-fluorescence markers of sepsis were studied, which are informative 24 to 48 hours before the appearance of obvious clinical and laboratory signs of significant changes in the general somatic status of patients. Conclusions: The proposed diagnostic and therapeutic approach is new and fundamentally important for diagnostics and monitoring of the process of treatment of patients with purulent-septic diseases and burn injuries. An in-depth understanding of the dynamics of septic complications and the corresponding changes of the main markers of these diseases during treatment is especially relevant. The use of infusion therapy with solutions of donor albumin as an effective pathogenetic treatment is scientifically justified. 展开更多
关键词 Purulent-Inflammatory Diseases SEPSIS Modified Pathogenetic diagnostic and Treatment model Method of Fluorescent Spectroscopy Biomarkers Albumin Infusion
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Intelligent diagnosis of retinal vein occlusion based on color fundus photographs
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作者 Yu-Ke Ji Rong-Rong Hua +3 位作者 Sha Liu Cui-Juan Xie Shao-Chong Zhang Wei-Hua Yang 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2024年第1期1-6,共6页
AIM:To develop an artificial intelligence(AI)diagnosis model based on deep learning(DL)algorithm to diagnose different types of retinal vein occlusion(RVO)by recognizing color fundus photographs(CFPs).METHODS:Totally ... AIM:To develop an artificial intelligence(AI)diagnosis model based on deep learning(DL)algorithm to diagnose different types of retinal vein occlusion(RVO)by recognizing color fundus photographs(CFPs).METHODS:Totally 914 CFPs of healthy people and patients with RVO were collected as experimental data sets,and used to train,verify and test the diagnostic model of RVO.All the images were divided into four categories[normal,central retinal vein occlusion(CRVO),branch retinal vein occlusion(BRVO),and macular retinal vein occlusion(MRVO)]by three fundus disease experts.Swin Transformer was used to build the RVO diagnosis model,and different types of RVO diagnosis experiments were conducted.The model’s performance was compared to that of the experts.RESULTS:The accuracy of the model in the diagnosis of normal,CRVO,BRVO,and MRVO reached 1.000,0.978,0.957,and 0.978;the specificity reached 1.000,0.986,0.982,and 0.976;the sensitivity reached 1.000,0.955,0.917,and 1.000;the F1-Sore reached 1.000,0.9550.943,and 0.887 respectively.In addition,the area under curve of normal,CRVO,BRVO,and MRVO diagnosed by the diagnostic model were 1.000,0.900,0.959 and 0.970,respectively.The diagnostic results were highly consistent with those of fundus disease experts,and the diagnostic performance was superior.CONCLUSION:The diagnostic model developed in this study can well diagnose different types of RVO,effectively relieve the work pressure of clinicians,and provide help for the follow-up clinical diagnosis and treatment of RVO patients. 展开更多
关键词 deep learning artificial intelligence Swin Transformer diagnostic model retinal vein occlusion color fundus photographs
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Transient elastography with controlled attenuation parameter for the diagnosis of colorectal polyps in patients with nonalcoholic fatty liver disease
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作者 Lan Wang Yan-Fei Li Li-Feng Dong 《World Journal of Clinical Cases》 SCIE 2024年第12期2050-2055,共6页
BACKGROUND The severity of nonalcoholic fatty liver disease(NAFLD)and lipid metabolism are related to the occurrence of colorectal polyps.Liver-controlled attenuation parameters(liver-CAPs)have been established to pre... BACKGROUND The severity of nonalcoholic fatty liver disease(NAFLD)and lipid metabolism are related to the occurrence of colorectal polyps.Liver-controlled attenuation parameters(liver-CAPs)have been established to predict the prognosis of hepatic steatosis patients.AIM To explore the risk factors associated with colorectal polyps in patients with NAFLD by analyzing liver-CAPs and establishing a diagnostic model.METHODS Patients who were diagnosed with colorectal polyps in the Department of Gastroenterology of our hospital between June 2021 and April 2022 composed the case group,and those with no important abnormalities composed the control group.The area under the