The increasing prevalence of diabetes has led to a growing population of endstage kidney disease(ESKD)patients with diabetes.Currently,kidney transplantation is the best treatment option for ESKD patients;however,it i...The increasing prevalence of diabetes has led to a growing population of endstage kidney disease(ESKD)patients with diabetes.Currently,kidney transplantation is the best treatment option for ESKD patients;however,it is limited by the lack of donors.Therefore,dialysis has become the standard treatment for ESKD patients.However,the optimal dialysis method for diabetic ESKD patients remains controversial.ESKD patients with diabetes often present with complex conditions and numerous complications.Furthermore,these patients face a high risk of infection and technical failure,are more susceptible to malnutrition,have difficulty establishing vascular access,and experience more frequent blood sugar fluctuations than the general population.Therefore,this article reviews nine critical aspects:Survival rate,glucose metabolism disorder,infectious complications,cardiovascular events,residual renal function,quality of life,economic benefits,malnutrition,and volume load.This study aims to assist clinicians in selecting individualized treatment methods by comparing the advantages and disadvantages of hemodialysis and peritoneal dialysis,thereby improving patients’quality of life and survival rates.展开更多
Potential mutagenic impurities in Active Pharmaceutical Ingredient, Meropenem Trihydrate were assessed and a novel analytical method for their quantification was developed and validated. This Liquid Chromatographic me...Potential mutagenic impurities in Active Pharmaceutical Ingredient, Meropenem Trihydrate were assessed and a novel analytical method for their quantification was developed and validated. This Liquid Chromatographic method using High Resolution Mass Spectrometer (LC-HRMS) technique is proved to be suitable for simultaneous quantification of all ten identified impurities with required specificity, sensitivity, resolution, precision, accuracy, and other method characteristics as per ICH Guidelines. The acceptable limit of less than 2.9 μg/g was considered for evaluations, based on drug substance dosage and duration of treatment. The method stands most sensitive with a Limit of Detection of 0.35 μg/g, considering the challenge full acceptance criteria as per current regulatory standards.展开更多
A new trust region algorithm for solving convex LC 1 optimization problem is presented.It is proved that the algorithm is globally convergent and the rate of convergence is superlinear under some reasonable assum...A new trust region algorithm for solving convex LC 1 optimization problem is presented.It is proved that the algorithm is globally convergent and the rate of convergence is superlinear under some reasonable assumptions.展开更多
Instead of normally tackling electric circuits by virtue oI the Klrctllaott＇s theorem wnose aim is to uerlvc voxt^gc, electric current, and electric impedence, our aim in this paper is to derive the characteristic fr...Instead of normally tackling electric circuits by virtue oI the Klrctllaott＇s theorem wnose aim is to uerlvc voxt^gc, electric current, and electric impedence, our aim in this paper is to derive the characteristic frequency of a three-loop mesoscopic LC circuit with three mutual inductances, e.g., for the radiating frequency of the three-loop LC oscillator, we adopt the invariant eigen-operator （lEO） method to realize our aim.展开更多
In this paper we present a filter-trust-region algorithm for solving LC1 unconstrained optimization problems which uses the second Dini upper directional derivative. We establish the global convergence of the algorith...In this paper we present a filter-trust-region algorithm for solving LC1 unconstrained optimization problems which uses the second Dini upper directional derivative. We establish the global convergence of the algorithm under reasonable assumptions.展开更多
A method to extract crude heparin sodium from pig intestinal mucosa by dialysis and spray drying was established. The pig intestinal mucosa was treated in the following steps: enzymolysis, resin exchange adsorption-wa...A method to extract crude heparin sodium from pig intestinal mucosa by dialysis and spray drying was established. The pig intestinal mucosa was treated in the following steps: enzymolysis, resin exchange adsorption-washing, elution, pressure filtration, dialysis, spray drying. Activity of the product was measured using a heparin anti-IIa factor assay kit. The yield of crude heparin obtained by this method was 2.79% higher than that of oven drying method;the production of 1 kg crude heparin sodium saved 43.4 pigs small intestine. The activity was 98.48 ± 2.49 IU/mg (n = 5), 15.18 IU/mg higher than that obtained by oven drying method. The product is pale white powder, attractive color and easy to dissolve.展开更多
