<strong>Background: </strong>Adhesive tape is the common method for endotracheal tube (ETT) secured to prevent tube displacement and unplanned extubation in an anesthesia setting. However, it is unclear wh...<strong>Background: </strong>Adhesive tape is the common method for endotracheal tube (ETT) secured to prevent tube displacement and unplanned extubation in an anesthesia setting. However, it is unclear which tape is superior for ETT fixation among the various tapes used in clinical practice. This study examines the force required to move 2 cm ETT and extubate ETT from an intubation manikin with five different adhesive tapes. <strong>Methods:</strong> We orally intubated an adult intubation manikin with an inner-diameter 7.5 mm ETT, inflated the cuff to 20 cm H<sub>2</sub>O. Then we secured ETT with five different adhesive tapes (Transpore tape<sup>TM</sup>, Urgosyval tape<span style="white-space:nowrap;"><sup>®</sup></span>, Transpore<sup>TM </sup>White tape, Multipore tape, Durapore<sup>TM</sup> tape) in a conventional fixation method. A digital force gauge was connected to the ETT and pulled in a direction erected to the oral cavity. We measured the force required to move 2 cm ETT and extubate ETT (defined as 5 cm ETT displacement) from the manikin. Data were analyzed with one-way analysis of variance, with <em>P</em> < 0.05. <strong>Results:</strong> Durapore<sup>TM</sup> tape had the largest average force of 2 cm displacement (58.9 ± 5.7N) (<em>P</em> < 0.05). The extubation force of Durapore<sup>TM</sup> tape (59.7 ± 4.9N) was larger than Urgosyval<span style="font-size:10px;"><sup>®</sup></span> tape (40.4 ± 2.9N) (<em>P</em> < 0.05), Transpore<sup>TM</sup> tape (48.7 ± 5.1N) (<em>P</em> < 0.05), Transpore White<sup>TM</sup> tape (48.7 ± 5.1N) (<em>P</em> < 0.05).<strong> Conclusion: </strong>Durapore<sup>TM</sup> tape was superior to the other four tapes (Transpore<sup>TM</sup> tape, Urgosyval<span style="font-size:10px;"><sup>®</sup></span> tape, Transpore<sup>TM</sup> white tape, Multipore tape) in holding the ETT in place in the manikin.展开更多
More and more attention is being focused on saline water utilization in irrigation due to the shortage of fresh water to agriculture in many regions. For purpose of reducing the risks of using of saline water for irri...More and more attention is being focused on saline water utilization in irrigation due to the shortage of fresh water to agriculture in many regions. For purpose of reducing the risks of using of saline water for irrigation, the mechanism of soil moisture and salinity distribution and transport should be well understood for developing optimum management strategies. In this paper, field experiments were carried out at Junggar Basin, China, to study the effects of drip irrigation water quality and drip tape arrangement on distribution of soil salinity and soil moisture. Six treatments were designed, including two drip tape arrangement modes and three irrigation water concentration levels (0.24, 4.68, and 7.42 dS m^-l). Results showed that, soil moisture content (SMC) directly beneath the drip tape in all treatments kept a relatively high value about 18% before boll opening stage; the SMC in the narrow strip in single tape arrangement (Ms) plot was obviously lower than that in the double tapes arrangement (Md) plot, indicating that less sufficient water was supplied under the same condition of irrigation depth, but there was no significant reduction in yield. Mulching had not significant influence on salt accumulation but the drip tape arrangement, under the same condition of irrigation water depth and quality, compared with Md, Ms reduced salt accumulation in root zone and brought about relatively high cotton yield.展开更多