receiver operating characteristic curve was used to predict the diagnostic efficiency.Differences were considered statistically significant when P<0.05.RESULTS The median triglyceride(TG)and liver-CAP in the case group were significantly greater than those in the control group(mmol/L,1.74 vs 1.05;dB/m,282 vs 254,P<0.05).TG and liver-CAP were found to be independent risk factors for colorectal polyps,with ORs of 2.338(95%CI:1.154–4.733)and 1.019(95%CI:1.006–1.033),respectively(P<0.05).And there was no difference in the diagnostic efficacy between liver-CAP and TG combined with liver-CAP(TG+CAP)(P>0.05).When the liver-CAP was greater than 291 dB/m,colorectal polyps were more likely to occur.CONCLUSION The levels of TG and liver-CAP in patients with colorectal polyps are significantly greater than those patients without polyps.Liver-CAP alone can be used to diagnose NAFLD with colorectal polyps. 展开更多
关键词 Colorectal polyps Nonalcoholic fatty liver disease Liver-controlled attenuation parameter Liver fibroscan diagnostic model
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Non-invasive model for predicting esophageal varices based on liver and spleen volume 被引量:1
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作者 Long-Bao Yang Gang Zhao +6 位作者 Xin-Xing Tantai Cai-Lan Xiao Si-Wen Qin Lei Dong Dan-Yan Chang Yuan Jia Hong Li 《World Journal of Clinical Cases》 SCIE 2022年第32期11743-11752,共10页
BACKGROUND Upper endoscopy is the gold standard for predicting esophageal varices in China.Guidelines and consensus suggest that patients with liver cirrhosis should undergo periodic upper endoscopy,most patients unde... BACKGROUND Upper endoscopy is the gold standard for predicting esophageal varices in China.Guidelines and consensus suggest that patients with liver cirrhosis should undergo periodic upper endoscopy,most patients undergo their first upper endoscopy when esophageal variceal bleeds.Therefore,it is important to develop a non-invasive model to early diagnose esophageal varices.AIM To develop a non-invasive predictive model for esophageal varices based on liver and spleen volume in viral cirrhosis patients.METHODS We conducted a cross-sectional study based on viral cirrhosis crowd in the Second Affiliated Hospital of Xi'an Jiaotong University.By collecting the basic information and clinical data of the participants,we derived the independent risk factors and established the prediction model of esophageal varices.The established model was compared with other models.Area under the receiver operating characteristic curve,calibration plot and decision curve analysis were used to test the discriminating ability,calibration ability and clinical practicability in both the internal and external validation.RESULTS The portal vein diameter,the liver and spleen volume,and volume change rate were the independent risk factors of esophageal varices.We successfully used the factors to establish the predictive model[area under the curve(AUC)0.87,95%CI:0.80-0.95],which showed better predictive value than other models.The model showed good discriminating ability,calibration ability and the clinical practicability in both modelling group and external validation group.CONCLUSION The developed non-invasive predictive model can be used as an effective tool for predicting esophageal varices in viral cirrhosis patients. 展开更多
关键词 GASTROSCOPY Esophageal varices Liver volume CIRRHOSIS Non-invasive diagnostic model Spleen volume
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Risk factors of non-arteritic anterior ischaemic optic neuropathy and central retinal artery occlusion
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作者 Chu-Han Ma Cong-Yao Wang +2 位作者 Ting-Ting Dai Ting-Ting Chen Wen-Hui Zhu 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2024年第5期869-876,共8页
