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DNA methylation and carcinogenesis in digestive neoplasms 被引量:1
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《World Journal of Gastroenterology》 SCIE CAS CSCD 1998年第2期82-85,共4页
DNAmethylationandcarcinogenesisindigestiveneoplasmsJavedYakoob,FANXueGong,HUGuoLingandZHANGZhengSubjecthea... DNAmethylationandcarcinogenesisindigestiveneoplasmsJavedYakoob,FANXueGong,HUGuoLingandZHANGZhengSubjectheadingsDNAmethylati... 展开更多
关键词 DNA METHYLATION mutation DNA METHYLTRANSFERASE genes suppressor tumor digestive system neoplasms p53 GENE GENE expression
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A Comprehensive Study of the Association between LEPR Gene rs1137101 Variant and Risk of Digestive System Cancers
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作者 HU Wei Qiong ZHOU Wei Guang +8 位作者 ZHOU Guang Wei LIAO Jia Xi SHI Jia Xing XIE FengYang LI Shou Heng WANG Yong FENG Xian Hong GU Xiu Li CHEN Bi Feng 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 2024年第5期445-456,共12页
Objective The leptin receptor,encoded by the LEPR gene,is involved in tumorigenesis.A potential functional variant of LEPR,rs1137101(Gln223Arg),has been extensively investigated for its contribution to the risk of dig... Objective The leptin receptor,encoded by the LEPR gene,is involved in tumorigenesis.A potential functional variant of LEPR,rs1137101(Gln223Arg),has been extensively investigated for its contribution to the risk of digestive system(DS)cancers,but results remain conflicting rather than conclusive.Here,we performed a case–control study and subsequent meta-analysis to examine the association between rs1137101 and DS cancer risk.Methods A total of 1,727 patients with cancer(gastric/liver/colorectal:460/480/787)and 800 healthy controls were recruited.Genotyping of rs1137101 was conducted using a polymerase chain reactionrestriction fragment length polymorphism(PCR-RFLP)assay and confirmed using Sanger sequencing.Twenty-four eligible studies were included in the meta-analysis.Results After Bonferroni correction,the case–control study revealed that rs1137101 was significantly associated with the risk of liver cancer in the Hubei Chinese population.The meta-analysis suggested that rs1137101 is significantly associated with the risk of overall DS,gastric,and liver cancer in the Chinese population.Conclusion The LEPR rs1137101 variant may be a genetic biomarker for susceptibility to DS cancers(especially liver and gastric cancer)in the Chinese population. 展开更多
关键词 LEPR gene rs1137101 digestive system cancers genetic susceptibility META-ANALYSIS
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Progression of hepatic hyperperfusion disorders revealed during follow-up CT scan of digestive system neoplasm
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作者 Shenjiang Li Wenjie Liang +7 位作者 Guangwen Ju Cui Li Changcheng Li Debin Liu Feng Zhu Yan Zhu Xuefeng Cui Liguang Zheng 《The Chinese-German Journal of Clinical Oncology》 CAS 2014年第1期19-22,共4页
Objective: The aim of this study was to investigate progression of hepatic hyperperfusion disorders revealed during follow-up contrast material-enhanced multi-slice spiral computed tomography (MSCT) scan of digesti... Objective: The aim of this study was to investigate progression of hepatic hyperperfusion disorders revealed during follow-up contrast material-enhanced multi-slice spiral computed tomography (MSCT) scan of digestive system neoplasm. Methods: Three-phase contrast material-enhanced MSCT were performed during the follow-up in patients with digestive system malignant tumor confirmed histologically. The progression of hepatic hyperperfusion disorders revealed on contrast material-enhanced CT image were investigated at the 2 years follow-up with approximately 6 months interval. Results: The hepatic hyperperfusion disorders were showed in 39 patients on follow-up contrast material-enhanced MSCT scans. Among the 39 patients, initial hyperperfusion disorders were revealed in 6 (15.38%), 26 (66.67%), and 7 (17.95%) patients in 6, 12, and 18 months during follow-up respectively. The initial hyperperfusion disorders revealed in 12 months were more frequent than those revealed in 6 months (X2 = 14.82, P 〈 0.05) and 18 months (X2 = 15.02, P 〈 0.05). Among the 39 patients, the hyperperfusion disorders progressed into liver metastasis based on typical CT findings in 37 (94.87%) patients, and were not obvious changes in 2 (5.13%) patients. Among the 37 patients, the hyperperfusion disorders progressed into metastasis in 10 (25.64%) patients in 6 months after the hyperperfusion disorders were revealed, and in 27(69.23%) patients in 12 months. The hyperperfusion disorders developing into metastasis were more in 12 months than those in 6 months (X2= 14.98, P 〈 0.05). Conclusion: Most hepatic hyperperfusion disorders revealed at the follow-up of digestive system neoplasm may be early manifestations of liver metastasis. The careful follow-up of hepatic hyperperfusion disorders is necessary. 展开更多
关键词 digestive system neoplasm hepatic perfusion disorders tomography X-ray computed PROGRESSION
