Evaluation of the Sensitivity and Specificity of the New Clinical Diagnostic and Classification Criteria for Kashin-Beck Disease,an Endemic Osteoarthritis,in China

This study aimed to evaluate the sensitivity and specificity of the new clinical diagnostic and classification criteria for Kashin-Beck disease （KBD） using six clinical markers： flexion of the distal part of fingers, deformed fingers, enlarged finger joints, shortened fingers, squat down, and dwarfism. One-third of the total population in Linyou County was sampled by stratified random sampling.

Diversity-accuracy assessment of multiple classifier systems for the land cover classification of the Khumbu region in the Himalayas

Land cover classification of mountainous environments continues to be a challenging remote sensing problem,owing to landscape complexities exhibited by the region.This study explored a multiple classifier system(MCS)approach to the classification of mountain land cover for the Khumbu region in the Himalayas using Sentinel-2 images and a cloud-based model framework.The relationship between classification accuracy and MCS diversity was investigated,and the effects of different diversification and combination methods on MCS classification performance were comparatively assessed for this environment.We present ten MCS models that implement a homogeneous ensemble approach,using the high performing Random Forest(RF)algorithm as the selected classifier.The base classifiers of each MCS model were developed using different combinations of three diversity techniques:(1)distinct training sets,(2)Mean Decrease Accuracy feature selection,and(3)‘One-vs-All’problem reduction.The base classifier predictions of each RFMCS model were combined using:(1)majority vote,(2)weighted argmax,and(3)a meta RF classifier.All MCS models reported higher classification accuracies than the benchmark classifier(overall accuracy with 95% confidence interval:87.33%±0.97%),with the highest performing model reporting an overall accuracy(±95% confidence interval)of 90.95%±0.84%.Our key findings include:(1)MCS is effective in mountainous environments prone to noise from landscape complexities,(2)problem reduction is indicated as a stronger method over feature selection in improving the diversity of the MCS,(3)although the MCS diversity and accuracy have a positive correlation,our results suggest this is a weak relationship for mountainous classifications,and(4)the selected diversity methods improve the discriminability of MCS against vegetation and forest classes in mountainous land cover classifications and exhibit a cumulative effect on MCS diversity for this context.

The revised Atlanta criteria 2012 altered the classification,severity assessment and management of acute pancreatitis

BACKGROUND： The Atlanta criteria for acute pancreatitis （AP） has been revised recently. This study was to evaluate its practical value in classification of AP, the severity assessment and management. METHODS： The clinical features, severity classification, out- come and risk factors for mortality of 3212 AP patients who had been admitted in Ruijin Hospital from 2004 to 2011 were analyzed based on the revised Atlanta criteria （RAC） and the original Atlanta criteria （OAC）.

EVALUATION OF INTERNATIONAL CLASSIFICATION CRITERIA (2002) FOR PRIMARY SJGREN'S SYNDROME IN CHINESE PATIENTS

Objective To evaluate the sensitivity and specificity of international classification criteria （2002） for primary Sjogren＇s syndrome （pSS） and the role of lower lip biopsy in diagnosis of pSS in Chinese patients. Mothoda Patients who were diagnosed by the experts/rheumatologists as pSS during 1990-2002 from the Department of Rheumatology, Peking Union Medical College Hospital were retrospectively collected as experimental group. Patients who were diagnosed as non-pSS connective tissue diseases or non-connective tissue diseases served as control group. Those with a history of head-neck radiation, hepatitis C virus infection, AIDS, lymphoma, sarcoidosis, graft versus host disease （GVHD）, and anti-acetylcholine drug use were exempted. Both groups were required to complete questionnaires about symptoms such as dry eyes and dry mouth, and complete the objective tests of keratoconjunctivitis and xerostomia including Schirmer test, corneal staining, unstimulated salivary flow, sialography, lower lip biopsy, and antinuclear antibodies （including anti-SSA/SSB antibodies） test. Results A total of 330 pSS patients were included in experimental group and 185 non-pSS patients in control group. The mean age of both groups matched （47.8 ± 10.9 years vs. 46.2±13.6 years, P 〉 0.05）. The sensitivities of the criteria in pSS patients with lower lip biopsy and in pSS patients without lower lip biopsy were 89.2% and 87.2%, respectively; the overall sensitivity was 88.5%. The specificity was 97.3%. A total of 11.3% pSS patients with negative anti-SSA/SSB antibodies were diagnosed as pSS by lower lip biopsy. Coadwion The international classification criteria （2002） for pSS is feasible in Chinese patients. It has high sensitivity and specificity, and may serve as diagnosis criteria in routine clinical practice.