A retained bile duct stone after operation for cholelithiasis still occurs and causes symptoms such as biliary colic and obstructive jaundice.An endoscopic retrograde cholangiopancreatography with endoscopic sphincter...A retained bile duct stone after operation for cholelithiasis still occurs and causes symptoms such as biliary colic and obstructive jaundice.An endoscopic retrograde cholangiopancreatography with endoscopic sphincterotomy(EST),followed by stone extraction,are usually an effective treatment for this condition.However,these procedures are associated with severe complications including pancreatitis,bleeding,and duodenal perforation.Nitrates such as glyceryl trinitrate(GTN) and isosorbide dinitrate(ISDN) are known to relax the sphincter of Oddi.In 6 cases in which a retained stone was detected following cholecystectomy,topical nitrate drip infusion via cystic duct tube(C-tube) was carried out.Retained stones of 2-3 mm diameter and no dilated common bile duct in 3 patients were removed by drip infusion of 50 mg GTN or 10 mg ISDN,which was the regular dose of intravenous injection.Three other cases failed,and EST in 2 cases and endoscopic biliary balloon dilatation in 1 case were performed.One patient developed an adverse event of nausea.Severe complications were not observed.We consider the topical nitrate drip infusion via C-tube to be old but safe,easy,and inexpensive procedure for retained bile duct stone following cholecystectomy,inasmuch as removal rate was about 50% in our cases.展开更多
Evaporation loss from the saturated soil beneath drip irrigation emitters highly influences the irrigation efficiency of drip krigation (D1]. Subsurface drip irrigation (SDI) is one good approach to curb this ineff...Evaporation loss from the saturated soil beneath drip irrigation emitters highly influences the irrigation efficiency of drip krigation (D1]. Subsurface drip irrigation (SDI) is one good approach to curb this inefficiency, but in a new irrigation method, straight tube irrigation (STI), the irrigation tubes do not need to be buried and thus STI is recommended to increase the irrigation efficiency under normal surface-applied DI. STI consists of only connectors and water-transference tubes that can directly transfer irrigation water from the lateral emitters in the drip line to the root zone of plants. Five-month field experiments were carried out in aeolian sand soil in the forest-belts of the Taklimakan Desert, which have poor water storage capacity, to compare the potential water saving between STI and DI. The preliminary results showed that, compared with DI, STI (1) improved the soil water content in soil depths from 40 to 100 cm under the soil surface; (2) achieved the same irrigation effects in relatively shorter irrigation durations; (3) had very little water loss due to deep seepage; and (4) formed a layer of dry sand about 10 to 30 cm thick immediately below the soil surface, which lessened evaporation loss of soil water beneath the emitters on the soil surface. This demonstrates that STI can maximize the water-saving potential of DI through the reduction of wetted soil perimeters on the soil surface. This is valuable information for water-saving engineering applications and projects with STI in arid and semiarid regions.展开更多
目的:分析长沙某院儿童静脉输液时输液管与针头分离的原因,探讨相应的对策,保障儿童输液安全。方法:回顾性选取2020年11月-2021年10月于长沙妇幼保健院门诊输液过程中发生输液管针头脱出输液瓶塞的400例患儿作为研究对象,收集患儿临床资...目的:分析长沙某院儿童静脉输液时输液管与针头分离的原因,探讨相应的对策,保障儿童输液安全。方法:回顾性选取2020年11月-2021年10月于长沙妇幼保健院门诊输液过程中发生输液管针头脱出输液瓶塞的400例患儿作为研究对象,收集患儿临床资料,分析输液管针头脱出输液瓶塞的原因。结果:400例患儿男236例(59.00%),女164例(41.00%);≤3岁311例(77.75%),4~7岁89例(22.25%);留置针输液122例(30.50%),非留置针输液278例(69.50%);输液部位在头部186例(46.50%),输液部位在手部195例(48.75%),输液部位在脚部19例(4.75%);发生于春季78例(19.50%),发生于夏季106例(26.50%),发生于秋季106例(26.50%),发生于冬季脱落110例(27.50%);输液第1天脱落170例(42.50%),输液第2天脱落162例(40.50%),输液第3、4天脱落68例(17.00%);输液时长0~30 min 177例(44.25%),输液时长31~60 min 145例(36.25%),输液时长>60 min 78例(19.50%)。400例患儿发生输液管与穿刺针头分离的主要原因为患儿玩耍拉扯、患儿哭吵躁动。不同性别、有无留置针患儿发生玩耍拉扯、哭吵躁动率比较,差异无统计学意义(P>0.05);≤3岁患儿发生玩耍拉扯、哭吵躁动率高于>3岁患儿,输液部位在手部时,患儿发生玩耍拉扯、哭吵躁动率高于输液部位在头部与脚部,输液季节在冬季时,患儿发生玩耍拉扯、哭吵躁动率高于其他季节,输液第1天,患儿发生玩耍拉扯、哭吵躁动率最高,输液时长31~60 min时,患儿最易发生玩耍拉扯、哭吵躁动,差异有统计学意义(P<0.05)。结论:长沙某院儿童静脉输液时输液管针头脱出输液瓶塞的主要原因为患儿玩耍拉扯、患儿哭吵躁动,此外还与患儿年龄、输液部位、输液季节、输液天次、输液时长有关,建议加强对患儿及家属的个性化健康教育,提供舒适的输液环境,以提高输液安全意识,保障儿童健康。展开更多
BACKGROUND: Thoracostomy tube insertion is one of the common bedside procedures in emergency medicine and many acute specialties. Dislodgement of thoracostomy tube from the connection tube of chest drainage system is ...BACKGROUND: Thoracostomy tube insertion is one of the common bedside procedures in emergency medicine and many acute specialties. Dislodgement of thoracostomy tube from the connection tube of chest drainage system is an important problem with potential complications such as contamination, infection and pneumothorax. Besides, mere loosening can also lead to malfunction. It is a common practice to tape the connection of the system. This study