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Practical hints for the diagnosis of mixed neuroendocrine-nonneuroendocrine neoplasms of the digestive system
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作者 Paola Mattiolo 《World Journal of Gastrointestinal Oncology》 SCIE 2024年第11期4326-4332,共7页
In this editorial,a comment on the article by Díaz-López et al published in the recent issue of the 2024 is provided.We focus on the practical implications critical for providing a correct and complete diagn... In this editorial,a comment on the article by Díaz-López et al published in the recent issue of the 2024 is provided.We focus on the practical implications critical for providing a correct and complete diagnosis of mixed neuroendocrine-nonneuroendocrine neoplasm(MiNEN)in the gastrointestinal system.The diagnosis of MiNEN begins with the recognition of neuroendocrine features in one component of a biphasic tumor.The non-neuroendocrine counterpart can be virtually represented by any neoplastic type,even though the most frequent histologies are glandular and squamous.However,qualification of the neuroendocrine component requires histological and immunohistochemical confirmation.Neuroendocrine tumors are characterized by a peculiar architectural organization and bland nuclei with granular“salt and pepper”chromatin.Although neuroendocrine carcinomas have multiple and variable presentations,they typically show a solid or organoid architecture.The histological aspect needs to be confirmed by immunohistochemistry,and a diagnosis is confirmed whenever the expression of keratin and neuroendocrine markers is observed.Once both histopathological and immunohistochemical features of neuroendocrine neoplasms are identified,it is important to consider the three major pitfalls of MiNEN diagnostics:(1)Entrapment of neuroendocrine non-neoplastic cells within the tumor mass;(2)Differential diagnosis with amphicrine neoplasms;and(3)Differential diagnosis of tumors that partially express neuroendocrine markers.According to the current guidelines for diagnosing digestive MiNEN,each component must represent at least 30%of the entire neoplastic mass.Although the high-grade histopathological subtype frequently determines disease prognosis,both components can significantly affect prognosis.Thus,if one of the components,either neuroendocrine or non-neuroendocrine,does not fulfill the volumetric criteria,the guidelines still encourage reporting it.These strict criteria are essential for correctly recognizing and characterizing digestive MiNENs.This task is essential because it has prognostic relevance and substantial potential value for guiding further studies in this field.In the future,systematic analyses should be performed to validate or reconsider the current 30%cutoff value. 展开更多
关键词 Mixed neuroendocrine-non-neuroendocrine neoplasm digestive system Neuroendocrine neoplasm Immunohistochemistry
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Retrospective study on mixed neuroendocrine non-neuroendocrine neoplasms from five European centres 被引量:17
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作者 Melissa Frizziero Xin Wang +15 位作者 Bipasha Chakrabarty Alexa Childs Tu V Luong Thomas Walter Mohid S Khan Meleri Morgan Adam Christian Mona Elshafie Tahir Shah Annamaria Minicozzi Wasat Mansoor Tim Meyer Angela Lamarca Richard A Hubner Juan W Valle Mairéad G McNamara 《World Journal of Gastroenterology》 SCIE CAS 2019年第39期5991-6005,共15页
BACKGROUND Mixed neuroendocrine non-neuroendocrine neoplasm(MiNEN)is a rare diagnosis,mainly encountered in the gastro-entero-pancreatic tract.There is limited knowledge of its epidemiology,prognosis and biology,and t... BACKGROUND Mixed neuroendocrine non-neuroendocrine neoplasm(MiNEN)is a rare diagnosis,mainly encountered in the gastro-entero-pancreatic tract.There is limited knowledge of its epidemiology,prognosis and biology,and the best management for affected patients is still to be defined.AIM To investigate clinical-pathological characteristics,treatment modalities and survival outcomes of a retrospective cohort of patients with a diagnosis of MiNEN.METHODS Consecutive patients with a histologically proven diagnosis of MiNEN were identified at 5 European centres.Patient data were retrospectively collected from medical records.Pathological samples were reviewed to ascertain compliance with the 2017 World Health Organisation definition of MiNEN.Tumour responses to systemic treatment were assessed according to the Response Evaluation Criteria in Solid Tumours 1.1.Kaplan-Meier analysis was applied to estimate survival outcomes.Associations between clinical-pathological characteristics and survival outcomes were explored using Log-rank test for equality of survivors functions(univariate)and Cox-regression analysis(multivariable).RESULTS Sixty-nine consecutive patients identified;Median age at diagnosis:64 years.Males:63.8%.Localised disease(curable):53.6%.Commonest sites of origin:colon-rectum(43.5%)and oesophagus/oesophagogastric junction(15.9%).The neuroendocrine component