A Review on the Classification and Grading Criteria of Road Transport Natural Disasters

This review summarizes and analyzes the basic information of various types of road transport natural disaster emergencies,refers to various types of road transport emergency plans,and combines the actual needs of road transport emergency rescue with national emergency related laws.It also proposes the classification criteria and grading standard for the emergencies of road transport natural disasters based on the classification and grading standard of the regulations,which provide a basis to take reasonable and effective disposal measures in the emergency response of road transport emergencies under natural disaster conditions.

The Derivation of Nutrient Criteria for the Adjacent Waters of Yellow River Estuary in China

Ecological protection and high-quality development of the Yellow River basin are becoming part of the national strategy in recent years.The Yellow River Estuary has been seriously affected by human activities.Especially,it has been severely polluted by the nitrogen and phosphorus from land sources,which have caused serious eutrophication and harmful algal blooms.Nutrient criteria,however,was not developed for the Yellow River Estuary,which hindered nutrient management measures and eutrophication risk assessment in this key ecological function zone of China.Based on field data during 2004-2019,we adopted the frequency distribution method,correlation analysis,Linear Regression Model(LRM),Classification and Regression Tree(CART)and Nonparametric Changepoint Analysis(nCPA)methods to establish the nutrient criteria for the adjacent waters of Yellow River Estuary.The water quality criteria of dissolved inorganic nitrogen(DIN)and soluble reactive phosphorus(SRP)are recommended as 244.0μg L^(−1) and 22.4μg L^(−1),respectively.It is hoped that the results will provide scientific basis for the formulation of nutrient standards in this important estuary of China.

Coal-rock gas:Concept,connotation and classification criteria

In recent years,great breakthroughs have been made in the exploration and development of natural gas in deep coal-rock reservoirs in Junggar,Ordos and other basins in China.In view of the inconsistency between the industrial and academic circles on this new type of unconventional natural gas,this paper defines the concept of"coal-rock gas"on the basis of previous studies,and systematically analyzes its characteristics of occurrence state,transport and storage form,differential accumulation,and development law.Coal-rock gas,geologically unlike coalbed methane in the traditional sense,occurs in both free and adsorbed states,with free state in abundance.It is generated and stored in the same set of rocks through short distance migration,occasionally with the accumulation from other sources.Moreover,coal rock develops cleat fractures,and the free gas accumulates differentially.The coal-rock gas reservoirs deeper than 2000 m are high in pressure,temperature,gas content,gas saturation,and free-gas content.In terms of development,similar to shale gas and tight gas,coal-rock gas can be exploited by natural formation energy after the reservoirs connectivity is improved artificially,that is,the adsorbed gas is desorbed due to pressure drop after the high-potential free gas is recovered,so that the free gas and adsorbed gas are produced in succession for a long term without water drainage for pressure drop.According to buried depth,coal rank,pressure coefficient,reserves scale,reserves abundance and gas well production,the classification criteria and reserves/resources estimation method of coal-rock gas are presented.It is preliminarily estimated that the coal-rock gas in place deeper than 2000 m in China exceeds 30×10^(12)m^(3),indicating an important strategic resource for the country.The Ordos,Sichuan,Junggar and Bohai Bay basins are favorable areas for large-scale enrichment of coal-rock gas.The paper summarizes the technical and management challenges and points out the research directions,laying a foundation for the management,exploration,and development of coal-rock gas in China.

