The formation mechanism of calcium vanadate and manganese vanadate and the difference between calcium and manganese in the reaction with vanadium are basic issues in the calcification roasting and manganese roasting p...The formation mechanism of calcium vanadate and manganese vanadate and the difference between calcium and manganese in the reaction with vanadium are basic issues in the calcification roasting and manganese roasting process with vanadium slag.In this work,CaO–V_(2)O_(5) and MnO_(2)–V_(2)O_(5) diffusion couples were prepared and roasted for different time periods to illustrate and compare the diffusion reaction mechanisms.Then,the changes in the diffusion product and diffusion coefficient were investigated and calculated based on scanning electron microscopy (SEM) with energy dispersive X-ray spectroscopy (EDS) analysis.Results show that with the extension of the roasting time,the diffusion reaction gradually proceeds among the CaO–V_(2)O_(5) and MnO_(2)–V_(2)O_(5) diffusion couples.The regional boundaries of calcium and vanadium are easily identifiable for the CaO–V_(2)O_(5) diffusion couple.Meanwhile,for the MnO_(2)–V_(2)O_(5) diffusion couple,MnO_(2) gradually decomposes to form Mn_(2)O_(3),and vanadium diffuses into the interior of Mn_(2)O_(3).Only a part of vanadium combines with manganese to form the diffusion production layer.CaV_(2)O_(6) and MnV_(2)O_(6) are the interfacial reaction products of the CaO–V_(2)O_(5) and MnO_(2)–V_(2)O_(5) diffusion couples,respectively,whose thicknesses are 39.85 and 32.13μm when roasted for 16 h.After 16 h,both diffusion couples reach the reaction equilibrium due to the limitation of diffusion.The diffusion coefficient of the CaO–V_(2)O_(5) diffusion couple is higher than that of the MnO_(2)–V_(2)O_(5) diffusion couple for the same roasting time,and the diffusion reaction between vanadium and calcium is easier than that between vanadium and manganese.展开更多
In recent years, there has been a growing interest in researching and developing new antimicrobial agents from various sources to combat microbial resistance. Therefore, a greater attention has been paid to antimicrob...In recent years, there has been a growing interest in researching and developing new antimicrobial agents from various sources to combat microbial resistance. Therefore, a greater attention has been paid to antimicrobial activity screening and evaluating methods. Several bioassays such as disk-diffusion, well diffusion and broth or agar dilution are well known and commonly used, but others such as flow cy- tofluorometric and bioluminescent methods are not widely used because they require specified equip- ment and further evaluation for reproducibility and standardization, even if they can provide rapid re- sults of the antimicrobial agent's effects and a better understanding of their impact on the viability and cell damage inflicted to the tested microorganism. In this review article, an exhaustive list of in vitro antimicrobial susceptibility testing methods and detailed information on their advantages and limita- tions are reported.展开更多
A nonconforming finite element method of finite difference streamline diffusion type is proposed to solve the time-dependent linearized Navier-Stokes equations. The backward Euler scheme is used for time discretizatio...A nonconforming finite element method of finite difference streamline diffusion type is proposed to solve the time-dependent linearized Navier-Stokes equations. The backward Euler scheme is used for time discretization. Crouzeix-Raviart nonconforming finite element approximation, namely, nonconforming (P1)2 - P0 element, is used for the velocity and pressure fields with the streamline diffusion technique to cope with usual instabilities caused by the convection and time terms. Stability and error estimates are derived with suitable norms.展开更多
This paper aims to present a new streamline diffusion method with low order rectangular Bernardi-Raugel elements to solve the generalized Oseen equations. With the help of the Bramble-Hilbert lemma, the optimal errors...This paper aims to present a new streamline diffusion method with low order rectangular Bernardi-Raugel elements to solve the generalized Oseen equations. With the help of the Bramble-Hilbert lemma, the optimal errors of the velocity and pressure are estimated, which are independent of the considered parameter e. With an interpolation postprocessing approach, the superconvergent error of the pressure is obtained. Finally, a numerical experiment is carried out to confirm the theoretical results.展开更多
