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Review on mechanisms and structure-activity relationship of hypoglycemic effects of polysaccharides from natural resources 被引量:6
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作者 Xiaolong Ji Jianhang Guo +3 位作者 Tengzheng Cao Tingting Zhang Yanqi Liu Yizhe Yan 《Food Science and Human Wellness》 SCIE CSCD 2023年第6期1969-1980,共12页
Diabetes mellitus(DM)is a common multifactorial disease,causing various complications,such as chronic metabolism.The current therapies for diabetes mellitus are commercial diabetic drugs that have different definite s... Diabetes mellitus(DM)is a common multifactorial disease,causing various complications,such as chronic metabolism.The current therapies for diabetes mellitus are commercial diabetic drugs that have different definite side effect.However,polysaccharides mainly extracted from natural resources,have advantages of safety,accessibility,and anti-diabetic potential.We have summarized recent research of natural polysaccharides with hypoglycemic activities,focusing on different pharmacological mechanisms in various cell and animal models.The relationships of structure-hypoglycemic effect are also discussed in detail.This review could provide a comprehensive perspective for better understanding on development and mechanism of natural polysaccharides against diabetes mellitus,which have been required by clinical studies yet. 展开更多
关键词 POLYSACCHARIDES Hypoglycemic effect MECHANISMS Structure-activity relationship
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A novel binary effective medium model to describe the prepeak stressstrain relationship of combined bodies of rock-like material and rock 被引量:2
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作者 Tienan Wang Yue Zhai +2 位作者 Huan Gao Yubai Li Ruifeng Zhao 《International Journal of Mining Science and Technology》 SCIE EI CAS CSCD 2023年第5期601-616,共16页
Combined bodies of rock-like material and rock are widely encountered in geotechnical engineering,such as tunnels and mines.The existing theoretical models describing the stress-strain relationship of a combined body ... Combined bodies of rock-like material and rock are widely encountered in geotechnical engineering,such as tunnels and mines.The existing theoretical models describing the stress-strain relationship of a combined body lack a binary feature.Based on effective medium theory,this paper presents the governing equation of the“elastic modulus”for combined and single bodies under triaxial compressive tests.A binary effective medium model is then established.Based on the compressive experiment of concretegranite combined bodies,the feasibility of determining the stress threshold based on crack axial strain is discussed,and the model is verified.The model is further extended to coal-rock combined bodies of more diverse types,and the variation laws of the compressive mechanical parameters are then discussed.The results show that the fitting accuracy of the model with the experimental curves of the concretegranite combined bodies and various types of coal-rock combined bodies are over 95%.The crack axial strain method can replace the crack volumetric strain method,which clarifies the physical meanings of the model parameters.The variation laws of matrix parameters and crack parameters are discussed in depth and are expected to be more widely used in geotechnical engineering. 展开更多
关键词 Combined body stress-strain relationship Hooke’s law effective medium theory Stress threshold determination
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Screening hepatoprotective effective components of Lonicerae japonica Flos based on the spectrum-effect relationship and its mechanism exploring 被引量:1
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作者 Song Wang Lin Yang +4 位作者 Ajiao Hou Songtao Liu Liu Yang Haixue Kuang Hai Jiang 《Food Science and Human Wellness》 SCIE CSCD 2023年第1期283-294,共12页
