Clinical observation on efficacy of compound of warming yang, descending turbidity and dredging collaterals in the treatment of diabetic kidney disease with Yin-Yang deficiency and blood stasis syndrome

Objective:To observe the clinical efficacy of compound of owarming yang,descending turbidity and dredging collaterals in the treatment of diabetic kidney disease with yin-yang deficiency and blood stasis syndrome.Methods:Seventy-six patients of diabetic kidney disease with yin-yang deficiency and blood stasis syndrome were randomly divided into observation group and control group,thirty-eight cases in each group.The control group was given conventional western medicine treatment,while the observation group took compound of owarming yang,descending turbidity and dredging collaterals orally on the basis of conventional western medicine treatment.The course of treatment covered for one month.Before and after treatment,we observed the scores of traditional Chinese medicine symptoms,indicators of renal function[serum creatinine(Scr),blood urea nitrogen(BUN),microalbuminuria(MALB)],indicators of glucose metabolism[fasting plasma glucose(FPG),2-hour postprandial blood glucose(2hPG),glycosylated hemoglobin(HbAlc)],indicators of hemorheology[plasma viscosity(PV),platelet aggregation rate(PAR),fibrinogen(FIB)],Cystatin-C(Cys-C),C-reactive protein(CRP)in the two groups.Results:After treatment,the clinical effect of the observation group was significantly better than the control group(P<0.05).The scores of traditional Chinese medicine symptoms,indicators of renal function(Scr、BUN、UAER),indicators of glucose metabolism(FPG、2hPG、HbAlc),indicators of hemorheology(PV、PAR、FIB),Cys-C and CRP in the two groups were decreased significantly compared with those before treatment(P<0.05),and the decrease in the observation group was superior to that in the control group(P<0.05).Conclusion:Compound of warming yang,descending turbidity and dredging collaterals has remarkable efficacy in treating of diabetic kidney disease patients with yin-yang deficiency and blood stasis syndrome by alleviating clinical symptoms,glucose metabolism,renal function and microcirculatory disturbance,and the mechanism related to alleviation of microinflammation.

江泳教授病证结合分人分型分期辨治带状疱疹

带状疱疹以剧烈疼痛为其特点,严重影响患者生活。西医治疗虽起效较快但使疼痛降低至初始程度一半时较易产生不良反应,且在预防及控制其并发症方面效果不佳。江泳教授以病为纲,认为带状疱疹以肝络血虚,热毒湿浊瘀滞肝络为其共性核心病机,结合患者不同证型的个性病机进行分型论治。江教授以“柔肝泻火,解毒除湿,通络止痛”为基本治则,创制“泻毒通络”方为基础验方,分人分型分期加减治疗带状疱疹,她认为病证结合辨治带状疱疹,可以最大化地优化临床疗效,更能发挥中医特色优势。

范伏元教授从“络脉不和”论治肺结节经验

范伏元教授基于络脉沟通内外、渗灌气血、联系脏腑的生理特点,从肺痹、肺积认识肺结节,以络脉不和为肺结节根本病机,从伏邪凝痰痹络、胃络不和痰瘀结为窠囊进行阐发,以“通络开痹,和荣散结”“和胃逐瘀,安神化浊”为核心治法,分别以疏风宣肺汤、加味温胆汤处方辨治,将宏观脏腑辨证调和诸脏与微观络脉辨证调和络脉营卫气血津液沟通渗灌相结合,临床疗效确切。

Correlativity between blood measures related to blood stasis blocking collaterals and gene expression of angiotensin-converting enzyme of renal cortex in diabetic rats and effect of stasis removing and collaterals dredging