This paper proposes a new nonconforming finite difference streamline diffusion method to solve incompressible time-dependent Navier-Stokes equations with a high Reynolds number. The backwards difference in time and th...This paper proposes a new nonconforming finite difference streamline diffusion method to solve incompressible time-dependent Navier-Stokes equations with a high Reynolds number. The backwards difference in time and the Crouzeix-Raviart (CR) element combined with the P0 element in space are used. The result shows that this scheme has good stabilities and error estimates independent of the viscosity coefficient.展开更多
A posteriori error estimate of the discontinuous-streamline diffusion method for first-order hyperbolic equations was presented, which can be used to adjust space mesh reasonably. A numerical example is given to illus...A posteriori error estimate of the discontinuous-streamline diffusion method for first-order hyperbolic equations was presented, which can be used to adjust space mesh reasonably. A numerical example is given to illustrate the accuracy and feasibility of this method.展开更多
This paper examines the numerical solution of the convection-diffusion equation in 2-D. The solution of this equation possesses singularities in the form of boundary or interior layers due to non-smooth boundary condi...This paper examines the numerical solution of the convection-diffusion equation in 2-D. The solution of this equation possesses singularities in the form of boundary or interior layers due to non-smooth boundary conditions. To overcome such singularities arising from these critical regions, the adaptive finite element method is employed. This scheme is based on the streamline diffusion method combined with Neumann-type posteriori estimator. The effectiveness of this approach is illustrated by different examples with several numerical experiments.展开更多
In this paper we make a close study of the finite analytic method by means of the maximum principles in differential equations and give the proof of the stability and convergence of the finite analytic method.
Oil-producing crops,including Helianthus annuus L.(H.annuus,Sunflower),have been used for the treatment of different human diseases since ancient times.This study aims to determine the antimicrobial and cytotoxic pote...Oil-producing crops,including Helianthus annuus L.(H.annuus,Sunflower),have been used for the treatment of different human diseases since ancient times.This study aims to determine the antimicrobial and cytotoxic potential of different polarities of seeds and flower extracts of locally grown H.annuus by well-established bioassays.To achieve the objects,the plant extracts were prepared from both flowers and seeds powder samples individually with methanol solvent by using a Soxhlet extraction method.The antimicrobial and cytotoxic potential of the flowers and seed extracts were determined by the in vitro diffusion and brine shrimp method(BSL).The results of the antimicrobial potential of both prepared flower and seed extracts of various polarities at different concentrations showed promising potential against the gram-positive and gram-negative bacterial strains,within the range of inhibition zone 0–20 mm.Among the flower extracts,the highest potential was obtained in water extract and the lowest potential was in butanol extract followed by water>ethyl acetate>hexane>methanol>chloroform>butanol extracts.However,from the seed extracts,the highest potential was obtained in water extract and the lowest potential was in the methanol extract followed by water>hexane>butanol>ethyl acetate>chloroform>methanol extract.On the other hand,the results of cytotoxicity among the flowers extracts against the brine shrimp method where the highest LC50 against brine shrimp nauplii were found to be 31.25μg/mL in water extract and the lowest LC50 was 1345.86μg/mL in chloroform extract followed by water>ethyl acetate>hexane>butanol>methanol>chloroform extract.Similarly,different polarities of seed extracts,the highest LC50 against brine shrimp nauplii was shown to be 109.56μg/mL in butanol extract and the lowest LC50 was 1513.56μg/mL in ethyl acetate extract followed by butanol>hexane>water>methanol>chloroform>ethyl acetate extract.In conclusion,the results showed that both flowers and seeds extracts at various concentrations have promising potential against the positive and negative bacterial strains and the highest potential water extract could be used as natural broad-spectrum antibiotics as herbal medicine to treat different human infectious diseases.展开更多