Lonicerae japonicae Flos(LF)is a kind of healthcare food with hepatoprotective function.This study was designed to explore the spectrum-effect relationships between UPLC fingerprints and the hepatoprotective effects o... Lonicerae japonicae Flos(LF)is a kind of healthcare food with hepatoprotective function.This study was designed to explore the spectrum-effect relationships between UPLC fingerprints and the hepatoprotective effects of LF.Fingerprints of ten batches of LF were established by UPLC-PDA.The inhibitory levels of AST and ALT were used as pharmacological indexes,and secoxyloganin,isochlorogenic acid A and isochlorogenic acid C were screened as hepatoprotective active compounds by grey relational analysis(GRA)and partial least squares regression analysis(PLSR).Caspase-3 was obtained by network pharmacology as a key target of hepatoprotective active compounds.Molecular docking is used to explore the interaction between small molecules and proteins.This work provided a general model of the combination of UPLC-PDA and hepatoprotective effect to study the spectrum-effect relationship of LF,which can be used to considerable methods and insight for the fundamental research of the material basis of similar healthcare food. 展开更多
关键词 Lonicerae japonicae Flos Hepatoprotective effect Spectrum-effect relationship Molecular docking MECHANISM
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“Buckets effect”in the kinetics of electrocatalytic reactions 被引量:2
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作者 Haowen Cui Yan-Xia Chen 《Journal of Energy Chemistry》 SCIE EI CAS CSCD 2024年第2期388-396,I0010,共10页
In this study,we systematically investigated the effect of proton concentration on the kinetics of the oxygen reduction reaction(ORR)on Pt(111)in acidic solutions.Experimental results demonstrate a rectangular hyperbo... In this study,we systematically investigated the effect of proton concentration on the kinetics of the oxygen reduction reaction(ORR)on Pt(111)in acidic solutions.Experimental results demonstrate a rectangular hyperbolic relationship,i.e.,the ORR current excluding the effect of other variables increases with proton concentration and then tends to a constant value.We consider that this is caused by the limitation of ORR kinetics by the trace oxygen concentration in the solution,which determines the upper limit of ORR kinetics.A model of effective concentration is further proposed for rectangular hyperbolic relationships:when the reactant concentration is high enough to reach a critical saturation concentration,the effective reactant concentration will become a constant value.This could be due to the limited concentration of a certain reactant for reactions involving more than one reactant or the limited number of active sites available on the catalyst.Our study provides new insights into the kinetics of electrocatalytic reactions,and it is important for the proper evaluation of catalyst activity and the study of structureperformance relationships. 展开更多
关键词 Oxygen reduction reaction KINETICS Zero order Rectangular hyperbolic relationship pH effect
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More tree growth reduction due to consecutive drought and its legacy effect for a semiarid larch plantation in Northwest China
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作者 Yanfang Wan Pengtao Yu +5 位作者 Yanhui Wang Jiamei Li Yushi Bai Yipeng Yu Bingbing Liu Xiaocha Wei 《Journal of Forestry Research》 SCIE EI CAS CSCD 2024年第2期188-196,共9页
Extreme climate has increasingly led to negative impacts on forest ecosystems globally,especially in semiarid areas where forest ecosystems are more vulnerable.However,it is poorly understood how tree growth is affect... Extreme climate has increasingly led to negative impacts on forest ecosystems globally,especially in semiarid areas where forest ecosystems are more vulnerable.However,it is poorly understood how tree growth is affected by different drought events.In 2006–2009,the larch plantations in the semiarid areas of Northwest China were negatively affected by four consecutive dry years,which was a very rare phenomenon that may occur frequently under future climate warming.In this study,we analyzed the effect of these consecutive dry years on tree growth based on the data of the tree rings in the dominant layer of the forest canopy on a larch plantation.We found that the tree-ring width index(RWI)in dry years was lower than that in normal years,and it experienced