To figure out the disease occurrence of landscape plants in the main urban area of Lu'an City,the author investigated the disease occurrence of landscape plants in park green space,residential green space,unit att...To figure out the disease occurrence of landscape plants in the main urban area of Lu'an City,the author investigated the disease occurrence of landscape plants in park green space,residential green space,unit attached green space and main road in the area under administration.The survey results showed that there were 29 species of urban landscape plant diseases,mainly powdery mildew and spot diseases.According to the characteristics of the diseases,the causes and problems of the diseases were analyzed,and the corresponding prevention and control measures were put forward.展开更多
This editorial presents an analysis of an article recently published in the World Journal of Clinical Cases.Kawasaki disease(KD)is a well-known pediatric vasculitis characterized by fever,rash,conjunctivitis,oral muco...This editorial presents an analysis of an article recently published in the World Journal of Clinical Cases.Kawasaki disease(KD)is a well-known pediatric vasculitis characterized by fever,rash,conjunctivitis,oral mucosal changes,and swelling of the extremities.This editorial aims to delve into the intricate relationship between KD and abdominal pain,drawing insights from recent research findings to provide a comprehensive understanding and potential avenues for future investigation.展开更多
Objective:To evaluate the Anaplasma phagocytophilum(A.phagocytophilum),Ehrlichia canis(E.canis,Dirofilaria immitis(D.immitis)(canine heartworm),Borrelia burgdorferi(B.burgdorferi)infections in countryside dogs from Yu...Objective:To evaluate the Anaplasma phagocytophilum(A.phagocytophilum),Ehrlichia canis(E.canis,Dirofilaria immitis(D.immitis)(canine heartworm),Borrelia burgdorferi(B.burgdorferi)infections in countryside dogs from Yunnan,Hainan and Anhui provinces.Methods:Serum samples were collected from 26 dogs in Yunnan.Hainan and Anhui provinces.The samples were tested using a commercial ELISA rapid diagnostic assay kit(SNAP^(?)4Dx^(?);IDEXX Laboratories,Inc.U.S.A.).Meaiiwliile,indirect immunofluorescence assay(IFA)recommended by WHO was conducted to delect IgG to A.phagocytophilum.Two methods were analyzed and compared.Results:The number of serologically positive dogs for IgG to A.phagocytophilum was only 2which was from Hainan province and none of the 26 dogs responded positive for E.canu.D.immitis(canine heartworm,and B.burgdorferi by ELISA rapid diagnostic method.The number of serologically positive dogs for IgG to A.phagocytophilum was 13(50%)by IFA method.Data of the two methods were analyzed by statistical software and the difference was statistically significant(P=0.002).Conclusions:It can be concluded that IFA method was more sensitive than ELISA rapid diagnostic method.However,we need conduct further and intensive epidemiology survey on tick-born diseases pathogens including.4.phagocytophilum,E.canis,D.immitis(canine heartworm),and B.burgdorferi which have public health significance.展开更多
Selenium supplements were not able to restore the ultrastructural changes in the myocardiurn of latent Keshan disease patients taken by using cardiac catheter endomyocardial biopsy. Observations on the changes of sele...Selenium supplements were not able to restore the ultrastructural changes in the myocardiurn of latent Keshan disease patients taken by using cardiac catheter endomyocardial biopsy. Observations on the changes of seleniurn status and the incidence of Keshan disease showed that new latent and naturally-occurring chronic cases were found in the endemic area even after selenium levels had been elevated in the residents to the levels typical in the non-endemic area. These results indicate that although selenium deficiency might be a primary pathogenetic geogen in the occurrence of Keshan disease, it is rather a conditional predisposing factor than a specific or initiative aetiologic factor for the occurrence of Keshan disease. Selenium supplmentation could apparently alleviate the higher platelet responsiveness of residents in the endemic area, which might contribute to eliminating the basis for the occurrence of the multifocal perivascular necroses in myocardium of acute and subacute Keshan disease展开更多
The tobacco pests and diseases in major flue-cured tobacco production areas of Shibing County were investigated, and the corresponding control counter- measures were put forward. The results showed that the common pes...The tobacco pests and diseases in major flue-cured tobacco production areas of Shibing County were investigated, and the corresponding control counter- measures were put forward. The results showed that the common pests and diseases, such as tobacco aphid, tobacco budworm, TMV, CMV, PVY, bacterial wilt and black shank, had occurred in flue-cured tobacco production in Shibing County.展开更多
[ Objective] To investigate the prevalence situation of swine reproductive failure diseases in Henan Province and provide reference for the immunization and prevention of swine reproductive failure diseases. [ Method]...[ Objective] To investigate the prevalence situation of swine reproductive failure diseases in Henan Province and provide reference for the immunization and prevention of swine reproductive failure diseases. [ Method] Between May 2009 and April 2010, all serum samples from the Henan Agriculture University, Animal Disease Detection and Diagnosis Center were detected, including 6 825 serum samples for detecting classical swine fever (CSF) antibody, 2 609 for porcine reproductive and respiratory syndrome (PRRS) antibody, 1 177 for pseudorabies rabies virus gE (PRV) antibody, 123 for porcine parvovirus (PPV) antibody and 53 for chlamydiosis antibody. [ Result] The antibody positive rates of sere for de- tecting above five diseases were 63.28%, 61.44%, 25.49%, 39.84% and 5.66%, respectively. [ Conclusion] The immunization and prevention of CSF, PRRS, PPV and PR in Henan Province needs to be strengthened urgently, and the chlamvdiosis has been effectively controlled.展开更多