was;predominant in 58.6%,poorly differentiated in 86.3%,and large cell in 81.25%,of cases analysed.Most distant metastases analysed(73.4%)were occupied only by a poorly differentiated neuroendocrine component.Ninety-four percent of patients with localised disease underwent curative surgery;53%also received perioperative treatment,most often in line with protocols for adenocarcinomas from the same sites of origin.Chemotherapy was offered to most patients(68.1%)with advanced disease,and followed protocols for pure neuroendocrine carcinomas or adenocarcinomas in equal proportion.In localised cases,median recurrence free survival(RFS);14.0 months(95%CI:9.2-24.4),and median overall survival(OS):28.6 months(95%CI:18.3-41.1).On univariate analysis,receipt of perioperative treatment(vs surgery alone)did not improve RFS(P=0.375),or OS(P=0.240).In advanced cases,median progression free survival(PFS);5.6 months(95%CI:4.4-7.4),and median OS;9.0 months(95%CI:5.2-13.4).On univariate analysis,receipt of palliative active treatment(vs best supportive care)prolonged PFS and OS(both,P<0.001).CONCLUSION MiNEN is most commonly driven by a poorly differentiated neuroendocrine component,and has poor prognosis.Advances in its biological understanding are needed to identify effective treatments and improve patient outcomes. 展开更多
关键词 MIXED NEUROENDOCRINE non-neuroendocrine neoplasm 2017 World Health ORGANISATION classification MIXED adeno-neuroendocrine carcinoma Gastro-enteropancreatic tract digestive system NEUROENDOCRINE neoplasms Survival outcomes
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Telomere,telomerase and digestive cancer 被引量:5
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作者 Javed Yakoob, HU Guo Ling, FAN Xue Gong and ZHANG Zheng 《World Journal of Gastroenterology》 SCIE CAS CSCD 1999年第4期62-65,共4页
Recentadvancessuggestthattelomeraseisasociatedwithcelularimmortalitywhichisahalmarkofcancer.TELOMERESHumante... Recentadvancessuggestthattelomeraseisasociatedwithcelularimmortalitywhichisahalmarkofcancer.TELOMERESHumantelomerescontainana... 展开更多
关键词 digestive system neoplasms TELOMERE TELOMERASE antitelomerase THERAPY
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Comparison of Ileal Digested Production of Parental Rice and Rice Genetically Modified With Cowpeas Trypsin Inhibitor 被引量:2
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作者 JUN-HUA HAN YUE-XIN YANG JIAN-HUA MEN LI-HUA BIAN JUN GUO 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 2006年第1期42-46,共5页
Objective To compare the ileal digestibility of protein and amino acids in parental rice and rice genetically modified with sck gene. Methods Six experimental swines were surgically fixed with a simple T-cannula at th... Objective To compare the ileal digestibility of protein and amino acids in parental rice and rice genetically modified with sck gene. Methods Six experimental swines were surgically fixed with a simple T-cannula at the terminal ileum and fed with parental rice and rice genetically modified with sck gene alternately. The ileum digesta were collected and analyzed for determination of apparent and true digestibility of protein and amino acids. Results The apparent and true digestibility of protein was similar in these two types of rice. Except for the apparent digestibility of lysine, there was no difference in the apparent and true digestibility of the other 17 amino acids. Conclusion The digestibility of protein and amino acids is not changed by the insertion of foreign gene, so it can meet the request of "substantial equivalence" in digestibility of protein and amino acids. 展开更多
关键词 genetically modified rice Apparent digestibility True digestibility
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Endoscopic submucosal tunnel dissection for largesuperficial esophageal squamous cell neoplasms 被引量:19
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作者 Ya-Qi Zhai Hui-Kai Li En-Qiang Linghu 《World Journal of Gastroenterology》 SCIE CAS 2016年第1期435-445,共11页
Endoscopic submucosal dissection(ESD)is a wellestablished treatment for superficial esophageal squamous cell neoplasms(SESCNs)with no risk of lymphatic metastasis.However,for large SESCNs,especially when exceeding two... Endoscopic submucosal dissection(ESD)is a wellestablished treatment for superficial esophageal squamous cell neoplasms(SESCNs)with no risk of lymphatic metastasis.However,for large SESCNs,especially when exceeding two-thirds of the esophageal circumference,conventional ESD is time-consuming and has an increased risk of adverse events.Based on the submucosal tunnel conception,endoscopic submucosal tunnel dissection(ESTD)was first introduced by us to remove large SESCNs,with excellent results.Studies from different centers also reported favorable results.Compared with conventional ESD,ESTD has a more rapid dissection speed and R0 resection rate.Currently in China,ESTD for large SESCNs is an important part of the digestive endoscopic tunnel technique,as is peroral endoscopic myotomy for achalasia and submucosal tunnel endoscopic resection for submucosal tumors of the muscularis propria.However,not all patients with SESCNs are candidates for ESTD,and postoperative esophageal strictures should also be taken into consideration,especially for lesions with a circumference greater than three-quarters.In this article,we describe our experience,review the literature of ESTD,and provide detailed information on indications,standard procedures,outcomes,and complications of ESTD. 展开更多