OBJECTIVE: To investigate the correlativity between the changes of blood measures related to blood stasis blocking collaterals and gene expression levels of angiotensin-converting enzyme(ACE)and ACE2 ofrenal cortex in diabetic rats with stasis blocking collaterals syndrome, as well as the effectof stasis removing and collaterals dredging.METHODS: Male Sprague-Dawley rats were divided randomly into normal control group(C group),high-carbohydrate-fat control group(H group) and streptozotocin(STZ)-injecting group. The diabeticrats were induced from rats in the STZ-injecting groupby high-carbohydrate-fat diet combined with STZ intraperitoneal injection, with sustained high-carbohydrate-fat diet fed afterwards, and were further divided into model group(M group)and Chinese medicine of stasis removing and collaterals dredging group(Z group). Rats in the Z group were fed with stasis-removing-and-collaterals-dredging herbal granule suspension intragastrically daily for 16 weeks, while drinking water of corresponding volume was administrated to the rats in other groups. At the end of the 16 th week after successful establishment of models, the ultrastructures of glomeruli in different groups were detected by a transmission electron microscopy; and blood measures related to blood stasis blocking collaterals, including lipid profile and blood viscosity measures, were tested, as well as the relative gene expressions of ACE and ACE2.RESULTS: Changes in ultrastructures of glomeruli in the M group were characterized by lack of clarity in structure and occasional thickening of glomerular basement membrane and extensive fusion in foot processes. The correlation analysis showed that there were positive correlations between lipid profile, blood viscosity, and the ACE mRNA expression levels in the M group(P<0.05), except for cholesterol. And except for triglyceride, the blood measures were in negative correlation with the ACE2 mRNA expression levels in the M group(P<0.05).Compared with the C and H groups, the lipid profile, plasma viscosity and blood viscosity were significantly higher(P<0.01). All the above-mentioned measures were significantly improved in the Z group rats(P<0.05). ACE mRNA expression was significantly higher in the M group thanin the C group(P<0.05). ACE2 mRNA level was significantly lower in the M group than in the C and H groups(P<0.01)and its levelin the Z group was higher than that in the M group(P<0.01).CONCLUSION: Blood measuresrelated to blood stasis blocking collaterals had positive linear correlations with ACE mRNAexpression and negative linear correlations with ACE2 mRNA expression in the M group. Chinese recipe of stasis removing and collaterals dredging could play a renal protecting role for diabetic rats by reducing lipid profile and blood viscosity, down-regulating ACE mRNA expression and up-regulating ACE2 mRNA expression.

基于“结者散之”辨治肺结节痰瘀互结证

肺结节之病机为肺气亏虚,外邪入体,肺之气络、血络先后受邪,气络生痰,血络生瘀,气络之痰与血络之瘀搏结成块,发而为病。从《黄帝内经》“结者散之”理论入手,治以清肺通络、祛痰化瘀为主,佐以疏肝理气,健脾渗湿之法,为肺结节的中医辨证及组方思路提供一定的借鉴与参考。

"External main and internal auxiliary" treatment on refractory radiation proctitis

Radiotherapy is an essential method in the comprehensive treatment of malignant tumors.However,radiation proctitis(RP)is a common complication of pelvic tumors after radiotherapy.Due to RP's various etiology and complex pathogenesis,it is currently no standard for traditional Chinese medicine(TCM)treatment.Professor Yuan-hong Zhao believes that refractory RP,which is named chronic hemorrhagic radiation proctitis(CHRP),should be classified as"Intestinal Wind Bleeding"(Bleeding like a note before defecation,bright red blood,no swelling and pain in the anus)and"Intestinal Afflux"(Refers to the symptoms of pus and blood in the lower mucus,similar to ulcerative colitis,peptic ulcer and other diseases in modern medicine.)in TCM.The critical pathogenesis of CHRP lies in local stasis and collaterals injury of intestinal collaterals.In general,it is a syndrome of excess and scarcity.External treatment with TCM is the preferred treatment strategy for CHRP,and the primary way is to disperse blood stasis and detoxify and nourish the intestinal collaterals.

基于络病理论论治输卵管阻塞性不孕

输卵管是输送孕卵的中空管腔结构,络脉是经脉横行而出的分支,络脉“以通为用”的生理特点与输卵管的结构功能相符。输卵管阻塞主要由盆腔炎性疾病等原因造成输卵管拾卵、运送受精卵的功能障碍。其病变过程较长,初起为营卫气血失和,久则血伤入络,酿生痰湿、血瘀等有形之邪阻塞络脉,形成输卵管阻塞性不孕。络病即络脉的病变,其中包含络脉的功能障碍和结构损伤,同时也涵盖了由此引发的脏腑组织的病理变化。二者均以“不通”为主要病理特点,“通络”是治疗的主要原则。因此在论治输卵管阻塞性不孕时,以“络病”理论分析其发病机制,总属肾精不足、肝气失和、脾气不足,病变日久形成血瘀、痰湿、湿热等有形之邪阻于络脉,影响络脉正常的生理功能,继而引起输卵管结构或功能障碍,阻碍精卵结合,构成不孕。临床可基于“络病”理论角度辨证治疗确立治法,依据不同的致病原因采用不同的“通络”方法,在输卵管阻塞性不孕的治疗中发挥中医特色,兼顾整体与局部,疏通输卵管,提高受孕率。

