Evaluation of the quality of olanzapine orally disintegrated tablets by multiple dissolution curves

Objective: To investigate the dissolution behavior similarity between Self-made praeparatum and reference praeparatum in different pH menstruum,using the Olanzapine Orally Disintegrating Tablets listed in abroad as the reference praeparatum. Methods: The dissolution curve of olanzapine in Self-made praeparatum and reference praeparatum was measured,the similarity of the dissolution curve was evalued by F2 similar factor. Results: The single-point dissolution of both Self-made praeparatum and reference praeparatum within 15 min was more than 85%. Conclusion: Self-made praeparatum and reference praeparatum were similar in dissolution behavior.

Effect of initial gravimetric water content and cyclic wetting-drying on soil-water characteristic curves of disintegrated carbonaceous mudstone

The soil-water characteristic curve(SWCC)is often used to estimate unsaturated soil properties(e.g.strength,permeability,volume change,solute and thermal diffusivity).The SWCC of soil samples is significantly affected by cyclic wetting-drying.To examine how water content and cyclic wetting-drying affect the SWCC of disintegrated carbonaceous mudstone(DCM),SWCC tests were implemented using a pressure-plate apparatus.In addition,SWCC models for DCM considering the initial gravimetric water content and cyclic wetting-drying were developed.The test results showed that the volumetric water content(θ)of the DCM first decreased rapidly and then became stable as matric suction(s)increased.The initial water content affected the SWCC by altering the pore structure of the DCM.For a given number of wetting-drying cycles,the higher the initial water content,the higher the stabilizedθ.At a given s value,θdecreased as the number of wetting-drying cycles increased,which suggests that cyclic wetting-drying reduces the water-holding capacity of DCM.The Gardner model for DCM was constructed considering initial water content and cyclic wetting-drying,and was effective at describing and predicting the SWCC model for DCM.

Influencer identification of dynamical networks based on an information entropy dimension reduction method

Identifying critical nodes or sets in large-scale networks is a fundamental scientific problem and one of the key research directions in the fields of data mining and network science when implementing network attacks, defense, repair and control.Traditional methods usually begin from the centrality, node location or the impact on the largest connected component after node destruction, mainly based on the network structure.However, these algorithms do not consider network state changes.We applied a model that combines a random connectivity matrix and minimal low-dimensional structures to represent network connectivity.By using mean field theory and information entropy to calculate node activity,we calculated the overlap between the random parts and fixed low-dimensional parts to quantify the influence of node impact on network state changes and ranked them by importance.We applied this algorithm and the proposed importance algorithm to the overall analysis and stratified analysis of the C.elegans neural network.We observed a change in the critical entropy of the network state and by utilizing the proposed method we can calculate the nodes that indirectly affect muscle cells through neural layers.

Complex systems and network science:a survey

Complex systems widely exist in nature and human society.There are complex interactions between system elements in a complex system,and systems show complex features at the macro level,such as emergence,self-organization,uncertainty,and dynamics.These complex features make it difficult to understand the internal operation mechanism of complex systems.Networked modeling of complex systems is a favorable means of understanding complex systems.It not only represents complex interactions but also reflects essential attributes of complex systems.This paper summarizes the research progress of complex systems modeling and analysis from the perspective of network science,including networked modeling,vital node analysis,network invulnerability analysis,network disintegration analysis,resilience analysis,complex network link prediction,and the attacker-defender game in complex networks.In addition,this paper presents some points of view on the trend and focus of future research on network analysis of complex systems.

SNCDM: Spinal Tumor Detection from MRI Images Using Optimized Super-Pixel Segmentation

Conferring to the American Association of Neurological Surgeons(AANS)survey,85%to 99%of people are affected by spinal cord tumors.The symptoms are varied depending on the tumor’s location and size.Up-to-the-min-ute,back pain is one of the essential symptoms,but it does not have a specific symptom to recognize at the earlier stage.Numerous significant research studies have been conducted to improve spine tumor recognition accuracy.Nevertheless,the traditional systems are consuming high time to extract the specific region and features.Improper identification of the tumor region affects the predictive tumor rate and causes the maximum error-classification problem.Consequently,in this work,Super-pixel analytics Numerical Characteristics Disintegration Model(SNCDM)is used to segment the tumor affected region.Estimating the super-pix-els of the affected region by this method reduces the variance between the iden-tified pixels.Further,the super-pixels are selected according to the optimized convolution network that effectively extracts the vertebral super-pixels features.Derived super-pixels improve the network learning and training process,which minimizes the maximum error classification problem also the efficiency of the system was evaluated using experimental results and analysis.