AIM:To investigate the difference in risk factors between non-arteritic anterior ischaemic optic neuropathy(NAION)and central retinal artery occlusion(CRAO)and develop a predictive diagnostic nomogram.METHODS:The stud... AIM:To investigate the difference in risk factors between non-arteritic anterior ischaemic optic neuropathy(NAION)and central retinal artery occlusion(CRAO)and develop a predictive diagnostic nomogram.METHODS:The study included 37 patients with monocular NAION,20 with monocular CRAO,and 24 with hypertension.Gender,age,and systemic diseases were recorded.Blood routine,lipids,hemorheology,carotid and brachial artery doppler ultrasound,and echocardiography were collected.The optic disc area,cup area,and cup-to-disc ratio(C/D)of the unaffected eye in the NAION and CRAO group and the right eye in the hypertension group were measured.RESULTS:The carotid artery intimal medial thickness(C-IMT)of the affected side of the CRAO group was thicker(P=0.039)and its flow-mediated dilation(FMD)was lower(P=0.049)than the NAION group.Compared with hypertension patients,NAION patients had higher whole blood reduced viscosity low-shear(WBRV-L)and erythrocyte aggregation index(EAI;P=0.045,0.037),and CRAO patients had higher index of rigidity of erythrocyte(IR)and erythrocyte deformation index(EDI;P=0.004,0.001).The optic cup and the C/D of the NAION group were smaller than the other two groups(P<0.0001).The diagnostic prediction model showed high diagnostic specificity(83.7%)and sensitivity(85.6%),which was highly related to hypertension,the C-IMT of the affected side,FMD,platelet(PLT),EAI,and C/D.CONCLUSION:CRAO patients show thicker C-IMT and worse endothelial function than NAION.NAION and CRAO may be related to abnormal hemorheology.A small cup and small C/D may be involved in NAION.The diagnostic nomogram can be used to preliminarily identify NAION and CRAO. 展开更多
关键词 non-arteritic anterior ischaemic optic neuropathy central retinal artery occlusion risk factors diagnostic prediction model NOMOGRAM
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TESTING THE ADEQUACY OF GARCH-TYPE MODELS IN TIME SERIES 被引量:1
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作者 吴鑑洪 朱力行 《Acta Mathematica Scientia》 SCIE CSCD 2009年第2期327-340,共14页
In this article a new approach for checking the adequacy of GARCH-type models in time series was proposed. The resulted tests involve weight functions, which provide them with the flexibility in choosing scores to enh... In this article a new approach for checking the adequacy of GARCH-type models in time series was proposed. The resulted tests involve weight functions, which provide them with the flexibility in choosing scores to enhance power performance. The choice of weight functions and the power properties of the tests are studied. For a large number of alternatives, asymptotically distribution-free maximin test is constructed. The tests are asymptotically chi-squared under the null hypothesis and easy to implement. Simulation results indicate that the tests perform well. 展开更多
关键词 GARCH-type models maximin test model diagnostic checking score type test
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The Pathogenetic Concept of the Diagnostic-Treatment Approach for Patients with Purulent-Septic Complications 被引量:1
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作者 Lesia Ostapiuk 《International Journal of Clinical Medicine》 2022年第1期1-21,共21页
<strong>Background: </strong>The significant improvement of immediate and long-term functional results of treating patients is the fundamental problem of modern medical science. A deep understanding of the... <strong>Background: </strong>The significant improvement of immediate and long-term functional results of treating patients is the fundamental problem of modern medical science. A deep understanding of the pathogenesis is the key point in creating the management strategy for patients with various diseases. Information about the mechanisms of origin and development of purulent-inflammatory diseases and sepsis is essential for finding effective ways to prevent and treat them. <strong>The aim of the research</strong> is to use the method of fluorescence spectroscopy in creating the pathogenetic diagnostic and treatment model for the prevention and treatment of purulent-inflammatory diseases and sepsis, modification of treatment tactics, search for new markers of purulent-septic diseases, as well as monitoring of patients during the treatment. <strong>Materials and methods: </strong>The proposed approach, along with standard diagnostic methods, was used to organize the treatment process of 100 patients with purulent-inflammatory diseases, including 15 patients with sepsis, 35 with acute inflammatory abdominal pathology, 20 patients with burn injury (main group) and 35 patients with burn injury (comparison group). <strong>Results:</strong> The behavior of spectral-fluorescent characteristics in their dynamics has been studied, and the new markers for assessing patients’ conditions have been proposed. Their effectiveness for the diagnosis of purulent-septic diseases has been proved, which advances the results of standard research methods by 24 - 48 hours.