Complications of button battery ingestion or insertion in children:a systematic review and pooled analysis of individual patient-level data

Background Button battery(BB)exposures are common in children and can have devastating consequences.We reviewed current evidence on the complications associated with BB exposure and identified predictors of outcomes using individual patient-level data.Data sources We carried out a systematic review and pooled analysis by searching MEDLINE,Embase,and Scopus up to May 19,2023.Included studies describe complications following BB exposures in children(aged<18 years).Odds ratios(ORs)were calculated using binary logistic regression to measure associations between predictive factors and different outcomes.Results Two-hundred seventeen studies(439 children)were included.The median age at presentation was 1.75[interquartile range(IQR)1.00–3.00]years and 399(90.9%)exposures were ingestions.Of the 380 cases reporting sex,162(42.6%)were female.Feeding(192,48.1%)and respiratory difficulties(138,34.6%)were common presenting features for ingestions,while symptomatology was site-specific for insertions.Common complications included oesophageal mucosal damage alone(105,26.3%)and tracheooesophageal fistula(93,23.3%)for ingestions,and nasal septal perforation(22,55.0%)and mucosal damage alone(13,32.5%)for insertions.Intestinal perforation occurred in 2.5%of ingestion cases,including perforation of Meckel's diverticulum,peritonitis,and jejunocolic fistula.Vascular complications were common among children who died.Age(≤2 years),battery exposure duration(>6 hours),and battery diameter(≥20 mm)were associated with common and severe complications of ingestions.Conclusion BB injuries are time-critical,with severe sequelae predominantly affecting young children.Diagnosis is challenging.Preventative work through regulation and safer battery design are required to eliminate this problem.