Durability classification of red beds rocks in central Yunnan based on particle size distribution and slaking procedure

Moisture induced disintegration of soft rock in Red Beds is common all over the world. The slake durability index test is most useful to quantify durability of the soft rocks. Based on a series of slaking test, this article aims to develop a durability classification involving particle size and slaking procedure. To describe the slaking procedure in detail,the Relative Slake Durability Index(Id_i) is proposed. The Id_i is the percentage ratio of the i^(th) weight of oven-dry retained portion to the(i-1)^(th) weight of ovendry retained portion. Results show that the Id_i of samples have a large difference in certain slaking procedure, whereas the traditional Durability Slake Index(Id) is almost constant. Considering this limitation of Id in durability classification, an advanced classification by applying the Id_i and disintegration ratio(DR) is further established in this article. Compared to the durability classification based on Slake Durability Index(Id), the new classification accounts for the particle size of the slaked material and the slaking procedure, so it provides a better measure of the degree of slaking. The classification recommended in this article divide the slake durability into three classes(i.e., low, medium and high class). Furthermore, it divides both the low class and the medium class into 3 subclasses.

ZONAL DISINTEGRATION MECHANISM OF DEEP CRACK-WEAKENED ROCK MASSES UNDER DYNAMIC UNLOADING

Size and quantity of fractured zone and non-fractured zone are controlled by cracks contained in deep rock masses. Zonal disintegration mechanism is strongly dependent on the interaction among cracks. The strong interaction among cracks is investigated using stress superposition principle and the Chebyshev polynomials expansion of the pseudo-traction. It is found from numerical results that crack nucleation, growth and coalescence lead to failure of deep crack- weakened rock masses. The stress redistribution around the surrounding rock mass induced by unloading excavation is studied. The effect of the excavation time on nucleation, growth, interaction and coalescence of cracks was analyzed. Moreover, the influence of the excavation time on the size and quantity of fractured zone and non-fractured zone was given. When the excavation time is short, zonal disintegration phenomenon may occur in deep rock masses. It is shown from numerical results that the size and quantity of fractured zone increase with decreasing excavation time, and the size and quantity of fractured zone increase with the increasing value of in-situ geostress.

Quantitative analysis of rockburst for surrounding rocks and zonal disintegration mechanism in deep tunnels

Rock masses without pre-existing macrocracks can usually be considered as granular materials with only microcracks.During the excavation of the tunnels,microcracks may nucleate,grow and propagate through the rock matrix;secondary microcracks may appear,and discontinuous and incompatible deformation of rock masses may occur.The classical continuum elastoplastic theory is not suitable for analyzing discontinuous and incompatible deformation of rock masses.Based on non-Euclidean model of the discontinuous and incompatible deformation of rock masses,the distribution of stresses in the surrounding rock masses in deep tunnels is fluctuant or wave-like.The stress concentration at the tips of microcracks located in vicinity of stress wave crest is comparatively large,which may lead to the unstable growth and coalescence of secondary microcracks,and consequently the occurrence of fractured zones.On the other hand,the stress concentration at the tips of microcracks located around stress wave trough is relatively small,which may lead to the arrest of microcracks,and thus the non-fractured zones.The alternate appearance of stress wave crest and trough thus may induce the alternate occurrence of fractured and non-fractured zones in deep rock masses.For brittle rocks,the dissipated energy of microcrack growth is small,but the elastic strain energy stored in rock masses may be larger than the dissipated energy growths of pre-existing microcracks and secondary microcracks.The sudden release of the residual elastic strain energy may lead to rockburst.Based on this understanding,the criteria of rockburst are established.Furthermore,the relationship between rockbursts and zonal disintegration in the surrounding rock masses around deep tunnels is studied.The influences of the in-situ stresses and the physico-mechanical parameters on the distribution of rockburst zones and the ejection velocity of rock fragments are investigated in detail.