儿童大叶性肺炎从“玄府-络脉”理论辨治探析

“玄府-络脉”是遍布人体全身的细微结构,具有畅达气机、输布津液、运转神机、调和阴阳的作用。儿童大叶性肺炎发病率高,临床归属中医学“风温肺热病”范畴,热、毒、痰、瘀、虚是其主要病理因素,肺络凝滞、玄府郁闭、脉络失养是其病机关键。基于玄府-络脉理论,临床治疗急性期以解毒祛邪、开玄通府为主,恢复期注重充养脉络,同时化瘀通络贯穿始终,为儿童大叶性肺炎治疗提供新思路。

从伏邪学说论治慢性萎缩性胃炎

慢性萎缩性胃炎(CAG)属于胃癌前疾病,具有发病隐匿、病程缠绵、容易迁延恶化等特点。广东省名中医刘凤斌教授多年诊疗CAG,认为CAG的病因、病程特性与伏邪致病过程密切相关,从伏邪学说论治CAG,遵循透邪外出、补益脾胃、祛瘀通络与清热养阴治疗原则,随证用药,疗效显著。

基于肾虚血瘀视角探讨老年性眼底病证治

老年性眼底病与衰老密切相关,肾虚、血瘀致衰得到医学界越来越多的关注。肾虚血瘀是老年性眼底病的病机核心,五脏虚损、肾为本是老年性眼底病发生的根本原因,目窍失养、血瘀为标是老年性眼底病发生的局部表现。老年性眼底病在中医整体观念的视角上,肾虚为本,目为标;从局部辨证出发,血瘀为发病的基本病理因素,络脉瘀阻为发病的病理基础,气血失和、目窍失养为发病的关键病机。由此提出老年性眼底病治疗原则为调补五脏,以肾为本;活血化瘀,剔络为要;祛邪扶正,通补兼施;为老年性眼底病的中医治疗提供新的思路。

张嗣兰辨治脱疽经验

脱疽病因病机复杂,病程较长,致残率高。张嗣兰教授提出了“解毒破瘀并重,调气扶正并行”的重要理论,认为气机阻滞、血脉瘀阻、肢节失养是其基本病机,将其分为寒湿凝滞证、湿热毒盛证、气血亏虚证、血脉瘀阻证4种中医证型。临证时根据不同分型及临床表现采用不同治疗方法,以化瘀通络贯穿始终,辅以温阳、益气、补血、清热解毒之法,同时重视局部外治法。形成了内外同治、整体辨证与局部外治相结合的临床思辨特点。

从“浊毒伏络”探讨糖尿病心肌病

糖尿病心肌病(DCM)属于中医学消渴并发心悸、胸痹范畴。结合现代浊毒理论、络病理论及糖尿病心肌病的病理特点,认为“浊毒伏络”是DCM起病之本,心络受损是DCM演变之机,气血阴阳俱虚是DCM的最终结局。根据“浊毒伏络”理论和疾病分期特点,治疗方面提倡早期化浊解毒、中期搜剔通络、后期补虚固本。

从“益气通络法”论治视网膜中央动脉阻塞

视网膜中央动脉阻塞(CRAO)是眼科致盲的重症之一,中医学将其归属“暴盲”范畴。益气通络法根植于中医学经络理论,对中医眼科学疾病的治疗具有重要的指导意义。本病以气虚为本,脉络瘀阻为标,气虚血瘀是病机的关键。治疗上,需抓住“脉络瘀阻”这一根结,首当注重补气,予益气通络法。使得经络气血运行通畅,瘀去络通。用药方面,宜在补气的基础上随证加活血、养阴、温阳等中药。同时,结合针刺疏通经络气血。此外,临床诊疗不可拘泥于传统概念的治疗时间窗,充分发挥中医药治疗的优势,注重中药及针灸治疗。