The 21 centimeter (21 cm) line emission from neutral hydrogen in the intergalactic medium (IGM) at high redshifts is strongly contaminated by foreground sources such as the diffuse Galactic synchrotron emission an...The 21 centimeter (21 cm) line emission from neutral hydrogen in the intergalactic medium (IGM) at high redshifts is strongly contaminated by foreground sources such as the diffuse Galactic synchrotron emission and free-free emission from the Galaxy, as well as emission from extragalactic radio sources, thus making its observation very complicated. However, the 21 cm signal can be recovered through its structure in frequency space, as the power spectrum of the foreground contamination is expected to be smooth over a wide band in frequency space while the 21 cm fluctuations vary significantly. We use a simple polynomial fitting to reconstruct the 21 cm signal around four frequencies 50, 100, 150 and 200 MHz with an especially small channel width of 20 kHz. Our calculations show that this multifrequency fitting approach can effectively recover the 21 cm signal in the frequency range 100 - 200 MHz. However, this method doesn't work well around 50 MHz because of the low intensity of the 21 cm signal at this frequency. We also show that the fluctuation of detector noise can be suppressed to a very low level by taking long integration times, which means that we can reach a sensitivity of ≈ 10 mK at 150 MHz with 40 antennas in 120 hours of observations.展开更多
In this formulation study,biocompatible non steroidal anti-inflammatory(NSAIDs)-loaded nanoparticles were designed as models to be further integrated in a prosthesis surface functionalization.A modified spontaneous em...In this formulation study,biocompatible non steroidal anti-inflammatory(NSAIDs)-loaded nanoparticles were designed as models to be further integrated in a prosthesis surface functionalization.A modified spontaneous emulsion-solvent diffusion methodology was used to produce drug-loaded PLGA nanoparticles without any purification or solvent evaporation requirements.Formulation parameters,such as lactide/glycolide ratio,polymer concentration,solvent/non solvent ratio and non solvent phase,as well as the non ionic tensioactive P188 co-precipitation composition were systematically explored.The optimized formulation(mean size:145 nm,surface charge:-13 m V) was employed to encapsulate various amounts of NSAIDs in a simple and scalable manner.The drug release was characterized in vitro by a complete release for 48 h.These results encourage upcoming preliminary steps for in vivo experiments of prosthesis surface functionalization.展开更多
Nonlinear optical crystals of L-Arginine maleate dihydrate were grown from liquid diffusion method. The lattice parameters of the crystal were identified using single crystal and powder crystal X-ray diffraction analy...Nonlinear optical crystals of L-Arginine maleate dihydrate were grown from liquid diffusion method. The lattice parameters of the crystal were identified using single crystal and powder crystal X-ray diffraction analyses. Fourier transform infrared spectroscopy and Fourier transform Raman spectroscopy were made to study the vibrational functional groups in the grown crystal. Optical absorption and transmission ranges were measured from UV-VIS-NIR spectrum. The molecular structure of the crystal is established through <sup>1</sup>H-NMR and <sup>13</sup>C-NMR studies. Thermal stabilities and decomposition of the grown crystal were studied from TG/DTA and DSC analyses. Nonlinear optical property of the crystal was determined by Kurtz and Perry powder technique.展开更多
Nonlinear governing equations are established for large deflection of incompressible fluid saturated poroelastic beams under constraint that diffusion of the pore fluid is only in the axial direction of the deformed b...Nonlinear governing equations are established for large deflection of incompressible fluid saturated poroelastic beams under constraint that diffusion of the pore fluid is only in the axial direction of the deformed beams. Then, the nonlinear bending of a saturated poroelastic cantilever beam with fixed end impermeable and flee end permeable, subjected to a suddenly applied constant concentrated transverse load at its free end, is examined with the Gaierkin truncation method. The curves of deflections and bending moments of the beam skeleton and the equivalent couples of the pore fluid pressure are shown in figures. The results of the large deflection and the small deflection theories of the cantilever poroelastic beam are compared, and the differences between them are revealed. It is shown that the results of the large deflection theory are less than those of the corresponding small deflection theory, and the times needed to approach its stationary states for the large deflection theory are much less than those of the small deflection theory.展开更多
