Delonix elata L.is a Ceasalpinaceae species and is traditionally used in India for treatment of skin diseases,liver diseases and rheumatic problems.However,systematic evaluation of its wound healing activity is lackin...Delonix elata L.is a Ceasalpinaceae species and is traditionally used in India for treatment of skin diseases,liver diseases and rheumatic problems.However,systematic evaluation of its wound healing activity is lacking.Thus,in the present study,we aimed to assess the wound healing activity of D.elata stem bark extract(DSE) and its isolated constituent quercetin-3-rhamnopyranosyl-(1-6) glucopyranoside(QRPG) in rats.The formulations effects on wound healing were assessed by the wound contraction rate,epithelialization period,tensile strength,content of the hydroxyproline,hexosamine and uronic acid in granulation tissue,histopathological studies and Col 1 α(I) expression level in wound tissue by reverse transcription polymerase chain reaction(RT-PCR) study.The topical application of DSE ointment caused faster epithelialization,significant wound contraction(100%),and better tensile strength(710.5 ± 10.5 g/cm^2),while QRPG showed wound epithelialization with 98.2%contraction,better than that of the control group(78.18%).The biochemical analysis of granulation tissue revealed that DSE and QRPG significantly increased hydroxyproline,hexosamine and uronic acid content.A significant increase in the expression of Col 1 α(I) was observed in the wound tissue of DSE and QRPG treated rats.DSE and QRPG were shown to enhance wound healing by increasing collagen synthesis through upregulation of Col 1 α(I),thus validating ethnomedicinal uses.展开更多
To compare the healing of purulent wounds with Shilajit dressing vs. Vishnevsky dressing in dogs with purulent wounds of >2 weeks of duration, eight dogs were chosen from same ages in two groups i.e., Shilajit and ...To compare the healing of purulent wounds with Shilajit dressing vs. Vishnevsky dressing in dogs with purulent wounds of >2 weeks of duration, eight dogs were chosen from same ages in two groups i.e., Shilajit and Vishnevsky dressing group. Dressing was done on every day basis for more than two weeks of follow up period. Main outcome of healing measure was completed at three weeks. Wound healing status was assessed at three days intervals till end of three weeks. Shilajit treated achieved complete decrease in the wound surface area, effect of healing score in Shilajit dressing group in comparison to the Vishnevsky dressing group at p > 0.05 level of significance. Shilajit is highly effective in achieving a characteristic feature of regenerative and granulation healing of purulent wounds as compared to Vishnevsky dressing group in dogs.展开更多
This study aims to explore the molecular aspects of the wound-healing potential of medicinal plants through preclinical and clinical research.This review focuses on the theoretical sup-port and therapeutic effects of ...This study aims to explore the molecular aspects of the wound-healing potential of medicinal plants through preclinical and clinical research.This review focuses on the theoretical sup-port and therapeutic effects of traditional herbal plants,herbal formulations,and active com-pounds in herbal medicine.It provides new insights into the management of diabetic wound healing with herbal medicine.A comprehensive literature review was conducted using key-words such as“herbal remedies”“diabetics”“wounds”“bioactive”“medicinal plant”and“growth factor”across several literature databases,namely,Wiley Online Library,Elsevier,Springer,PubMed,and Google Scholar.The available literature provides a basis for tradition-al remedies found to be effective in healing wounds by targeting key molecules involved in wound pathology,including collagen I&III,vascular endothelial growth factor(VEGF),tu-mor necrosis factor-alpha(TNF-α),nuclear factor kappa B(NF-κB),transforming growth fac-tor(TGF)-β1,hydroxyproline(collagen component),superoxide dismutase(SOD),and Cata-lase(CAT).Numerous studies have investigated the presence of bioactive compounds in many plants for their wound-healing effects.The results underscore the potential of various plants in wound healing,highlighting the need for further pharmacological research before clinical application.These findings support the conventional use of herbal remedies and pro-vide the basis for future research into the development of new therapeutic alternatives for wound healing.展开更多
