Correlation between ^99mTcO₄<sup style="margin-left:-7px;">-</sup>Thyroid Scintigraphy and Blood Test in Primary Hyperthyroidism

Background: The 99mTcO4- thyroid scintigraphy is commonly used for hyperthyroidism diagnosis. Uptake value of 99mTcO4- on thyroid scintigraphy is an indicator of hyperthyroidism activity. Although, the correlation between free T3 value and free T4 value is not necessary clear in primary hyperthyroidism. Introduction: This study investigated the correlation between results of blood test and uptake of 99mTcO4- on thyroid scintigraphy in primary hyperthyroidism. Methodlogy: In this retrspective study, uptake was calculated in patients diagnosed with primary hyperthyroidism (Graves’ disease/Basedow’s disease) based on clinical findings, blood tests, thyroid ultrasound, and 99mTcO4- thyroid scintigraphy (uptake ≥3%) at St. Marianna University School of Medicine Hospital between 1 January 2010 and 31 December 2019. This uptake of 99mTcO4- was compared with results of blood tests. Results: Fifty-four consecutively arriving patients at the hospital (12 men, 42 women;mean age 43.0 ± 14.0 years) were selected. Free T3 (n = 54) was 14.6 ± 6.8 pg/mL, free T4 (n = 53) was 5.0 ± 2.3 ng/mL, and uptake on thyroid scintigraphy was 10.0% ± 7.1%. The correlation coefficients were 0.60 (p < 0.01) between free T4 (all case), 0.39 (p < 0.01) between free T4 (under 7 ng/mL), 0.12 (p = 0.70) between free T4 (above 7 ng/mL) and 99mTcO4- thyroid scintigraphy uptake. Conclusion: In primary hyperthyroidism (Graves’ disease), there is a correlation between free T4 value and 99mTcO4- thyroid scintigraphy uptake, but there is no correlation in patients with high free T4 level.

单发直径5cm以内肝细胞癌行射频消融与手术切除疗效比较

目的比较单发直径≤5cm的肝细胞癌患者行射频消融术与手术切除的疗效，为临床治疗方案选择提供循证参考。方法检索2005—2012年发表的比较射频消融术与手术切除治疗直径≤5cm的单发肿瘤的对照研究，两者问肝功能无显著差异是筛选的必要条件。检索数据库包括Pubmed、EMBASE等。应用Revman5．0软件比较射频消融术与手术切除的患者1、3、5年总体及无瘤生存率。根据各研究间的异质性选择随机效应模型或者固定效应模型行Meta分析，比较射频消融术与手术切除的初始治疗效果。结果5项研究符合入组要求，共包括644例患者，其中270例接受射频消融术，374例接受手术切除。所有研究患者中射频消融术与手术切除组肝功能差异无统计学意义。Meta分析结果显示，对于单发肿瘤直径≤5em的患者，行射频消融术与手术切除的1、3、5年总体生存率差异无统计学意义（P〉0．05）。然而，手术切除患者的1、3、5年无瘤生存率优于射频消融术，差异具有统计学意义（P〈0．05）。结论对于直径≤5cm的单发肿瘤，射频消融术可取得与手术切除相当的术后生存时间，但射频消融术后局部复发率较高，无瘤生存率较手术切除低。

X连锁凋亡抑制蛋白表达对肿瘤患者生存预后影响的Meta分析

目的分析X连锁凋亡抑制蛋白（XIAP）表达对肿瘤患者总生存期（OS）预后的影响，为其临床应用提供有效证据。方法计算机检索CochraneLibrary、Embase、Medline、WebofScience、ElsevierSD、Pubmed、万方、CNKI和VIP数据库，查找研究XIAP表达与肿瘤患者预后相关的队列研究，文献检索时限均从建库至2014年12月10日。对符合条件的研究，由两位研究者按照纳入和排除标准，独立筛选文献、提取资料、评价质量，并交叉核对后，采用Stata12．0软件进行Meta分析。结果共纳入25篇文献，包含26项研究（n=3583）。Meta分析结果显示XIAP高表达不利于肿瘤患者OS，合并风险比（HR）为1．21，95％CI：1．02—1．44，P=0．032；按时间顺序累积Meta分析表明XIAP高表达对肿瘤患者有不利的趋势。亚组分析本次研究的异质性可能来于肝癌、手术、直接提取以及临界值（5％～25％）亚组，Meta回9-3分析发现肿瘤类别能解释67．03％的异质性来源，敏感性分析表明本次分析结果不稳定。结论XIAP高表达或阳性对肿瘤患者的0S预后不利，但其结论有待进一步研究证实，尤其需要对同类型肿瘤患者做系统性和大样本临床研究。