Objectives To evaluate the relationship of renal dysfunction,coronary heart disease and percutaneous coronary intervention(PCI).Methods(l)The subjects:There were 376 patients who come from department of cardiology of ...Objectives To evaluate the relationship of renal dysfunction,coronary heart disease and percutaneous coronary intervention(PCI).Methods(l)The subjects:There were 376 patients who come from department of cardiology of our hospital in this study undergoing coronary angiography.The patients were divided into two groups? according to coronary angiography:coronary artery disease(group A,n =263),in which 141 patients with renal dysfunction(group A1) and 122 patients with normal renal function(group A2):patients with other kinds of cardiovascular disease but normal coronary angiography(group B.n=113).Before the coronary angiography, all patients were measured the serum creatinine, microalbuminuria,fasting blood-glucose,triglycerides,total cholesterol,high density lipoprotein,low density lipoprotein, blood pressure in fasting 12 hours.(2)The diagnostic criteria for renal dysfunction:male serum creatinine】115 umol/L and/or microalbuminuria】30 mg,female】107 umol/L and/ or】30 mg.Results(1)The differences of renal function indexes in the group A and B:The mean level of microalbuminuria and serum creatinine was higher significantly in group A than that of the group B(43.48±38.93 vs.11.23±7.07 and 101.52±37.22 vs.80.62±17.4 respectively.Conclusions The coronary heart disease patients with renal dysfunction had more severe coronary artery stenosis,The renal dysfunction is a strong and independent risk factors for the coronary heart disease and beeds more revascularization therapy.展开更多
Previous researches show that the total electron content (TEC) in the ionospheric exhibits anomalous disturbances a few days or hours prior to earthquakes. The paper used TEC data from Internet GPS Service ( IGS),...Previous researches show that the total electron content (TEC) in the ionospheric exhibits anomalous disturbances a few days or hours prior to earthquakes. The paper used TEC data from Internet GPS Service ( IGS), and examined 50 earthquakes of magnitude Ms ≥ 7.0 during 2007 - 2009 worldwide. The result shows significant anomalous increases and decreases about 7 days prior to 94% of the earthquakes.展开更多
Cardiovascular disease(CVD)is the major cause of death in many regions around the world,and several of its risk factors might be linked to diets.To improve public health and the understanding of this topic,we look at ...Cardiovascular disease(CVD)is the major cause of death in many regions around the world,and several of its risk factors might be linked to diets.To improve public health and the understanding of this topic,we look at the recent Minnesota Coronary Experiment(MCE)analysis that used t-test and Cox model to evaluate CVD risks.However,these parametric methods might suffer from three problems:small sample size,right-censored bias,and lack of long-term evidence.To overcome the first of these challenges,we utilize a nonparametric permutation test to examine the relationship between dietary fats and serum total cholesterol.To address the second problem,we use a resampling-based rank test to examine whether the serum total cholesterol level affects CVD deaths.For the third issue,we use some extra-Framingham Heart Study(FHS)data with an A/B test to look for meta-relationship between diets,risk factors,and CVD risks.We show that,firstly,the link between low saturated fat diets and reduction in serum total cholesterol is strong.Secondly,reducing serum total cholesterol does not robustly have an impact on CVD hazards in the diet group.Lastly,the A/B test result suggests a more complicated relationship regarding abnormal diastolic blood pressure ranges caused by diets and how these might affect the associative link between the cholesterol level and heart disease risks.This study not only helps us to deeply analyze the MCE data but also,in combination with the long-term FHS data,reveals possible complex relationships behind diets,risk factors,and heart disease.展开更多
Moyamoya disease and cerebrovascular atherosclerotic disease are both chronic ischemic diseases with similar presentations of vascular cognitive impairment. The aim of the present study was to investigate the patterns...Moyamoya disease and cerebrovascular atherosclerotic disease are both chronic ischemic diseases with similar presentations of vascular cognitive impairment. The aim of the present study was to investigate the patterns of microstructural damage associated with vascular cognitive impairment in the two diseases. The study recruited 34 patients with moyamoya disease(age 43.9 ± 9.2 years; 20 men and 14 women, 27 patients with cerebrovascular atherosclerotic disease(age: 44.6 ± 7.6 years; 17 men and 10 women), and 31 normal controls(age 43.6 ± 7.3 years; 18 men and 13 women) from Huashan Hospital of Fudan University in China. Cognitive function was assessed using the Mini-Mental State Examination, long-term delayed recall of Auditory Verbal Learning Test, Trail Making Test Part B, and the Symbol Digit Modalities Test. Single-photon emission-computed tomography was used to examine cerebral perfusion. Voxel-based morphometry and tract-based spatial statistics were performed to identify regions of gray matter atrophy and white matter deterioration in patients and normal controls. The results demonstrated that the severity of cognitive impairment was similar between the two diseases in all tested domains. Patients with moyamoya disease and those with cerebrovascular atherosclerotic disease suffered from disturbed supratentorial hemodynamics. Gray matter atrophy in bilateral middle cingulate cortex and parts of the frontal gyrus was prominent in both diseases, but in general, was more severe and more diffuse in those with moyamoya disease. White matter deterioration was significant for both diseases in the genu and body of corpus callosum, in the anterior and superior corona radiation, and in the posterior thalamic radiation, but in moyamoya disease, it was more diffuse and more severe. Vascular cognitive impairment was associated with regional microstructural damage, with a potential link between, gray and white matter damage. Overall, these results provide insight into the pathophysiological nature of vascular cognitive impairment. This study was approved by the Institutional Review Board in Huashan Hospital, China(approval No. 2014-278). This study was registered with ClinicalTrials.gov on December 2, 2014 with the identifier NCT02305407.展开更多
