Comparison of different methods of nasogastric tube insertion in anesthetized and intubated patients: A meta-analysis

BACKGROUND Several techniques of nasogastric tube(NGT)insertion have been described in the literature with different success rates.AIM To systematically search the literature and conduct a meta-analysis comparing the success rates,insertion time and complications associated with different techniques of NGT insertion in anesthetized and intubated patients.METHODS An electronic search of the PubMed,Scopus,CENTRAL(Cochrane Central Register of Controlled Trials),and Google Scholar databases were performed up to October 31,2019.We included 17 randomized controlled trials with 2500 participants in the meta-analysis.RESULTS As compared to the conventional method,successful insertion of the NGT on first attempt was higher with modified techniques such as the reverse Sellick’s maneuver[relative risk(RR)1.94;95%confidence interval(CI):1.62-2.31],use of a frozen NGT(RR 1.55;95%CI:1.13-2.13),inserting the NGT with neck flexion and lateral neck pressure(RR 1.64;95%CI:1.10-2.45),endotracheal tube-assisted(RR 1.88;95%CI:1.52-2.32)and video-assisted placements(RR 1.60;95%CI:1.31-1.95).All the modified techniques also led to comparatively higher insertion success rates than the conventional technique.CONCLUSION The use of modified techniques of NGT insertion such as the reverse Sellick’s maneuver,neck flexion with lateral neck pressure,frozen NGT,endotracheal tube-guided or video-assisted methods result in a significantly better chance of successful tube insertion at first attempt as compared to the conventional technique.All modified techniques also significantly improve the overall chance of successful NGT placement as compared to the conventional method.

Emergent use of tube tip in pharynx technique in“cannot intubate cannot oxygenate”situation:A case report

BACKGROUND A“cannot intubate,cannot oxygenate(CICO)”situation is a life-threatening condition that requires emergent management to establish a route for oxygenation to prevent oxygen desaturation.In this paper,we describe airway management in a patient with an extended parotid tumor that invaded the airways during CICO using the endotracheal tube tip in the pharynx(TTIP)technique.CASE SUMMARY A 43-year-old man was diagnosed with parotid tumor for>10 years.Computed tomography and nasopharyngeal fiberoptic examination revealed a substantial mass from the right parotid region with a deep extension through the lateral pharyngeal region to the retropharyngeal region and obliteration of the nasopharynx to the oropharynx.Tumor excision was arranged.However,we encountered CICO during anesthesia induction.An endotracheal tube was used as an emergency supraglottic airway device(TTIP)to ventilate the patient in a CICO situation where other tools such as laryngeal mask airway or mask ventilation were not suitable for this complicated and difficult airway.The patient did not experience desaturation despite sudden loss of definite airway.During tracheostomy,the pulse oximetry remained 100%with our technique of ventilating the patient.The arterial blood gas analysis revealed PaCO_(2)35.7 mmHg and PaO2242.5 mmHg upon 50%oxygenation afterward.CONCLUSION Using an endotracheal tube as a supraglottic airway device,patients may have increased survival without experiencing life-threatening desaturation.

Effects of Tube Depth and Infusion Rate of Continuous Humidification by Endotracheal Intubation on Humidification Effect

Objective: To investigate the continuous humidification tube insertion depth of endotracheal intubation and the flow rate of the wetting effect. Methods: From October 2008 to May 2010, among 132 patients of oral and maxillofacial surgery with tracheal intubation, continuous infusion can be adjusted to the wet method;according to the wet pipe, insertion depth of the flow rate is divided into four groups, by four different depths and velocities of the wetting effect, to be analyzed. Results: B group was significantly lower than other groups satisfied with indicators of four significantly different effects of humidification. Conclusion: When continuous humidification tube insertion depth of endotracheal intubation is 10 - 12 cm, and flow rate is 15 - 20 ml/h, the wetting effect will achieve greater satisfaction.