a rapidly decreasing trend from 2006 to 2009(slope=-0.139 year^(-1),r=-0.94)due to water supply deficits in those dry years.Drought induced legacy effects of tree growth reduction,and consecutive dry years corresponded with greater growth reductions and legacy effects.Growth reductions and legacy effects were significantly stronger in the third and fourth consecutive dry years than that of single dry year(p<0.05),which might have been due to the cumulative stress caused by consecutive dry years.Our results showed that larch trees experienced greater tree growth reduction due to consecutive dry years and their legacy effect,and the trees had lower recovery rates after consecutive dry years.Our results highlight that consecutive dry years pose a new threat to plantations under climate warming,and thus,the effect of climate extremes on tree growth should be considered in growth models in semiarid areas. 展开更多
关键词 Tree rings Drought effects Legacy effects Growth-climate relationships Larix principis-rupprechtii
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Different mechanisms underlie similar species-area relationships in two tropical archipelagoes
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作者 Shengchun Li Tieyao Tu +5 位作者 Shaopeng Li Xian Yang Yong Zheng Liang-Dong Guo Dianxiang Zhang Lin Jiang 《Plant Diversity》 SCIE CAS CSCD 2024年第2期238-246,共9页
Despite much research in the field of island biogeography,mechanisms regulating insular diversity remain elusive.Here,we aim to explore mechanisms underlying plant species-area relationships in two tropical archipelag... Despite much research in the field of island biogeography,mechanisms regulating insular diversity remain elusive.Here,we aim to explore mechanisms underlying plant species-area relationships in two tropical archipelagoes in the South China Sea.We found positive plant species-area relationships for both coral and continental archipelagoes.However,our results showed that different mechanisms contributed to similar plant species-area relationships between the two archipelagoes.For coral islands,soil nutrients and spatial distance among communities played major roles in shaping plant community structure and species diversity.By contrast,the direct effect of island area,and to a lesser extent,soil nutrients determined plant species richness on continental islands.Intriguingly,increasing soil nutrients availability(N,P,K)had opposite effects on plant diversity between the two archipelagoes.In summary,the habitat quality effect and dispersal limitation are important for regulating plant diversity on coral islands,whereas the passive sampling effect,and to a lesser extent,the habitat quality effect are important for regulating plant diversity on continental islands.More generally,our findings indicate that island plant species-area relationships are outcomes of the interplay of both niche and neutral processes,but the driving mechanisms behind these relationships depends on the type of islands. 展开更多
关键词 Coral and continental islands Plant diversity Soil nutrients Species-area relationships The sampling effect
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Research on the path of effective management of participation in joint-venture railway companies by China railway group
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作者 Shaoni Zhou Zhitian Zhou Chenxia Kang 《Railway Sciences》 2024年第4期530-539,共10页
Purpose-Following the regional restructuring,the number of joint-venture railway companies in which the Group participates has significantly increased.This paper aims to explore the challenges faced by China Railway G... Purpose-Following the regional restructuring,the number of joint-venture railway companies in which the Group participates has significantly increased.This paper aims to explore the challenges faced by China Railway Group in managing participation in joint-venture railway companies.The study seeks to propose specific approaches to ensure the effective management of these companies,thereby maximizing the benefits of the regional restructuring and supporting the development of a strong transportation country and a modern infrastructure system.Design/methodology/approach-Based