关键词 ENDOSCOPIC SUBMUCOSAL TUNNEL DISSECTION ESOPHAGEAL SQUAMOUS cell neoplasms digestiveendoscopic TUNNEL technique ENDOSCOPIC submucosaldissection
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Clinical significance of CA_(19-9) in diagnosis of digestive tract tumors
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作者 ZHAO JiZong and WU BoHeng 《World Journal of Gastroenterology》 SCIE CAS CSCD 1997年第4期55-56,共2页
IM To evaluate the clinical value of CA199 in diagnosing and differentiating the gastrointestinal tumors and in monitoring the patients treated surgically.METHODS Gastric cancer (n=70), colorectal cancer (n=90), pan... IM To evaluate the clinical value of CA199 in diagnosing and differentiating the gastrointestinal tumors and in monitoring the patients treated surgically.METHODS Gastric cancer (n=70), colorectal cancer (n=90), pancreatic cancer (n=7), esophageal cancer (n=10), benign disorder (n=30), and normal adults (n=111) as control were studied. Fasting blood samples were obtained from each patient and normal adult. The serum CA199 concentration was measured with radioimmunoassay.RESULTS The mean CA199 level in gastric cancer (17069kU/L±9145kU/L) and in colorectal cancer (8721kU/L±3955kU/L) was significantly higher than that in the control (11254kU/L±600kU/L). Compared with the normal adults, the CA199 level was much higher in pancreatic cancer patients (126658kU/L±52131kU/L) (P<001). However, the CA199 concentrations in nonrecurrent gastric (1263kU/L±362kU/L) and colorectal cancers (1414kU/L±326kU/L) and benign disorders (1423kU/L±260kU/L) were similar to the control. The differences were not statistically significant (P>005). The demarcation value of CA199 between the negative and positive was <310kU/L. The sensitivity of CA199 for gastric, colorectal, pancreatic and esophageal cancers and gastrointestinal benign disorders was 473%, 500%, 833%, 200% and 0%, respectively. The specificity of CA199 for digestive system malignant diseases was all 100%. 展开更多
关键词 digestive system neoplasms CA199 tumor related ANTIGEN STOMACH neoplasms colorectal neoplasms pancreatic neoplasms ESOPHAGEAL neoplasms
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Characterics of upper digestive tract diseasesin fishermen of the Bohai Bay
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作者 WANG Yuan Ben 1, WANG Yuan Ping 1, ZOU Jing 1, BAI Bao Jie 2, REN Guo Chun 2 and CAI Ben Qing 2 《World Journal of Gastroenterology》 SCIE CAS CSCD 1997年第3期43-45,共3页
AIM To study the characteristics of upper digestive tract diseases (UDTDs) in the fishermen of the Bohai Bay. METHODS An investigation was carried out in 1488 fishermen with symptoms of UDTDs except liver, biliary ... AIM To study the characteristics of upper digestive tract diseases (UDTDs) in the fishermen of the Bohai Bay. METHODS An investigation was carried out in 1488 fishermen with symptoms of UDTDs except liver, biliary and pancreatic diseases during the period from December 1991 to February 1995, which included medical history inquiry, physical, gastroscopic and pathological examinations, detection of Helicobacter pylori ( H. pylori) infection, and nitrate content in their drinking water. RESULTS Among the 1488 subjects investigated, 1467 suffered from one or more diseases among 14 kinds of UDTDs, most of which were chronic atrophic gastritis (CAG, 1103 cases), peptic ulcer (268 cases), and cancer of the upper digestive tract (25 cases). CONCLUSION Incidence rate of UDTDs tends to be high among the fishermen, especially CAG, peptic ulcer and upper digestive tract cancer, and complicated state of illness due to their special life habits, and high nitrate content in their drinking water, etc, and UDTDs in fishermen is significantly different from that in inland residents in clinical manifestations. 展开更多
关键词 digestive TRACT disease GASTROSCOPY nitrate Helicobacter pylori gastritis ATROPHIC PEPTIC ulcer digestive system neoplasms
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Cleaner production for continuous digester processes based on hybrid Pareto genetic algorithm
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作者 JIN Fu\|jiang, WANG Hui, LI Ping (Institute of Industrial Process Control, Zhejiang University, Hangzhou 310027, China. 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 2003年第1期129-135,共7页