A liquid chromatography tandem mass spectrometry (LC-MS/MS) based method was developed for the simultaneous monitoring plasma levels of Sitagliptin (STG) and Pioglitazone (PIO) for applicability to pharmacokinetic stu...A liquid chromatography tandem mass spectrometry (LC-MS/MS) based method was developed for the simultaneous monitoring plasma levels of Sitagliptin (STG) and Pioglitazone (PIO) for applicability to pharmacokinetic studies. The method was based on HPLC separation on the reversed phase Phenomenex Synergy C18 column (30 mm length, 4.6 mm internal diameter, and 4.0 μm particle size) at a temperature of 40?C using a binary gradient mobile phase consisting of methanol and 2 mM ammonium acetate buffer pH adjusted to 4.5 with acetic acid, at a flow rate of 1 mL?min?1. Tolbutamide was used as an internal standard. Detection of analytes was achieved with LC-MS/MS system in Multiple Reaction Monitoring (MRM) mode. The method was validated over concentration range of 10.98 - 2091.77 ng?mL?1 for SIT and 8.25 - 1571.63 ng?mL?1 for PIO and lower limit of quantification was 10.98 ng?mL?1 and 8.25 ng?mL?1 for STG and PIO respectively. Recoveries from spiked controls were within acceptance criteria for all the analytes and internal standard at all QC levels. Within batch and between batch accuracy for STG was found within 96.9% - 100.3% and for PIO was found within 100.0% - 104.3%. Within batch and between batch precision for STG was less than 3.1% CV (coefficient of variation) and for PIO was less than 5.3% CV at all concentrations levels. This method was successfully applied to monitor pharmacokinetics profile of both STG and PIO on simultaneous oral administration to rats. This method can be applicable for pharmacokinetic drug-drug interaction studies.展开更多
The acute toxic effects of ammonium sulphate to fresh-water catfish, Heteropneustes fossilis (H.fossilis) have been studied by determining LC50 values with 95% confidence limits, by the graphic method, the logistic me...The acute toxic effects of ammonium sulphate to fresh-water catfish, Heteropneustes fossilis (H.fossilis) have been studied by determining LC50 values with 95% confidence limits, by the graphic method, the logistic method, the Spearman and Karber method and the trimmed Spearman-Karber method. The trimmed Spearman-Karber method was found the most ideal for ammonium salt toxicity test. The flaws in the trimmed Spearman-Karber method are also discussed.展开更多
针对变流器不同位置杂散电感准确获取困难的问题,提出一种基于LC高频振荡原理的杂散电感多参数提取方法,充分利用变流器自身结构,通过3个现场实验主动构建不同的谐振电路,并根据它们的振荡频率计算变流器不同位置的杂散电感。首先阐述...针对变流器不同位置杂散电感准确获取困难的问题,提出一种基于LC高频振荡原理的杂散电感多参数提取方法,充分利用变流器自身结构,通过3个现场实验主动构建不同的谐振电路,并根据它们的振荡频率计算变流器不同位置的杂散电感。首先阐述了高频振荡法的基本原理,建立了不同谐振实验的等值电路模型。然后,以1700 V/450 A IGBT变流器系统为例,通过仿真与实验进行了可行性与有效性验证。最后,通过实验与传统双脉冲法进行了对比分析。研究表明:所提出的方法可有效提取变流器内不同位置的杂散电感参数,与双脉冲法提取开关杂散电感结果基本一致,精度可达纳亨级。展开更多
基金Supported by Science and Technology Department of Jilin Province,No.YDZJ202201ZYTS110 and No.20200201352JC.
文摘The increasing prevalence of diabetes has led to a growing population of endstage kidney disease(ESKD)patients with diabetes.Currently,kidney transplantation is the best treatment option for ESKD patients;however,it is limited by the lack of donors.Therefore,dialysis has become the standard treatment for ESKD patients.However,the optimal dialysis method for diabetic ESKD patients remains controversial.ESKD patients with diabetes often present with complex conditions and numerous complications.Furthermore,these patients face a high risk of infection and technical failure,are more susceptible to malnutrition,have difficulty establishing vascular access,and experience more frequent blood sugar fluctuations than the general population.Therefore,this article reviews nine critical aspects:Survival rate,glucose metabolism disorder,infectious complications,cardiovascular events,residual renal function,quality of life,economic benefits,malnutrition,and volume load.This study aims to assist clinicians in selecting individualized treatment methods by comparing the advantages and disadvantages of hemodialysis and peritoneal dialysis,thereby improving patients’quality of life and survival rates.
文摘Potential mutagenic impurities in Active Pharmaceutical Ingredient, Meropenem Trihydrate were assessed and a novel analytical method for their quantification was developed and validated. This Liquid Chromatographic method using High Resolution Mass Spectrometer (LC-HRMS) technique is proved to be suitable for simultaneous quantification of all ten identified impurities with required specificity, sensitivity, resolution, precision, accuracy, and other method characteristics as per ICH Guidelines. The acceptable limit of less than 2.9 μg/g was considered for evaluations, based on drug substance dosage and duration of treatment. The method stands most sensitive with a Limit of Detection of 0.35 μg/g, considering the challenge full acceptance criteria as per current regulatory standards.
