OBJECTIVE To evaluate the effect and safety of a Molecular Adsorbent Recycling System （MARS） in treating posthepatoectomy hepatic failure （AHF） patients surgically treated for primary hepatocellular carcinoma （HC...OBJECTIVE To evaluate the effect and safety of a Molecular Adsorbent Recycling System （MARS） in treating posthepatoectomy hepatic failure （AHF） patients surgically treated for primary hepatocellular carcinoma （HCC）. METHODS 12 AHF patients induced by resection of HCC were treated with MARS before orthotopic liver transplantation （OLT）. Their vital signs, urine volume, APACHElll and Glasgow scores were monitored. Routine laboratory blood tests, measurements of coagulatory function, liver and kidney function, serum ammonia, lactic acid and blood gas were conducted before and after treatment with MARS. All of the patients were followed up for a period of 6 months after OLT for prognosis and complication assessment. RESULTS Each patient was treated with MARS for 2-5 times （average of 3.6） with a length of 8-24 h each time. Their mean arterial blood pressure and urine volume were improved, APACHE III and Glasgow scores were better. Liver function was improved with the following alterations before and after treatment with MARS： serum ammonia （127.1±21.4 umol/L vs. 77.4±19.7 umol/L, P〈0.05）, lactic acid （6.53±0.45 mmol/L vs. 3.75± 0.40 mmol/L, P〈0.05） and total bilirubin （452.3±153.7 umol/L vs. 230.9± 115.2 umol/L, P〈0.05）. However, there was no significant change in platelet count （44.25±3.60×10^9/L vs. 43.19±8.26×10^9/L, P〉0.05） on international normalized ratio （INR） （2.74±0.50 vs. 2.82±0.60, P〉0.05）, which showed the safety of MARS. For all patients no serious adverse effects occurred during the treatment with MARS. CONCLUSION MARS is effective and safe for treatment of AHF patients with HCC, especially as a bridge to OLT when a donor organ is not available.展开更多
在当前经济全球化的背景下,为了促进我国会计研究向纵深发展,为广大会计研究人员提供学术切磋、合作和交流的平台,由中南财经政法大学和澳大利亚科廷科技大学(Curtin University of Technology)共同发起的"2008会计与财务国际学术...在当前经济全球化的背景下,为了促进我国会计研究向纵深发展,为广大会计研究人员提供学术切磋、合作和交流的平台,由中南财经政法大学和澳大利亚科廷科技大学(Curtin University of Technology)共同发起的"2008会计与财务国际学术研讨会(AFIC)"将于2008年11月4日至11月5日在中南财经政法大学举行。现面向海内外相关领域专家学者诚征会议论文。对于参会的优秀论文,我们将以论文集的方式出版。本次国际学术研讨会会议语言及论文均要求使用英语。本次会议的主要议题(但不限于):展开更多
文摘OBJECTIVE To evaluate the effect and safety of a Molecular Adsorbent Recycling System （MARS） in treating posthepatoectomy hepatic failure （AHF） patients surgically treated for primary hepatocellular carcinoma （HCC）. METHODS 12 AHF patients induced by resection of HCC were treated with MARS before orthotopic liver transplantation （OLT）. Their vital signs, urine volume, APACHElll and Glasgow scores were monitored. Routine laboratory blood tests, measurements of coagulatory function, liver and kidney function, serum ammonia, lactic acid and blood gas were conducted before and after treatment with MARS. All of the patients were followed up for a period of 6 months after OLT for prognosis and complication assessment. RESULTS Each patient was treated with MARS for 2-5 times （average of 3.6） with a length of 8-24 h each time. Their mean arterial blood pressure and urine volume were improved, APACHE III and Glasgow scores were better. Liver function was improved with the following alterations before and after treatment with MARS： serum ammonia （127.1±21.4 umol/L vs. 77.4±19.7 umol/L, P〈0.05）, lactic acid （6.53±0.45 mmol/L vs. 3.75± 0.40 mmol/L, P〈0.05） and total bilirubin （452.3±153.7 umol/L vs. 230.9± 115.2 umol/L, P〈0.05）. However, there was no significant change in platelet count （44.25±3.60×10^9/L vs. 43.19±8.26×10^9/L, P〉0.05） on international normalized ratio （INR） （2.74±0.50 vs. 2.82±0.60, P〉0.05）, which showed the safety of MARS. For all patients no serious adverse effects occurred during the treatment with MARS. CONCLUSION MARS is effective and safe for treatment of AHF patients with HCC, especially as a bridge to OLT when a donor organ is not available.
文摘在当前经济全球化的背景下,为了促进我国会计研究向纵深发展,为广大会计研究人员提供学术切磋、合作和交流的平台,由中南财经政法大学和澳大利亚科廷科技大学(Curtin University of Technology)共同发起的"2008会计与财务国际学术研讨会(AFIC)"将于2008年11月4日至11月5日在中南财经政法大学举行。现面向海内外相关领域专家学者诚征会议论文。对于参会的优秀论文,我们将以论文集的方式出版。本次国际学术研讨会会议语言及论文均要求使用英语。本次会议的主要议题(但不限于):