Micro-Mechanism of Disintegration of RE-Silicide Alloy Containing Phosphorus

The microstructure of the RE silicide alloy was studied by SEM. The feature of the phase and the distribution of Ca, P, Al were analyzed, especially the distribution of micro-cracks and its composition were determined. The result demonstrates that only a few phosphides contribute to the spontaneous crumbling of the RE silicide alloy by reacting with water and forming oxide or phosphorus oxide. The phosphorus content is not the critical factor of disintegration in the alloy studied.

Application of thermally stimulated acoustic emission method to assess the thermal resistance and related properties of coals

Traditional methods of coal thermal resistance characterization are informative but considerably timeconsuming and require utilization of a complex and expensive equipment. This limits the effectiveness of their application. In this paper, authors experimentally investigated potential application of thermally stimulated acoustic emission method for developing of relatively simple and rapid coals thermal resistance assessment method. Features of thermally stimulated acoustic emission of anthracite, lignites and bituminous coal samples subject to cyclic thermal loading have been experimentally investigated.For the first time, it has been shown that there exists a relationship of such patterns with structural parameters and properties of the coal samples, as well as their thermal resistance. The results indicate the possibility of applying the method of thermally stimulated acoustic emission to control processes of cryogenic disintegration and thermal resistance of fossil coals. The description of the equipment and methodological support needed for the implementation of this method have been provided.

Usefulness and limitations of taste sensors in the evaluation of palatability and taste-masking in oral dosage forms

The purpose of this review is to discuss the advantages and limitations of taste sensors in the evaluation of the taste of palatability of different oral dosage forms. First, we consider some ways in which the palatability of various pharmaceutical formulations including orally disintegrating tablets(ODTs) are tested using two different taste sensors. Second, we focus on the evaluation of palatability of ODTs. We compare the usefulness of three pieces of apparatus for estimating the disintegration time of ODTs. Finally, we compare the characteristics of the two taste sensors in the evaluation of palatability of various kinds of drug formulations.

Predicting oral disintegrating tablet formulations by neural network techniques

Oral disintegrating tablets(ODTs) are a novel dosage form that can be dissolved on thetongue within 3 min or less especially for geriatric and pediatric patients. Current ODT for-mulation studies usually rely on the personal experience of pharmaceutical experts andtrial-and-error in the laboratory, which is inefficient and time-consuming. The aim of cur-rent research was to establish the prediction model of ODT formulations with direct com-pression process by artificial neural network(ANN) and deep neural network(DNN) tech-niques. 145 formulation data were extracted from Web of Science. All datasets were dividedinto three parts: training set(105 data), validation set(20) and testing set(20). ANN andDNN were compared for the prediction of the disintegrating time. The accuracy of the ANNmodel have reached 85.60%, 80.00% and 75.00% on the training set, validation set and testingset respectively, whereas that of the DNN model were 85.60%, 85.00% and 80.00%, respec-tively. Compared with the ANN, DNN showed the better prediction for ODT formulations.It is the first time that deep neural network with the improved dataset selection algorithmis applied to formulation prediction on small data. The proposed predictive approach couldevaluate the critical parameters about quality control of formulation, and guide researchand process development. The implementation of this prediction model could effectivelyreduce drug product development timeline and material usage, and proactively facilitatethe development of a robust drug product.

Study on Wave-influenced resistance to erosion of silty soil in Huanghe (Yellow) River Delta

Along with the reduction of sediment yield of the Huanghe （Yellow） River, the erosion of the Huanghe River Delta aggravates, which has becomes an important factor that threatens the coastal protection structures. Starting from the study of the erosion resistibility of the sediment, this paper explores the internal mechanism of erosion phenomenon. This paper takes Diaokou as the study area and takes soils as samples which are mixed with clay into reconstructed samples whose ratio of clay content are 5%, 10%, 15%, 20% respectively, then dynamic tri-axial apparatus is applied to simulate wave loads of different intensity; then the resistibility of soil to erosion is determined via concentrated flow test and the structural property is determined via the disintegration test. Finally, the resistibility to erosion and the structural property of the non-compressed soil samples are compared with the compressed data. The results indicates that liquefaction failure exerts significant influence on the resistibility to erosion and the structural property of the silty soil in the Huanghe River Delta. Therefore, in the future erosion studies, the liquefaction phenomenon shall be fully considered.