on the change in the shareholding relationship between China Railway Group and the joint-venture railway companies,and considering the current situation of the regional restructuring of these companies,as well as the insights from existing literature and typical case studies,this paper proposes some specific paths for effective management of joint-stock railway companies which China Railway Group participated in.Findings-The problems in participation management are the unclear dual leadership role of the party committee,the lack of discourse power,the lack of synergy between shareholders,the increasing risk of sustainable operation of the loss-making companies and the role of dispatched personnel is not fully played.Based on the theories,combined with the existing research and practical cases,the paper proposed specific approaches,such as perfecting top-level system design,maintaining the discourse power,carrying out differentiated management,arranging personnel rationally,arranging shareholders synergy,and innovating methods to provide references for China Railway Group’s subsequent management of joint venture railway companies.Originality/value-This paper contributes to the existing literature by providing a comprehensive analysis of the challenges faced by China Railway Group in managing participation in joint-venture railway companies following the regional restructuring.The study offers novel insights and practical recommendations for addressing these challenges.The findings can serve as valuable references for China Railway Group’s subsequent management of joint-venture railway companies which participated in,as well as for other stateowned enterprises facing similar challenges in managing their joint ventures. 展开更多
关键词 China railway group Joint venture railway companies Participated relationship effective management
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How to conduct an acupuncture dose–effect relationship study? A discussion based on study methodology 被引量:2
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作者 Boxuan Li Menglong Zhang +8 位作者 Sakhorn Ngaenklangdon Hailun Jiang Weiming Zhu Bifang Zhuo Chenyang Qin Yuanhao Lyu Yuzheng Du Shizhe Deng Zhihong Meng 《Acupuncture and Herbal Medicine》 2022年第4期221-228,共8页
Acupuncture therapy is widely used in the clinic,and its therapeutic effects have been proven by numerous studies.The dose–effect relationship of acupuncture is a fundamental aspect of the acupuncture research system... Acupuncture therapy is widely used in the clinic,and its therapeutic effects have been proven by numerous studies.The dose–effect relationship of acupuncture is a fundamental aspect of the acupuncture research system.Recent studies found that different acupuncture dosages altered study results directly,indicating the importance of screening the optimal stimulation dosage.However,the system for studying the acupuncture dose–effect relationship is still in its infancy,and the methodology of the system needs to be improved.This review aimed to define the factors impacting acupuncture“dosage”and“effect,”and to improve the methodological system for research on the dose–effect relationship of acupuncture.By summarizing the current findings of acupuncture dose–effect studies,we discussed the vital acupuncture parameters and methodological problems that influence the relationship between acupuncture dosage and its effects.These factors consist of specific influencing factors(acupoint selection,acupuncture manipulation parameters,de qi response)and nonspecific influencing factors(comparison selection,blinding procedure,patient expectancy).Our perspectives offer suggestions for the design of acupuncture dosage–effect trials.Further studies need to be conducted to establish the methodological system and provide systematic evidence of the acupuncture dose–effect relationship. 展开更多
关键词 ACUPUNCTURE Dose–effect relationship METHODOLOGY Review
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Effects of Selenium on Fusarium Growth and Associated Fermentation Products and the Relationship with Chondrocyte Viability 被引量:2