Classification Criteria of Narrow/Wide Ice-ResistantConical Structures Based on Direct Measurements

Ice-induced structural vibration generally decreases with an increase in structural width at the waterline. Definitions of wide/narrow ice-resistant conical structures, according to ice-induced vibration, are directly related to structure width, sea ice parameters, and clearing modes of broken ice. This paper proposes three clearing modes for broken ice acting on conical structures: complete clearing, temporary ice pile up, and ice pile up. In this paper, sea ice clearing modes and the formation requirements of dynamic ice force are analyzed to explore criteria determining wide/narrow ice-resistant conical structures. According to the direct measurement data of typical prototype structures, quantitative criteria of the ratio of a cone width at waterline(D) to sea ice thickness(h) is proposed. If the ratio is less than 30(narrow conical structure), broken ice is completely cleared and a dynamic ice force is produced; however, if the ratio is larger than 50(wide conical structure), the front stacking of broken ice or dynamic ice force will not occur.

Classification criteria for spondyloarthropathies

Spondyloarthropathies(SpA)are a group of inflammatory arthritis which consist of ankylosing spondylitis(AS),reactive arthritis,arthritis/spondylitis associated with psoriasis(PsA),and arthritis/spondylitis associated with inflammatory bowel diseases.It is now more important than ever to diagnose and treat SpA early.New therapeutic agents including blockers of tumor necrosis factor have yielded tremendous responses not only in advanced disease but also in the early stages of the disease.Sacroiliitis on conventional radiography is the result of structural changes which may appear late in the disease process.However,magnetic resonance imaging(MRI)can visualize active inflammation at sacroiliac joints and spine in recent onset disease.The modified New York criteria,the European Spondyloarthropathy Study Group criteria and the Amor criteria do not include advanced imaging techniques like MRI which is very sensitive to the early Inflammatory changes.Assessment of SpondyloArthritis international Society has defined MRI methods for the assessment of sacroiliac joints and spine,criteria for inflammatory back pain and developed new criteria for classification of axial and peripheral spondyloarthritis.These new criteria are intended to be used for patients with SpA at the very early stage of their disease.Also,classification of psoriatic arthritis study group developed criteria for the classification of PsA.The widespread use of these criteria in clinical trials will provide evidence for a better definition of early disease and recognize many patients who may further develop classical AS or PsA.These efforts will guide therapeutic trials of potent drugs like biological agents in the early stage of these diseases.

Evaluation Criteria Based on Mutual Information for Classifications Including Rejected Class

与用表演措施的常规评估标准不同，信息理论基于在场的标准在机器学习的应用的一个唯一的有益的特征。然而，我们仍然远非正在拥有熵类型标准的深入的理解，说，在与常规基于表演的标准的关系。这份报纸学习通用分类问题，它包括一拒绝，或未知，班。我们在场基本公式和分类基于信息学习的图解的图理论。一个靠近形式的方程为通用分类问题在规范的相互的信息和扩充混乱矩阵之间被导出。敏感方程的三个定理和定理集合为学习在相互的信息和常规表演索引之间的关系被给。我们也与常规标准比较举与相互的信息标准的优点和限制有关的数字例子和几讨论。

Human Brucellosis Mimicking Axial Spondyloarthritis: a Challenge for Rheumatologists when Applying the 2009 ASAS Criteria

Although the development of the 2009 Sp A classification criteria by Assessment of Spondylo Arthritis international Society（ASAS） represents an important step towards a better definition of the early disease stage particularly in axial spondyloarthritis（ax Sp A）, the specificity of the criteria has been criticized these days. As the commonest zoonotic infection worldwide, human brucellosis can mimic a large number of diseases, including Sp A. This study was performed to determine the frequency of rheumatologic manifestations in patients with brucellosis and the chance of misdiagnosing them as having ax Sp A in central China. The results showed that clinical manifestations of ax Sp A could be observed in brucellosis. Over half of patients had back pain, and one fifth of the patients with back pain were less than 45 years old at onset and had the symptom for more than 3 months. Two young males were falsely classified as suffering from ax Sp A according to the ASAS criteria, and one with MRI proved sacroiliitis was once given Etanercept for treatment. Therefore, differential diagnosis including human brucellosis should always be kept in mind when applying the ASAS criteria, even in traditionally non-endemic areas.