Pulping production process produces a large amount of wastewater and pollutant emitted, which has become one of the main pollution sources in pulp and paper industry. To solve this problem, it is necessary to implemen... Pulping production process produces a large amount of wastewater and pollutant emitted, which has become one of the main pollution sources in pulp and paper industry. To solve this problem, it is necessary to implement cleaner production by using modeling and optimization technology. This paper studies the modeling and multi\|objective genetic algorithms for continuous digester process. First, model is established, in which environmental pollution and saving energy factors are considered. Then hybrid genetic algorithm based on Pareto stratum\|niche count is designed for finding near\|Pareto or Pareto optimal solutions in the problem and a new genetic evaluation and selection mechanism is proposed. Finally using the real data from a pulp mill shows the results of computer simulation. Through comparing with the practical curve of digester,this method can reduce the pollutant effectively and increase the profit while keeping the pulp quality unchanged. 展开更多
关键词 cleaner production multi\|objective optimization genetic algorithm Pareto stratum concentration of residual alkali Kamyr continuous digester
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Synchronous manifestation of colorectal cancer and intraductal papillary mucinous neoplasms
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作者 Milko Bozhidarov Mirchev Irina Boeva +2 位作者 Monika Peshevska-Sekulovska Veselin Stoitsov Milena Peruhova 《World Journal of Clinical Cases》 SCIE 2023年第15期3408-3417,共10页
High rates of extrapancreatic malignancies,in particular colorectal cancer(CRC),have been detected in patients with intraductal papillary mucinous neoplasm(IPMN).So far,there is no distinct explanation in the literatu... High rates of extrapancreatic malignancies,in particular colorectal cancer(CRC),have been detected in patients with intraductal papillary mucinous neoplasm(IPMN).So far,there is no distinct explanation in the literature for the development of secondary or synchronous malignancies in patients with IPMN.In the past few years,some data related to common genetic alterations in IPMN and other affiliated cancers have been published.This review elucidated the association between IPMN and CRC,shedding light on the most relevant genetic alterations that may explain the possible relationship between these entities.In keeping with our findings,we suggested that once the diagnosis of IPMN is made,special consideration of CRC should be undertaken.Presently,there are no specific guidelines regarding colorectal screening programs for patients with IPMN.We recommend that patients with IPMNs are at high-risk for CRC,and a more rigorous colorectal surveillance program should be implemented. 展开更多
关键词 Colorectal cancer Intraductal papillary mucinous neoplasm genetic alterations Extrapancreatic malignancies Synchronous neoplasms
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Cytochrome P450 2E1 genetic polymorphism and gastric cancer in Changle,Fujian Province 被引量:26
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作者 Lin Cai~1 Shun-Zhang Yu~2 Zuo-Feng Zhang~3 1 Department of Epidemiology,Fujian Medical University,Fuzhou 350004,Fujian Province,China2 Department of Epidemiology,Shanghai Medical University,Shanghai 200032,China3 Department of Epidemiology,UCLA School of Public Health,Los Angeles California,USA 《World Journal of Gastroenterology》 SCIE CAS CSCD 2001年第6期792-795,共4页
AIM: Genetic polymorphism in enzymes of carcinogen metabolism has been found to have the influence on the susceptibility to cancer. Cytochrome P450 2E1 (CYP2E1) is considered to play an important role in the metabolic... AIM: Genetic polymorphism in enzymes of carcinogen metabolism has been found to have the influence on the susceptibility to cancer. Cytochrome P450 2E1 (CYP2E1) is considered to play an important role in the metabolic activation of procarcinogens such as N-nitrosoamines and low molecular weight organic compounds. The purpose of this study is to determine whether CYP450 2E1 polymorphisms are associated with risks of gastric cancer. METHODS: We conducted a population based case-control study in Changle county, Fujian Province, a high-risk region of gastric cancer in China. Ninety-one incident gastric cancer patients and ninety-four healthy controls were included in our study. Datas including demographic characteristics, diet intake, and alcohol and tobacco consumption of individuals in our study were completed by a standardized questionnaire.PCR-RFLP revealed three genotypes:heterozygote (C1/C2) and two homozygotes (C1/C1 and C2/C2) in CYP2E1. RESULTS: The frequency of variant genotypes (C1/C2 and C2/C2) in gastric cancer cases and controls was 36.3% and 24.5%, respectively. The rare homozygous C2/C2 genotype was found in 6 individuals in gastric cancer group(6.6%), whereas there was only one in the control group (1.1%). However, there was no statistically significant difference between the two groups (two-tailed Fisher's exact test P=0.066). Individuals in gastric cancer group were more likely to carry genotype C1/C2 (odds ratio, OR=1.50) and C2/C2 (OR=7.34) than individuals in control group (chi(2) =4.597, for trend P=0.032). The frequencies of genotypes with the C2 allele (C1/C2 and C2/C2 genotypes) were compared with those of genotypes without C2 allele (C1/C1 genotype) among individuals in gastric cancer group and control group according to the pattern of gastric cancer risk factors. The results show that individuals who exposed to these gastric cancer risk factors and carry the C2 allele seemed to have a higher risk of developing gastric cancer. CONCLUSION: Polymorphism of CYP2E1 gene may have some effect in the development of gastric cancer in Changle county, Fujian Province. 展开更多