The transient mass transter processes in the natural drying of wood particle materials were experimental;y studied A new theory tio determme the mass transfer parameters in the Materials was developed in terms of grad...The transient mass transter processes in the natural drying of wood particle materials were experimental;y studied A new theory tio determme the mass transfer parameters in the Materials was developed in terms of gradient transformation method(GTM).By making use of GTM.Thewater vapour diffusion coefficient and the surtaee emission coefficent of wood chip were expermentally determined both in air phase and in solid phase.It Was found that the internal resistance to water vapour diffusion in the air phase of wood partiele aggregates is around ten to the third power as large as that in common air The drag coefficient was given to quantify the effect The phenomenon of undersurface diffusion in wood partiele bed was quantitatively modelled.The dimensionless Fourier snumber and the Biot's number for mass transfer were theoretically derived.The study showed that Biot's number for the problem investigated was the ratio of the characteristie length of wood partiele bed to the penetrating depth of the undersurface.An analytical solution of the nonlinear goveming equation for water transport process in the aggregates of wood chip was obtained by introducing the variable coefficients measured in the study into the governing equation.The comparison between the analytical solution and the observed moisture content of wood chip showed that the deviation was less than ±7%.The thermophysieal properties of wood particle materials are little known at present.The knowledge provided in the paper will be and in the handling.researeh or engineering application of wood chip.wood shavingsete.展开更多
In this paper,we consider a modified nonlinear dynamic diffusion(DD)method for convection-diffusion-reaction equations.This method is free of stabilization parameters and capable of precluding spurious oscillations.We...In this paper,we consider a modified nonlinear dynamic diffusion(DD)method for convection-diffusion-reaction equations.This method is free of stabilization parameters and capable of precluding spurious oscillations.We develop a reliable and efficient residual-type a posteriori error estimator,which is robust with respect to the diffusivity parameter.Furthermore,we propose a linearized adaptive DD algorithm based on the a posteriori estimator.Finally,we perform numerical experiments to verify the theoretical analysis and the performance of the adaptive algorithm.展开更多
The low diffusion (LD) particle method, proposed by Burt and Boyd, is modified for the near-continuum two-phase flow simulations. The LD method has the advantages of easily coupling with the direct simulation Monte ...The low diffusion (LD) particle method, proposed by Burt and Boyd, is modified for the near-continuum two-phase flow simulations. The LD method has the advantages of easily coupling with the direct simulation Monte Carlo (DSMC) method for multi-scale flow simulations and dramatically reducing the numerical diffusion error and statistical scatter of the equilibrium particle methods. Liquidor solid-phase particles are introduced in the LD method. Their velocity and temperature updating are respectively, calculated from the motion equation and the temperature equation according to the local gas properties. Coupling effects from condensed phase to gas phase are modeled as momentum and energy sources, which are respectively, equal to the negative values of the total momentum and energy increase in liquid or solid phase. The modified method is compared with theoretical results for unsteady flows, and good agreements are obtained to indicate the reliability of the one-way gas-to-particle coupling models. Hybrid LD-DSMC algorithm is implemented and performed for nozzle discharging gas-liquid flow to show the prospect of the LD-DSMC scheme for multi-scale two-phase flow simulations.展开更多
Noise reduction is one of the most important concerns in electronic speckle pattern interferometry(ESPI). According to partial differential equation(PDE) filtering theory, we present an anisotropic PDE noisereduction ...Noise reduction is one of the most important concerns in electronic speckle pattern interferometry(ESPI). According to partial differential equation(PDE) filtering theory, we present an anisotropic PDE noisereduction model based on fringe structure information for interferometric fringe patterns. This model is based on coherence diffusion and Perona-Malik(P-M) diffusion. The former can protect the structure information of fringe pattern, while the latter can effectively filter off the noise inside the fringes. The proposed model generated by the two diffusion methods helps to obtain good effects of denoising and fidelity. ESPI fringes and the phase pattern are tested. Experimental results validate the performance of the proposed filtering model.展开更多