Multi-criteria classification approach with polynomial aggregation function and incomplete certain information

The relationship between the importance of criterion and the criterion aggregation function is discussed, criterion＇s weight and combinational weights between some criteria are defined, and a multi-criteria classification method with incomplete certain information and polynomial aggregation function is proposed. First, linear programming is constructed by classification to reference alternative set （assignment examples） and incomplete certain information on criterion＇s weights. Then the coefficient of the polynomial aggregation function and thresholds of categories are gained by solving the linear programming. And the consistency index of alternatives is obtained, the classification of the alternatives is achieved. The certain criteria＇s values of categories and uncertain criteria＇s values of categories are discussed in the method. Finally, an example shows the feasibility and availability of this method.

Using classification assignment rules to assess land-use change impacts on forest biodiversity at local-to-national scales

Background： Ecosystem representation is one key component in assessing the biodiversity impacts of land-use changes that will irrevocably alter natural ecosystems. We show how detailed vegetation plot data can be used to assess the potential impact of inundation by a proposed hydroelectricity dam in the Mokihinui gorge, New Zealand, on representation of natural forests. Specifically we ask： 1） How well are the types of forest represented Locally, regionally, and nationally; and 2） How does the number of distinct communities （i.e. beta diversity） in the target catchment compare with other catchments nationally？ Methods： For local and regional comparisons plant species composition was recorded on 45 objectively located 400 m2 vegetation plots established in each of three gorges, with one being the proposed inundation area of the Mokihinui lower gorge. The fuzzy classification framework of noise clustering was used to assign these plots to a specific alliance and association of a pre-existing national-scale classification. NationaLly, we examined the relationship between the number of alliances and associations in a catchment and either catchment size or the number of plots per catchment by fitting Generalised Additive Models. Results： The four alliances and five associations that were observed in the Mokihinui lower gorge arepresent in the region but limited locally. One association was narrowly distributed nationally, but is the mostfrequent association in the Mokihinui lower gorge; inundation may have consequences of national importance to its long-term persistence. That the Mokihinui lower gorge area had nearly twice as many plots that could not be assigned to pre- existing alliances and associations than either the Mokihinui upper or the Karamea lower gorges and proportionally more than the national dataset emphasises the compositional distinctiveness of this gorge. These outlier plots in the Mokihinui lower gorge may be unsorted assemblages of species or reflect sampling bias or that native- dominated woody riparian vegetation is rare on the landscape. At a national scale, the Mokihinui catchment has a higher diversity of forest alliances and associations （i.e. beta-diversity） than predicted based on catchment size and sampling intensity. Conclusions： Our analytical approach demonstrates one transparent solution to a common conservation planning problem： assessing how well ecosystems that will be destroyed by a proposed land-use change are represented using a multi-scale spatial and compositional framework. We provide a useful tool for assessing potential consequences of land-use change that can help guide decision making.

Land Cover Changes and Drivers in the Water Source Area of the Middle Route of the South-to-North Water Diversion Project in China from 2000 to 2015