<strong> Conclusions:</strong> The proposed diagnostic and treatment approach is fundamentally important for diagnosis and monitoring during the treatment of patients with purulent-septic diseases. Particularly relevant is the proposal to modify the treatment process for these patients, associated with the use of infusion of donor albumin solutions. 展开更多
关键词 Purulent-Inflammatory Diseases SEPSIS Рathogenetic diagnostic and Treatment model Method of Fluorescent Spectroscopy Albumin Infusion
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Blood microRNAs as potential diagnostic markers for hemorrhagic stroke 被引量:3
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作者 Bridget Martinez Philip V.Peplow 《Neural Regeneration Research》 SCIE CAS CSCD 2017年第1期13-18,共6页
Proper medical treatment of a stroke victim relies on accurate and rapid differentiation between ischemic and hemorrhagic stroke,which in current practice is performed by computerized tomography(CT) or magnetic reso... Proper medical treatment of a stroke victim relies on accurate and rapid differentiation between ischemic and hemorrhagic stroke,which in current practice is performed by computerized tomography(CT) or magnetic resonance imaging(MRI) scans.A panel of micro RNAs could be an extremely useful clinical tool for distinguishing between hemorrhagic and ischemic stroke.This review has shown that blood miRNA profile can distinguish hemorrhagic from ischemic stroke in patients and in experimental animal models.It also seems likely they can differentiate between intracerebral and subarachnoid hemorrhage stroke.The miRNA profile in cerebrospinal fluid could be a useful diagnostic tool for subarachnoid hemorrhagic stroke.Decreased or increased miRNA levels may be needed either as prevention or treatment of stroke.Administration in vivo of miR-130 a inhibitor or miRNA mimic(miR-367,miR-223) in an intracerebral hemorrhage animal model improved neurological outcomes. 展开更多
关键词 blood microRNAs diagnostic biomarkers hemorrhagic stroke human patients rat and mouse models
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ASSESSMENT OF THE POEM2 MODEL FOR SIMULATING TROPICAL INTRASEASONAL OSCILLATION
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作者 王阔 马浩 +2 位作者 李娟 顾伯辉 吴浩 《Journal of Tropical Meteorology》 SCIE 2018年第3期323-333,共11页
The intraseasonal oscillation(ISO) of the atmosphere is closely related to weather and climate systems and is also an important aspect of extended numerical weather forecast research. This phenomenon is significant in... The intraseasonal oscillation(ISO) of the atmosphere is closely related to weather and climate systems and is also an important aspect of extended numerical weather forecast research. This phenomenon is significant in tropical regions and is one of the key indices for assessing the simulation capability of a climate model. To better evaluate numerical model simulations of the tropical ISO using the 10-year historic data calculated by the POEM2 climate system model developed by the University of Hawaii in the U.S., we utilized the methods of variance and power spectral analysis to compare and assess the simulation ability of this model for the ISO in tropical regions. Our results showed that the simulated variance results for the 850 h Pa zonal wind and outgoing long-wave radiation(OLR) by POEM2 are overall consistent with the observed distribution pattern, and the simulated variance is relatively larger than the observed in the North Indian Ocean and West Pacific regions. With respect to the summer model, the winter model can better simulate the eastward propagation motion of the Madden-Julian oscillation(MJO) and the 850 h Pa zonal wind. In comparison, the summer model can better simulate the northward propagation motion of MJO and atmospheric precipitation than the winter model. The eastward propagation speed of the simulated MJO signal is faster in the model than in the observation, and the high frequency region for the power spectra of meteorological element anomalies are