Three new diterpene alkaloids,tangutidines A-C(1-3),and four known alkaloids(4-7)were isolated from the whole plant of Aconitum tanguticum,from which amphoteric diterpene alkaloids(1-3)were obtained for the first time...Three new diterpene alkaloids,tangutidines A-C(1-3),and four known alkaloids(4-7)were isolated from the whole plant of Aconitum tanguticum,from which amphoteric diterpene alkaloids(1-3)were obtained for the first time.The structures of 1-3 were elucidated by detailed interpretation of spectroscopic data,including MS and NMR data.All of them were evaluated for their cytotoxic activities.展开更多
Chemical investigation on the ethanol extract from the whole plants of Delphinium chrysotrichum resulted in the isolation of two new diterpene alkaloids named delphatisine A （1） and delphatisine B （2）, respectivel...Chemical investigation on the ethanol extract from the whole plants of Delphinium chrysotrichum resulted in the isolation of two new diterpene alkaloids named delphatisine A （1） and delphatisine B （2）, respectively. The structures of the new compounds were deduced on the basis of their spectral data （IR, HREIMS, EIMS, 1 D, 2D-NMR）. This is the first report on the isolation of diterpenoid alkaloids from the D. chrysotrichum.展开更多
Chemical investigation on the ethanol extract from the roots of Spiraea japonica var. acuta resulted in the isolation of two new diterpene alkaloids named spiratines A and B (1-2), respectively.
An investigation of the alkaloids of Delphinium swinanense var. leptopogon resulted in the isolation and identification of two new C(19)-diterpene alkaloids named swinanine A and B, together with one known tatsiensine...An investigation of the alkaloids of Delphinium swinanense var. leptopogon resulted in the isolation and identification of two new C(19)-diterpene alkaloids named swinanine A and B, together with one known tatsiensine. The structures of the new alkaloids were established from spectraf evidence.展开更多
Two new N-methyladenine-containing diterpenes,nemoechines F（l）and G（2）,were isolated from the South China Sea sponge Agelas aff.nemoechinata.The structures were assigned on the basis of spectroscopic date.Compound...Two new N-methyladenine-containing diterpenes,nemoechines F（l）and G（2）,were isolated from the South China Sea sponge Agelas aff.nemoechinata.The structures were assigned on the basis of spectroscopic date.Compound 2 showed weak activity against Jurkat cell lines with IC50 of 17.1 μmol/L展开更多
The chemical constituents from Aconitum richardsonianum var.pseudosessiliflorum were investigated.The roots of this plant were extracted three times with 90% EtOH at the room temperature.The ethanol extracts were comb...The chemical constituents from Aconitum richardsonianum var.pseudosessiliflorum were investigated.The roots of this plant were extracted three times with 90% EtOH at the room temperature.The ethanol extracts were combined and concentrated under reduced pressure to yield residue,which was suspended in water and successively partitioned with chloroform.The chloroform extraction was isolated and purified by silica gel and Sephadex LH-20 column chromatography.Six compounds were isolated and elucidated as delelatine（1）,isodelpheline（2）,3-acetylaconitine（3）,isoatisine（4）,nordhagenine A（5）and yunaconitine（6）.Compounds 1-5 were obtained from Aconitum Brunneum for the first time.Compound（1）showed significant cytotoxic activities（IC50=4.36 μM）against the human tumor cell line P388.展开更多
Bullatine G has many biological effects such as anti-inflammatory,anti-anxiety,anti-tumor,anti-arrhythmia and anti-heart failure effect.In order to provide a theoretical basis for the further study and clinical applic...Bullatine G has many biological effects such as anti-inflammatory,anti-anxiety,anti-tumor,anti-arrhythmia and anti-heart failure effect.In order to provide a theoretical basis for the further study and clinical application of bullatine G,this article reviews the biological activity of bullatine G in recent years.展开更多
基金the Second Tibetan Plateau Scientific Expedition and Research(STEP)program(2019QZKK0502)the National Natural Science Foundation of China(No.81673329)Authors are grateful for Dr.Ming Zhang from northwest institute of plateau biology,Chinese Academy of Sciences,for the assistance for obtaining plant materials.
文摘Three new diterpene alkaloids,tangutidines A-C(1-3),and four known alkaloids(4-7)were isolated from the whole plant of Aconitum tanguticum,from which amphoteric diterpene alkaloids(1-3)were obtained for the first time.The structures of 1-3 were elucidated by detailed interpretation of spectroscopic data,including MS and NMR data.All of them were evaluated for their cytotoxic activities.
文摘Chemical investigation on the ethanol extract from the whole plants of Delphinium chrysotrichum resulted in the isolation of two new diterpene alkaloids named delphatisine A （1） and delphatisine B （2）, respectively. The structures of the new compounds were deduced on the basis of their spectral data （IR, HREIMS, EIMS, 1 D, 2D-NMR）. This is the first report on the isolation of diterpenoid alkaloids from the D. chrysotrichum.
基金financially supported by the National Foundation for Outstanding Young Scientists to X.J.Hao(No.39525025).
文摘Chemical investigation on the ethanol extract from the roots of Spiraea japonica var. acuta resulted in the isolation of two new diterpene alkaloids named spiratines A and B (1-2), respectively.
文摘An investigation of the alkaloids of Delphinium swinanense var. leptopogon resulted in the isolation and identification of two new C(19)-diterpene alkaloids named swinanine A and B, together with one known tatsiensine. The structures of the new alkaloids were established from spectraf evidence.
基金supported by the National Natural Science Foundation of China (Nos. 41376142 and 41476107)NSFCShandong Joint Fund for Marine Science Research Centers (No. U1406402)
文摘Two new N-methyladenine-containing diterpenes,nemoechines F（l）and G（2）,were isolated from the South China Sea sponge Agelas aff.nemoechinata.The structures were assigned on the basis of spectroscopic date.Compound 2 showed weak activity against Jurkat cell lines with IC50 of 17.1 μmol/L
基金financially supported by the Scientific Research Program Funded by Shaanxi Provincial Department(2010JK74909JK672)+1 种基金by the Special Research Fund for the Doctoral Program of Higher Education(20096118110008)the Natural Science Foundation of Shaanxi Province(SJ08B16)
文摘The chemical constituents from Aconitum richardsonianum var.pseudosessiliflorum were investigated.The roots of this plant were extracted three times with 90% EtOH at the room temperature.The ethanol extracts were combined and concentrated under reduced pressure to yield residue,which was suspended in water and successively partitioned with chloroform.The chloroform extraction was isolated and purified by silica gel and Sephadex LH-20 column chromatography.Six compounds were isolated and elucidated as delelatine（1）,isodelpheline（2）,3-acetylaconitine（3）,isoatisine（4）,nordhagenine A（5）and yunaconitine（6）.Compounds 1-5 were obtained from Aconitum Brunneum for the first time.Compound（1）showed significant cytotoxic activities（IC50=4.36 μM）against the human tumor cell line P388.
基金Supported by the Talent Training Program for the Reform and Development of Local Colleges and University of the Central Government(2020GSP16)。
文摘Bullatine G has many biological effects such as anti-inflammatory,anti-anxiety,anti-tumor,anti-arrhythmia and anti-heart failure effect.In order to provide a theoretical basis for the further study and clinical application of bullatine G,this article reviews the biological activity of bullatine G in recent years.