We propose a hybrid scheme combing the diffuse interface method and the material point method to simulate the complex interactions between the multiphase compressible flow and elastoplastic solid.The multiphase flow i...We propose a hybrid scheme combing the diffuse interface method and the material point method to simulate the complex interactions between the multiphase compressible flow and elastoplastic solid.The multiphase flow is modelled by the multi-component model and solved using a generalized Godunov method in the Eulerian grids,while the elastoplastic solid is solved by the classical material point method in a combination of Lagrangian particles and Eulerian background grids.In order to facilitate the simulation of fluid-solid interactions,the solid variables are further interpolated to the cell center and coexist with the fluid in the same cell.An instantaneous relaxation procedure of velocity and pressure is adopted to simulate the momentum and energy transfers between various materials,and to keep the system within a tightly coupled interaction.Several numerical examples,including shock tube problem,gasbubble problem,air blast,underwater explosion and high speed impact applications are presented to validate the numerical scheme.展开更多
基金supported by the National Natural Science Foundation of China(Nos.52174277 and 51874077)the Fundamental Funds for the Central Universities,China(No.N2225032)+1 种基金the China Postdoctoral Science Foundation(No.2022M720683)the Postdoctoral Fund of Northeastern University,China。
文摘The formation mechanism of calcium vanadate and manganese vanadate and the difference between calcium and manganese in the reaction with vanadium are basic issues in the calcification roasting and manganese roasting process with vanadium slag.In this work,CaO–V_(2)O_(5) and MnO_(2)–V_(2)O_(5) diffusion couples were prepared and roasted for different time periods to illustrate and compare the diffusion reaction mechanisms.Then,the changes in the diffusion product and diffusion coefficient were investigated and calculated based on scanning electron microscopy (SEM) with energy dispersive X-ray spectroscopy (EDS) analysis.Results show that with the extension of the roasting time,the diffusion reaction gradually proceeds among the CaO–V_(2)O_(5) and MnO_(2)–V_(2)O_(5) diffusion couples.The regional boundaries of calcium and vanadium are easily identifiable for the CaO–V_(2)O_(5) diffusion couple.Meanwhile,for the MnO_(2)–V_(2)O_(5) diffusion couple,MnO_(2) gradually decomposes to form Mn_(2)O_(3),and vanadium diffuses into the interior of Mn_(2)O_(3).Only a part of vanadium combines with manganese to form the diffusion production layer.CaV_(2)O_(6) and MnV_(2)O_(6) are the interfacial reaction products of the CaO–V_(2)O_(5) and MnO_(2)–V_(2)O_(5) diffusion couples,respectively,whose thicknesses are 39.85 and 32.13μm when roasted for 16 h.After 16 h,both diffusion couples reach the reaction equilibrium due to the limitation of diffusion.The diffusion coefficient of the CaO–V_(2)O_(5) diffusion couple is higher than that of the MnO_(2)–V_(2)O_(5) diffusion couple for the same roasting time,and the diffusion reaction between vanadium and calcium is easier than that between vanadium and manganese.
文摘In recent years, there has been a growing interest in researching and developing new antimicrobial agents from various sources to combat microbial resistance. Therefore, a greater attention has been paid to antimicrobial activity screening and evaluating methods. Several bioassays such as disk-diffusion, well diffusion and broth or agar dilution are well known and commonly used, but others such as flow cy- tofluorometric and bioluminescent methods are not widely used because they require specified equip- ment and further evaluation for reproducibility and standardization, even if they can provide rapid re- sults of the antimicrobial agent's effects and a better understanding of their impact on the viability and cell damage inflicted to the tested microorganism. In this review article, an exhaustive list of in vitro antimicrobial susceptibility testing methods and detailed information on their advantages and limita- tions are reported.
基金supported by the National Natural Science Foundation of China(No.10771150)the National Basic Research Program of China(No.2005CB321701)+1 种基金the Program for New Century Excellent Talents in University(No.NCET-07-0584)the Natural Science Foundation of Sichuan Province(No.07ZB087)
文摘A nonconforming finite element method of finite difference streamline diffusion type is proposed to solve the time-dependent linearized Navier-Stokes equations. The backward Euler scheme is used for time discretization. Crouzeix-Raviart nonconforming finite element approximation, namely, nonconforming (P1)2 - P0 element, is used for the velocity and pressure fields with the streamline diffusion technique to cope with usual instabilities caused by the convection and time terms. Stability and error estimates are derived with suitable norms.