目的探讨苯扎氯铵溶液在处理犬咬伤伤口中的临床应用效果。方法将2016年12月-2017年12月于我院急诊外科就诊的378例犬咬伤患者随机分为实验组(n=188)和对照组(n=190)。实验组应用碘伏溶液联合苯扎氯铵溶液处置伤口,对照组采用常规的碘...目的探讨苯扎氯铵溶液在处理犬咬伤伤口中的临床应用效果。方法将2016年12月-2017年12月于我院急诊外科就诊的378例犬咬伤患者随机分为实验组(n=188)和对照组(n=190)。实验组应用碘伏溶液联合苯扎氯铵溶液处置伤口,对照组采用常规的碘伏溶液处置伤口。观察并记录对伤口处置时疼痛指数及伤口愈合感染率。结果实验组相比对照组伤口疼痛明显减轻(NPRS:2.87±0.94 vs 5.98±1.01,P=0.000 1),实验组的感染率明显低于对照组(7.43%vs 14.21%,P=0.021)。结论采用苯扎氯铵溶液冲洗伤口,可减轻患者疼痛,有较好的抗感染效果。展开更多
基金partially supported by the Department of Biotechnology,New Delhi,India(Grant no.BT/PR11505/SPD/24/337/2008BT/PR9128/INF/22/190/2013)
文摘Delonix elata L.is a Ceasalpinaceae species and is traditionally used in India for treatment of skin diseases,liver diseases and rheumatic problems.However,systematic evaluation of its wound healing activity is lacking.Thus,in the present study,we aimed to assess the wound healing activity of D.elata stem bark extract(DSE) and its isolated constituent quercetin-3-rhamnopyranosyl-(1-6) glucopyranoside(QRPG) in rats.The formulations effects on wound healing were assessed by the wound contraction rate,epithelialization period,tensile strength,content of the hydroxyproline,hexosamine and uronic acid in granulation tissue,histopathological studies and Col 1 α(I) expression level in wound tissue by reverse transcription polymerase chain reaction(RT-PCR) study.The topical application of DSE ointment caused faster epithelialization,significant wound contraction(100%),and better tensile strength(710.5 ± 10.5 g/cm^2),while QRPG showed wound epithelialization with 98.2%contraction,better than that of the control group(78.18%).The biochemical analysis of granulation tissue revealed that DSE and QRPG significantly increased hydroxyproline,hexosamine and uronic acid content.A significant increase in the expression of Col 1 α(I) was observed in the wound tissue of DSE and QRPG treated rats.DSE and QRPG were shown to enhance wound healing by increasing collagen synthesis through upregulation of Col 1 α(I),thus validating ethnomedicinal uses.
文摘To compare the healing of purulent wounds with Shilajit dressing vs. Vishnevsky dressing in dogs with purulent wounds of >2 weeks of duration, eight dogs were chosen from same ages in two groups i.e., Shilajit and Vishnevsky dressing group. Dressing was done on every day basis for more than two weeks of follow up period. Main outcome of healing measure was completed at three weeks. Wound healing status was assessed at three days intervals till end of three weeks. Shilajit treated achieved complete decrease in the wound surface area, effect of healing score in Shilajit dressing group in comparison to the Vishnevsky dressing group at p > 0.05 level of significance. Shilajit is highly effective in achieving a characteristic feature of regenerative and granulation healing of purulent wounds as compared to Vishnevsky dressing group in dogs.
文摘This study aims to explore the molecular aspects of the wound-healing potential of medicinal plants through preclinical and clinical research.This review focuses on the theoretical sup-port and therapeutic effects of traditional herbal plants,herbal formulations,and active com-pounds in herbal medicine.It provides new insights into the management of diabetic wound healing with herbal medicine.A comprehensive literature review was conducted using key-words such as“herbal remedies”“diabetics”“wounds”“bioactive”“medicinal plant”and“growth factor”across several literature databases,namely,Wiley Online Library,Elsevier,Springer,PubMed,and Google Scholar.The available literature provides a basis for tradition-al remedies found to be effective in healing wounds by targeting key molecules involved in wound pathology,including collagen I&III,vascular endothelial growth factor(VEGF),tu-mor necrosis factor-alpha(TNF-α),nuclear factor kappa B(NF-κB),transforming growth fac-tor(TGF)-β1,hydroxyproline(collagen component),superoxide dismutase(SOD),and Cata-lase(CAT).Numerous studies have investigated the presence of bioactive compounds in many plants for their wound-healing effects.The results underscore the potential of various plants in wound healing,highlighting the need for further pharmacological research before clinical application.These findings support the conventional use of herbal remedies and pro-vide the basis for future research into the development of new therapeutic alternatives for wound healing.
文摘目的探讨苯扎氯铵溶液在处理犬咬伤伤口中的临床应用效果。方法将2016年12月-2017年12月于我院急诊外科就诊的378例犬咬伤患者随机分为实验组(n=188)和对照组(n=190)。实验组应用碘伏溶液联合苯扎氯铵溶液处置伤口,对照组采用常规的碘伏溶液处置伤口。观察并记录对伤口处置时疼痛指数及伤口愈合感染率。结果实验组相比对照组伤口疼痛明显减轻(NPRS:2.87±0.94 vs 5.98±1.01,P=0.000 1),实验组的感染率明显低于对照组(7.43%vs 14.21%,P=0.021)。结论采用苯扎氯铵溶液冲洗伤口,可减轻患者疼痛,有较好的抗感染效果。