In this study,microstructural brain damage in Parkinson's disease patients was examined using diffusion tensor imaging and tract-based spatial statistics.The analyses revealed the presence of neuronal damage in the s...In this study,microstructural brain damage in Parkinson's disease patients was examined using diffusion tensor imaging and tract-based spatial statistics.The analyses revealed the presence of neuronal damage in the substantia nigra and putamen in the Parkinson's disease patients.Moreover,disease symptoms worsened with increasing damage to the substantia nigra,confirming that the substantia nigra and basal ganglia are the main structures affected in Parkinson's disease.We also found that microstructural damage to the putamen,caudate nucleus and frontal lobe positively correlated with depression.Based on the tract-based spatial statistics,various white matter tracts appeared to have microstructural damage,and this correlated with cognitive disorder and depression.Taken together,our results suggest that diffusion tensor imaging and tract-based spatial statistics can be used to effectively study brain function and microstructural changes in patients with Parkinson's disease.Our novel findings should contribute to our understanding of the histopathological basis of cognitive dysfunction and depression in Parkinson's disease.展开更多
BACKGROUND In December 2019,the first patient with 2019-novel coronavirus(2019-nCoV)was reported in Wuhan,China,and the disease spread rapidly across the country and surrounding countries within 2 mo.As of February 29...BACKGROUND In December 2019,the first patient with 2019-novel coronavirus(2019-nCoV)was reported in Wuhan,China,and the disease spread rapidly across the country and surrounding countries within 2 mo.As of February 29,2020,a total of 91 confirmed cases had been reported in Gansu Province.This case report of the diagnosis and treatment of an elderly patient with 2019-nCoV pneumonia complicated by acute exacerbation of chronic obstructive pulmonary disease in Gansu Province aims to provide a better reference for the treatment of patients in the future.CASE SUMMARY The patient,a 94-year-old female,lived in Maiji District of Tianshui,Gansu Province,China.On January 30,2020,she was admitted to the Fourth People’s Hospital of Tianshui after 9 d of close contact with a patient with 2019-nCoV pneumonia.She was subsequently admitted to Gansu Provincial Hospital of Traditional Chinese Medicine for isolation and transferred to Tianshui Gansu Provincial Hospital of Infectious Diseases on February 3,2020 for treatment.Upon initial examination,her body temperature was 36.7°C,pulse was 80,breathing was 20,and blood pressure was 130/80 mmHg.She was conscious with normal development and normal nutrition.The pharynx was not red,and bilateral tonsils were not red and swollen.The lungs sounded slightly coarse with no dry or wet rales.The first symptoms were cough and fatigue on 2 February.The patient was hospitalized for 12 d.After active treatment,she was discharged on February 14 with a good prognosis.CONCLUSION A history of exposure to the affected area or patient is a major cause of 2019-nCoV infection,and population clustering is a high risk factor for transmission.Patients may not necessarily have respiratory system symptoms as the only clinical manifestation but may also have concomitant or first onset digestive symptoms.Attention should be paid to the prevention and treatment of multiple organ dysfunction syndrome.Nucleic acid testing is extremely important and needs to be repeated several times.Laboratory and auxiliary examination indicators during the first week of admission are extremely important.It is feasible to carry out dynamic and continuous index monitoring,which can predict and guide the prevention and treatment of multiple organ dysfunction and the prognosis of the disease.展开更多
Today,coronavirus appears as a serious challenge to the whole world.Epidemiological data of coronavirus is collected through media and web sources for the purpose of analysis.New data on COVID-19 are available daily,y...Today,coronavirus appears as a serious challenge to the whole world.Epidemiological data of coronavirus is collected through media and web sources for the purpose of analysis.New data on COVID-19 are available daily,yet information about the biological aspects of SARS-CoV-2 and epidemiological characteristics of COVID-19 remains limited,and uncertainty remains around nearly all its parameters’values.This research provides the scientic and public health communities better resources,knowledge,and tools to improve their ability to control the infectious diseases.Using the publicly available data on the ongoing pandemic,the present study investigates the incubation period and other time intervals that govern the epidemiological dynamics of the COVID-19 infections.Formulation of the testing hypotheses for different countries with a 95%level of condence,and descriptive statistics have been calculated to analyze in which region will COVID-19 fall according to the tested hypothesized mean of different countries.The results will be helpful in decision making as well as in further mathematical analysis and control strategy.Statistical tools are used to investigate this pandemic,which will be useful for further research.The testing of the hypothesis is done for the differences in various effects including standard errors.Changes in states’variables are observed over time.The rapid outbreak of coronavirus can be stopped by reducing its transmission.Susceptible should maintain safe distance and follow precautionary measures regarding COVID-19 transmission.展开更多