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作者 YIN Hong ZHANG Yan +3 位作者 ZHANG Feng HU Jin Tao ZHAO Yu Meng CHENG Bo Lun 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 2017年第2期134-138,共5页
This study determined the effects of selenium on the growth of Fusorium strains and the effects of products extracted from the fungal cultures on relevant indicators of chondrocytes injury.
关键词 effects of Selenium on Fusarium Growth and Associated Fermentation Products and the relationship with Chondrocyte Viability
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Spectrum-Effect Relationship Between High Performance Liquid Chromatography Fingerprints and Anticoccidial Activities of a Compound Chinese Medicine 被引量:5
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作者 XIAO Sui FEI Chen-zhong +3 位作者 ZHANG Li-fang ZHENG Wen-li ZHANG Ke-yu XUE Fei-qun 《Journal of Integrative Agriculture》 SCIE CAS CSCD 2014年第5期1082-1089,共8页
Quality control and screening of active substances in traditional Chinese medicines have been performed using fingerprint analysis. The spectrum-effect relationship between chromatography fingerprints and efficacy of ... Quality control and screening of active substances in traditional Chinese medicines have been performed using fingerprint analysis. The spectrum-effect relationship between chromatography fingerprints and efficacy of herbal drugs is considered as a potentially useful method for determining active ingredients in complex mixtures. The study was designed to develop a method for determining the bioactive components of a compound Chinese medicine called Tiefeng based on spectrum-effect relationships between high-performance liquid chromatography (HPLC) fingerprints and anticoccidial activities. Four peaks of the established HPLC fingerprint indicate the main bioactive components of this medicine. In addition, pharrnacodynamic atlas was defined and used to assess the anticoccidial activity of Tiefeng from different sources for the first time. We found that the level of anticoccidial activity of Tiefeng was consistent with the degree of similarity between the pharmacodynamic atlas and chromatogram of any sample. Furthermore, effect of this medicine was related with the main active constituents, along with the origin and the harvesting time. 展开更多
关键词 herb medicine FINGERPRINT anticoccidial index spectrum-effect relationship
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Spectrum-effect relationship between HPLC fingerprints and bioactive components of Radix Hedysari on increasing the peak bone mass of rat 被引量:6
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作者 Xin-Yue Chen San-Hu Gou +2 位作者 Zhi-Qiang Shi Zhi-Yuan Xue Shi-Lan Feng 《Journal of Pharmaceutical Analysis》 SCIE CAS CSCD 2019年第4期266-273,共8页
The traditional Chinese medicine of Radix Hedysari plays an important role in invigorating gas for ascending, benefiting blood for promoting production of fluid, and promoting circulation for removing obstruction in c... The traditional Chinese medicine of Radix Hedysari plays an important role in invigorating gas for ascending, benefiting blood for promoting production of fluid, and promoting circulation for removing obstruction in collaterals, which is consistent with the principle of treatment for osteoporosis. This study is designed to investigate the bioactive components on increasing peak bone mass (PBM) by exploring the spectrum-effect relationship between chromatography fingerprints and effect. Multiple indicators are selected to evaluate the pharmacological activity. In fingerprints, 21 common peaks are obtained, five of which are identified. Furthermore, gray relational analysis (GRA) is a quantitative method of gray system theory and is used to describe the correlation degree of common peaks and pharmacological activities with relational value. 21 components are then divided into three different regions, of which ononin and calycosin play an extremely significant role in increasing PBM. In addition, factor analysis and hierarchical cluster analysis (HCA) are used to screen the optimal producing area for Radix Hedysari. This provides a comprehensive and efficient method to improve the quality evaluation of Radix Hedysari, confirming the bioactive components for PBM-enhancement and further develop its medicinal value. 展开更多