aimed to evaluate the materials and methods of connection of chest drain system to minimize drainage dislodgement. METHODS: We conducted an experimental study to assess the tightness of the connection with various taping materials and methods. We selected three commonly used adhesive materials(3M^(tm) Transpore^(tm) Medical tape, 3M^(tm) Micropore^(tm) Medical tape, 3M^(tm) Soft Cloth Tape on Liner) and three different methods(cross method, straight method, nylon band) to secure the junction between the thoracostomy tube and the bi-conical adaptor in the drainage system. The measured outcome was the weight causing visible loosening of the junction between thoracotomy tube and the adaptor.RESULTS: For each taping material and taping method, 10 trials were performed. The median weight required to disconnect the junction is 26.22 lb for Transpore^(tm), 31.29 lb for Micropore^(tm) and 32.44 lb for Soft Cloth Tape on Liner. A smaller force was required to disconnect if Transpore^(tm) is used(P<0.001). There was no statistical signifi cant difference between Micropore^(tm) and Soft Cloth Tape on Liner(P=0.98). The median disconnecting force is 32.44 lb for straight taping method, 40.55 lb for cross taping method and 21.15 lb for plastic band. The cross-taping method was the more secure method(P<0.0001 when compared with plastic band)(P=0.033 when compared with straight method).CONCLUSION: Cross-taping is the most secure method among the tested varieties in connecting the thoracostomy tube to the chest drainage system. Transpore^(tm) is not a recommended material for thoracostomy tube taping.展开更多
An experimental study was carried out to investigate the influence of double twisted-tape inserts (DTs) in micro-fin tubes (MFs) on heat transfer, friction factor and thermal performance factor characteristics of ...An experimental study was carried out to investigate the influence of double twisted-tape inserts (DTs) in micro-fin tubes (MFs) on heat transfer, friction factor and thermal performance factor characteristics of the compound devices in the following configurations: (1) twisted tapes acted in the same direction (for co-swirl) while MF and twisted tapes acted in the same (parallel) direction (MF-CoDTs:P), (2) twisted tapes acted in the same direction (for co-swirl) while micro-fin tube and twisted tapes acted in opposite directions (MF-CoDTs:O) and (3) twisted tapes acted in opposite directions for counter swirl (MF-CDTs). The MF alone and the MF equipped with a single twisted tape in parallel/opposite arrangement were also considered for comparison. The experiments were conducted for the flows with the Reynolds numbers between 5 650 and 17 000, under uniform heat flux condition. The experimental results indicate that MF-CDTs induce stronger swirl/turbulence flow, resulting in higher heat transfer rate, friction factor and thermal performance factor than other combined devices. The thermal performance factors associated with the use of MF-CDTs were found to be higher than those associated with the uses of MF-CoDTs:P, MF-CoDTs:O and MF alone up to 9.3%, 6.5% and 56.4%, respectively. The empirical correlations developed using the present experimental data for the Nusselt number, friction factor and thermal performance factor are also reported.展开更多
We have investigated the effects of ZrC and ZrB2 doping on the superconducting properties of the powder-in-tube processed MgB2/Fe tapes. Sam- ples were characterized by X-ray diffraction (XRD), scanning electron micro...We have investigated the effects of ZrC and ZrB2 doping on the superconducting properties of the powder-in-tube processed MgB2/Fe tapes. Sam- ples were characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM/EDX), transport and magnetic measurements. We confirmed the fol- lowing quite different roles of ZrC and ZrB2 in MgB2. ZrC doping was found to decrease the transport critical current density (Jc) at 4.2 K, while the critical temperature (Tc) kept constant. In contrast, the Jc values in magnetic fields were enhanced greatly by the ZrB2 addition, which resulted in a decrease in Tc by only 0.5 K. The reason for different effects of two dopants is also discussed.展开更多
基金Supported by the State Key Development Program for Basic Research of China (No.G2000263001) and the National Natural Science Foundation of China (No.20776046).