新型一次性气管插管固定器在无痛胃镜中的临床应用效果

目的探讨新型一次性气管插管固定器在无痛胃镜中的临床应用效果。方法根据无痛胃镜中使用的固定器,将患者分为两组,对照组采用传统塑料咬口,观察组采用新型一次性气管插管固定器(胃镜保),两组患者均行无痛胃镜检查。运用倾向评分匹配,消除两组混杂因素后,分析影响不良反应的相关因素。进一步比较两组患者经皮动脉血氧饱和度(SpO2)、一次性插管成功率、进镜时间、置管稳固性、医护人员吸痰和供氧便捷性情况。结果1∶1匹配后,对照组和观察组各纳入患者124例,两组患者临床资料比较,差异无统计学意义(P>0.05),各变量达到均衡,匹配良好。结果表明,观察组躁动、咬口脱出、胃镜咬瘪和咽痛发生率明显低于对照组(P<0.05)。进一步分析,两组患者检查前SpO2和心率(HR)比较,差异无统计学意义(P>0.05);检查中,对照组HR较检查前明显加快,SpO2明显降低,差异均有统计学意义(P<0.05);观察组变化不明显。观察组插管固定后稳定性和一次性插管成功率明显高于对照组,进镜时间明显短于对照组,差异均有统计学意义(P<0.05)。另外,观察组吸痰和供氧便捷性更高。单因素和多因素Logistic回归分析表明,年龄>70岁、BMI≥24 kg/m^(2)和未采用新型一次性气管插管固定器,是导致无痛胃镜检查中不良反应发生的独立危险因素。结论无痛胃镜检查中使用新型一次性气管插管固定器,安全性和操作便捷性高,值得临床推广使用。

Univent Tube在双腔管插管困难病例中的应用

目的 观察UniventTube用于双腔管插管困难开胸手术的价值。方法 利用UniventTube插管容易 ,管径较细 ,可用光导引导插管等特点 ,对 8例气管造瘘后、病人气管细小、小下颌等病例 ,采用UniventTube进行开胸手术的单肺通气。结果 8例困难病例中 ,UniventTube均能很好解决开胸手术单肺通气问题 ,无一例出现与UniventTube相关的合并症。结论 UniventTube操作简单 ,效果确切 ,能很好解决传统双腔管一些难以解决的问题。但由于UniventTube自身存在一些缺陷 ,如价格昂贵、吸引不畅、对位困难等 ,所以UniventTube不能全部替代传统双腔管用于开胸手术单肺通气。

自制弯金属吸引管用于气管切开手术引导插管的临床效果

目的探讨在气管切开手术插管困难时,以自制的弯金属吸引管为引导进行插管的效果。方法对特定患者,先将气管套管套入弯制好的金属吸引管且靠近后端,然后在鼻内镜辅助观察或直视下,将吸引管前端插入气管内,随即将气管套管沿着吸引管身往前推,插入气管。结果能确保气管套管插入气管内,减少了盲目插管失败引起窒息的风险。结论在鼻内镜辅助观察或直视下,使用自制弯金属吸引管用于气管切开手术插管困难患者的引导插管,可提高插管成功率。但手工弯制质量不稳定,期望未来医疗器械厂批量生产此器械。

左双腔气管导管两种插管方法的比较

目的探讨头正中位左双腔气管导管(DLT)逆时针旋转90°与头右偏位左DLT逆时针旋转180°两种插管方法的左主支气管插管成功率。方法选取2021年12月至2022年6月北京协和医院胸外科拟接受左DLT插管的肺切除术患者648例,随机分为90°组和180°组,每组324例,其中,90°组采用患者头正中位、左DLT支气管套囊越过声门后逆时针旋转90°的传统插管方法进行插管;180°组采用患者头右偏位、左下颌角与胸骨正中对齐左DLT逆时针旋转180°的方法进行插管。比较两组患者左DLT置入左主支气管的插管成功率以及隆突黏膜损伤情况。结果648例患者中,男336例,女312例,年龄39.0~75.0岁,平均(54.6±9.0)岁。90°组和180°组首次插管成功率分别为80.3%、75.0%,差异无统计学意义(P=0.109)。180°组第2次插管成功率显著高于90°组(P<0.001)。90°组和180°组插管后隆突黏膜损伤率分别为23.8%、25.6%,差异无统计学意义(P=0.585)。结论与传统插管方法相比,患者头右偏位、左DLT逆时针旋转180°的插管方法不能提高首次左主支气管插管的成功率,但作为一种补救插管方法可以提高再次左主支气管插管的成功率。