关键词 Factor ANALYSIS GRAY RELATIONAL ANALYSIS Hierarchical cluster ANALYSIS PEAK BONE mass RADIX Hedysari Spectrum-effect relationship
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Combined effect of bicarbonate and water in photosynthetic oxygen evolution and carbon neutrality 被引量:1
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作者 Yanyou Wu 《Acta Geochimica》 EI CAS CSCD 2023年第1期77-88,共12页
Carbon neutrality is widely concerned and highly valued by many countries.Biosphere has always maintained the balance between oxidized organic substances and assimilated organic matter,resulting in netzero carbon diox... Carbon neutrality is widely concerned and highly valued by many countries.Biosphere has always maintained the balance between oxidized organic substances and assimilated organic matter,resulting in netzero carbon dioxide(CO_(2)) emissions and maintaining its own carbon neutrality.Nature has set a good example for human beings to coordinate oxygen(O_(2)) balance and CO_(2)balance,and achieve carbon neutrality.How does photosynthetic oxygen evolution initiate carbon and water neutrality?My synthesis shows that photo system Ⅱ functions as carbonic anhydrase to catalyze the reaction of CO_(2)hydration under physiological conditions,and CO_(2)hydration coupled with chemical equilibrium,H^(+)+HCO_(3)^(-)→1/2O_(2)+2e^(-)+2H^(+)+CO_(2),occurs in a photosystem Ⅱ corecomplex.Meanwhile,I focused on the revisiting of four classical heavy oxygen(O^(18)) labeling experiments and found that bicarbonate can promote photo synthetic oxygen evolution,and that photo synthetic oxygen evolution can alternately come from bicarbonate and water,not only water.Bicarbonate photolysis and water photolysis account for half of the photo synthetic oxygen evolution respectively,which can well explain the bicarbonate effect,Dole effect and plants’ environmental adaptability.Photosynthetic oxygen evolution initiated the journey of water metabolism and carbon metabolism in nature,which led to the coupling as 1:1(mol/mol) stoichiometric relationship between the reduction of CO_(2)and oxidation of organic carbon,coordinated the evolution of the atmosphere,hydrosphere,lithosphere and biosphere,and realized "carbon neutrality" in the whole Earth system. 展开更多
关键词 Bicarbonate photolysis Bicarbonate effect Carbonic anhydrase Dole effect Water photolysis Stoichiometric relationship Carbon metabolism
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Mediating role of physical activity in the relationship between psychological distress and intimate relationships among stroke patients 被引量:1
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作者 Chang-Yue Luo Peng Jiao +2 位作者 Shu-Min Tu Lin Shen Yong-Mei Sun 《World Journal of Psychiatry》 SCIE 2023年第12期1096-1105,共10页
BACKGROUND Stroke patients often experience psychological distress,which can impact their intimate relationships with spouses,subsequently influencing their treatment and recovery.Physical activity is considered a key... BACKGROUND Stroke patients often experience psychological distress,which can impact their intimate relationships with spouses,subsequently influencing their treatment and recovery.Physical activity is considered a key rehabilitation method for stroke patients.This paper aims to analyze whether psychological distress affects intimate relationship between spouses through physical activity.AIM To explore the mediating effect of physical activity between psychological distress and intimate relationship in stroke patients.METHODS A total of 256 stroke patients who underwent treatment at the First People’s Hospital of Shangqiu between July 2021 and July 2022 were enrolled in this study.The participants completed questionnaires,including the Kessler Psychological Distress Scale(K10),the Quality of Relationship Index(QRI),International Physical Activity Questionnaire,and a general information questionnaire.Data analysis were performed using SPSS 23.0.The Harman test was employed to detect common method deviations,and Spearman correlation was used for correlation analysis.The mediating effect was assessed using Process 3.4.1,with significance testing of the regression coefficients