疏血通注射液治疗急性冠脉综合征研究进展

疏血通注射液有活血化瘀,通经活络的功效,主要用于治疗瘀血阻络型急性脑梗塞。有研究表明,疏血通注射液治疗急性冠脉综合征(Acute coronary syndrome,ACS)有较好疗效,还可缩短经皮冠状动脉介入治疗术后患者康复时间,提高治疗有效率,降低再入院率,节约医疗成本。本文梳理了疏血通注射液治疗ACS相关理论及临床研究,对其治疗ACS的本草依据、药理作用、临床应用、治疗机制以及安全性、经济性等方面进行综述,希望为疏血通在治疗ACS中的运用提供一定的科学依据并拓宽其在心血管疾病中的研究思路。

基于“补-养-通”法探析黄褐斑治疗

黄褐斑是一种获得性色素沉着,是具有损美性的皮肤疾病。中西医治疗各有方法,但中医治疗具有独特的优势。黄莺教授认为黄褐斑发病有虚有实,常以肝肾亏虚为本,络脉瘀滞为标,治疗需标本层次分明,以“补-养-通”立法,即培补肝肾、养血益气以治本,通脉化瘀、消痰化滞以治标,结合中医外治技法,内服外治,常有奏效。

基于络病理论探讨乳腺增生症的辨治思路

乳腺增生症是中年女性最常见的疾病,既非炎症也非肿瘤,以乳房疼痛和乳房肿物严重影响女性的身心健康及生活质量,且有一定癌变风险。针对乳腺增生症,西医暂未发现有效的治疗方法,而中医药在治疗乳腺增生症方面,尤其具有自身特点和优势。近年来络病理论的兴盛为本病的临床治疗提供新思路,络病理论是中医重要病机学说,乳腺增生症的辨治与络病理论密切相关,目前少见从络病理论探讨乳腺增生症的辨治研究。文章从络病理论探讨乳腺增生症,认为乳腺增生症具有“久病入络、由气及血、络脉本虚”的病理特点,符合络病的疾病特征。文章通过文献溯源的方式梳理络病理论的发展历程,提出乳腺增生症始生、演进的基本病机为“气络不利,血络瘀阻”,由气及血,由浅入深,后期“络瘀-络损-络虚”。乳腺增生症微环境体现“浓、黏、凝、聚”的病理状态,文章结合络病理论与乳腺增生症的关联,提出乳腺增生症始生期、演进期以通为主,后期络虚通补的治疗大法。故就络病理论与乳腺增生症的辨治思路进行探赜,以期为临床治疗乳腺增生症提供新方法。

名老中医郑学军治疗臁疮经验

臁疮是中医外科学常见疾病,病因复杂,缠绵难愈。山西省名中医郑学军主任认为脉络湿瘀,日久蕴热成毒为本病病机之关键,内治以“调血利水、化瘀通络”为大法,自拟静脉Ⅰ号方为基本方,各期随证加减(溃疡前期为湿瘀阻络证、溃疡期为湿热瘀毒证、溃疡愈合期为本虚邪恋证);外治以“祛腐生肌”为原则,采用新法炼制红升丹,自制改良生肌玉红油纱,外用于创面;中药熏洗法用于各阶段,常用燥湿解毒洗剂、溃疡洗剂熏洗生肌;重用缠缚,促进静脉回流,减轻下肢水肿。诸法内外相佐,中西结合,取效甚佳。通过分析郑学军主任对臁疮的认识及用药经验规律,总结郑老临证经验,传承学术思想,并附验案一则,以供同道参考。