Summary: To investigate the changes in neurological symptoms and signs, as well as serum copper, serum ceruloplasmin after hepatic transplantation in patients with Wilson’s disease, neurological symptoms and signs, s...Summary: To investigate the changes in neurological symptoms and signs, as well as serum copper, serum ceruloplasmin after hepatic transplantation in patients with Wilson’s disease, neurological symptoms and signs, serum copper, serum ceruloplasmin before and after hepatic transplantation in 18 patients with Wilson’s disease were observed, and those changes were followed up in 20 non-operative controls treated with penicillamine. Our results showed that the neurological symptoms and signs, serum copper and serum ceruloplasmin were improved in the operative group but deteriorated in the non-operative control group. Our study showed that hepatic transplantation is better than penicillamine in the treatment of Wilson’s disease.展开更多
The current study relates to designing a swarming computational paradigm to solve the influenza disease system(IDS).The nonlinear system’s mathematical form depends upon four classes:susceptible individuals,infected ...The current study relates to designing a swarming computational paradigm to solve the influenza disease system(IDS).The nonlinear system’s mathematical form depends upon four classes:susceptible individuals,infected people,recovered individuals and cross-immune people.The solutions of the IDS are provided by using the artificial neural networks(ANNs)together with the swarming computational paradigm-based particle swarmoptimization(PSO)and interior-point scheme(IPA)that are the global and local search approaches.The ANNs-PSO-IPA has never been applied to solve the IDS.Instead a merit function in the sense of mean square error is constructed using the differential form of each class of the IDS and then optimized by the PSOIPA.The correctness and accuracy of the scheme are observed to perform the comparative analysis of the obtained IDS results with the Adams solutions(reference solutions).An absolute error in suitable measures shows the precision of the proposed ANNs procedures and the optimization efficiency of the PSOIPA.Furthermore,the reliability and competence of the proposed computing method are enhanced through the statistical performances.展开更多
AIM:To investigate the capability of a biochemical and clinical model,BioCliM,in predicting the survival of cirrhotic patients.METHODS:We prospectively evaluated the survival of 172 cirrhotic patients.The model was co...AIM:To investigate the capability of a biochemical and clinical model,BioCliM,in predicting the survival of cirrhotic patients.METHODS:We prospectively evaluated the survival of 172 cirrhotic patients.The model was constructed using clinical(ascites,encephalopathy and variceal bleeding) and biochemical(serum creatinine and serum total bilirubin) variables that were selected from a Cox proportional hazards model.It was applied to estimate 12-,52-and 104-wk survival.The model's calibration using the Hosmer-Lemeshow statistic was computed at 104 wk in a validation dataset.Finally,the model's validity was tested among an independent set of 85 patients who were stratified into 2 risk groups(low risk≤8 and high risk>8).RESULTS:In the validation cohort,all measures of fi t,discrimination and calibration were improved when the biochemical and clinical model was used.The proposed model had better predictive values(c-statistic:0.90,0.91,0.91) than the Model for End-stage Liver Disease(MELD) and Child-Pugh(CP) scores for 12-,52-and 104-wk mortality,respectively.In addition,the Hosmer-Lemeshow(H-L) statistic revealed that the biochemical and clinical model(H-L,4.69) is better calibrated than MELD(H-L,17.06) and CP(H-L,14.23).There were no significant differences between the observed and expected survival curves in the stratified risk groups(low risk,P=0.61;high risk,P=0.77).CONCLUSION:Our data suggest that the proposed model is able to accurately predict survival in cirrhotic patients.展开更多
The occurrence of maize diseases was systematically studied at different growth stages of maize in different areas of Anhui Province. It was found that maize has a long optimal growth period in Anhui Province, and the...The occurrence of maize diseases was systematically studied at different growth stages of maize in different areas of Anhui Province. It was found that maize has a long optimal growth period in Anhui Province, and the maize planting structure is complex. The northern region is mainly planted with summer maize in large scale, while the southern region is mainly planted with spring maize in scattered pattern. In terms of diseases, the south spring maize suffered from more diverse diseases than the north summer maize. The main maize disease in Suzhou, Bozhou, Fuyang and Bengbu areas was southern rust, which was common with the highest diseased plant rate of 76%. The main maize diseases in Lu'an, Anqing, Chizhou, Tongling and Xuancheng were rust, maize rough dwarf virus(MRDV), southern leaf blight and sheath blight. Other diseases such as northern leaf blight, stalk rot and maize smut occurred commonly. The diseased plant rate of maize rust was in the range of 25%-47%.展开更多
基金Supported by Youth Project of Natural Science Foundation of Anhui Province(2008085QC135)Postdoctoral Workstation Project of West Anhui University(WXBSH2020003)+4 种基金Key Program of Natural Science Research Project for Anhui Universities(KJ2021A0954)Forestry Carbon Sequestration Self-funded Science and Technology Project of Anhui Province(LJH[2022]267)Subject of Lu'an Forestry Bureau(0045021093)School-level Quality Engineering Project of West Anhui University(wxxy2021017)Provincial Quality Engineering Project of West Anhui University(2022jyxm1765).