conducted using the bias-corrected percentile Bootstrap method(5000 iterations,95%confidence interval).Statistical significance was set at P<0.05.RESULTS The results showed that patients scored an average of 21.61±6.44 points on the K10,32.40±6.19 points on the QRI;the median physical activity level according to the International Physical Activity Questionnaire was 1861(566,2846)MET·min/w.The level of physical activity(the physical activity intensity of the patients reflected by the Interna-tional Physical Activity Questionnaire-Long Form scale)negatively correlated with psychological distress and intimacy(P<0.05),and positively correlated with each other(P<0.05),with the correlation stronger at lower physical activity levels compared to higher ones.The mediating effect of physical activity between psychological distress and intimate relationship was calculated to be 40.23%.Bootstrap analysis further validated the results.The mediating effect of psychological distress on intimate relationships through physical activity level was-0.284,with a confidence interval of-0.409 to-0.163,excluding 0,confirming a significant mediating effect of psychological distress on intimate relationships.CONCLUSION Physical activity significantly affects relationship between psychological distress and intimate relationships among stroke patients.Addressing the role of physical activity may have implications for improving patient outcomes and rehabilitation strategies. 展开更多
关键词 STROKE Cross-sectional study Psychological distress Intimate relationship Mediating effect Physical activity level
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Dose-dependent effects of pentabrominated diphenyl ethers on sexual hormone and histology of male reproductive system in rats
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作者 Lingyan Yuan Meiqing Fan Ping Zhan 《Journal of Biomedical Science and Engineering》 2012年第6期302-306,共5页
Polybrominated diphenyl ethers (PBDEs) used as flame retardants are widely used in a variety of consumer products, like textiles, foam and building materials. They are persistent in the environment, and increasing lev... Polybrominated diphenyl ethers (PBDEs) used as flame retardants are widely used in a variety of consumer products, like textiles, foam and building materials. They are persistent in the environment, and increasing levels of PBDEs have been found both biota and human tissue samples. In the present study we examined the dose-dependent effects of pentabrominated diphenyl ether (PBDE-99) on the serum hormone and histology of reproductive system in male rats. 40 health 4-week-old SD rats were divided into 4 groups randomly. The treated rats were orally administered with BDE-99 at the dose of 60,120 or 180 mg/kg, while controls received equal volume of corn oil. We examined the changes of serum hormone levels, histopathology, and PCNA after 30 days exposure to BDE-99. With increasing doses of BDE-99, testis organ coefficient increased, serum hormone levels lower, PCNA positive expression reduced, and the degeneration of seminiferous epithelium were revealed in treated group. These indicators with significant dose-effect relationship showed that BDE-99 can reduce the serum sex hormone levels and cause severe degeneration of seminiferous epithelium. 展开更多
关键词 Pentabrominated DIPHENYL ETHERS Male REPRODUCTIVE System the relationship of dose-effect
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The Difference Between Males and Females Regarding the Effect of Children on Relationships
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作者 Sarah Kadzomba 《Psychology Research》 2013年第5期243-251,共9页
关键词 儿童 女性 男性 人际关系 社会关系 津巴布韦 非结构化 数据收集
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The Relationship between the Plasmodium Falciparum Clearance and the Clinical Effect of the Case with Cerebral Malaria Treated with Artemisinin
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作者 Guo-li Lin Hong Shi +3 位作者 Yuan-kai Wu Xiang-yong Li Jian-hua Huang Wei-min Ke 《国际感染病学(电子版)》 CAS 2014年第3期129-132,共4页
Malaria is 1 mosquito-borne disease,which is most commonly caused by a parasite called Plasmodium falciparum(P.falciparum).Cerebral malaria is the most severe neurological complication presented in
