This paper was to develop a weft-knitted stent coated by a drng-loaded electro-spun fibrous membrane and then investigate its morphology, mechan/cal properties and in vitro drug release property. This work was started...This paper was to develop a weft-knitted stent coated by a drng-loaded electro-spun fibrous membrane and then investigate its morphology, mechan/cal properties and in vitro drug release property. This work was started by weft-knitting of an inner layer of such stent using polydioxanone （PDO） and silkf＇dment. Subsequently, 5-fluorouracil （5-FU） and curcnmin（CUR） loaded silk fibroin （SF） membranes were coated on the surface of the weft- knitted stent using electro-spinning technique to endow the drug delivery funct/on of the stent. The results show that the radial compression strength and c/renmferentlal expanding strength can reach above （9.1±0.4） cN/cm2 and （205.0± 0.2） cN/mm, respectively. The drug releasing behaviors can be sustained for 400 h. It is concluded that the stents have potential application as anintestinal stent in the future.展开更多
The drug release behavior of degradable polymer--polycaprolactone-poly (ethyleneglycol)block copolymer(PCE) in vitro was investigated by using 5-Fluoro-uracil (5-Fu) asa model drug under a condition of pH 7. 4 at 37C....The drug release behavior of degradable polymer--polycaprolactone-poly (ethyleneglycol)block copolymer(PCE) in vitro was investigated by using 5-Fluoro-uracil (5-Fu) asa model drug under a condition of pH 7. 4 at 37C. It is found that the release rate of 5-Fufrom PCE increased with increasing polyether content of the copolymer. The results showthat the increasing polyether content of the copolymer caused increasing hydrophilicity anddecreasing crystallinity of the PCE copolymer. Thus, the drug release behavior and thedegradable property of the PCE can be controlled by adjusting the composition of thecopolymer.展开更多
基金National Natural Science Foundation of China(No.51603140)Natural Science Foundation of Jiangsu Province,China(No.BK20150372)+2 种基金University Science Research Project of Jiangsu Province,China(No.16KJB540003)Key Industry Technology Innovation,Science and Technology Project of Suzhou,China(No.SYG201638)Sino-Germany Joint Project,China(No.GZ1094)
文摘This paper was to develop a weft-knitted stent coated by a drng-loaded electro-spun fibrous membrane and then investigate its morphology, mechan/cal properties and in vitro drug release property. This work was started by weft-knitting of an inner layer of such stent using polydioxanone （PDO） and silkf＇dment. Subsequently, 5-fluorouracil （5-FU） and curcnmin（CUR） loaded silk fibroin （SF） membranes were coated on the surface of the weft- knitted stent using electro-spinning technique to endow the drug delivery funct/on of the stent. The results show that the radial compression strength and c/renmferentlal expanding strength can reach above （9.1±0.4） cN/cm2 and （205.0± 0.2） cN/mm, respectively. The drug releasing behaviors can be sustained for 400 h. It is concluded that the stents have potential application as anintestinal stent in the future.
文摘The drug release behavior of degradable polymer--polycaprolactone-poly (ethyleneglycol)block copolymer(PCE) in vitro was investigated by using 5-Fluoro-uracil (5-Fu) asa model drug under a condition of pH 7. 4 at 37C. It is found that the release rate of 5-Fufrom PCE increased with increasing polyether content of the copolymer. The results showthat the increasing polyether content of the copolymer caused increasing hydrophilicity anddecreasing crystallinity of the PCE copolymer. Thus, the drug release behavior and thedegradable property of the PCE can be controlled by adjusting the composition of thecopolymer.