The Middle Route of the South-to-North Water Diversion Project(MR-SNWDP)in China,with construction beginning in 2003,diverts water from Danjiangkou Reservoir to North China for residential,agriculture and industrial use.The water source area of the MR-SNWDP is the region that is most sensitive to and most affected by the construction of this water diversion project.In this study,we used Landsat Thematic Mapper(TM)and HJ-1 A/B images from 2000 to 2015 by an object-based approach with a hierarchical classification method for mapping land cover in the water source area.The changes in land cover were illuminated by transfer matrixes,single dynamic degree,slope zones and fractional vegetation cover(FVC).The results indicated that the area of cropland decreased by 31%and was replaced mainly by shrub over the past 15 years,whereas forest and settlements showed continuous increases of 29.2% and 77.7%,respectively.The changes in cropland were obvious in all slope zones and decreased most remarkably(–43.8%)in the slope zone above 25°.Compared to the FVC of forest and shrub,significant improvement was exhibited in the FVC of grassland,with a growth rate of 16.6%.We concluded that local policies,including economic development,water conservation and immigration resulting from the construction of the MR-SNWDP,were the main drivers of land cover changes;notably,they stimulated the substantial and rapid expansion of settlements,doubled the wetlands and drove the transformation from cropland to settlements in immigration areas.

Geographical Patterns of Chinese Ethnic Minority Population Composition and Ethnic Diversity

Ethnicity is a carrier of language and culture.Spatial distribution of ethnic diversity is fundamental for identifying and reconstructing the migration patterns and evolution histories of cultures and languages.Utilizing the Chinese 4th National Census (1990) data,we investigated the specific time geographical patterns of population and diversity of Chinese ethnicminorities.As anticipated,results show that Chineseminorities are chiefly concentrated in dis-tant plateaus and mountains in the southwest,northwest and northeast of China.Further,population density centers of the 10 majorminorities are rather scattered,alternatively dominating at different parts of the country.This study pro-vides a first comprehensive quantitative test on a prevailing notion of 'six plates and three corridors' on the empirical clustering patterns of Chinese ethnicminorities.There are more consistent evidences supporting this notion in the north of China,with the central and southern regions showing more complex patterns,potentially transformed by processes such as migration,fragmentation,and percolation.The results of this study suggest that a geographical ap-proach can provide heuristic and complementary information for better understanding of historical social processes.

Simplified criteria for diagnosing superficial esophageal squamous neoplasms using Narrow Band Imaging magnifying endoscopy

AIM To simplify the diagnostic criteria for superficial esophageal squamous cell carcinoma(SESCC) on Narrow Band Imaging combined with magnifying endoscopy(NBI-ME).METHODS This study was based on the post-hoc analysis of a randomized controlled trial. We performed NBI-ME for 147 patients with present or a history of squamous cell carcinoma in the head and neck, or esophagus between January 2009 and June 2011. Two expert endoscopistsdetected 89 lesions that were suspicious for SESCC lesions, which had been prospectively evaluated for the following 6 NBI-ME findings in real time: "intervascular background coloration"; "proliferation of intrapapillary capillary loops(IPCL)"; and "dilation", "tortuosity", "change in caliber", and "various shapes(VS)" of IPCLs(i.e., Inoue's tetrad criteria). The histologic examination of specimens was defined as the gold standard for diagnosis. A stepwise logistic regression analysis was used to identify candidates for the simplified criteria from among the 6 NBI-ME findings for diagnosing SESCCs. We evaluated diagnostic performance of the simplified criteria compared with that of Inoue's criteria.RESULTS Fifty-four lesions(65%) were histologically diagnosed as SESCCs and the others as low-grade intraepithelial neoplasia or inflammation. In the univariate analysis, proliferation, tortuosity, change in caliber, and VS were significantly associated with SESCC(P < 0.01). The combination of VS and proliferation was statistically extracted from the 6 NBI-ME findings by using the stepwise logistic regression model. We defined the combination of VS and proliferation as simplified dyad criteria for SESCC. The areas under the curve of the simplified dyad criteria and Inoue's tetrad criteria were 0.70 and 0.73, respectively. No significant difference was shown between them. The sensitivity, specificity, and accuracy of diagnosis for SESCC were 77.8%, 57.1%, 69.7% and 51.9%, 80.0%, 62.9% for the simplified dyad criteria and Inoue's tetrad criteria, respectively.CONCLUSION The combination of proliferation and VS may serve as simplified criteria for the diagnosis of SESCC using NBIME.