基金supported by the National Natural Science Foundation of China(Nos.11271340 and11671369)
文摘This paper aims to present a new streamline diffusion method with low order rectangular Bernardi-Raugel elements to solve the generalized Oseen equations. With the help of the Bramble-Hilbert lemma, the optimal errors of the velocity and pressure are estimated, which are independent of the considered parameter e. With an interpolation postprocessing approach, the superconvergent error of the pressure is obtained. Finally, a numerical experiment is carried out to confirm the theoretical results.
基金supported by the National Natural Science Foundation of China(Nos.11271273 and 11271298)
文摘This paper proposes a new nonconforming finite difference streamline diffusion method to solve incompressible time-dependent Navier-Stokes equations with a high Reynolds number. The backwards difference in time and the Crouzeix-Raviart (CR) element combined with the P0 element in space are used. The result shows that this scheme has good stabilities and error estimates independent of the viscosity coefficient.
文摘A posteriori error estimate of the discontinuous-streamline diffusion method for first-order hyperbolic equations was presented, which can be used to adjust space mesh reasonably. A numerical example is given to illustrate the accuracy and feasibility of this method.
文摘This paper examines the numerical solution of the convection-diffusion equation in 2-D. The solution of this equation possesses singularities in the form of boundary or interior layers due to non-smooth boundary conditions. To overcome such singularities arising from these critical regions, the adaptive finite element method is employed. This scheme is based on the streamline diffusion method combined with Neumann-type posteriori estimator. The effectiveness of this approach is illustrated by different examples with several numerical experiments.
文摘In this paper we make a close study of the finite analytic method by means of the maximum principles in differential equations and give the proof of the stability and convergence of the finite analytic method.
文摘Oil-producing crops,including Helianthus annuus L.(H.annuus,Sunflower),have been used for the treatment of different human diseases since ancient times.This study aims to determine the antimicrobial and cytotoxic potential of different polarities of seeds and flower extracts of locally grown H.annuus by well-established bioassays.To achieve the objects,the plant extracts were prepared from both flowers and seeds powder samples individually with methanol solvent by using a Soxhlet extraction method.The antimicrobial and cytotoxic potential of the flowers and seed extracts were determined by the in vitro diffusion and brine shrimp method(BSL).The results of the antimicrobial potential of both prepared flower and seed extracts of various polarities at different concentrations showed promising potential against the gram-positive and gram-negative bacterial strains,within the range of inhibition zone 0–20 mm.Among the flower extracts,the highest potential was obtained in water extract and the lowest potential was in butanol extract followed by water>ethyl acetate>hexane>methanol>chloroform>butanol extracts.However,from the seed extracts,the highest potential was obtained in water extract and the lowest potential was in the methanol extract followed by water>hexane>butanol>ethyl acetate>chloroform>methanol extract.On the other hand,the results of cytotoxicity among the flowers extracts against the brine shrimp method where the highest LC50 against brine shrimp nauplii were found to be 31.25μg/mL in water extract and the lowest LC50 was 1345.86μg/mL in chloroform extract followed by water>ethyl acetate>hexane>butanol>methanol>chloroform extract.Similarly,different polarities of seed extracts,the highest LC50 against brine shrimp nauplii was shown to be 109.56μg/mL in butanol extract and the lowest LC50 was 1513.56μg/mL in ethyl acetate extract followed by butanol>hexane>water>methanol>chloroform>ethyl acetate extract.In conclusion,the results showed that both flowers and seeds extracts at various concentrations have promising potential against the positive and negative bacterial strains and the highest potential water extract could be used as natural broad-spectrum antibiotics as herbal medicine to treat different human infectious diseases.