文摘<strong>Background: </strong>Adhesive tape is the common method for endotracheal tube (ETT) secured to prevent tube displacement and unplanned extubation in an anesthesia setting. However, it is unclear which tape is superior for ETT fixation among the various tapes used in clinical practice. This study examines the force required to move 2 cm ETT and extubate ETT from an intubation manikin with five different adhesive tapes. <strong>Methods:</strong> We orally intubated an adult intubation manikin with an inner-diameter 7.5 mm ETT, inflated the cuff to 20 cm H<sub>2</sub>O. Then we secured ETT with five different adhesive tapes (Transpore tape<sup>TM</sup>, Urgosyval tape<span style="white-space:nowrap;"><sup>®</sup></span>, Transpore<sup>TM </sup>White tape, Multipore tape, Durapore<sup>TM</sup> tape) in a conventional fixation method. A digital force gauge was connected to the ETT and pulled in a direction erected to the oral cavity. We measured the force required to move 2 cm ETT and extubate ETT (defined as 5 cm ETT displacement) from the manikin. Data were analyzed with one-way analysis of variance, with <em>P</em> < 0.05. <strong>Results:</strong> Durapore<sup>TM</sup> tape had the largest average force of 2 cm displacement (58.9 ± 5.7N) (<em>P</em> < 0.05). The extubation force of Durapore<sup>TM</sup> tape (59.7 ± 4.9N) was larger than Urgosyval<span style="font-size:10px;"><sup>®</sup></span> tape (40.4 ± 2.9N) (<em>P</em> < 0.05), Transpore<sup>TM</sup> tape (48.7 ± 5.1N) (<em>P</em> < 0.05), Transpore White<sup>TM</sup> tape (48.7 ± 5.1N) (<em>P</em> < 0.05).<strong> Conclusion: </strong>Durapore<sup>TM</sup> tape was superior to the other four tapes (Transpore<sup>TM</sup> tape, Urgosyval<span style="font-size:10px;"><sup>®</sup></span> tape, Transpore<sup>TM</sup> white tape, Multipore tape) in holding the ETT in place in the manikin.
基金supported by the National Natural Science Foundation of China(40771097)the Special Fund of Industrial(Agriculture)Research for Public Welfare of China(200903001)
文摘More and more attention is being focused on saline water utilization in irrigation due to the shortage of fresh water to agriculture in many regions. For purpose of reducing the risks of using of saline water for irrigation, the mechanism of soil moisture and salinity distribution and transport should be well understood for developing optimum management strategies. In this paper, field experiments were carried out at Junggar Basin, China, to study the effects of drip irrigation water quality and drip tape arrangement on distribution of soil salinity and soil moisture. Six treatments were designed, including two drip tape arrangement modes and three irrigation water concentration levels (0.24, 4.68, and 7.42 dS m^-l). Results showed that, soil moisture content (SMC) directly beneath the drip tape in all treatments kept a relatively high value about 18% before boll opening stage; the SMC in the narrow strip in single tape arrangement (Ms) plot was obviously lower than that in the double tapes arrangement (Md) plot, indicating that less sufficient water was supplied under the same condition of irrigation depth, but there was no significant reduction in yield. Mulching had not significant influence on salt accumulation but the drip tape arrangement, under the same condition of irrigation water depth and quality, compared with Md, Ms reduced salt accumulation in root zone and brought about relatively high cotton yield.