关键词 Polymorphism genetic Aged Asian Continental Ancestry Group Case-Control Studies China Cytochrome P-450 CYP2E1 Female Gene Frequency genetic Predisposition to Disease Humans Male Middle Aged Research Support Non-U.S. Gov't Stomach neoplasms
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Genetic factors determining the host response to Helicobacter pylori 被引量:7
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作者 A.S.Pea 《World Journal of Gastroenterology》 SCIE CAS CSCD 2000年第5期624-625,共2页
INTRODUCTIONThe strongest evidence that H.pylori infection isthe cause of peptic ulcer is that treatment withantibiotics as the only regimen,is not only effectivefor the clearance and eradication of the infection,but ... INTRODUCTIONThe strongest evidence that H.pylori infection isthe cause of peptic ulcer is that treatment withantibiotics as the only regimen,is not only effectivefor the clearance and eradication of the infection,but more importantly for the healing of the ulcer orthe remission of gastric lymphoma.However,it isstill a matter of controversy and research as to 展开更多
关键词 HELICOBACTER pylori/genetics PEPTIC ulcer/therapy antibiotics INTERLEUKIN-1 stomach neoplasms INTERLEUKIN-12 tumor necrosis factor
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Epigenetic changes of pituitary tumor-derived transforming gene 1 in pancreatic cancer 被引量:4
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作者 Zhang, Mang-Li Lu, Sen Zheng, Shu-Sen 《Hepatobiliary & Pancreatic Diseases International》 SCIE CAS 2008年第3期313-317,共5页
BACKGROUND: Pancreatic cancer is a devastating disease with abnormal genetic changes. The pituitary tumor-derived transforming gene (PTTG) is considered to be implicated in the tumorigenesis of cancers when the gene i... BACKGROUND: Pancreatic cancer is a devastating disease with abnormal genetic changes. The pituitary tumor-derived transforming gene (PTTG) is considered to be implicated in the tumorigenesis of cancers when the gene is epigenetically transformed. In this study, we investigated the relationships between aberrant expression and epigenetic changes of the PTTG1 gene in pancreatic cancer. METHODS: We chose 4 cell lines (PANC-1, Colo357, T3M-4 and PancTu I) and pancreatic ductal adenocarcinoma (PDAC) tissues. After using restriction isoschizomer endonucleases (Msp I /Hpa II) to digest the DNA sequence (5'-CCGG-3'), we performed PCR reaction to amplify the product. And RT-PCR was applied to determine the gene expression. RESULTS: The mRNA expression of the PTTG1 gene was higher in pancreatic tumor than in normal tissue. The gene was also expressed in the 4 PDAC cell lines. The methylation states of the upstream regions of the PTTG1 gene were almost identical in normal, tumor pancreatic tissues and the 4 PDAC cell lines. Some (5'-CCGG-3') areas in the upstream region of PTTG1 were methylated, while some others were unmethylated. CONCLUSIONS: The oncogene PTTG1 was overexpressed in pancreatic tumor tissues and verified by RT-PCR detection. The methylation status of DNA in promoter areas was involved in the gene expression with the help of other factors in pancreatic cancer. 展开更多
关键词 pancreatic neoplasms pituitary tumor-derived transforming gene epigenesis genetic
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Blastic Plasmacytoid Dendritic Cell Neoplasm:Progress in Cell Origin,Molecular Biology,Diagnostic Criteria and Therapeutic Approaches 被引量:8
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作者 Wei CHENG Tian-tian YU +2 位作者 Ai-ping TANG Ken HE YOUNG Li YUI 《Current Medical Science》 SCIE CAS 2021年第3期405-419,共15页
Blastic plasmacytoid dendritic cell neoplasm(BPDCN)is a rare hematological malignancy characterized by recurrent skin nodules,an aggressive clinical course with rapid involvement of hematological organs,and a poor pro... Blastic plasmacytoid dendritic cell neoplasm(BPDCN)is a rare hematological malignancy characterized by recurrent skin nodules,an aggressive clinical course with rapid involvement of hematological organs,and a poor prognosis with poor overall survival.BPDCN is derived from plasmacytoid dendritic cells(pDCs)and its pathogenesis is unclear.The tumor cells show aberrant expression of CD4,CD56,interleukin-3 receptor alpha chain(CD 123),blood dendritic cell antigen 2(BDCA 2/CD303),blood dendritic cell antigen 4(BDCA4)and transcription factor(E protein)E2-2(TCF4).The best treatment drugs are based on experience by adopting those used for either leukemia or lymphoma.Relapse with drug resistance generally occurs quickly.Stem cell transplantation after the first complete remission is recommended and tagraxofusp is the first targeted therapy.In this review,we summarize the differentiation of BPDCN from its cell origin,its connection with normal pDCs,clinical characteristics,genetic mutations and advances in treatment of BPDCN.This review provides insights into the mechanisms of and new therapeutic approaches for BPDCN. 展开更多