基金funded by the State Basic Research Planning Development Engineering-project (2009CB421303-2)the National Natural Science Foundation of China (40501012)the Knowledge Innovation Program from the Chinese Academy of Sciences (KZCX2-XB2-04)
基金supported by the National Natural Science Foundation of China (Grant No 50479017)the Program for Changjiang Scholars and Innovative Research Teams in Universities (Grant No IRT071)
文摘The 21 centimeter (21 cm) line emission from neutral hydrogen in the intergalactic medium (IGM) at high redshifts is strongly contaminated by foreground sources such as the diffuse Galactic synchrotron emission and free-free emission from the Galaxy, as well as emission from extragalactic radio sources, thus making its observation very complicated. However, the 21 cm signal can be recovered through its structure in frequency space, as the power spectrum of the foreground contamination is expected to be smooth over a wide band in frequency space while the 21 cm fluctuations vary significantly. We use a simple polynomial fitting to reconstruct the 21 cm signal around four frequencies 50, 100, 150 and 200 MHz with an especially small channel width of 20 kHz. Our calculations show that this multifrequency fitting approach can effectively recover the 21 cm signal in the frequency range 100 - 200 MHz. However, this method doesn't work well around 50 MHz because of the low intensity of the 21 cm signal at this frequency. We also show that the fluctuation of detector noise can be suppressed to a very low level by taking long integration times, which means that we can reach a sensitivity of ≈ 10 mK at 150 MHz with 40 antennas in 120 hours of observations.
基金financially supported by the European Erasmus program
文摘In this formulation study,biocompatible non steroidal anti-inflammatory(NSAIDs)-loaded nanoparticles were designed as models to be further integrated in a prosthesis surface functionalization.A modified spontaneous emulsion-solvent diffusion methodology was used to produce drug-loaded PLGA nanoparticles without any purification or solvent evaporation requirements.Formulation parameters,such as lactide/glycolide ratio,polymer concentration,solvent/non solvent ratio and non solvent phase,as well as the non ionic tensioactive P188 co-precipitation composition were systematically explored.The optimized formulation(mean size:145 nm,surface charge:-13 m V) was employed to encapsulate various amounts of NSAIDs in a simple and scalable manner.The drug release was characterized in vitro by a complete release for 48 h.These results encourage upcoming preliminary steps for in vivo experiments of prosthesis surface functionalization.
文摘Nonlinear optical crystals of L-Arginine maleate dihydrate were grown from liquid diffusion method. The lattice parameters of the crystal were identified using single crystal and powder crystal X-ray diffraction analyses. Fourier transform infrared spectroscopy and Fourier transform Raman spectroscopy were made to study the vibrational functional groups in the grown crystal. Optical absorption and transmission ranges were measured from UV-VIS-NIR spectrum. The molecular structure of the crystal is established through <sup>1</sup>H-NMR and <sup>13</sup>C-NMR studies. Thermal stabilities and decomposition of the grown crystal were studied from TG/DTA and DSC analyses. Nonlinear optical property of the crystal was determined by Kurtz and Perry powder technique.
基金the National Natural Science Foundation of China(No.10272070)Shanghai Leading Academic Discipline Project(No.Y0103)
文摘Nonlinear governing equations are established for large deflection of incompressible fluid saturated poroelastic beams under constraint that diffusion of the pore fluid is only in the axial direction of the deformed beams. Then, the nonlinear bending of a saturated poroelastic cantilever beam with fixed end impermeable and flee end permeable, subjected to a suddenly applied constant concentrated transverse load at its free end, is examined with the Gaierkin truncation method. The curves of deflections and bending moments of the beam skeleton and the equivalent couples of the pore fluid pressure are shown in figures. The results of the large deflection and the small deflection theories of the cantilever poroelastic beam are compared, and the differences between them are revealed. It is shown that the results of the large deflection theory are less than those of the corresponding small deflection theory, and the times needed to approach its stationary states for the large deflection theory are much less than those of the small deflection theory.