文摘A retained bile duct stone after operation for cholelithiasis still occurs and causes symptoms such as biliary colic and obstructive jaundice.An endoscopic retrograde cholangiopancreatography with endoscopic sphincterotomy(EST),followed by stone extraction,are usually an effective treatment for this condition.However,these procedures are associated with severe complications including pancreatitis,bleeding,and duodenal perforation.Nitrates such as glyceryl trinitrate(GTN) and isosorbide dinitrate(ISDN) are known to relax the sphincter of Oddi.In 6 cases in which a retained stone was detected following cholecystectomy,topical nitrate drip infusion via cystic duct tube(C-tube) was carried out.Retained stones of 2-3 mm diameter and no dilated common bile duct in 3 patients were removed by drip infusion of 50 mg GTN or 10 mg ISDN,which was the regular dose of intravenous injection.Three other cases failed,and EST in 2 cases and endoscopic biliary balloon dilatation in 1 case were performed.One patient developed an adverse event of nausea.Severe complications were not observed.We consider the topical nitrate drip infusion via C-tube to be old but safe,easy,and inexpensive procedure for retained bile duct stone following cholecystectomy,inasmuch as removal rate was about 50% in our cases.
基金Tarim Oilfield Corporation of China National Petroleum Corporation for providing funds
文摘Evaporation loss from the saturated soil beneath drip irrigation emitters highly influences the irrigation efficiency of drip krigation (D1]. Subsurface drip irrigation (SDI) is one good approach to curb this inefficiency, but in a new irrigation method, straight tube irrigation (STI), the irrigation tubes do not need to be buried and thus STI is recommended to increase the irrigation efficiency under normal surface-applied DI. STI consists of only connectors and water-transference tubes that can directly transfer irrigation water from the lateral emitters in the drip line to the root zone of plants. Five-month field experiments were carried out in aeolian sand soil in the forest-belts of the Taklimakan Desert, which have poor water storage capacity, to compare the potential water saving between STI and DI. The preliminary results showed that, compared with DI, STI (1) improved the soil water content in soil depths from 40 to 100 cm under the soil surface; (2) achieved the same irrigation effects in relatively shorter irrigation durations; (3) had very little water loss due to deep seepage; and (4) formed a layer of dry sand about 10 to 30 cm thick immediately below the soil surface, which lessened evaporation loss of soil water beneath the emitters on the soil surface. This demonstrates that STI can maximize the water-saving potential of DI through the reduction of wetted soil perimeters on the soil surface. This is valuable information for water-saving engineering applications and projects with STI in arid and semiarid regions.
文摘目的:分析长沙某院儿童静脉输液时输液管与针头分离的原因,探讨相应的对策,保障儿童输液安全。方法:回顾性选取2020年11月-2021年10月于长沙妇幼保健院门诊输液过程中发生输液管针头脱出输液瓶塞的400例患儿作为研究对象,收集患儿临床资料,分析输液管针头脱出输液瓶塞的原因。结果:400例患儿男236例(59.00%),女164例(41.00%);≤3岁311例(77.75%),4~7岁89例(22.25%);留置针输液122例(30.50%),非留置针输液278例(69.50%);输液部位在头部186例(46.50%),输液部位在手部195例(48.75%),输液部位在脚部19例(4.75%);发生于春季78例(19.50%),发生于夏季106例(26.50%),发生于秋季106例(26.50%),发生于冬季脱落110例(27.50%);输液第1天脱落170例(42.50%),输液第2天脱落162例(40.50%),输液第3、4天脱落68例(17.00%);输液时长0~30 min 177例(44.25%),输液时长31~60 min 145例(36.25%),输液时长>60 min 78例(19.50%)。400例患儿发生输液管与穿刺针头分离的主要原因为患儿玩耍拉扯、患儿哭吵躁动。不同性别、有无留置针患儿发生玩耍拉扯、哭吵躁动率比较,差异无统计学意义(P>0.05);≤3岁患儿发生玩耍拉扯、哭吵躁动率高于>3岁患儿,输液部位在手部时,患儿发生玩耍拉扯、哭吵躁动率高于输液部位在头部与脚部,输液季节在冬季时,患儿发生玩耍拉扯、哭吵躁动率高于其他季节,输液第1天,患儿发生玩耍拉扯、哭吵躁动率最高,输液时长31~60 min时,患儿最易发生玩耍拉扯、哭吵躁动,差异有统计学意义(P<0.05)。结论:长沙某院儿童静脉输液时输液管针头脱出输液瓶塞的主要原因为患儿玩耍拉扯、患儿哭吵躁动,此外还与患儿年龄、输液部位、输液季节、输液天次、输液时长有关,建议加强对患儿及家属的个性化健康教育,提供舒适的输液环境,以提高输液安全意识,保障儿童健康。
