AIM:To investigate whether MYC and BCL-2 coexpression has prognostic significance in primary gastrointestinal diffuse large B-cell lymphoma(PGI-DLBCL)patients,and explore its associations with patients’clinical param...AIM:To investigate whether MYC and BCL-2 coexpression has prognostic significance in primary gastrointestinal diffuse large B-cell lymphoma(PGI-DLBCL)patients,and explore its associations with patients’clinical parameters.METHODS:Fresh and paraffin-embedded tumor tissue samples from 60 PGI-DLBCL patients who had undergone surgery at the Tianjin Medical University Cancer Institute and Hospital from January 2005 to May 2010 were obtained,and 30 lymphoid tissue samples from reactive lymph nodes of age-and sexmatched patients represented control samples.Staging and diagnostic procedures were conducted according to the Lugano staging system.All patients had been treated with three therapeutic modalities:surgery,chemotherapy,or radiotherapy.Expression of MYC and BCL-2 were detected at both protein and m RNA levels by immunohistochemistry and real-time RT-PCR.RESULTS:Positive expression levels of MYC and BCL-2proteins were detected in 35%and 45%of patients,respectively.MYC+/BCL-2+protein was present in30%of patients.MYC and BCL-2 protein levels were correlated with high MYC and BCL-2 m RNA expression,respectively(both P<0.05).We found that advancedstage disease(atⅡE-Ⅳ)was associated with MYC and BCL-2 coexpression levels(P<0.05).In addition,MYC+/BCL-2+patients had more difficulty in achieving complete remission than others(P<0.05).Presenceof MYC protein expression only affected overall survivaland progression-free survival(PFS)when BCL-2 proteinwas coexpressed.The adverse prognostic impact ofMYC+/BCL-2+protein on PFS remained significant(P<0.05)even after adjusting for age,Lugano stage,international prognostic index,and BCL-2 proteinexpression in a multivariable model.CONCLUSION:MYC+/BCL-2+patients have worsechemotherapy response and poorer prognosis thanpatients who only express one of the two proteins,suggesting that assessment of MYC and BCL-2 expressionby immunohistochemistry has clinical significance inpredicting clinical outcomes of PGI-DLBCL patients.展开更多
Molecular communication(MC) is a kind of communication technology based on biochemical molecules for internet of bio-nano things, in which the biochemical molecule is used as the information carrier for the interconne...Molecular communication(MC) is a kind of communication technology based on biochemical molecules for internet of bio-nano things, in which the biochemical molecule is used as the information carrier for the interconnection of nano-devices. In this paper, the basic principle of diffusion based MC and the corresponding key technologies are comprehensively surveyed. In particular, the state-ofthe-art achievements relative to the diffusion based MC are discussed and compared, including the system model, the system performance analysis with key influencing factors, the information coding and modulation techniques. Meanwhile, the multi-hop nano-network based on the diffusion MC is presented as well. Additionally, given the extensiveness of the research area, open issues and challenges are presented to spur future investigations, in which the involvement of channel model, information theory, self-organizing nano-network, and biochemical applications are put forward.展开更多
A modified version of the Cotte, Lions, Morel and Coil theory for image selective smoothing and edge detection is proposed. Comparing with their model, the most important advantage of this modification is that the con...A modified version of the Cotte, Lions, Morel and Coil theory for image selective smoothing and edge detection is proposed. Comparing with their model, the most important advantage of this modification is that the convolution with Gaussian processes in the filtering process is replaced by solving an initial-boundary value problem for the heat equation, which simplifies the numerical scheme to some extent. Numerical experiments on natural images are presented for this model.展开更多
Thermal transport in amorphous materials has remained one of the fundamental questions in solid state physics while involving a very large field of applications.Using a heat conduction theory incorporating coherence,w...Thermal transport in amorphous materials has remained one of the fundamental questions in solid state physics while involving a very large field of applications.Using a heat conduction theory incorporating coherence,we demonstrate that the strong phase correlation between local and non-propagating modes,commonly named diffusons in the terminology of amorphous systems,triggers the conduction of heat.By treating the thermal vibrations as collective excitations,the significant contribution of diffusons,predominantly relying on coherence,further reveals interesting temperature and length dependences of thermal conductivity.The propagation length of diffuson clusters is found to reach the micron,overpassing the one of propagons.The explored wavelike behavior of diffusons uncovers the unsolved physical picture of mode correlation in prevailing models and further provides an interpretation of their ability to transport heat.This work introduces a framework for understanding thermal vibrations and transport in amorphous materials,as well as an unexpected insight into the wave nature of thermal vibrations.展开更多