concentrated in wavenumber 2-3 in the simulation and in wavenumber 1-2 in the observation. The multivariate combined empirical orthogonal function(EOF) results showed that this model can simulate the relationship between high-low level wind distributions and precipitation over the East Indian Ocean and the West Pacific, but the simulated signal is weaker than the observed. The lagging correlation of time coefficients between the first two EOFs from observation and simulation shows a similar cycle. Thus, these results indicate that in the future, the POEM2 climate system model needs to optimize the involved physical processes and parameterization scheme, strengthen the dynamic description of the mixed Rossby gravity wave, and improve the simulated ability of wavenumber 1. 展开更多
关键词 model diagnostics power spectrum analysis POEM2 model MJO
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Modeling Inflation in Bangladesh
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作者 Mohammad Lutfor Rahman Mynul Islam Manik Roy 《Open Journal of Statistics》 2020年第6期998-1009,共12页
Inf<span style="font-family:Verdana;">lation has </span><span style="font-family:Verdana;">a </span><span style="font-family:Verdana;">substantial impact on ... Inf<span style="font-family:Verdana;">lation has </span><span style="font-family:Verdana;">a </span><span style="font-family:Verdana;">substantial impact on an economy because it affects the financial value of money and stability in the economy. Government </span><span style="font-family:Verdana;">and non-govern</span><span style="font-family:Verdana;">- </span><span style="font-family:Verdana;">ment policies might be hindered due to the excessive rate of inflation. This paper aims to model and forecast inflation by the Box-Jenkins autoregressive integrated moving average (ARIMA) technique using annual time series data on inflation from 1987 to 2017 in Bangladesh. It is found that ARIMA (2, 1, 0) model is the best optimal to forecast inflation for a period of up to eight years. Graphical tools</span><span style="font-family:Verdana;">,</span><span style="font-family:Verdana;"> as well as theoretical tests such as Ljung-Box, Shapiro-Wilk, and runs tests have been used in the model diagnostics.</span> 展开更多
关键词 ARIMA INFLATION Forecasting model Validity model diagnostics BANGLADESH
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New Method for Building Vector of Diagnostic Signs to Classify Technical States of Marine Diesel Engine by Torsional Vibrations on Shaft-Line
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作者 Do Duc Luu Cao Duc Hanh Nguyen Xuan Tru 《Sustainable Marine Structures》 2020年第2期35-38,共4页
Vector of diagnostic signs(VDS)using torsional vibration(TV)signal on the main propulsion plant(MPP)is the vector of z maxima(or minima)values of the TV signal in accordance with the cylinder firing orders.The technic... Vector of diagnostic signs(VDS)using torsional vibration(TV)signal on the main propulsion plant(MPP)is the vector of z maxima(or minima)values of the TV signal in accordance with the cylinder firing orders.The technical states of the marine diesel engine(MDE)include R=z+1 classes and are presented in z-dimensional space coordinate of VDS.The presentation of Dk,k=1÷R using z diagnostic signs(Vi,i=1÷z)is nonfigurative and quite complicated.This paper aims to develop a new method for converting VDS from z-dimensional to 2-dimensional space(two-axes)based on the firing orders of the diesel cylinders,as an equivalent geometrical sign of the all diagnostic signs.The proposed model is useful for presenting a technical state Dk in two-dimensional space(x,y)for better visualization.The paper verifies the simulation of the classification illustration of the 7–state classes for the MDE 6S46-MCC,installed on the motor vessel(MV)34000DWT,using the new above mentioned method.The seven technical state classes(for 6-cylinder MDE,z=6)are drawn separately and visually in the Descartes.The received results are valuable to improve smart diagnostic system for analyzing normal/misfire states of cylinders in operation regimes. 展开更多
关键词 Two-dimensional vector of diagnostic signs of torsional vibration signal New model of VDS for misfiring diagnostics of MDE Vision diagnostics of MDE by torsional vibration signal
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