文摘BACKGROUND: Thoracostomy tube insertion is one of the common bedside procedures in emergency medicine and many acute specialties. Dislodgement of thoracostomy tube from the connection tube of chest drainage system is an important problem with potential complications such as contamination, infection and pneumothorax. Besides, mere loosening can also lead to malfunction. It is a common practice to tape the connection of the system. This study aimed to evaluate the materials and methods of connection of chest drain system to minimize drainage dislodgement. METHODS: We conducted an experimental study to assess the tightness of the connection with various taping materials and methods. We selected three commonly used adhesive materials(3M^(tm) Transpore^(tm) Medical tape, 3M^(tm) Micropore^(tm) Medical tape, 3M^(tm) Soft Cloth Tape on Liner) and three different methods(cross method, straight method, nylon band) to secure the junction between the thoracostomy tube and the bi-conical adaptor in the drainage system. The measured outcome was the weight causing visible loosening of the junction between thoracotomy tube and the adaptor.RESULTS: For each taping material and taping method, 10 trials were performed. The median weight required to disconnect the junction is 26.22 lb for Transpore^(tm), 31.29 lb for Micropore^(tm) and 32.44 lb for Soft Cloth Tape on Liner. A smaller force was required to disconnect if Transpore^(tm) is used(P<0.001). There was no statistical signifi cant difference between Micropore^(tm) and Soft Cloth Tape on Liner(P=0.98). The median disconnecting force is 32.44 lb for straight taping method, 40.55 lb for cross taping method and 21.15 lb for plastic band. The cross-taping method was the more secure method(P<0.0001 when compared with plastic band)(P=0.033 when compared with straight method).CONCLUSION: Cross-taping is the most secure method among the tested varieties in connecting the thoracostomy tube to the chest drainage system. Transpore^(tm) is not a recommended material for thoracostomy tube taping.
基金the Thailand Research Fund (TRF),Office of Higher Education Commission and Mahanakorn University of Technology (MUT) for financial support of this research(Grant No.MRG5480026)
文摘An experimental study was carried out to investigate the influence of double twisted-tape inserts (DTs) in micro-fin tubes (MFs) on heat transfer, friction factor and thermal performance factor characteristics of the compound devices in the following configurations: (1) twisted tapes acted in the same direction (for co-swirl) while MF and twisted tapes acted in the same (parallel) direction (MF-CoDTs:P), (2) twisted tapes acted in the same direction (for co-swirl) while micro-fin tube and twisted tapes acted in opposite directions (MF-CoDTs:O) and (3) twisted tapes acted in opposite directions for counter swirl (MF-CDTs). The MF alone and the MF equipped with a single twisted tape in parallel/opposite arrangement were also considered for comparison. The experiments were conducted for the flows with the Reynolds numbers between 5 650 and 17 000, under uniform heat flux condition. The experimental results indicate that MF-CDTs induce stronger swirl/turbulence flow, resulting in higher heat transfer rate, friction factor and thermal performance factor than other combined devices. The thermal performance factors associated with the use of MF-CDTs were found to be higher than those associated with the uses of MF-CoDTs:P, MF-CoDTs:O and MF alone up to 9.3%, 6.5% and 56.4%, respectively. The empirical correlations developed using the present experimental data for the Nusselt number, friction factor and thermal performance factor are also reported.
基金This work was supported by the National Natural Science Foundation of China(Grant No.50472063).
文摘We have investigated the effects of ZrC and ZrB2 doping on the superconducting properties of the powder-in-tube processed MgB2/Fe tapes. Sam- ples were characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM/EDX), transport and magnetic measurements. We confirmed the fol- lowing quite different roles of ZrC and ZrB2 in MgB2. ZrC doping was found to decrease the transport critical current density (Jc) at 4.2 K, while the critical temperature (Tc) kept constant. In contrast, the Jc values in magnetic fields were enhanced greatly by the ZrB2 addition, which resulted in a decrease in Tc by only 0.5 K. The reason for different effects of two dopants is also discussed.