文摘The transient mass transter processes in the natural drying of wood particle materials were experimental;y studied A new theory tio determme the mass transfer parameters in the Materials was developed in terms of gradient transformation method(GTM).By making use of GTM.Thewater vapour diffusion coefficient and the surtaee emission coefficent of wood chip were expermentally determined both in air phase and in solid phase.It Was found that the internal resistance to water vapour diffusion in the air phase of wood partiele aggregates is around ten to the third power as large as that in common air The drag coefficient was given to quantify the effect The phenomenon of undersurface diffusion in wood partiele bed was quantitatively modelled.The dimensionless Fourier snumber and the Biot's number for mass transfer were theoretically derived.The study showed that Biot's number for the problem investigated was the ratio of the characteristie length of wood partiele bed to the penetrating depth of the undersurface.An analytical solution of the nonlinear goveming equation for water transport process in the aggregates of wood chip was obtained by introducing the variable coefficients measured in the study into the governing equation.The comparison between the analytical solution and the observed moisture content of wood chip showed that the deviation was less than ±7%.The thermophysieal properties of wood particle materials are little known at present.The knowledge provided in the paper will be and in the handling.researeh or engineering application of wood chip.wood shavingsete.
基金supported in part by the Education Science Foundation of Chongqing(KJZD-K201900701)project supported by Scientific and Technological Research Program of Chongqing Municipal Education Commission(Grant No.KJZD-M202300705)the National Natural Science Foundation of China(No.12171340).
文摘In this paper,we consider a modified nonlinear dynamic diffusion(DD)method for convection-diffusion-reaction equations.This method is free of stabilization parameters and capable of precluding spurious oscillations.We develop a reliable and efficient residual-type a posteriori error estimator,which is robust with respect to the diffusivity parameter.Furthermore,we propose a linearized adaptive DD algorithm based on the a posteriori estimator.Finally,we perform numerical experiments to verify the theoretical analysis and the performance of the adaptive algorithm.
文摘The low diffusion (LD) particle method, proposed by Burt and Boyd, is modified for the near-continuum two-phase flow simulations. The LD method has the advantages of easily coupling with the direct simulation Monte Carlo (DSMC) method for multi-scale flow simulations and dramatically reducing the numerical diffusion error and statistical scatter of the equilibrium particle methods. Liquidor solid-phase particles are introduced in the LD method. Their velocity and temperature updating are respectively, calculated from the motion equation and the temperature equation according to the local gas properties. Coupling effects from condensed phase to gas phase are modeled as momentum and energy sources, which are respectively, equal to the negative values of the total momentum and energy increase in liquid or solid phase. The modified method is compared with theoretical results for unsteady flows, and good agreements are obtained to indicate the reliability of the one-way gas-to-particle coupling models. Hybrid LD-DSMC algorithm is implemented and performed for nozzle discharging gas-liquid flow to show the prospect of the LD-DSMC scheme for multi-scale two-phase flow simulations.
基金supported by the National Natural Science Foundation of China under Grant No.61102150
文摘Noise reduction is one of the most important concerns in electronic speckle pattern interferometry(ESPI). According to partial differential equation(PDE) filtering theory, we present an anisotropic PDE noisereduction model based on fringe structure information for interferometric fringe patterns. This model is based on coherence diffusion and Perona-Malik(P-M) diffusion. The former can protect the structure information of fringe pattern, while the latter can effectively filter off the noise inside the fringes. The proposed model generated by the two diffusion methods helps to obtain good effects of denoising and fidelity. ESPI fringes and the phase pattern are tested. Experimental results validate the performance of the proposed filtering model.
文摘We propose a hybrid scheme combing the diffuse interface method and the material point method to simulate the complex interactions between the multiphase compressible flow and elastoplastic solid.The multiphase flow is modelled by the multi-component model and solved using a generalized Godunov method in the Eulerian grids,while the elastoplastic solid is solved by the classical material point method in a combination of Lagrangian particles and Eulerian background grids.In order to facilitate the simulation of fluid-solid interactions,the solid variables are further interpolated to the cell center and coexist with the fluid in the same cell.An instantaneous relaxation procedure of velocity and pressure is adopted to simulate the momentum and energy transfers between various materials,and to keep the system within a tightly coupled interaction.Several numerical examples,including shock tube problem,gasbubble problem,air blast,underwater explosion and high speed impact applications are presented to validate the numerical scheme.