Clinical trials have demonstrated that some patients with chronic myeloid leukemia(CML)treated for several years with tyrosine kinase inhibitors(TKIs)who have maintained a molecular response can successfully discontin...Clinical trials have demonstrated that some patients with chronic myeloid leukemia(CML)treated for several years with tyrosine kinase inhibitors(TKIs)who have maintained a molecular response can successfully discontinue treatment without relapsing.Treatment free remission(TFR)can be reached by approximately 50%of patients who discontinue.Despite having similar levels of deep molecular response and an identical duration of treatment,the factors that influence the successful discontinuation of CML patients remain to be determined.In this review we will explore the factors identified to date that can help predict whether a patient will successfully achieve TFR.We will also discuss the need for the identification of predictive biomarkers associated with a high probability of achieving TFR for the future personalized identification of patients who are suitable for the discontinuation of TKI treatment.展开更多
We consider a SEIR epidemic model with infectious force in latent period and infected period under discontinuous treatment.The treatment rate has at most a finite number of jump discontinuities in every compact interv...We consider a SEIR epidemic model with infectious force in latent period and infected period under discontinuous treatment.The treatment rate has at most a finite number of jump discontinuities in every compact interval.By using Lyapunov theory for discontinuous differential equations and other techniques on non-smooth analysis,the basic reproductive number Ro is proved to be a sharp threshold value which completely determines the dynamics of the model.If Ro<1,then there exists a disease-free equilibrium which is globally stable.If Ro>1,the disease-free equilibrium becomes unstable and there exists an endemic equilibrium which is globally stable.We discuss that the disease will die out in a finite time which is impossible for the corresponding SEIR model with continuous treatment.Furthermore,the numerical simulations indicate that strengthening treatment measure after infective individuals reach some level is beneficial to disease control.展开更多
文摘Clinical trials have demonstrated that some patients with chronic myeloid leukemia(CML)treated for several years with tyrosine kinase inhibitors(TKIs)who have maintained a molecular response can successfully discontinue treatment without relapsing.Treatment free remission(TFR)can be reached by approximately 50%of patients who discontinue.Despite having similar levels of deep molecular response and an identical duration of treatment,the factors that influence the successful discontinuation of CML patients remain to be determined.In this review we will explore the factors identified to date that can help predict whether a patient will successfully achieve TFR.We will also discuss the need for the identification of predictive biomarkers associated with a high probability of achieving TFR for the future personalized identification of patients who are suitable for the discontinuation of TKI treatment.
基金supported by the National Nature Science Foundation of China(11271154).
文摘We consider a SEIR epidemic model with infectious force in latent period and infected period under discontinuous treatment.The treatment rate has at most a finite number of jump discontinuities in every compact interval.By using Lyapunov theory for discontinuous differential equations and other techniques on non-smooth analysis,the basic reproductive number Ro is proved to be a sharp threshold value which completely determines the dynamics of the model.If Ro<1,then there exists a disease-free equilibrium which is globally stable.If Ro>1,the disease-free equilibrium becomes unstable and there exists an endemic equilibrium which is globally stable.We discuss that the disease will die out in a finite time which is impossible for the corresponding SEIR model with continuous treatment.Furthermore,the numerical simulations indicate that strengthening treatment measure after infective individuals reach some level is beneficial to disease control.
