Inclusion complexation between ibuprofen (IBF) and βcyclodextrin (βCD) was investigated. Phase solubility studies of the complexation suggested the formation of a 1:3 complex and a 2:3 complex between IBF and βCD a...Inclusion complexation between ibuprofen (IBF) and βcyclodextrin (βCD) was investigated. Phase solubility studies of the complexation suggested the formation of a 1:3 complex and a 2:3 complex between IBF and βCD at room temperature (23℃) and at 37℃ respectively. Solid inclusion complexes were prepared by the homogeneous coprecipitation method. Scanning electron microscopy, differential scanning calorimetry, IR spectroscopy, and Xray diffractometry were used for the characterization and evaluation of the complexes. The solubility and dissolution rate of the complexes formed were found to have improved considerably over that of the physical mixture and the drug alone, indicating that βcyclodextrin played an important role in the solubilization of ibuprofen.展开更多
文摘Inclusion complexation between ibuprofen (IBF) and βcyclodextrin (βCD) was investigated. Phase solubility studies of the complexation suggested the formation of a 1:3 complex and a 2:3 complex between IBF and βCD at room temperature (23℃) and at 37℃ respectively. Solid inclusion complexes were prepared by the homogeneous coprecipitation method. Scanning electron microscopy, differential scanning calorimetry, IR spectroscopy, and Xray diffractometry were used for the characterization and evaluation of the complexes. The solubility and dissolution rate of the complexes formed were found to have improved considerably over that of the physical mixture and the drug alone, indicating that βcyclodextrin played an important role in the solubilization of ibuprofen.