In recent years, the fluorescence photobleaching recovery (FPR) technique has been used for conducting a series of studies on the lateral mobility of proteins and lipids of the cell membrane. This technique was first ...In recent years, the fluorescence photobleaching recovery (FPR) technique has been used for conducting a series of studies on the lateral mobility of proteins and lipids of the cell membrane. This technique was first introduced by Peters et al. and later improved and developed by Koppel et al. Now it has become the principal method for a quantitative measurement of the lateral mobility of membrane components such as proteins. Hence increasing importance has been attached to it.展开更多
With the support by the National Natural Science Foundation of China,Prof.Liang Dong’s laboratory at Shenzhen Institutes of Advanced Technology,Chinese Academy of Sciences,reported a novel MR diffusion tensor imaging...With the support by the National Natural Science Foundation of China,Prof.Liang Dong’s laboratory at Shenzhen Institutes of Advanced Technology,Chinese Academy of Sciences,reported a novel MR diffusion tensor imaging method using distributed compressed sensing,which was published in Magnetic Resonance in Medicine(2014,71(2):763—772).展开更多
将优化问题抽象成目标函数后,目标函数和启发式优化算法的匹配程度决定了优化求解的效率.为反映目标函数的优化特征并指导优化算法及其参数的选择,本文模拟绝热量子计算中的多基态演化,提出了一种适应度地形探索算法.根据基态波函数倾...将优化问题抽象成目标函数后,目标函数和启发式优化算法的匹配程度决定了优化求解的效率.为反映目标函数的优化特征并指导优化算法及其参数的选择,本文模拟绝热量子计算中的多基态演化,提出了一种适应度地形探索算法.根据基态波函数倾向于向势能较小处收敛且收敛程度受量子效应强度影响的特性,用目标函数编码势能场后算法引入了一个量子效应递减的多基态演化过程,用其持续收敛的基态波函数簇反映目标函数的适应度地形.根据量子路径积分,算法由尺度递减的扩散蒙特卡罗(diffusion Monte Carlo,DMC)实现.实验表明算法综合直观地反映了适应度地形的众多特征,所得信息能直接指导后续优化,其计算模式和启发式优化相似,无需引入其他计算,这为适应度地形研究引入了新的视角.展开更多
综合应用冲激滤波器、改进的前向后向(forward and backward,FAB)扩散滤波器和全变差(total-variation,TV)扩散算法,提出一种双正交映射约束的混合偏微分方程扩散图像放大算法。改进的FAB滤波器能够很好地增强图像的小边缘,参数约束的...综合应用冲激滤波器、改进的前向后向(forward and backward,FAB)扩散滤波器和全变差(total-variation,TV)扩散算法,提出一种双正交映射约束的混合偏微分方程扩散图像放大算法。改进的FAB滤波器能够很好地增强图像的小边缘,参数约束的冲激滤波器可增强图像的强边缘,基于水平集方法实现的TV扩散可以消除边缘的锯齿波,使边缘光滑,所提算法综合以上优点。利用退化模型的低通滤波器的双正交滤波器得到一个空域双正交映射,放大图像完全满足退化模型,使放大图像对于退化模型可逆。仿真实验表明,与其他算法相比,所提算法有较好的性能,得到的放大图像更加自然,在弱边缘和中等强度边缘都有更好的视觉效果。展开更多
基金Supported by National Natural Science Foundation of China,No.30672208,No.81270603 and No.31301161Tianjin Natural Science Foundation of China,No.13JCYBJC22800
文摘AIM:To investigate whether MYC and BCL-2 coexpression has prognostic significance in primary gastrointestinal diffuse large B-cell lymphoma(PGI-DLBCL)patients,and explore its associations with patients’clinical parameters.METHODS:Fresh and paraffin-embedded tumor tissue samples from 60 PGI-DLBCL patients who had undergone surgery at the Tianjin Medical University Cancer Institute and Hospital from January 2005 to May 2010 were obtained,and 30 lymphoid tissue samples from reactive lymph nodes of age-and sexmatched patients represented control samples.Staging and diagnostic procedures were conducted according to the Lugano staging system.All patients had been treated with three therapeutic modalities:surgery,chemotherapy,or radiotherapy.Expression of MYC and BCL-2 were detected at both protein and m RNA levels by immunohistochemistry and real-time RT-PCR.RESULTS:Positive expression levels of MYC and BCL-2proteins were detected in 35%and 45%of patients,respectively.MYC+/BCL-2+protein was present in30%of patients.MYC and BCL-2 protein levels were correlated with high MYC and BCL-2 m RNA expression,respectively(both P<0.05).We found that advancedstage disease(atⅡE-Ⅳ)was associated with MYC and BCL-2 coexpression levels(P<0.05).In addition,MYC+/BCL-2+patients had more difficulty in achieving complete remission than others(P<0.05).Presenceof MYC protein expression only affected overall survivaland progression-free survival(PFS)when BCL-2 proteinwas coexpressed.The adverse prognostic impact ofMYC+/BCL-2+protein on PFS remained significant(P<0.05)even after adjusting for age,Lugano stage,international prognostic index,and BCL-2 proteinexpression in a multivariable model.CONCLUSION:MYC+/BCL-2+patients have worsechemotherapy response and poorer prognosis thanpatients who only express one of the two proteins,suggesting that assessment of MYC and BCL-2 expressionby immunohistochemistry has clinical significance inpredicting clinical outcomes of PGI-DLBCL patients.