改良正压拔管技术在ICU经口气管插管拔除时的效果

目的探讨改良正压拔管技术在ICU经口气管插管拔除时的临床效果。方法选取2022年1月至2023年4月岑溪市人民医院收治的124例ICU患者作为研究对象,按照掷硬币法将其分为试验组(63例)与对照组(61例),试验组采用改良正压拔管技术,对照组采用传统负压拔管技术。比较两组患者拔管前和拔管后1、15min的生命体征(包括心率、血压、呼吸、血氧饱和度)以及拔管后的并发症发生率。结果两组患者拔管后1min时的收缩压均高于本组拔管前时;试验组拔管后15min时的平均动脉压低于本组拔管前和拔管后1min时;试验组拔管后15min时的呼吸慢于本组拔管后1min时,对照组拔管后1min时的呼吸快于本组拔管前时;两组患者拔管后1min时的血氧饱和度均低于本组拔管前时,差异有统计学意义(P<0.05)。试验组拔管后15min的高血压、心动过速、氧饱和度下降、呼吸急促、严重咳嗽、咽喉疼痛、上气道痉挛的发生率均低于对照组,差异有统计学意义(P<0.05);两组患者的拔管失败发生率比较,差异无统计学意义(P>0.05)。结论两种技术在ICU经口气管插管拔除后1min均会引起收缩压升高、血氧饱和度降低,但改良正压拔管技术所带来的并发症发生率较低,值得临床应用和推广。

加速康复外科理念指导的双腔气管插管麻醉在胸腔镜肺癌手术中的应用

目的:探讨胸腔镜非小细胞肺癌手术中采用加速康复外科(ERAS)理念指导的双腔气管插管麻醉管理对术后麻醉苏醒质量及安全的影响。方法:选取2021年12月至2023年3月行胸腔镜肺叶切除术的95例非小细胞肺癌患者作为研究对象,根据信封法将其随机分为ERAS组(n=48)与对照组(n=47)。对照组采用常规管理+双腔气管插管全麻方案,ERAS组在对照组基础上实施ERAS理念管理。比较两组手术时间、住院时间、住院费用、术后恢复自主呼吸时间、苏醒时间、拔管时间及手术前后肿瘤坏死因子-α、降钙素原、C-反应蛋白水平,并统计不良反应及肺部并发症发生率。结果:两组手术时间差异无统计学意义(P>0.05);ERAS组住院费用少于对照组,住院时间、恢复自主呼吸时间、苏醒时间及拔管时间均短于对照组(P<0.05),术后肿瘤坏死因子-α、降钙素原及C-反应蛋白水平低于对照组(P<0.05)。两组术后不良反应、肺部并发症发生率差异无统计学意义(P>0.05)。结论:胸腔镜非小细胞肺癌手术中应用ERAS理念指导的双腔气管插管麻醉管理可有效改善患者苏醒质量,缩短住院时间,降低炎症因子水平,促进康复进程。

预见性护理在ICU气管插管非计划拔管中的应用探究

探讨预见性护理在ICU气管插管非计划拔管中的应用及效果。将河北省人民医院2020年5月—2021年5月入住ICU的120例气管插管患者随机分为观察组和对照组,每组各60例。观察组采用预见性护理的方法对气管插管患者进行护理,对照组采用常规护理方法,观察两组患者气管插管的非计划拔管率、平均住院时间及患者满意度情况。结果显示,观察组气管插管非计划拔管发生率为3.33%,显著低于对照组的13.33%,差异有统计学意义(P<0.05);观察组患者的平均住院时间为(9.93±3.05)d,显著短于对照组的(11.62±3.35)d,差异有统计学意义(P<0.05);观察组患者的满意度为93.33%,显著高于对照组患者的83.33%,差异有统计学意义(P<0.05)。研究发现,预见性护理可降低气管插管非计划拔管的发生率,缩短患者平均住院时间,提高患者的满意度,值得在临床推广应用。

A prospective randomized trial of transnasal ileus tube vs nasogastric tube for adhesive small bowel obstruction

AIM:To study the therapeutic efficacy of a new transnasal ileus tube advanced endoscopically for adhesive small bowel obstruction.METHODS:A total of 186 patients with adhesive small bowel obstruction treated from September 2007 to February 2011 were enrolled into this prospective randomized controlled study.The endoscopically advanced new ileus tube was used for gastrointestinal decompression in 96 patients and ordinary nasogastric tube(NGT) was used in 90 patients.The therapeutic efficacy was compared between the two groups.RESULTS:Compared with the NGT group,the ileus tube group experienced significantly shorter time for relief of clinical symptoms and improvement in the findings of abdominal radiograph(4.1 ± 2.3 d vs 8.5 ± 5.0 d) and laboratory tests(P < 0.01).The overall effectiveness rate was up to 89.6% in the ileus tube group and 46.7% in the NGT group(P < 0.01).And 10.4% of the patients in the ileus tube group and 53.3% of the NGT group underwent surgery.For recurrent adhesive bowel obstruction,ileus tube was also significantly more effective than NGT(95.8% vs 31.6%).In the ileus tube group,the drainage output on the first day and the length of hospital stay were significantly different depending on the treatment success or failure(P < 0.05).The abdominal radiographic improvement was correlated with whether or not the patient underwent surgery.CONCLUSION:Ileus tube can be used for adhesive small bowel obstruction.Endoscopic placement of the ileus tube is convenient and worthy to be promoted despite the potential risks.