文摘To figure out the disease occurrence of landscape plants in the main urban area of Lu'an City,the author investigated the disease occurrence of landscape plants in park green space,residential green space,unit attached green space and main road in the area under administration.The survey results showed that there were 29 species of urban landscape plant diseases,mainly powdery mildew and spot diseases.According to the characteristics of the diseases,the causes and problems of the diseases were analyzed,and the corresponding prevention and control measures were put forward.
基金Supported by The Hubei Pediatric Alliance Medical Research Project,No.HPAMRP202117。
文摘This editorial presents an analysis of an article recently published in the World Journal of Clinical Cases.Kawasaki disease(KD)is a well-known pediatric vasculitis characterized by fever,rash,conjunctivitis,oral mucosal changes,and swelling of the extremities.This editorial aims to delve into the intricate relationship between KD and abdominal pain,drawing insights from recent research findings to provide a comprehensive understanding and potential avenues for future investigation.
基金supported by the National Basic Research Program of China(973 Program)2010CB530200(2010CB530206)the China-US Collaborative Program on Emerging and Re-emerging Infectious Disease(No.1U2GGH000018-01)
文摘Objective:To evaluate the Anaplasma phagocytophilum(A.phagocytophilum),Ehrlichia canis(E.canis,Dirofilaria immitis(D.immitis)(canine heartworm),Borrelia burgdorferi(B.burgdorferi)infections in countryside dogs from Yunnan,Hainan and Anhui provinces.Methods:Serum samples were collected from 26 dogs in Yunnan.Hainan and Anhui provinces.The samples were tested using a commercial ELISA rapid diagnostic assay kit(SNAP^(?)4Dx^(?);IDEXX Laboratories,Inc.U.S.A.).Meaiiwliile,indirect immunofluorescence assay(IFA)recommended by WHO was conducted to delect IgG to A.phagocytophilum.Two methods were analyzed and compared.Results:The number of serologically positive dogs for IgG to A.phagocytophilum was only 2which was from Hainan province and none of the 26 dogs responded positive for E.canu.D.immitis(canine heartworm,and B.burgdorferi by ELISA rapid diagnostic method.The number of serologically positive dogs for IgG to A.phagocytophilum was 13(50%)by IFA method.Data of the two methods were analyzed by statistical software and the difference was statistically significant(P=0.002).Conclusions:It can be concluded that IFA method was more sensitive than ELISA rapid diagnostic method.However,we need conduct further and intensive epidemiology survey on tick-born diseases pathogens including.4.phagocytophilum,E.canis,D.immitis(canine heartworm),and B.burgdorferi which have public health significance.
文摘Selenium supplements were not able to restore the ultrastructural changes in the myocardiurn of latent Keshan disease patients taken by using cardiac catheter endomyocardial biopsy. Observations on the changes of seleniurn status and the incidence of Keshan disease showed that new latent and naturally-occurring chronic cases were found in the endemic area even after selenium levels had been elevated in the residents to the levels typical in the non-endemic area. These results indicate that although selenium deficiency might be a primary pathogenetic geogen in the occurrence of Keshan disease, it is rather a conditional predisposing factor than a specific or initiative aetiologic factor for the occurrence of Keshan disease. Selenium supplmentation could apparently alleviate the higher platelet responsiveness of residents in the endemic area, which might contribute to eliminating the basis for the occurrence of the multifocal perivascular necroses in myocardium of acute and subacute Keshan disease
文摘The tobacco pests and diseases in major flue-cured tobacco production areas of Shibing County were investigated, and the corresponding control counter- measures were put forward. The results showed that the common pests and diseases, such as tobacco aphid, tobacco budworm, TMV, CMV, PVY, bacterial wilt and black shank, had occurred in flue-cured tobacco production in Shibing County.