基金Supported by the National Natural Science Foundation of P.R.China(1 9971 0 0 2 ) and the Subject ofBeijing Educational Committ
文摘A new trust region algorithm for solving convex LC 1 optimization problem is presented.It is proved that the algorithm is globally convergent and the rate of convergence is superlinear under some reasonable assumptions.
基金Project supported by the National Natural Science Foundation of China(Grant No.11775208)
文摘Instead of normally tackling electric circuits by virtue oI the Klrctllaott＇s theorem wnose aim is to uerlvc voxt^gc, electric current, and electric impedence, our aim in this paper is to derive the characteristic frequency of a three-loop mesoscopic LC circuit with three mutual inductances, e.g., for the radiating frequency of the three-loop LC oscillator, we adopt the invariant eigen-operator （lEO） method to realize our aim.
基金Supported by CERG: CityU 101005 of the Government of Hong Kong SAR, Chinathe National Natural ScienceFoundation of China, the Specialized Research Fund of Doctoral Program of Higher Education of China (Grant No.20040319003)the Natural Science Fund of Jiangsu Province of China (Grant No. BK2006214)
文摘In this paper we present a filter-trust-region algorithm for solving LC1 unconstrained optimization problems which uses the second Dini upper directional derivative. We establish the global convergence of the algorithm under reasonable assumptions.
文摘A method to extract crude heparin sodium from pig intestinal mucosa by dialysis and spray drying was established. The pig intestinal mucosa was treated in the following steps: enzymolysis, resin exchange adsorption-washing, elution, pressure filtration, dialysis, spray drying. Activity of the product was measured using a heparin anti-IIa factor assay kit. The yield of crude heparin obtained by this method was 2.79% higher than that of oven drying method;the production of 1 kg crude heparin sodium saved 43.4 pigs small intestine. The activity was 98.48 ± 2.49 IU/mg (n = 5), 15.18 IU/mg higher than that obtained by oven drying method. The product is pale white powder, attractive color and easy to dissolve.
文摘A liquid chromatography tandem mass spectrometry (LC-MS/MS) based method was developed for the simultaneous monitoring plasma levels of Sitagliptin (STG) and Pioglitazone (PIO) for applicability to pharmacokinetic studies. The method was based on HPLC separation on the reversed phase Phenomenex Synergy C18 column (30 mm length, 4.6 mm internal diameter, and 4.0 μm particle size) at a temperature of 40?C using a binary gradient mobile phase consisting of methanol and 2 mM ammonium acetate buffer pH adjusted to 4.5 with acetic acid, at a flow rate of 1 mL?min?1. Tolbutamide was used as an internal standard. Detection of analytes was achieved with LC-MS/MS system in Multiple Reaction Monitoring (MRM) mode. The method was validated over concentration range of 10.98 - 2091.77 ng?mL?1 for SIT and 8.25 - 1571.63 ng?mL?1 for PIO and lower limit of quantification was 10.98 ng?mL?1 and 8.25 ng?mL?1 for STG and PIO respectively. Recoveries from spiked controls were within acceptance criteria for all the analytes and internal standard at all QC levels. Within batch and between batch accuracy for STG was found within 96.9% - 100.3% and for PIO was found within 100.0% - 104.3%. Within batch and between batch precision for STG was less than 3.1% CV (coefficient of variation) and for PIO was less than 5.3% CV at all concentrations levels. This method was successfully applied to monitor pharmacokinetics profile of both STG and PIO on simultaneous oral administration to rats. This method can be applicable for pharmacokinetic drug-drug interaction studies.
文摘The acute toxic effects of ammonium sulphate to fresh-water catfish, Heteropneustes fossilis (H.fossilis) have been studied by determining LC50 values with 95% confidence limits, by the graphic method, the logistic method, the Spearman and Karber method and the trimmed Spearman-Karber method. The trimmed Spearman-Karber method was found the most ideal for ammonium salt toxicity test. The flaws in the trimmed Spearman-Karber method are also discussed.
文摘针对变流器不同位置杂散电感准确获取困难的问题,提出一种基于LC高频振荡原理的杂散电感多参数提取方法,充分利用变流器自身结构,通过3个现场实验主动构建不同的谐振电路,并根据它们的振荡频率计算变流器不同位置的杂散电感。首先阐述了高频振荡法的基本原理,建立了不同谐振实验的等值电路模型。然后,以1700 V/450 A IGBT变流器系统为例,通过仿真与实验进行了可行性与有效性验证。最后,通过实验与传统双脉冲法进行了对比分析。研究表明:所提出的方法可有效提取变流器内不同位置的杂散电感参数,与双脉冲法提取开关杂散电感结果基本一致,精度可达纳亨级。