Critical importance of tracheal tube cuff pressure management

The ideal range for tracheal tube cuff pressures is usually taken to be between 20 to 30 cm H2 O. This is easily measured with a cuff pressure manometer and should be measured in each instance. The importanceof tracheal tube cuff pressures is highlighted by the spectrum of airway complications that can occur with incorrect cuff pressures. High cuff pressures can result in complications ranging from sore throat and hoarseness to tracheal stenosis, necrosis, and even rupture. In such cases, the postulated causative factor is diminished blood flow to tracheal mucosa due to excessive cuff pressure on the tracheal wall. This hypothesized ischemic injury then produces healing fibrosis months or even years later. On the other hand, cuff pressures that are too low place the patient at risk for aspiration of gastric contents and consequently, aspiration pneumonitis and pneumonia. This is why the authors recommend that cuff pressures be measured following all intubations.

重症卒中患者早期不同气道开放方式对肺部感染及气管插管的影响

目的 研究重症卒中患者早期应用口咽通气管或鼻咽通气管的临床应用效果。方法 连续纳入2020年6月—2022年6月首都医科大学附属北京天坛医院急诊抢救室收治的重症卒中患者,根据患者留置口咽通气管、鼻咽通气管、未留置口/鼻咽通气管分为口咽通气管组、鼻咽通气管组、对照组,对其临床资料进行回顾性分析。比较各组间临床特征、入院7 d内肺部感染发生情况、序贯气管插管转化率及转化时间。结果 共纳入213例重症卒中患者,男性123例,脑出血119例,脑梗死94例。鼻咽通气管组79例,口咽通气管组68例,对照组66例。鼻咽通气管组入院7 d内误吸发生率低于对照组(10.13%vs. 19.70%,P=0.034)及口咽通气管组(10.13%vs. 22.06%,P=0.021)。鼻咽通气管组入院7 d内肺部感染发生率低于对照组(32.91%vs. 59.09%,P=0.018)与口咽通气管组(32.91%vs. 45.59%,P=0.023)。鼻咽通气管组、口咽通气管组、对照组三组7 d院内全因死亡率(30.38%vs. 32.35%vs. 34.84%,P=0.660)整体差异无统计学意义。鼻咽通气管组7 d内气管插管转化率低于口咽通气管组(12.66%vs. 44.12%,P=0.022)与对照组(12.66%vs. 43.94%,P=0.031)。鼻咽通气管组气管插管转化时间较口咽通气管组[(6.72±2.15)d vs.(4.12±1.23)d,P=0.022]、对照组[(6.72±2.15)d vs.(3.12±1.33)d,P=0.011]延长。入院7 d血气分析可见鼻咽通气管组[(83.56±8.31)mmHg vs.(76.34±8.63)mmHg,P=0.007]及口咽通气管组[(84.56±5.84)mmHg vs.(76.34±8.63)mmHg,P=0.003]血氧分压高于对照组,而鼻咽通气管组[(37.67±11.22)mmHg vs.(48.56±9.62)mmHg,P=0.012]及口咽通气管组[(36.45±17.53)mmHg vs.(48.56±9.62)mmHg,P=0.009]二氧化碳分压低于对照组。结论 重症卒中早期给予口咽通气管或鼻咽通气管开放气道能改善呼吸道不畅,提高血氧分压、降低二氧化碳潴留。但鼻咽通气管与口咽通气管相比,可减少卒中后误吸的发生,降低肺部感染概率,延缓气管插管转化时间,降低气管插管转化率,缩短住院时间。

A Comparison of the Best Place to Fix Endotracheal Tubes for Men and Women When Men and Women Are in the Same Height