文摘[ Objective] To investigate the prevalence situation of swine reproductive failure diseases in Henan Province and provide reference for the immunization and prevention of swine reproductive failure diseases. [ Method] Between May 2009 and April 2010, all serum samples from the Henan Agriculture University, Animal Disease Detection and Diagnosis Center were detected, including 6 825 serum samples for detecting classical swine fever (CSF) antibody, 2 609 for porcine reproductive and respiratory syndrome (PRRS) antibody, 1 177 for pseudorabies rabies virus gE (PRV) antibody, 123 for porcine parvovirus (PPV) antibody and 53 for chlamydiosis antibody. [ Result] The antibody positive rates of sere for de- tecting above five diseases were 63.28%, 61.44%, 25.49%, 39.84% and 5.66%, respectively. [ Conclusion] The immunization and prevention of CSF, PRRS, PPV and PR in Henan Province needs to be strengthened urgently, and the chlamvdiosis has been effectively controlled.
文摘Objectives To evaluate the relationship of renal dysfunction,coronary heart disease and percutaneous coronary intervention(PCI).Methods(l)The subjects:There were 376 patients who come from department of cardiology of our hospital in this study undergoing coronary angiography.The patients were divided into two groups? according to coronary angiography:coronary artery disease(group A,n =263),in which 141 patients with renal dysfunction(group A1) and 122 patients with normal renal function(group A2):patients with other kinds of cardiovascular disease but normal coronary angiography(group B.n=113).Before the coronary angiography, all patients were measured the serum creatinine, microalbuminuria,fasting blood-glucose,triglycerides,total cholesterol,high density lipoprotein,low density lipoprotein, blood pressure in fasting 12 hours.(2)The diagnostic criteria for renal dysfunction:male serum creatinine】115 umol/L and/or microalbuminuria】30 mg,female】107 umol/L and/ or】30 mg.Results(1)The differences of renal function indexes in the group A and B:The mean level of microalbuminuria and serum creatinine was higher significantly in group A than that of the group B(43.48±38.93 vs.11.23±7.07 and 101.52±37.22 vs.80.62±17.4 respectively.Conclusions The coronary heart disease patients with renal dysfunction had more severe coronary artery stenosis,The renal dysfunction is a strong and independent risk factors for the coronary heart disease and beeds more revascularization therapy.
基金supported by the National Key Technology R&D Program(2008BAC35B02)Director Teawdotion of Institute of seismology.CEA(IS200926039)
文摘Previous researches show that the total electron content (TEC) in the ionospheric exhibits anomalous disturbances a few days or hours prior to earthquakes. The paper used TEC data from Internet GPS Service ( IGS), and examined 50 earthquakes of magnitude Ms ≥ 7.0 during 2007 - 2009 worldwide. The result shows significant anomalous increases and decreases about 7 days prior to 94% of the earthquakes.
基金Chongqing Technology Innovation and Application Development Project,Grant/Award Number:CSTB2022TIAD-KPX0067Sichuan Science and Technology Program,Grant/Award Number:2022YFS0048+1 种基金National Natural Science Foundation of China,Grant/Award Number:62372316National Science and Technology Major Project,Grant/Award Numbers:2018ZX10201002,2021YFF1201200。
文摘Cardiovascular disease(CVD)is the major cause of death in many regions around the world,and several of its risk factors might be linked to diets.To improve public health and the understanding of this topic,we look at the recent Minnesota Coronary Experiment(MCE)analysis that used t-test and Cox model to evaluate CVD risks.However,these parametric methods might suffer from three problems:small sample size,right-censored bias,and lack of long-term evidence.To overcome the first of these challenges,we utilize a nonparametric permutation test to examine the relationship between dietary fats and serum total cholesterol.To address the second problem,we use a resampling-based rank test to examine whether the serum total cholesterol level affects CVD deaths.For the third issue,we use some extra-Framingham Heart Study(FHS)data with an A/B test to look for meta-relationship between diets,risk factors,and CVD risks.We show that,firstly,the link between low saturated fat diets and reduction in serum total cholesterol is strong.Secondly,reducing serum total cholesterol does not robustly have an impact on CVD hazards in the diet group.Lastly,the A/B test result suggests a more complicated relationship regarding abnormal diastolic blood pressure ranges caused by diets and how these might affect the associative link between the cholesterol level and heart disease risks.This study not only helps us to deeply analyze the MCE data but also,in combination with the long-term FHS data,reveals possible complex relationships behind diets,risk factors,and heart disease.