关键词 blastic plasmacytoid dendritic cell neoplasm plasmacytoid dendritic cell genetic mutations IMMUNOPHENOTYPE THERAPEUTICS
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Genetic polymorphisms in genes regulating cell death and prognosis of patients with rectal cancer receiving postoperative chemoradiotherapy 被引量:2
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作者 Hongxia Chen Luxi Yin +13 位作者 Jie Yang Ningxin Ren Jinna Chen Qixuan Lu Ying Huang Yanru Feng Weihu Wang Shulian Wang Yueping Liu Yongwen Song Yexiong Li Jing Jin Wen Tan Dongxin Lin 《Cancer Biology & Medicine》 SCIE CAS CSCD 2023年第4期297-316,共20页
Objective:The identification of biomarkers for predicting chemoradiotherapy efficacy is essential to optimize personalized treatment.This study determined the effects of genetic variations in genes involved in apoptos... Objective:The identification of biomarkers for predicting chemoradiotherapy efficacy is essential to optimize personalized treatment.This study determined the effects of genetic variations in genes involved in apoptosis,pyroptosis,and ferroptosis on the prognosis of patients with locally advanced rectal cancer receiving postoperative chemoradiotherapy(CRT).Methods:The Sequenom MassARRAY was used to detect 217 genetic variations in 40 genes from 300 patients with rectal cancer who received postoperative CRT.The associations between genetic variations and overall survival(OS)were evaluated using hazard ratios(HRs)and 95%confidence intervals(CIs)computed using a Cox proportional regression model.Functional experiments were performed to determine the functions of the arachidonate 5-lipoxygenase(ALOX5)gene and the ALOX5 rs702365 variant.Results:We detected 16 genetic polymorphisms in CASP3,CASP7,TRAILR2,GSDME,CASP4,HO-1,ALOX5,GPX4,and NRF2 that were significantly associated with OS in the additive model(P<0.05).There was a substantial cumulative effect of three genetic polymorphisms(CASP4 rs571407,ALOX5 rs2242332,and HO-1 rs17883419)on OS.Genetic variations in the CASP4 and ALOX5 gene haplotypes were associated with a higher OS.We demonstrated,for the first time,that rs702365[G]>[C]represses ALOX5 transcription and corollary experiments suggested that ALOX5 may promote colon cancer cell growth by mediating an inflammatory response.Conclusions:Polymorphisms in genes regulating cell death may play essential roles in the prognosis of patients with rectal cancer who are treated with postoperative CRT and may serve as potential genetic biomarkers for individualized treatment. 展开更多
关键词 Rectal neoplasms genetic variation regulated cell death overall survival ALOX5
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GSTM1,GSTT1,GSTP1 and CYP1A1 genetic polymorphisms and susceptibility to esophageal cancer in a French population:Different pattern of squamous cell carcinoma and adenocarcinoma 被引量:7
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作者 Ahmed Abbas Karine Delvinquière +4 位作者 Mathilde Lechevrel Pierre Lebailly Pascal Gauduchon Guy Launoy Fran ois Sichel 《World Journal of Gastroenterology》 SCIE CAS CSCD 2004年第23期3389-3393,共5页
AIM:To evaluate the association between CYP1A1 and GSTs genetic polymorphisms and susceptibility to esophageal squamous cell carcinoma(SCC)and esophageal adenocarcinoma(ADC)in a high risk area of northwest of France. ... AIM:To evaluate the association between CYP1A1 and GSTs genetic polymorphisms and susceptibility to esophageal squamous cell carcinoma(SCC)and esophageal adenocarcinoma(ADC)in a high risk area of northwest of France. METHODS:A case-control study was conducted to investigate the genetic polymorphisms of these enzymes (CYPIAI*2C and GSTP1 exon 7 Val alleles,GSTMI*2/*2 and GSTTl *2/*2 null genotypes).A total of 79 esophageal cancer cases and 130 controls were recruited. RESULTS:GSTMI*2/*2 and CYPIAI*IA/*2C genotype frequencies were higher among squamous cell carcinomas at a level dose to statistical significance(OR =1.83,95% CI 0.88-3.83,P=0.11;OR=3.03,95% CI 0.93-9.90,P=0.07, respectively).For GSTP1 polymorphism,no difference was found between controls and cases,whatever their histological status.Lower frequency of GSTT1 deletion was observed in ADC group compared to controls with a statistically significant difference(OR=13.31,95% CI 1.66-106.92,P<0.01). CONCLUSION:In SCC,our results are consistent with the strong association of this kind of tumour with tobacco exposure.In ADC,our results suggest 3 distinct hypotheses: (1)activation of exogenous procarcinogens,such as small halogenated compounds by GSTT1;(2)contribution of GSTT1 to the inflammatory response of esophageal mucosa,which is known to be a strong risk factor for ADC, possibly through leukotriene synthesis;(3)higher sensitivity to the inflammatory process associated with intracellular depletion of glutathione. 展开更多