Features of the total disintegration events of heavy emulsion targets caused by 4.5 A GeV/c ^16O

Total disintegration events produced by 4.5 A GeV/c ^16O-AgBr interactions are analysed to investigate the characteristics of secondary charged particles produced in such collisions. The multiplicity distributions of grey, black, and relativistic charged particles can be well represented by Gaussian distribution. The average multiplicity of grey particles is found to increase with the mass of projectile increasing, while that of black particles is found to decrease with the mass of projectile increasing. This result is in good agreement with the prediction of fireball model. Finally, the linear dependence between grey and black particles is observed, but there is no distinct dependence between the production of relativistic charged particles and the target excitation.

Experimental study on the physico-mechanical properties of Tamusu mudstone — A potential host rock for high-level radioactive waste in Inner Mongolia of China

Tamusu mudstone, located in Bayin Gobi Basin in Inner Mongolia of China, has been selected as a potential host rock for high-level radioactive waste(HLW) disposal in China. A series of tests has been carried out, including X-ray diffraction(XRD) tests, scanning electron microscopy(SEM) tests, disintegration tests, permeability tests and triaxial compression tests, to estimate the physico-mechanical properties of Tamusu mudstone in this work. The mineral composition of Tamusu mudstone was analyzed and it was considered as a stable rock due to its low disintegration rate, i.e. approximately 0.11%after several wet/dry cycles. Based on the results of permeability test, it was found that Tamusu mudstone has a low permeability, with the magnitude of about 10—20m^(2). The low permeability makes the mudstone well prevent nuclide migration and diffusion, and might be influenced by temperature.The triaxial tests show that Tamusu mudstone is a stiff mudstone with high compressive strength, which means that the excavation disturbed zone would be smaller compared to other types of mudstone due to construction and operation of HLW repositories. Finally, the properties of Tamusu mudstone were compared with those of Opalinus clay, Callovo-Oxfordian(COx) argillite, and Boom clay to further discuss the possibility of using Tamusu mudstone as a potential nuclear waste disposal medium.

Development and characterization of seed gums from Tamarindus indica and Cassia fistula as disintegrating agent for fast disintegrating Thai cordial tablet

Crude seed gum and their carboxymethyl derivatives from Tamarindus indica and Cassia fistula seeds were developed and characterized to apply as the pharmaceutical disintegrant in fast disintegrating Thai cordial tablet. The chemical structure of crude gum was chemically modified via carboxymethylation. Degree of substitution(DS) of carboxymethylated gums was determined. Carboxymethylated gums with minimum and maximum DS values were chosen for further application. IR absorption spectra of gum samples were observed to verify their chemical structure changes. In physical properties, the intrinsic viscosity and swelling property of all gum samples were evaluated. The results showed that carboxymethylated gums had higher intrinsic viscosity than those of crude gum. Moreover, they could swell and be soluble in cold water better than those of crude gums. In conclusion, the modified gums from both plants could provide higher hardness and be better used than that crude gums for fast disintegrating Thai cordial tablet. However, this is a preliminary assessment to expressing pharmaceutical application possibility of these gums as disintegrants, diluents and drug release controlling agents.

Effects of the Dicranopteris linearis root system and initial moisture content on the soil disintegration characteristics of gully erosion

Benggang erosion is caused by a special type of gully erosion in southern China that seriously endangers the local ecology and environment.In this study,typical Benggang collapsing-wall soils were used as the study area to investigate the effects of different initial moisture contents and dicranopteris linearis root weight densities,as well as their interactions on disintegration in orthogonal test method.The results showed that the rate of soil disintegration decreased as a linear function of the initial moisture content.The soil disintegration rate tended to rise and then fall as the root weight density increased,reflecting an optimum root weight density of 0.75-1.00 g/100 cm3.The incorporation of dicranopteris linearis roots was most effective for soil consolidation in the shallow layers of soil.In addition,the disintegration rate of the collapsing-wall soils increases as the soil layer deepened.The dicranopteris linearis root system and initial moisture content had an interactive effect that was more pronounced in deeper soils.However,the combined effect of these processes was always dominated by the initial moisture content.Moderate initial soil moisture content(0.20-0.24 g/g)and the addition of a high root density in dicranopteris linearis(0.75-1.00 g/100 cm3)were the optimal combinations that reduced the disintegration rate.In conclusion,maintaining a suitable natural moisture content in collapsing-wall soils and taking measures that use plants to consolidate soil can effectively prevent and control the occurrence of Benggang erosion.The results of this study provided further insight into the factors that influence soil disintegration and offered a scientific basis for soil erosion management in the southern China.

