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题名黑河流域莺落峡站河道内生态需水研究
被引量:4
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作者
邹悦
张勃
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机构
西北师范大学地理与环境科学学院
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出处
《地理科学进展》
CSCD
北大核心
2012年第5期625-631,共7页
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基金
国家自然科学基金项目(40961038)
中国科学院知识创新工程重要方向项目(KZCX2-YW-Q10-4)
+1 种基金
公益性行业(气象)科研专项(GYHY200806021-07)
生态经济学省级重点学科项目(5001-021)
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文摘
生态需水是当前水问题研究中的一个热点问题,对于生态环境急剧恶化的内陆干旱区来说,这一研究尤为紧迫。气候变化及人类活动导致水文变异,进而改变了当地生态系统的水文及生态平衡状况。文章采用黑河流域莺落峡站1947-2006年月径流序列资料,运用差积曲线-秩检验联合法来识别水文过程变异点并分析变异成因,然后对各月平均流量序列用线性矩法推求GEV分布参数,求出概率密度最大流量,将其视为相应月河道内生态流量,可以得到黑河莺落峡站河道内生态需水情况。结果表明,基于水文变异情况分析河道内生态需水的计算方法在黑河上游是可行的;水文变异前后,站点满足生态需水频率会发生显著变化,因气候原因而导致的径流量变化是很难避免的,科学合理计算生态需水对干旱区河流生态管理和经济社会可持续发展有重要作用和意义。
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关键词
河道内生态需水
水文变异
差积曲线-秩检验联合法
黑河
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Keywords
ecological water demand
hydrological change
difference plot curve-combined method of rank test
Heihe River
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分类号
TV213.4
[水利工程—水文学及水资源]
P333
[天文地球—水文科学]
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题名胃癌血管侵犯的临床病理分析
被引量:8
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作者
余亮
吕成余
赵有财
陈维
袁爱华
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机构
南京医科大学附属南京医院普通外科
南京医科大学附属南京医院病理科
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出处
《中华消化外科杂志》
CAS
CSCD
北大核心
2015年第3期207-211,共5页
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基金
南京市科技计划项目(201106016)
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文摘
目的探讨胃癌血管侵犯与患者临床病理因素及预后的关系,分析影响胃癌患者预后的相关因素。方法回顾性分析2007年1月至2010年12月南京医科大学附属南京医院收治的206例胃癌患者的临床病理资料。收集胃癌患者手术切除的肿瘤标本,采用免疫组织化学染色检测肿瘤标的本血管侵犯情况。采用门诊和电话方式进行随访,随访时间截至2014年3月。计数资料比较采用r检验。采用Kaplan-Meier法绘制生存曲线,Log-rank检验进行生存分析和单因素分析。采用COX模型逐步后退法进行多因素分析。结果206例患者中,血管侵犯率为27.67%(57/206)。胃癌患者的不同肿瘤分化程度、神经侵犯、T分期、N分期、TNM分期胃癌组织中血管侵犯率比较,差异有统计学意义(χ^2=14.396,9.569,15.579,43.453,30.732,P〈0.05)。188例患者获得术后随访,随访率为91.26%(188/206),随访时间为6.0~60.0个月,中位随访时间为34.0个月。188例获得随访患者中,血管侵犯患者中位生存时间为32.4个月,5年累积生存率为19.6%;血管未侵犯患者中位生存时间为40.7个月,5年累积生存率为42.0%,两者生存情况比较,差异有统计学意义(χ^2=9.364,P〈0.05)。单因素分析结果显示:肿瘤直径、肿瘤分化程度、神经侵犯、血管侵犯、T分期、N分期、TNM分期是影响胃癌患者预后的相关因素(χ^2=9.241,17.486,11.243,9.364,27.666,216.745,49.887,P〈0.05)。多因素分析结果显示:肿瘤直径≥5cm、血管侵犯、T分期为T4期、N分期为N3期、TNM分期为Ⅲ期是影响胃癌患者预后的独立危险因素(HR=0.502,0.456,0.052,0.001,0.735,95%可信区间:0.334—0.754,0.289~0.720,0.004—0.664,0.000~0.006,0.159~3.398,P〈0.05)。结论胃癌患者血管侵犯可能与肿瘤进展有关。肿瘤直径≥5cm、血管侵犯、T分期为T4期、N分期为N3期、TNM分期为Ⅲ期是影响胃癌患者预后的独立危险因素。血管侵犯可作为判断胃癌患者预后不良的指标。
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关键词
胃肿瘤
血管侵犯
预后
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Keywords
Gastric neoplasms
Blood vessel invasion
ProgObjective To investigate the relationship between blood vessel invasion (BVI) and clinico- pathologic features and prognosis in patients with gastric cancer, and analyze related factors affecting the prognosis of patients. methods The clinicopathological data of 206 patients with gastric cancer who were admitted to the Nanjing Hospital Affiliated to Nanjing Medical University from January 2007 to December 2010 were retrospectively analyzed. The BVI of surgical tumor specimens in all patients was detected by immunohistochemical staininng. All the patients were followed up via outpatient examination and telephone interview up to March 2014. The count data were analyzed using the chi-square test. The survival curve was drawn by Kaplan-Meier method. The survival ana- lysis and univariate analysis were done using the Log-rank test, and multivariate analysis was done using the COX regression model. Results The BVI rate of 206 patients was 27.67% (57/206). The BVI rate of tumor tissues, tumor differentiation, perineural invasion, T stage, N stage and TNM stage in all patients with gastric cancer were compared, showing significant differences (X2= 14. 396, 9. 569, 15. 579, 43. 453, 30. 732, P 〈 0.05). After operation, 188 patients were followed up for 6.0-60.0 months ( median, 34.0 months), with the follow-up rate of 91.26% (188/206). Among 188 patients with follow-up, the median survival time and 5-year cumulative survival rate in patients with BVI and with negative BVI were 32.4 months and 19.6%, 40.7 months and 42.0%, respec- tively, with a significant difference in the survival of patients (X2 = 9. 364, P 〈 0.05 ). The results of univariate analysis showed that the diameter of tumor, tumor differentiation, perineural invasion, BVI, T stage, N stage and TNM stage were factors affecting thnosis
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分类号
R735.2
[医药卫生—肿瘤]
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