Background: Comparison of the tracheal tube depth over the same body height of men and women based upon intubation depth markings. Methods: Kashan University of Medical Sciences ethics committee approved the study and written informed consent was taken for each patient. Patients undergoing surgery requiring general anesthesia with oro-tracheal intubation were included in a prospective observational study. After induction of general anesthesia, the endotracheal tube was secured at the point at which the cuff was just below the vocal cord on laryngoscopy. Results: In a statistical study of 682 intubated patients which consisted of 499 women and 183 men, 28 cases of laryngoscopic view grade III and IV were excluded from the study. The measurement markings on the ETT at the level of right corner of the mouth were 20.65 ± 0.13 and 18.52 ± 0.08 for men and women respectively (CI 95%). Patient’s height has a meaningful correlation with the measurement of the fixation point of the ETT. Pearson correlation coefficient between the securing point of the tube and height was 0.2 and 0.357 for men and women respectively. In most cases of men and women of the same height, Mann-Whitney U test rejected the hypothesis that the tube can be fixed in the particular point. Conclusions: In general, men are taller than women. Comparing the fixation depth of the tube, even when man and woman have the same body height, the endotracheal tube might be placed in a deeper level for men rather than women.

重症超声评估流程在机械通气撤机拔管中的应用价值

目的探讨重症超声评估流程在机械通气撤机拔管中的应用价值。方法选取2021年1至10月于英德市人民医院重症医学科(ICU)采用机械通气的208例患者作为研究对象,按时间段将其分为对照组102例与研究组106例,其中2021年1至5月患者作为对照组,2021年6至10月患者作为研究组。对照组经治疗在撤离呼吸机拔除气管插管前,根据主管医生对患者体格检查、影像学及实验室检查结果评估,决定是否拔管。研究组在对照组的基础上,采用自行设计程序化重症超声评估流程,对机械通气患者心功能、肺部影像状况、膈肌功能及吞咽功能量化评估,决定是否拔管。比较两组患者机械通气时间、ICU平均住院时间、ICU气管插管拔管后48 h内再插管率、ICU转出后48 h内重返率。结果研究组患者的机械通气时间和ICU平均住院时间均短于对照组,差异有统计学意义(P<0.05)。研究组患者的ICU气管插管拔管后48 h内再插管率和ICU转出后48 h内重返率均低于对照组,差异有统计学意义(P<0.05)。结论自行设计程序化重症超声评估流程决定是否拔出气管插管,能缩短患者机械通气时间和ICU平均住院时间,降低ICU气管插管拔管后48 h内再插管率和ICU转出后48 h内重返率。

3种形状气囊导管对气囊上滞留物封闭效果的实验研究

目的探讨3种形状气囊导管对不同黏稠度气囊上滞留物的封闭效果,为临床气道管理提供参考。方法用20 mL注射器制作9个气管模型分为3组,每组锥形、柱形、梭形气囊导管各1根。使用持续测压仪予导管气囊充气并维持压力29~30 cmH2O,将机械通气患者气囊上Ⅰ度、Ⅱ度、Ⅲ度滞留物分别注入气囊导管上,观察30、60、120、240、360、480 min气囊上滞留物的渗漏情况。不同黏稠度滞留物每组重复操作10次。结果3种形状气囊导管不同黏稠度滞留物、不同观察时间渗漏量比较,差异有统计学意义(均P<0.05)。结论锥形气囊的封闭效果最好,柱形气囊次之,梭形气囊最差;随着时间延长,各形状气囊导管均会渗漏。建议临床可选用带冲洗式的柱形或锥形气囊导管,及时冲洗及抽吸气囊上滞留物,以预防经口咽途径的呼吸机相关性肺炎的发生。

针对性护理应用于患者留置胃管及对插管效果的研究

目的探讨针对性护理措施在患者留置胃管中的应用及对插管效果的研究。方法选择2021年1月—2021年7月采取过留置胃管的280例患者作为本次研究的对象;采用随机数表法分为两组,对照组(137例)和试验组(143例);对照组给予常规的护理方法,试验组采取针对性护理;对比两组患者的负面情绪、舒适情况以及插管成功率。结果试验组同对照组相比,前者在SAS评分方面以及焦虑患者数量方面均明显低于后组(P<0.05);在舒适度方面,试验组极微不适的患者分别占比为54.55%,而对照组极微不适的患者占比仅为9.49%,前组明显高于后组(P<0.05);试验组难以忍受的患者占比低至0.00%,明显低于对照组的占比19.71%(P<0.05);试验组同对照组患者相比,前组患者的一次成功率高达93.01%,明显高于对照组71.53%的一次成功率(P<0.05)。结论在患者的留置胃管过程中,给予其针对性护理措施能够很大程度上缓解患者的负面情绪,提高舒适度和一次插管的成功率,应广泛应用于临床治疗过程中。