关键词 ACYLTRANSFERASES ADENOCARCINOMA Adult Aged Aged 80 and over Carcinoma Squamous Cell Case-Control Studies Cytochrome P-450 CYP1A1 Esophageal neoplasms Female France genetic Predisposition to Disease Genotype Glutathione Transferase Humans Male Middle Aged Polymorphism genetic Research Support Non-U.S. Gov't Risk Factors
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Efficacy Differences of First-line EGFR-TKIs Alone vs in Combination with Chemotherapy in Advanced Lung Adenocarcinoma Patients with Sensitive EGFR Mutation and Concomitant Non-EGFR Genetic Alterations 被引量:1
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作者 Guowei ZHANG Ruirui CHENG +7 位作者 Yuanyuan NIU Huijuan WANG Xiangtao YAN Mina ZHANG Xiaojuan ZHANG Jinpo YANG Chunhua WEI Zhiyong MA 《中国肺癌杂志》 CAS CSCD 北大核心 2022年第9期651-657,共7页
Background and objective:Epidermal growth factor receptor(EGFR)mutations are often associated with non-EGFR genetic alterations,which maybe a reason for the poor efficacy of EGFR tyrosine kinase inhibitors(TKIs).Here ... Background and objective:Epidermal growth factor receptor(EGFR)mutations are often associated with non-EGFR genetic alterations,which maybe a reason for the poor efficacy of EGFR tyrosine kinase inhibitors(TKIs).Here we conducted this study to explore whether EGFR-TKIs combined with chemotherapy would benefit advanced lung adenocarcinoma patients with both sensitive EGFR mutation and concomitant non-EGFR genetic alterations.Materials and methods:Cases of advanced lung adenocarcinoma with EGFR mutation combined with concomitant nonEGFR genetic alterations were retrospectively collected.And the patients were required to receive first-line EGFR-TKIs and chemotherapy combination or EGFR-TKIs monotherapy.Demographic,clinical and pathological data were collected,and the electronic imaging data were retrieved to evaluate the efficacy and time of disease progression.Survival data were obtained through face-to-face or telephone follow-up.The differences between the two groups in objective response rate(ORR),disease control rate(DCR),progression-free survival(PFS)and overall survival(OS)were investigated.Results:107 patients were included,including 63 cases in the combination group and 44 cases in the monotherapy group.The ORR were 78%and 50%(P=0.003),and DCR were 97%and 77%(P=0.002),respectively.At a median follow-up of 13.7 mon,a PFS event occurred in 38.1%and 81.8%of patients in the two groups,with median PFS of18.8 mon and 5.3 mon,respectively(P<0.000,1).Median OS was unreached in the combination group,and 27.8 mon in the monotherapy group(P=0.31).According to the Cox multivariate regression analysis,combination therapy was an independent prognostic factor of PFS.Conclusion:In patients with EGFR-mutant advanced lung adenocarcinoma with concomitant non-EGFR genetic alterations,combination of TKIs and chemotherapy was significantly superior to EGFR-TKIs monotherapy,which should be the preferred treatment option. 展开更多
关键词 Lung neoplasms EGFR mutation Concomitant genetic alteration Targeted therapy CHEMOTHERAPY
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GSTT1,GSTM1 and CYP2E1 genetic polymorphisms in gastric cancer and chronic gastritis in a Brazilian population 被引量:11
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作者 Jucimara Colombo Ana Elizabete Silva +3 位作者 Andréa Regina Baptista Rossit Alaor Caetano Aldenis Albaneze Borim Durval Wohnrath 《World Journal of Gastroenterology》 SCIE CAS CSCD 2004年第9期1240-1245,共6页
AIM:To test the hypothesis that,in the Southeastern Brazilian population,the GSTT1,GSTM1 and CYP2E1 polymorphisms and putative risk factors are associated with an increased risk for gastric cancer. METHODS:We conducte... AIM:To test the hypothesis that,in the Southeastern Brazilian population,the GSTT1,GSTM1 and CYP2E1 polymorphisms and putative risk factors are associated with an increased risk for gastric cancer. METHODS:We conducted a study on 100 cases of gastric cancer (GC),100 cases of chronic gastritis (CG),and 150 controls (C).Deletion of the GSTT1 and GSTM1 genes was assessed by multiplex PCR.CYP2E1/Pst1 genotyping was performed using a PCR-RFLP assay. RESULTS:No relationship between GSTT1/GSTM1 deletion and the c1/c2 genotype of CYP2E1 was observed among the three groups.However,a significant difference between CG and C was observed,due to a greater number of GSTT1/GSTM1 positive genotypes in the CG group.The GSTT1 null genotype occurred more frequently in Negroid subjects,and the GSTM1 null genotype in Caucasians,while the GSTM1 positive genotype was observed mainly in individuals with chronic gastritis infected with H pylori. CONCLUSION:Our findings indicate that there is no obvious relationship between the GSTT1,GSTM1 and CYP2E1 polymorphisms and gastric cancer. 展开更多
关键词 Polymorphism genetic Adolescent Adult Aged Aged 80 and over Brazil Case-Control Studies Chronic Disease Cytochrome P-450 CYP2E1 Female Gastritis Genotype Glutathione Transferase Humans Male Middle Aged Research Support Non-U.S. Gov't Risk Factors Stomach neoplasms
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