基金supported by the National Natural Science Foundation of China,No.81771237(to YXG)the National Key Basic Research Program of China(973 Program),No.2014CB541604(to YXG)+1 种基金the "Shu Guang" Project of Shanghai Municipal Education Commission and Shanghai Education Development Foundation,China,No.16SG02(to LC)the Scientific Research Project of Huashan Hospital of Fudan University of China,No.2016QD082(to YL)
文摘Moyamoya disease and cerebrovascular atherosclerotic disease are both chronic ischemic diseases with similar presentations of vascular cognitive impairment. The aim of the present study was to investigate the patterns of microstructural damage associated with vascular cognitive impairment in the two diseases. The study recruited 34 patients with moyamoya disease(age 43.9 ± 9.2 years; 20 men and 14 women, 27 patients with cerebrovascular atherosclerotic disease(age: 44.6 ± 7.6 years; 17 men and 10 women), and 31 normal controls(age 43.6 ± 7.3 years; 18 men and 13 women) from Huashan Hospital of Fudan University in China. Cognitive function was assessed using the Mini-Mental State Examination, long-term delayed recall of Auditory Verbal Learning Test, Trail Making Test Part B, and the Symbol Digit Modalities Test. Single-photon emission-computed tomography was used to examine cerebral perfusion. Voxel-based morphometry and tract-based spatial statistics were performed to identify regions of gray matter atrophy and white matter deterioration in patients and normal controls. The results demonstrated that the severity of cognitive impairment was similar between the two diseases in all tested domains. Patients with moyamoya disease and those with cerebrovascular atherosclerotic disease suffered from disturbed supratentorial hemodynamics. Gray matter atrophy in bilateral middle cingulate cortex and parts of the frontal gyrus was prominent in both diseases, but in general, was more severe and more diffuse in those with moyamoya disease. White matter deterioration was significant for both diseases in the genu and body of corpus callosum, in the anterior and superior corona radiation, and in the posterior thalamic radiation, but in moyamoya disease, it was more diffuse and more severe. Vascular cognitive impairment was associated with regional microstructural damage, with a potential link between, gray and white matter damage. Overall, these results provide insight into the pathophysiological nature of vascular cognitive impairment. This study was approved by the Institutional Review Board in Huashan Hospital, China(approval No. 2014-278). This study was registered with ClinicalTrials.gov on December 2, 2014 with the identifier NCT02305407.
文摘In this study,microstructural brain damage in Parkinson's disease patients was examined using diffusion tensor imaging and tract-based spatial statistics.The analyses revealed the presence of neuronal damage in the substantia nigra and putamen in the Parkinson's disease patients.Moreover,disease symptoms worsened with increasing damage to the substantia nigra,confirming that the substantia nigra and basal ganglia are the main structures affected in Parkinson's disease.We also found that microstructural damage to the putamen,caudate nucleus and frontal lobe positively correlated with depression.Based on the tract-based spatial statistics,various white matter tracts appeared to have microstructural damage,and this correlated with cognitive disorder and depression.Taken together,our results suggest that diffusion tensor imaging and tract-based spatial statistics can be used to effectively study brain function and microstructural changes in patients with Parkinson's disease.Our novel findings should contribute to our understanding of the histopathological basis of cognitive dysfunction and depression in Parkinson's disease.
文摘BACKGROUND In December 2019,the first patient with 2019-novel coronavirus(2019-nCoV)was reported in Wuhan,China,and the disease spread rapidly across the country and surrounding countries within 2 mo.As of February 29,2020,a total of 91 confirmed cases had been reported in Gansu Province.This case report of the diagnosis and treatment of an elderly patient with 2019-nCoV pneumonia complicated by acute exacerbation of chronic obstructive pulmonary disease in Gansu Province aims to provide a better reference for the treatment of patients in the future.CASE SUMMARY The patient,a 94-year-old female,lived in Maiji District of Tianshui,Gansu Province,China.On January 30,2020,she was admitted to the Fourth People’s Hospital of Tianshui after 9 d of close contact with a patient with 2019-nCoV pneumonia.She was subsequently admitted to Gansu Provincial Hospital of Traditional Chinese Medicine for isolation and transferred to Tianshui Gansu Provincial Hospital of Infectious Diseases on February 3,2020 for treatment.Upon initial examination,her body temperature was 36.7°C,pulse was 80,breathing was 20,and blood pressure was 130/80 mmHg.She was conscious with normal development and normal nutrition.The pharynx was not red,and bilateral tonsils were not red and swollen.The lungs sounded slightly coarse with no dry or wet rales.The first symptoms were cough and fatigue on 2 February.The patient was hospitalized for 12 d.After active treatment,she was discharged on February 14 with a good prognosis.CONCLUSION A history of exposure to the affected area or patient is a major cause of 2019-nCoV infection,and population clustering is a high risk factor for transmission.Patients may not necessarily have respiratory system symptoms as the only clinical manifestation but may also have concomitant or first onset digestive symptoms.Attention should be paid to the prevention and treatment of multiple organ dysfunction syndrome.Nucleic acid testing is extremely important and needs to be repeated several times.Laboratory and auxiliary examination indicators during the first week of admission are extremely important.It is feasible to carry out dynamic and continuous index monitoring,which can predict and guide the prevention and treatment of multiple organ dysfunction and the prognosis of the disease.