插管式机器人空管状态检测方法

针对利用插管式机器人在巡视络筒机设备时,存在无法检测储管纱圆盘均匀排布孔内是否存在管纱的问题,提出了一种基于图像识别的空管状态检测方法。结合络筒机及插管式机器人工作机制,将集嵌入式控制系统、相机模组于一体的空管检测机构固定在竖直机械立柱上,并随插管式机器人做水平往复直线运动。嵌入式控制系统通过捕获插管式机器人发送的锭位信号,实现该锭位储管纱圆盘图像采集,通过学习、调节、分块定域、矫正等准备环节及分级处理环节进行图像处理,并将处理后各均匀排布孔内管纱的实时情况经由通信接口传输至插管式机器人。最后搭建实验平台,进行空管状态检测稳定性测试。结果表明,本文方法检测效果稳定、准确度高,且成本低、安装简单,便于实际工程应用。

胸椎旁阻滞联合非气管插管麻醉对胸腔镜术中血流动力学的影响

目的分析胸腔镜手术应用胸段椎旁置管阻滞联合非插管麻醉的临床应用效果。方法选择2018年4月-2020年6月在某院行胸腔镜手术患者117例,按随机数字表法分为2组,研究组76例,采用胸段椎旁置管阻滞复合非气管插管麻醉下进行,对照组41例,采用气管插管麻醉下进行。比较两组的临床手术指标、血流动力学指标以及并发症情况。结果研究组患者的麻醉优良率89.47%高于对照组的73.17%,手术时间、麻醉时间、术后禁食时间、开始进食时间、术后住院时间、下地活动时间均短于对照组(P<0.05),术后护理强度、术后6 h VAS评分低于对照组(P<0.05);观察组在T_(1)-T_(7)时间点的SBP、DBP、MAP、HR水平明显低于对照组(P<0.05),PET_(CO2)水平(除在T_(7)时间点)明显高于对照组(P<0.05),且与T_(0)时间点比较,两组在T_(1)-T_(6)时间点的以上指标,差异有明显统计学意义(P<0.05);研究组患者的并发症发生率明显低于对照组(P<0.05)。结论胸段椎旁置管阻滞麻醉复合非气管插管应用于胸腔镜手术具有麻醉效果好,生命体征稳定,且保留患者自主呼吸,术后恢复快。

LISA技术联合NCPAP治疗新生儿呼吸窘迫综合征的有效性分析

目的:探究经胃管注入肺表面活性物质(pulmonary surfactant,PS)治疗(LISA技术)联合新生儿持续气道正压通气(neonatal continuous positive airway pressure ventilation,NCPAP)治疗新生儿呼吸窘迫综合征的有效性。方法:选取2021年7月-2022年10月于阳江市人民医院就诊的80例符合入组标准的呼吸窘迫综合征新生儿作为本次研究对象。根据随机数表法将患儿分为对照组和研究组,各40例。研究组应用LISA技术联合NCPAP治疗,对照组应用经气管插管注入PS技术(INSURE技术)联合NCPAP治疗。比较两组治疗前后动脉血气指标、近期治疗效果及并发症发生情况。结果:两组治疗前及治疗后1 h、12 h、24 h血p H值、动脉血氧分压(arterial partial pressure of oxygen,PaO_(2))和动脉血二氧化碳分压(arterial partial pressure of carbon dioxide,PaCO_(2))比较,差异无统计学意义(P>0.05);治疗后1 h、12 h、24 h,两组血pH值、PaO2较治疗前均升高,PaCO_(2)较治疗前均降低,差异有统计学意义(P<0.05)。研究组治疗总有效率为92.5%,高于对照组的85.0%,但两组比较差异无统计学意义(P>0.05)。研究组并发症发生率为7.5%,显著低于对照组的32.5%,差异有统计学意义(P<0.05)。结论:LISA技术联合NCPAP方案治疗新生儿呼吸窘迫综合征有良好的效果,可以有效改善血pH值、PaO_(2)及PaCO_(2)水平,降低术后并发症发生率。