Physical-mechanical properties of microbially induced calcite precipitation-treated loess and treatment mechanism

Loess disintegration can lead to geotechnical engineering problems,e.g.,slope erosion,wetting-induced landslide,and hydroconsolidation.Microbially induced calcite precipitation(MICP)technique is a potential loess reinforcing method.This study investigated the physical-mechanical properties of MICP-treated loess and then explored the mechanism of loess modification by MICP.Here,loess first underwent MICP treatment,i.e.,mixing loess with Sporosarcina pasteurii and cementation solution(CS).Then,the effects of the CS concentration(0.2,0.6,0.8,and 1 M)on the physical and mechanical properties of the MICP-treated loess were tested.Finally,the static contact angle test,scanning electron microscopy(SEM),and X-ray diffractometry(XRD)were conducted to study the mechanism of MICP treatment on loess.Results showed the following property changes of loess after MICP treatment:the liquid limit decreased by 1.7%,the average particle size increased from 6 to 47μm,the specific gravity decreased from 2.65 to 2.43,the unconfined compressive strength increased from 37 to 71 k Pa,and the disintegration time increased from 10 to 25 min.Besides,the shear strength also increased,and the shear strength parameters(cohesion c and internal friction angle?)varied with the CS concentration.The static contact angle tests indicated that the water absorption ability of loess was reduced after MICP treatment.SEM and XRD results verified that the CaCO_(3)from MICP was attributed to the above results.The above findings explained the mechanism of MICP treatment of loess:the CaCO_(3)coats and cements the particles,and fills the pores of loess,improving the strength and water stability of loess.

Main Pathways in Primary Sludge Disintegration by Sonication and Enhancement of Sonication

The main pathways of primary sludge(PS)ultrasonic disintegration were analyzed at the sonication frequency of 20 kH z and the thermal effect on PS disintegration was investigated.By adding Na HCO3as a scavenger to entrap the free hydroxyl radicals,cavitation contributed to 82.91%of the total sonication effect.The power consumed by temperature rising accounted for more than40%of ultrasound power input at the power density of 0.215 W/m L and the sonication time of 10 min.With the thermal insulation of polyfoam coating during sonication,a 18.37%of soluble chemical oxygen demand(SCOD)increment was observed.With the process of pre-heating the PS before sonication,64.15%of SCOD increment was achieved.Compared with the particle size of 13.77μm for the sonicated PS,the sludge mean particle size decreased to 12.83 and11.98μm by applying polyfoam coating and pre-heating the PS to enhance the cavitation and thermal effect.It suggested that if thermal energy consumption was relieved during the sonication process of PS,more energy could be used to disintegrate the sludge.

On a New Elementary Particle from the Disintegration of the Symplectic &#39t Hooft-Veltman-Wilson Fractal Spacetime

't Hooft-Veltman Wilson dimensional regularization depends crucially upon Borel summability which entails strong links to the modern mathematical theory of transfinite sets and consequently to the fractal-Cantorian spacetime proposal of Ord-Nottale-El Naschie. Starting from the above, we interpret the main step of the mathematical analysis in terms of elementary particles interaction. Thus 't Hooft-Veltman “perturbation” parameter which measures the deviation of the regulated space from the four dimensionality of spacetime is interpreted as an elementary particle with a topological mass charge equal to 0.18033989, i.e. double the magnitude of Hardy’s quantum entanglement. In turn, Hardy’s quantum entanglement which may be interpreted geometrically as a consequence of the zero set embedded in an empty set could also be interpreted as an exchange of pseudo elementary particles with a topological mass charge equal to Hardy’s entanglement where is the Hausdorff dimension of the zero set of the corresponding 't Hooft-Veltman spacetime.