The transports of the dynamic biochemical signals in the non-reversing pulsatile flows in the mixing microchannel of a Y-shaped microfluidic device are ana- lyzed. The results show that the mixing micro-channel acts a...The transports of the dynamic biochemical signals in the non-reversing pulsatile flows in the mixing microchannel of a Y-shaped microfluidic device are ana- lyzed. The results show that the mixing micro-channel acts as a low-pass filter, and the biochemical signals are nonlinearly modulated by the pulsatile flows, which depend on the biochemical signal frequency, the flow signal frequency, and the biochemical signal transporting distance. It is concluded that, the transfer characteristics of the dynamic biochemical signals, which are transported in the time-varying flows, should be carefully considered for better loading biochemical signals on the cells cultured on the bottom of the microfluidic channel.展开更多
A reproducing kernel collocation method based on strong formulation is introduced for transient dynamics. To study the stability property of this method, an algorithm based on the von Neumann hypothesis is proposed to...A reproducing kernel collocation method based on strong formulation is introduced for transient dynamics. To study the stability property of this method, an algorithm based on the von Neumann hypothesis is proposed to predict the critical time step. A numerical test is conducted to validate the algorithm. The numerical critical time step and the predicted critical time step are in good agreement. The results are compared with those obtained based on the radial basis collocation method, and they axe in good agreement. Several important conclusions for choosing a proper support size of the reproducing kernel shape function are given to improve the stability condition.展开更多
基金Project supported by the National Natural Science Foundation of China(Nos.11172060 and11672065)
文摘The transports of the dynamic biochemical signals in the non-reversing pulsatile flows in the mixing microchannel of a Y-shaped microfluidic device are ana- lyzed. The results show that the mixing micro-channel acts as a low-pass filter, and the biochemical signals are nonlinearly modulated by the pulsatile flows, which depend on the biochemical signal frequency, the flow signal frequency, and the biochemical signal transporting distance. It is concluded that, the transfer characteristics of the dynamic biochemical signals, which are transported in the time-varying flows, should be carefully considered for better loading biochemical signals on the cells cultured on the bottom of the microfluidic channel.
基金Project supported by the Western Transport Technical Project of Ministry of Transport of China(No. 2009318000046)
文摘A reproducing kernel collocation method based on strong formulation is introduced for transient dynamics. To study the stability property of this method, an algorithm based on the von Neumann hypothesis is proposed to predict the critical time step. A numerical test is conducted to validate the algorithm. The numerical critical time step and the predicted critical time step are in good agreement. The results are compared with those obtained based on the radial basis collocation method, and they axe in good agreement. Several important conclusions for choosing a proper support size of the reproducing kernel shape function are given to improve the stability condition.