Nudivirus Genomics: Diversity and Classification

Nudiviruses represent a diverse group of arthropod specific, rod-shaped and dsDNA viruses. Due to similarities in pathology and morphology to members of the family Baculoviridae, they have been previously classified as the so-called “non-occluded” baculoviruses. However, presently they are taxonomically orphaned and are not assigned to any virus family because of the lack of genetic relatedness to Baculoviridae,. Here, we report on recent progress in the genomic analysis of Heliothis zea nudivirus 1 (HzNV-1), Oryctes rhinoceros nudivirus (OrNV), Gryllus bimaculatus nudivirus (GbNV) and Heliotis zea nudivirus 2 (HzNV-2). Gene content comparison and phylogenetic analyses indicated that the viruses share 15 core genes with baculoviruses and form a monophyletic sister group to them. Consequences of the genetic relationship are discussed for the classification of nudiviruses.

HIV Diversity and Classification, Role in Transmission

The hallmark of HIV-1 is its extensive genetic diversity that emanates mainly from high mutations. Phylogenetically, HIV can be classified into geographically confined groups, types, subtypes and circulating recombinant forms (CRFs) that are however subject to change over time. HIV genetic diversity may partially explain the observed heterogeneity in HIV prevalence and has also been reported to impact on viral transmissibility and differential rates of disease progression. The aim of this review is to present a simple overview of the principles and concepts of HIV diversity and classification. Tracking the presence of new HIV strains is not only important for surveillance purposes but is also critical in facilitating personalized targeted therapy as well as forming the basis for development of the much anticipated effective vaccines against this scourge.

Bicycle Level of Service Evaluation Method for Urban Road Segment

As a sustainable mode of transportation, bicycles significantly improve daily mobility. In order to provide theoretics support for improvement of the bicycling environment, this paper proposed bicycle level of service (BLOS) evaluation method for urban road segment according to cyclists’ perception. First, influence factors of BLOS were identified from aspects of road facility, traffic characteristics, and environmental condition. Second, bicycling videos were recorded and a satisfaction survey was conducted. Four BLOS evaluation models for different separation facilities were established. Last, bicycling behavioral stages of travelers were divided based on the transtheoretical model. A new BLOS classification criterion was proposed according to travelers’ demand of different stages.

Assessing the Potential of Mangrove Educotourism to Marine Protected Area: A Case of Tioman and Tulai Islands, Pahang, Malaysia

Mangroves composition and species are richly diverse in Tioman and Tulai Island. A total of 23 mangrove species have been found consisting of exclusive and non-exclusive species in Kg. Juara, Kg. Nipah, Kg. Paya, Kg. Genting and Tulai Island. The abundance mangrove species are Rhizophora X lamarckii, Rhizophora apiculata, Rhizophora mucronata and Brugueira gymnorrhiza. From supervised classification, total of 59.90 hectares mangrove covers have been identified in both islands, with 86.49% in Tioman Island (52.76 hectares) and 13.51% in Tulai Island (7.14 hectares). A new hybrid species has been found (Rhizophora X lamarckii) dominated in Tulai Island, combination between Rhizophora stylosa and Rhizophora apiculata. At the mean time only mangrove area in Teluk Bakau, Tulai Island is considered as the focal destination of tourists to the area. However, other mangrove areas in Tioman Island are also potential to be promoted as tourist destination areas. Although the mangrove area is only a part of the scenery, its presence obviously enhances tourist attraction. The basic facilities such as information counter, walking trails, garbage boxes and toilets are considered necessary. The main information panel and site map should be provided on the mangrove sites. Boardwalks may be constructed for visitor to access the mangrove area without destroying the root system and stand. The actual site of these facilities and on-site information guides should be strategically placed in order to provide beneficial information and as well as to sustain the biophysical stability of the sites. Since mangroves provide various important functions in nature, it hopes that the mangrove educotourism activity will influence the people and community’s attitudes to the environment, conservation and sustainable development in a very positive way.