文摘Today,coronavirus appears as a serious challenge to the whole world.Epidemiological data of coronavirus is collected through media and web sources for the purpose of analysis.New data on COVID-19 are available daily,yet information about the biological aspects of SARS-CoV-2 and epidemiological characteristics of COVID-19 remains limited,and uncertainty remains around nearly all its parameters’values.This research provides the scientic and public health communities better resources,knowledge,and tools to improve their ability to control the infectious diseases.Using the publicly available data on the ongoing pandemic,the present study investigates the incubation period and other time intervals that govern the epidemiological dynamics of the COVID-19 infections.Formulation of the testing hypotheses for different countries with a 95%level of condence,and descriptive statistics have been calculated to analyze in which region will COVID-19 fall according to the tested hypothesized mean of different countries.The results will be helpful in decision making as well as in further mathematical analysis and control strategy.Statistical tools are used to investigate this pandemic,which will be useful for further research.The testing of the hypothesis is done for the differences in various effects including standard errors.Changes in states’variables are observed over time.The rapid outbreak of coronavirus can be stopped by reducing its transmission.Susceptible should maintain safe distance and follow precautionary measures regarding COVID-19 transmission.
文摘Summary: To investigate the changes in neurological symptoms and signs, as well as serum copper, serum ceruloplasmin after hepatic transplantation in patients with Wilson’s disease, neurological symptoms and signs, serum copper, serum ceruloplasmin before and after hepatic transplantation in 18 patients with Wilson’s disease were observed, and those changes were followed up in 20 non-operative controls treated with penicillamine. Our results showed that the neurological symptoms and signs, serum copper and serum ceruloplasmin were improved in the operative group but deteriorated in the non-operative control group. Our study showed that hepatic transplantation is better than penicillamine in the treatment of Wilson’s disease.
基金This research received funding support from the NSRF via the Program Man-agement Unit for Human Resources&Institutional Development,Research and Innovation(Grant Number B05F640092).
文摘The current study relates to designing a swarming computational paradigm to solve the influenza disease system(IDS).The nonlinear system’s mathematical form depends upon four classes:susceptible individuals,infected people,recovered individuals and cross-immune people.The solutions of the IDS are provided by using the artificial neural networks(ANNs)together with the swarming computational paradigm-based particle swarmoptimization(PSO)and interior-point scheme(IPA)that are the global and local search approaches.The ANNs-PSO-IPA has never been applied to solve the IDS.Instead a merit function in the sense of mean square error is constructed using the differential form of each class of the IDS and then optimized by the PSOIPA.The correctness and accuracy of the scheme are observed to perform the comparative analysis of the obtained IDS results with the Adams solutions(reference solutions).An absolute error in suitable measures shows the precision of the proposed ANNs procedures and the optimization efficiency of the PSOIPA.Furthermore,the reliability and competence of the proposed computing method are enhanced through the statistical performances.
文摘AIM:To investigate the capability of a biochemical and clinical model,BioCliM,in predicting the survival of cirrhotic patients.METHODS:We prospectively evaluated the survival of 172 cirrhotic patients.The model was constructed using clinical(ascites,encephalopathy and variceal bleeding) and biochemical(serum creatinine and serum total bilirubin) variables that were selected from a Cox proportional hazards model.It was applied to estimate 12-,52-and 104-wk survival.The model's calibration using the Hosmer-Lemeshow statistic was computed at 104 wk in a validation dataset.Finally,the model's validity was tested among an independent set of 85 patients who were stratified into 2 risk groups(low risk≤8 and high risk>8).RESULTS:In the validation cohort,all measures of fi t,discrimination and calibration were improved when the biochemical and clinical model was used.The proposed model had better predictive values(c-statistic:0.90,0.91,0.91) than the Model for End-stage Liver Disease(MELD) and Child-Pugh(CP) scores for 12-,52-and 104-wk mortality,respectively.In addition,the Hosmer-Lemeshow(H-L) statistic revealed that the biochemical and clinical model(H-L,4.69) is better calibrated than MELD(H-L,17.06) and CP(H-L,14.23).There were no significant differences between the observed and expected survival curves in the stratified risk groups(low risk,P=0.61;high risk,P=0.77).CONCLUSION:Our data suggest that the proposed model is able to accurately predict survival in cirrhotic patients.
基金Supported by Discipline Construction of Anhui Academy of Agricultural Sciences(16A1133)
文摘The occurrence of maize diseases was systematically studied at different growth stages of maize in different areas of Anhui Province. It was found that maize has a long optimal growth period in Anhui Province, and the maize planting structure is complex. The northern region is mainly planted with summer maize in large scale, while the southern region is mainly planted with spring maize in scattered pattern. In terms of diseases, the south spring maize suffered from more diverse diseases than the north summer maize. The main maize disease in Suzhou, Bozhou, Fuyang and Bengbu areas was southern rust, which was common with the highest diseased plant rate of 76%. The main maize diseases in Lu'an, Anqing, Chizhou, Tongling and Xuancheng were rust, maize rough dwarf virus(MRDV), southern leaf blight and sheath blight. Other diseases such as northern leaf blight, stalk rot and maize smut occurred commonly. The diseased plant rate of maize rust was in the range of 25%-47%.