Prediction of displacement demand to assess seismic performance of structures is a necessary step where nonlinear static procedures are followed.While such predictions have been well established in literature for fixe...Prediction of displacement demand to assess seismic performance of structures is a necessary step where nonlinear static procedures are followed.While such predictions have been well established in literature for fixed-base structures,fewer bodies of researches have been carried out on the effect of rocking and uplifting of shallow foundations supported by soil,on such prediction.This paper aimed to investigate the effect of soil structure interaction on displacement amplification factor C1 using the beam on nonlinear Winkler foundation concept.A practical range of natural period,force reduction factors,and wide range of anticipated behavior from rocking,uplifting and hinging are considered and using thousands nonlinear time history analysis,displacement amplification factors are evaluated.The results indicate that the suggested equations in current rehabilitation documents underestimate displacement demands in the presence of foundation rocking and uplift.Finally,using regression analyses,new equations are proposed to estimate mean values of C1.展开更多
Buckling-restrained braces(BRBs)have shown their capability to provide building structures with stiffness,strength,and ductility.Estimating the seismic drifts of buckling-restrained braced frames(BRBFs)is an important...Buckling-restrained braces(BRBs)have shown their capability to provide building structures with stiffness,strength,and ductility.Estimating the seismic drifts of buckling-restrained braced frames(BRBFs)is an important design step to control structural and non-structural damage.In current practice of seismic design,the estimation of seismic drifts of BRBFs is performed by using empirical calculations that are independent upon either the type of the structural system or the design level of seismicity.In these empirical calculations,the seismic drifts are estimated by amplifying the reduced elastic drifts obtained under design lateral loading with a displacement amplification factor(DAF).The value of DAF is considered equal to the product of the response modification factor R and the inelastic displacement ratioρ.The goal of the current research is to assess the value ofρfor low-to mid-rise BRBFs designed under low and high levels of seismicity.This goal has been achieved by conducting a series of elastic and inelastic time-history analyses pertaining to an ensemble of earthquake records on 3-,6-and 9-story BRBFs.The results indicate that theρ-ratio increases with an increase in design seismic intensity and an increase in experienced inelasticity.The range ofρfor low seismicity designs ranges from 0.63 to 0.9,while for high seismicity designs this range stretches from 0.83 to 1.29.It has been found that the consideration of a generalρ-ratio of 1.0 is a reasonable estimation for the design of the BRBFs considered in this study.展开更多
Herein,we propose a novel photoelectrochemical(PEC) biosensor for dual microRNAs(miRNAs) highly sensitive and simultaneous biosensing based on strand displaced amplification(SDA) reaction.The recognition of HmiR-21 an...Herein,we propose a novel photoelectrochemical(PEC) biosensor for dual microRNAs(miRNAs) highly sensitive and simultaneous biosensing based on strand displaced amplification(SDA) reaction.The recognition of HmiR-21 and Hlet-7 a by microRNA-21 and let-7 a leads to their change in hairpin structures,subsequently initiating the immobilization of abundant CdS quantum dots(CdS QD s) and methylene blue(MB) based on SDA reaction.The immobilized CdS QDs and MB produce both high PEC currents under430 nm light and 627 nm light illumination,respectively,and the generated PEC currents are closely relied on target miRNAs amounts.Thus,highly sensitive and simultaneous detection of microRNA-21 and let-7 a was readily achieved with detection limit at 6.6 fmol/L and 15.4 fmol/L based on 3σ,respectively.Further,this PEC biosensor was applied in simultaneous analysis of miRNA-21 and let-7 a in breast cancer patient’s serum with acceptable results.We expect this biosensor will find more useful application in diagnosis of miRNA-related diseases.展开更多
文摘Prediction of displacement demand to assess seismic performance of structures is a necessary step where nonlinear static procedures are followed.While such predictions have been well established in literature for fixed-base structures,fewer bodies of researches have been carried out on the effect of rocking and uplifting of shallow foundations supported by soil,on such prediction.This paper aimed to investigate the effect of soil structure interaction on displacement amplification factor C1 using the beam on nonlinear Winkler foundation concept.A practical range of natural period,force reduction factors,and wide range of anticipated behavior from rocking,uplifting and hinging are considered and using thousands nonlinear time history analysis,displacement amplification factors are evaluated.The results indicate that the suggested equations in current rehabilitation documents underestimate displacement demands in the presence of foundation rocking and uplift.Finally,using regression analyses,new equations are proposed to estimate mean values of C1.
文摘Buckling-restrained braces(BRBs)have shown their capability to provide building structures with stiffness,strength,and ductility.Estimating the seismic drifts of buckling-restrained braced frames(BRBFs)is an important design step to control structural and non-structural damage.In current practice of seismic design,the estimation of seismic drifts of BRBFs is performed by using empirical calculations that are independent upon either the type of the structural system or the design level of seismicity.In these empirical calculations,the seismic drifts are estimated by amplifying the reduced elastic drifts obtained under design lateral loading with a displacement amplification factor(DAF).The value of DAF is considered equal to the product of the response modification factor R and the inelastic displacement ratioρ.The goal of the current research is to assess the value ofρfor low-to mid-rise BRBFs designed under low and high levels of seismicity.This goal has been achieved by conducting a series of elastic and inelastic time-history analyses pertaining to an ensemble of earthquake records on 3-,6-and 9-story BRBFs.The results indicate that theρ-ratio increases with an increase in design seismic intensity and an increase in experienced inelasticity.The range ofρfor low seismicity designs ranges from 0.63 to 0.9,while for high seismicity designs this range stretches from 0.83 to 1.29.It has been found that the consideration of a generalρ-ratio of 1.0 is a reasonable estimation for the design of the BRBFs considered in this study.
基金funded by the National Natural Science Foundation of China (Nos.21605093 and 21775082)the Shandong Province Higher Educational Program for Young Innovation Talents+1 种基金the Special Foundation for Distinguished Taishan Scholar of Shandong Province (No.ts201511052)the Major Program of Shandong Province Natural Science Foundation (No. ZR2018ZC0127)。
文摘Herein,we propose a novel photoelectrochemical(PEC) biosensor for dual microRNAs(miRNAs) highly sensitive and simultaneous biosensing based on strand displaced amplification(SDA) reaction.The recognition of HmiR-21 and Hlet-7 a by microRNA-21 and let-7 a leads to their change in hairpin structures,subsequently initiating the immobilization of abundant CdS quantum dots(CdS QD s) and methylene blue(MB) based on SDA reaction.The immobilized CdS QDs and MB produce both high PEC currents under430 nm light and 627 nm light illumination,respectively,and the generated PEC currents are closely relied on target miRNAs amounts.Thus,highly sensitive and simultaneous detection of microRNA-21 and let-7 a was readily achieved with detection limit at 6.6 fmol/L and 15.4 fmol/L based on 3σ,respectively.Further,this PEC biosensor was applied in simultaneous analysis of miRNA-21 and let-7 a in breast cancer patient’s serum with acceptable results.We expect this biosensor will find more useful application in diagnosis of miRNA-related diseases.
