The seleno substituted aromatic compounds were prepared via the Diels-Alder reaction of seleno substituted 3-sulfolenes with dimethyl acetylenedicarboxylate followed by DDQ dehydrogenation.
The crystal structure of the title compound with good acetylcholinesterase inhibitory activity （C21H19NO8, Mr = 413.37） has been determined by single-crystal X-ray diffraction analysis. The crystal is of monoclinic,...The crystal structure of the title compound with good acetylcholinesterase inhibitory activity （C21H19NO8, Mr = 413.37） has been determined by single-crystal X-ray diffraction analysis. The crystal is of monoclinic, space group P21 with a = 10.257（3）, b = 8.954（3）, c = 11.541（4） A°, β= 109.772（6）°, V= 997.5（6）A°^3, Dc= 1.376 g/cm^3, μ = 0.107 mm^-1, Z= 2, F（000） = 432, S = 1.041, the final R = 0.0356 and wR = 0.0884. In the molecular structure, the ring of N（1）-C（5）-C（6）-C（7）-C（8）-C（13） is of twisting-boat conformation, and the ring of N（1 ）-C（1 ）- C（2）-C（3）-C（4）-C（5） is nearly a plane.展开更多
The title compound, methyl 2-（diphenylamino）-4-phenyl-1,3-thiazole-5-carboxylate, was synthesized and studied by single-crystal X-ray diffraction method. The structure of the product was confirmed by IR, 1H- and 13C...The title compound, methyl 2-（diphenylamino）-4-phenyl-1,3-thiazole-5-carboxylate, was synthesized and studied by single-crystal X-ray diffraction method. The structure of the product was confirmed by IR, 1H- and 13C-NMR spectroscopy and elemental analysis. These experimental studies were supported by quantum mechanical calculations. The structure was solved in monoclinic, space group P21/c with a = 9.573（3）, b = 19.533（7）, c = 9.876（3）, β = 92.35（4）°, V = 1845.2（10）3, T = 85（2） K, Z = 4, R = 0.040 and wR = 0.089 for 6424 observed reflections with I2σ（I）.展开更多
Benzohydroxamic acid reacts with dimethyl acetylenedicarboxylate in the presence of 10 mol% NaOAc to gen- erate （E）-N-（1,4-dimethoxy-l,4-dioxobutan-2-ylidene）-l-phenylcarboxamide oxide in good-to-excellent yield i...Benzohydroxamic acid reacts with dimethyl acetylenedicarboxylate in the presence of 10 mol% NaOAc to gen- erate （E）-N-（1,4-dimethoxy-l,4-dioxobutan-2-ylidene）-l-phenylcarboxamide oxide in good-to-excellent yield in water at room temperature for 2 h, which supplies a simple, efficient and environmentally friendly method to syn- thesize a wide range of nitrones. The benefits of this strategy not only conform to the requirment of green chemisty, but also possess atom economy.展开更多
文摘The seleno substituted aromatic compounds were prepared via the Diels-Alder reaction of seleno substituted 3-sulfolenes with dimethyl acetylenedicarboxylate followed by DDQ dehydrogenation.
基金The project was supported by the Foundation of Science and Technology Department of Guangdong Province (2003C103006, 2004B30101007)
文摘The crystal structure of the title compound with good acetylcholinesterase inhibitory activity （C21H19NO8, Mr = 413.37） has been determined by single-crystal X-ray diffraction analysis. The crystal is of monoclinic, space group P21 with a = 10.257（3）, b = 8.954（3）, c = 11.541（4） A°, β= 109.772（6）°, V= 997.5（6）A°^3, Dc= 1.376 g/cm^3, μ = 0.107 mm^-1, Z= 2, F（000） = 432, S = 1.041, the final R = 0.0356 and wR = 0.0884. In the molecular structure, the ring of N（1）-C（5）-C（6）-C（7）-C（8）-C（13） is of twisting-boat conformation, and the ring of N（1 ）-C（1 ）- C（2）-C（3）-C（4）-C（5） is nearly a plane.
基金supported by Urmia Branch,Islamic Azad University
文摘The title compound, methyl 2-（diphenylamino）-4-phenyl-1,3-thiazole-5-carboxylate, was synthesized and studied by single-crystal X-ray diffraction method. The structure of the product was confirmed by IR, 1H- and 13C-NMR spectroscopy and elemental analysis. These experimental studies were supported by quantum mechanical calculations. The structure was solved in monoclinic, space group P21/c with a = 9.573（3）, b = 19.533（7）, c = 9.876（3）, β = 92.35（4）°, V = 1845.2（10）3, T = 85（2） K, Z = 4, R = 0.040 and wR = 0.089 for 6424 observed reflections with I2σ（I）.
文摘Benzohydroxamic acid reacts with dimethyl acetylenedicarboxylate in the presence of 10 mol% NaOAc to gen- erate （E）-N-（1,4-dimethoxy-l,4-dioxobutan-2-ylidene）-l-phenylcarboxamide oxide in good-to-excellent yield in water at room temperature for 2 h, which supplies a simple, efficient and environmentally friendly method to syn- thesize a wide range of nitrones. The benefits of this strategy not only conform to the requirment of green chemisty, but also possess atom economy.
