Drug combination based on synergistic effect is commonly used in clinical practice,especially in the application of traditional medicine.Exploring the combination mechanism could help to better utilize this synergisti...Drug combination based on synergistic effect is commonly used in clinical practice,especially in the application of traditional medicine.Exploring the combination mechanism could help to better utilize this synergistic advantage.However,current research focuses more on the efficacy enhancing of drugs,while ignoring the toxicity reducing effects.Here,we established two drug synergy patterns based on the different situations of drugs and targets,in order to better illuminate the synergistic mechanism of drugs.展开更多
[ Objective] This paper aimed to understand drug resistance of Escherichia coli isolated from pets in Guangzhou. I Method ] Broth microdilution method was used to determine the minimal inhibitory concentration （MIC）...[ Objective] This paper aimed to understand drug resistance of Escherichia coli isolated from pets in Guangzhou. I Method ] Broth microdilution method was used to determine the minimal inhibitory concentration （MIC） of ceftiofur, enrofloxacin and other 11 kinds of antibiotics for antimicrobial agent susceptibility testing of 120 strains of clinical E. coli and the experimental data were processed by WHONET 5.4 software. Based on the results of drug resistance pattern analysis, it helped to analyze and study the resistance mechanism. EResultl Clinical E. coli isolated from pets showed a different drug resistance to the 13 kinds of veterinary clinical antibiotics, and the different sources of E. coli also showed a different drug resistance pattern.[Cenclmion] The study provided a theoretical basis for the clinical use of drugs and druq resistance surveillance.展开更多
Background:Based on the theory of"cancer toxin"in traditional Chinese medicine(TCM),combined with data mining method,this paper discusses the prescription and medication law of macroscopic"cancer toxin&...Background:Based on the theory of"cancer toxin"in traditional Chinese medicine(TCM),combined with data mining method,this paper discusses the prescription and medication law of macroscopic"cancer toxin".Methods Sort out the relevant prescriptions of macroscopic"cancer toxin"and carry out correlation analysis.Results The results showed that the main therapeutic drugs for macroscopic"cancer toxin"were invigorating the spleen and Qi,regulating the Qi mechanism,eliminating toxin and pathogenic factors,eliminating dampness and swelling,promoting blood circulation and removing blood stasis,attacking toxin,softening and firmness,and dredging collaterals to relieve pain.Conclusion High frequency medicine embodies the core of tangible macroscopic"cancer toxin"treatment,and the new prescription composition embodies the fundamental treatment.At the same time,the mechanism of macroscopic"cancer toxin"was analyzed to pave the way for further clinical practice.展开更多
基金This work was supported by the National Natural Science Foundation of China(No.82003982,82274313,82204746).
文摘Drug combination based on synergistic effect is commonly used in clinical practice,especially in the application of traditional medicine.Exploring the combination mechanism could help to better utilize this synergistic advantage.However,current research focuses more on the efficacy enhancing of drugs,while ignoring the toxicity reducing effects.Here,we established two drug synergy patterns based on the different situations of drugs and targets,in order to better illuminate the synergistic mechanism of drugs.
基金supported by the Special Fund Project for the Institute Science and Technology Development and Demostration Extention of Henan Provincial Academy of Argricultural Sciences(Research of Zoonotic Small Animal Diseases)the Project for the 2012 Annual"University Students'Innovation Training Program",Southwest University for Nationalities(201210656017)the Special Fund Project for the Central University Basic Scientific Research Fund,Southwest University for Nationalities(11NZYTD02)
文摘[ Objective] This paper aimed to understand drug resistance of Escherichia coli isolated from pets in Guangzhou. I Method ] Broth microdilution method was used to determine the minimal inhibitory concentration （MIC） of ceftiofur, enrofloxacin and other 11 kinds of antibiotics for antimicrobial agent susceptibility testing of 120 strains of clinical E. coli and the experimental data were processed by WHONET 5.4 software. Based on the results of drug resistance pattern analysis, it helped to analyze and study the resistance mechanism. EResultl Clinical E. coli isolated from pets showed a different drug resistance to the 13 kinds of veterinary clinical antibiotics, and the different sources of E. coli also showed a different drug resistance pattern.[Cenclmion] The study provided a theoretical basis for the clinical use of drugs and druq resistance surveillance.
文摘Background:Based on the theory of"cancer toxin"in traditional Chinese medicine(TCM),combined with data mining method,this paper discusses the prescription and medication law of macroscopic"cancer toxin".Methods Sort out the relevant prescriptions of macroscopic"cancer toxin"and carry out correlation analysis.Results The results showed that the main therapeutic drugs for macroscopic"cancer toxin"were invigorating the spleen and Qi,regulating the Qi mechanism,eliminating toxin and pathogenic factors,eliminating dampness and swelling,promoting blood circulation and removing blood stasis,attacking toxin,softening and firmness,and dredging collaterals to relieve pain.Conclusion High frequency medicine embodies the core of tangible macroscopic"cancer toxin"treatment,and the new prescription composition embodies the fundamental treatment.At the same time,the mechanism of macroscopic"cancer toxin"was analyzed to pave the way for further clinical practice.