关键词 The relationship between the Plasmodium Falciparum Clearance and the Clinical effect of the Case with Cerebral Malaria Treated with Artemisinin RBC Figure Email
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壳三糖对帕金森病小鼠氧化应激的影响
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作者 王斌 闫华 +4 位作者 姜启兴 许艳顺 刘晓丽 杨方 夏文水 《食品与发酵工业》 CAS CSCD 北大核心 2024年第10期10-16,共7页
帕金森病(Parkinson′s disease,PD)的重要发病机制之一是氧化应激,而壳寡糖具有较好的抗氧化活性且在PD等神经性疾病中具有良好的保护效果。将小鼠分为空白组、模型组、低剂量组(35 mg/kg)、中剂量组(70 mg/kg)和高剂量组(140 mg/kg),... 帕金森病(Parkinson′s disease,PD)的重要发病机制之一是氧化应激,而壳寡糖具有较好的抗氧化活性且在PD等神经性疾病中具有良好的保护效果。将小鼠分为空白组、模型组、低剂量组(35 mg/kg)、中剂量组(70 mg/kg)和高剂量组(140 mg/kg),利用1-甲基-4-苯基-1,2,3,6-四氢吡啶(1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine,MPTP)对小鼠腹腔注射诱导PD模型,并通过行为学、病理指标和氧化应激相关指标对各组小鼠进行评估,探究了壳三糖对于PD小鼠保护效果的量效关系及保护机制。结果显示,低中高3个剂量组壳三糖均能缓解PD小鼠的行为学障碍和纹状体中酪氨酸羟化酶(tyrosine hydroxylase,TH)表达量的减少,且中剂量组效果最佳。壳三糖干预显著降低了PD小鼠纹状体中丙二醛(malondialdehyde,MDA)含量,提高了还原型谷胱甘肽(glutathione,GSH)含量、总抗氧化能力(total antioxidant capacity,T-AOC)以及过氧化氢酶(catalase,CAT)、超氧化物歧化酶(superoxide dismutase,SOD)的表达,上调了核因子E2相关因子(NF-E2-related factor 2,Nrf2)/血红素氧化酶(heme oxygenase,HO-1)信号通路。结果表明,中剂量壳三糖对MPTP诱导的PD有更明显的缓解作用,其作用机制可能是通过提高抗氧化酶表达和上调Nrf2/HO-1信号通路,降低PD小鼠氧化应激从而缓解PD。 展开更多
关键词 壳三糖 帕金森病 氧化应激 神经保护 量效关系
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乳酸对电加热卷烟气溶胶不同形态烟碱释放规律的影响
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作者 何红梅 刘献军 +6 位作者 饶先立 郑晓云 李朝建 王鸣 石怀彬 徐如彦 尤晓娟 《中国烟草学报》 CAS CSCD 北大核心 2024年第4期10-20,共11页
【目的】探索调控加热卷烟劲头与刺激之间平衡的方法,提高加热卷烟感官舒适度。【方法】基于二氯甲烷-水双相萃取体系的加热卷烟游离态烟碱测定方法,考察了乙酸、丙酸及乳酸3种酸类香料对电加热卷烟不同形态烟碱释放规律的影响。【结果... 【目的】探索调控加热卷烟劲头与刺激之间平衡的方法,提高加热卷烟感官舒适度。【方法】基于二氯甲烷-水双相萃取体系的加热卷烟游离态烟碱测定方法,考察了乙酸、丙酸及乳酸3种酸类香料对电加热卷烟不同形态烟碱释放规律的影响。【结果】①乳酸最能影响气溶胶中游离态烟碱释放量。②除烟芯材料总烟碱外,烟芯材料pH值、游离态烟碱含量、游离态烟碱系数以及气溶胶pH值、游离态烟碱释放量、总烟碱释放量、烟碱转移率均呈现随乳酸增加而降低趋势。③乳酸施加量与烟芯材料、气溶胶关键指标之间存在较强的线性量效关系。④随抽吸口序的递增,气溶胶游离态烟碱系数整体呈可识别的下降趋势,前6口下降趋势更为明显,表明游离态烟碱更倾向于在抽吸前6口释放出来。【结论】可通过乳酸对气溶胶总烟碱及游离态烟碱释放进行定量控制,使加热卷烟在劲头与刺激之间取得平衡,改善高烟碱释放量加热卷烟的感官舒适度。 展开更多
关键词 电加热卷烟 乳酸 气溶胶 游离态烟碱 量效关系 逐口
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Relationship between biological features and the SMVS's inhibitory effect on mating behavior of Nilaparvata lugens (Stal)
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作者 FU Qiang and ZHANG Zhitao, CNRRI, Hangzhou 310006, China 《Chinese Rice Research Newsletter》 1997年第3期3-4,共2页
Our previous studies revealed that second malevibration signal (SMVS) restrained the matingbehavior of N. lugens, the influences of threebiological features (density, age, and wingform) on SMVS’s inhibitory effect we... Our previous studies revealed that second malevibration signal (SMVS) restrained the matingbehavior of N. lugens, the influences of threebiological features (density, age, and wingform) on SMVS’s inhibitory effect were hereinstudied by playing back its record. The dura-tion of playback was 4 h. Except otherwisestatement, N. lugens tested were virginmacropterous males and females aged 4-6 d af-ter emergence, and the density was 5 pairs (5females and 5 males) of N. lugens per cage (4cm in diameter and 8 cm in height). The in-hibitory effect of SMVS was evaluated usingmating rate (i. e. the rate of females withspermatophore). The results were as follows: 展开更多
关键词 Stal relationship between biological features and the SMVS’s inhibitory effect on mating behavior of Nilaparvata lugens
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水土保持生态建设下的黄土高原典型流域水沙响应 被引量:2
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作者 赵阳 张永娥 +4 位作者 王昭艳 张国军 辛艳 刘冰 魏小燕 《中国水土保持科学》 CSCD 北大核心 2024年第1期21-26,共6页
为探讨黄土高原多沙粗沙区流域水沙关系演变特征及其对水土流失治理的响应,以黄河中游无定河流域为研究对象,综合采用水沙关系曲线、数理统计等多种方法,系统分析1956—2019年间无定河流域水沙关系多时间尺度演变特征及其与水土流失治... 为探讨黄土高原多沙粗沙区流域水沙关系演变特征及其对水土流失治理的响应,以黄河中游无定河流域为研究对象,综合采用水沙关系曲线、数理统计等多种方法,系统分析1956—2019年间无定河流域水沙关系多时间尺度演变特征及其与水土流失治理的协同响应。研究结果表明:1)研究时段内,无定河流域年径流及年输沙量呈锐减趋势(P<0.05),且均在1970年左右发生减少突变;2)流域水沙关系在年际和场次洪水尺度上均发生深刻变化。2010年以后,暴雨频发导致流域内侵蚀物源头供应明显增加,流域河道泥沙输送能力小幅提高;3)水土保持措施实施对流域水沙锐减影响较大。2000年前后在相似降雨条件下,单位降雨量径流量和单位降雨量输沙量较20世纪70年代减少47%和62%。水土保持措施面积增加与流域径流输沙减少呈现较好的一致性,流域水土流失治理在提高黄河多沙粗沙区流域下垫面抗侵蚀能力等方面发挥重要作用。研究结果可为科学认知区域水土流失治理成效及入黄泥沙锐减成因提供参考。 展开更多
关键词 水沙关系 极端暴雨 土壤侵蚀 治理成效 黄河
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