温阳化痰通络汤联合温针灸对气虚血瘀型缺血性脑卒中偏瘫患者神经功能、运动功能的影响

目的:观察温阳化痰通络汤联合温针灸对气虚血瘀型缺血性脑卒中偏瘫患者神经功能、运动功能的影响。方法:选取2020年5月至2022年2月唐河县人民医院治疗的缺血性脑卒中偏瘫患者120例,遵循简单随机数字表法分为观察组与对照组,每组60例。两组患者入院后均给予常规治疗,统一进行肢体康复,包括侧卧位躯干控制训练、健侧踏板站立平衡训练等。对照组另给予温针灸治疗,观察组给予温阳化痰通络汤联合温针灸治疗。观察两组治疗前后中医证候评分、肢体运动能力、日常生活活动能力、全血黏度(低切、高切)、红细胞聚集指数、纤维蛋白原(fibrinogen,FIB)等,并比较凝血酶时间(thrombin time,TT)、活化部分凝血活酶时间(activated partially thrombin time,APTT)、三酰甘油(three acyl glycerin,TG)、总胆固醇(total cholesterol,TC)变化情况及不良反应发生情况。结果:观察组治疗后中医证候评分均低于对照组,差异有统计学意义(P<0.05);观察组治疗后全血黏度(高切、低切)、红细胞聚集指数、FIB均低于对照组,差异有统计学意义(P<0.05);观察组治疗后APTT、PT长于对照组,TC、TG水平低于对照组,差异有统计学意义(P<0.05);观察组治疗后上肢MRC六级肌力评分、下肢Fugl-Meyer评测法评分均高于对照组,差异有统计学意义(P<0.05);观察组治疗后日常生活活动能力优于对照组,差异有统计学意义(P<0.05);两组均未见明显不良反应发生。结论:温阳化痰通络汤联合温针灸治疗气虚血瘀型缺血性脑卒中偏瘫,能明显改善患者中医证候、日常生活活动能力,还可有效促进肢体运动功能、神经功能的恢复。

糖尿病肾病临床经验总结

糖尿病肾病(Diabetic Kidney Disease,DKD)是长期糖尿病引起的肾脏病变,为我国终末期肾病的重要病因。本病迁延难愈,发病率也逐年提高。在西医治疗暂无重大突破之时,如何发挥中医药的独特优势有着重大意义。导师黄新艳,国家重点学科带头人,从事中医临床工作数十载。黄老师认为DKD中医病机以气阴两虚为基础,兼有瘀血、湿浊之邪为标。在治疗上,应抓住患者气阴两虚之本,施以健脾补肾、益气养阴方药,使其正气不致衰惫;并佐以散瘀通络、利湿化浊等法,祛除病邪。黄老师对于患者病之气阴两虚,常选用参芪地黄汤合水陆二仙丹为主方进行加减。方中参芪地黄汤可行补气滋阴,补肾健脾之功;水陆二仙丹则取其补肾固精之效。两方合用共奏固本培元,滋阴益气功效。针对患者瘀血、湿浊之邪,黄老师则辅以牡丹皮、桃仁、红花等药活血化瘀,苍术、泽泻、茯苓等药化湿泄浊。消渴病肾病的病机基础虽为气阴两虚,然临床上患者病情常有所偏重,需根据其气虚、阴虚等的侧重综合分析,随证加减。除此之外,黄师亦常常配合中医外治法,如中药灌肠、针灸、穴位注射、耳针等内外兼治,以求达到最佳疗效,提高患者生活质量。现分享黄师相关诊疗心得如下,以供探讨。

活血化瘀通络法治疗肝硬化合并上消化道出血肝脾血瘀证的临床观察

目的:探究活血化瘀通络法治疗肝硬化合并上消化道出血肝脾血瘀证的效果。方法:按随机数字表法将2018年3月—2021年4月于洛阳新区人民医院消化内科就诊的76例肝硬化合并上消化道出血肝脾血瘀证患者分为2组,每组38例。对照组患者采用生长抑素联合垂体后叶素注射液治疗,研究组在对照组治疗基础上加用活血化瘀通络法治疗。比较两组患者临床疗效、中医证候积分、治疗情况、血流动力学指标的变化及不良反应情况。结果:研究组治疗总有效率高于对照组(P<0.05);治疗后与对照组比较,研究组患者胁痛如刺、朱砂掌、肝或脾肿大、肋胁久痛、面色晦暗等症状积分降低,平均止血时间缩短,平均输血量减少,门静脉及脾静脉内径缩小,门静脉及脾静脉血流量减少(P<0.01)。两组患者治疗期间均未见明显不良反应。结论:肝硬化合并上消化道出血肝脾血瘀证患者应用活血化瘀通络法治疗获得较好的临床效果,临床症状均得到有效改善,短时间内便可有效止血,输血量较少,且血流动力学指标改善明显,无明显不良反应,安全可靠。