基金supported in part by the National Natural Science Foundation of China (Grant No.61361166005)the State Major Science and Technology Special Projects (Grant No.2016ZX03001020006)
文摘Molecular communication(MC) is a kind of communication technology based on biochemical molecules for internet of bio-nano things, in which the biochemical molecule is used as the information carrier for the interconnection of nano-devices. In this paper, the basic principle of diffusion based MC and the corresponding key technologies are comprehensively surveyed. In particular, the state-ofthe-art achievements relative to the diffusion based MC are discussed and compared, including the system model, the system performance analysis with key influencing factors, the information coding and modulation techniques. Meanwhile, the multi-hop nano-network based on the diffusion MC is presented as well. Additionally, given the extensiveness of the research area, open issues and challenges are presented to spur future investigations, in which the involvement of channel model, information theory, self-organizing nano-network, and biochemical applications are put forward.
基金Partially supported by National Natural Science Foundation and the Shanghai Qimingxing grant. # 97QA14040
文摘A modified version of the Cotte, Lions, Morel and Coil theory for image selective smoothing and edge detection is proposed. Comparing with their model, the most important advantage of this modification is that the convolution with Gaussian processes in the filtering process is replaced by solving an initial-boundary value problem for the heat equation, which simplifies the numerical scheme to some extent. Numerical experiments on natural images are presented for this model.
基金This work is partially supported by CREST JST(No.JPMJCR19I1 and JPMJCR19Q3)This research used the computational resources of the Oakforest-PACS supercomputer system,The University of Tokyo+1 种基金This project is also supported in part by the grants from the National Natural Science Foundation of China(Grant Nos.12075168 and 11890703)Science and Technology Commission of Shanghai Municipality(Grant No.19ZR1478600).
文摘Thermal transport in amorphous materials has remained one of the fundamental questions in solid state physics while involving a very large field of applications.Using a heat conduction theory incorporating coherence,we demonstrate that the strong phase correlation between local and non-propagating modes,commonly named diffusons in the terminology of amorphous systems,triggers the conduction of heat.By treating the thermal vibrations as collective excitations,the significant contribution of diffusons,predominantly relying on coherence,further reveals interesting temperature and length dependences of thermal conductivity.The propagation length of diffuson clusters is found to reach the micron,overpassing the one of propagons.The explored wavelike behavior of diffusons uncovers the unsolved physical picture of mode correlation in prevailing models and further provides an interpretation of their ability to transport heat.This work introduces a framework for understanding thermal vibrations and transport in amorphous materials,as well as an unexpected insight into the wave nature of thermal vibrations.
文摘In recent years, the fluorescence photobleaching recovery (FPR) technique has been used for conducting a series of studies on the lateral mobility of proteins and lipids of the cell membrane. This technique was first introduced by Peters et al. and later improved and developed by Koppel et al. Now it has become the principal method for a quantitative measurement of the lateral mobility of membrane components such as proteins. Hence increasing importance has been attached to it.
文摘With the support by the National Natural Science Foundation of China,Prof.Liang Dong’s laboratory at Shenzhen Institutes of Advanced Technology,Chinese Academy of Sciences,reported a novel MR diffusion tensor imaging method using distributed compressed sensing,which was published in Magnetic Resonance in Medicine(2014,71(2):763—772).
文摘将优化问题抽象成目标函数后,目标函数和启发式优化算法的匹配程度决定了优化求解的效率.为反映目标函数的优化特征并指导优化算法及其参数的选择,本文模拟绝热量子计算中的多基态演化,提出了一种适应度地形探索算法.根据基态波函数倾向于向势能较小处收敛且收敛程度受量子效应强度影响的特性,用目标函数编码势能场后算法引入了一个量子效应递减的多基态演化过程,用其持续收敛的基态波函数簇反映目标函数的适应度地形.根据量子路径积分,算法由尺度递减的扩散蒙特卡罗(diffusion Monte Carlo,DMC)实现.实验表明算法综合直观地反映了适应度地形的众多特征,所得信息能直接指导后续优化,其计算模式和启发式优化相似,无需引入其他计算,这为适应度地形研究引入了新的视角.
文摘综合应用冲激滤波器、改进的前向后向(forward and backward,FAB)扩散滤波器和全变差(total-variation,TV)扩散算法,提出一种双正交映射约束的混合偏微分方程扩散图像放大算法。改进的FAB滤波器能够很好地增强图像的小边缘,参数约束的冲激滤波器可增强图像的强边缘,基于水平集方法实现的TV扩散可以消除边缘的锯齿波,使边缘光滑,所提算法综合以上优点。利用退化模型的低通滤波器的双正交滤波器得到一个空域双正交映射,放大图像完全满足退化模型,使放大图像对于退化模型可逆。仿真实验表明,与其他算法相比,所提算法有较好的性能,得到的放大图像更加自然,在弱边缘和中等强度边缘都有更好的视觉效果。
