Grating-based x-ray phase contrast imaging has attracted increasing interest in recent decades as multimodal and laboratory source usable method.Specific efforts have been focused on establishing a new extraction meth...Grating-based x-ray phase contrast imaging has attracted increasing interest in recent decades as multimodal and laboratory source usable method.Specific efforts have been focused on establishing a new extraction method to perform practical applications.In this work,noise properties of multi-combination information of newly established information extraction method,so-called angular signal radiography method,are investigated to provide guidelines for targeted and specific applications.The results show that how multi-combination of images can be used in targeted practical applications to obtain a high-quality image in terms of signal-to-noise ratio.Our conclusions can also hold true for upcoming targeted practical applications such as biomedical imaging,non-destructive imaging,and materials science.展开更多
目的探讨自主研发的16通道高分辨盆腔专用线圈(16C)在3.0 T盆腔MRI中的应用价值。材料和方法前瞻性招募35例行盆腔MRI的患者,分别用16C线圈和32通道的体部线圈(32C)采集相同的轴位和矢状位T2WI序列。比较相同序列图像中第三骶椎、子宫...目的探讨自主研发的16通道高分辨盆腔专用线圈(16C)在3.0 T盆腔MRI中的应用价值。材料和方法前瞻性招募35例行盆腔MRI的患者,分别用16C线圈和32通道的体部线圈(32C)采集相同的轴位和矢状位T2WI序列。比较相同序列图像中第三骶椎、子宫肌层、前列腺外周带、直肠壁和闭孔内肌的信噪比(signal to noise ratio,SNR)及对比噪声比(contrast to noise ratio,CNR)。由两位诊断医师各自对两组图像质量和直肠轴位图像直肠壁分层结构的显示度进行主观评分。结果两组线圈相同序列的T2WI矢状位第三骶椎、子宫肌层、前列腺外周带和轴位闭孔内肌的SNR差异具有统计学意义(P<0.05),矢状位第三骶椎、子宫肌层和轴位直肠壁对肌肉的CNR差异具有统计学意义(P<0.05),16C组高于32C组。两组线圈相同序列的T2WI图像质量主观评价差异具有统计学意义(P<0.05),16C组图像质量更优。在轴位T2WI直肠壁分层结构的显示度评价方面两组图像差异具有统计学意义(P<0.05),16C组更优。结论16C线圈在3.0 T磁共振设备上成像质量更好,更有利于盆腔疾病的诊断。展开更多
目的探讨联合应用AIR-魔毯线圈磁共振成像(MRI)对胸椎结核扫描图像信噪比(signal to noise ratio,SNR)、对比噪声比(contrast to noise ratio,CNR)和脂肪抑制成像效果的价值。方法选取我院80例经手术病理证实为胸椎结核患者,按1:1随机...目的探讨联合应用AIR-魔毯线圈磁共振成像(MRI)对胸椎结核扫描图像信噪比(signal to noise ratio,SNR)、对比噪声比(contrast to noise ratio,CNR)和脂肪抑制成像效果的价值。方法选取我院80例经手术病理证实为胸椎结核患者,按1:1随机分为两组,应用常规线圈(脊柱相控阵线圈,头颈联合线圈)、常规线圈联合AIR魔毯线圈对两组患者分别进行扫描。扫描序列包括胸椎矢状位T_(2)WI,T_(1)WI,T_(2)FLEX,进一步测量、比较SNR,CNR及脂肪抑制效果,分析MRI多序列诊断胸腰椎结核的准确率、特异度和灵敏度。结果常规线圈联合AIR-魔毯线圈扫描组,胸椎矢状位图像的SNR、CNR及压脂效果优于常规线圈组。结论联合应用AIR-魔毯线圈的图像SNR、CNR得到提高,脂肪抑制效果稳定良好。展开更多
Laser speckle contrast imaging(LSCI)is an optical imaging method,which can monitor microvascularflow variation directly without addition of any ectogenous dye.All the existing laser speckle contrast analysis(LASCA)met...Laser speckle contrast imaging(LSCI)is an optical imaging method,which can monitor microvascularflow variation directly without addition of any ectogenous dye.All the existing laser speckle contrast analysis(LASCA)methods are a combination of spatial and temporal statistics.In this study,we have proposed a new method,Gaussian kernel laser speckle contrast analysis(gLASCA),which processes the raw images primarily with the Gaussian kernel operator along the spatial direction of bloodflow.We explored the properties of gLASCA in the simulation and animal cerebral ischemia perfusion model.Compared with the other existing speckle processing methods based on spatial,temporal,spatial-temporal or anisotropic linear structure;the present gLASCA method has a high spatial-temporal resolution to respond the change of velocity especially in microvasculature.Besides,the gLASCA method obtains approximately 10.2%and 7.1%higher contrast-to-noise ratio(CNR)over the anisotropic linear method(aLASCA)in the simulation and experiment models.For these advantages,gLASCA could be a better method for local microvascular laser speckle imaging in terms of cerebral ischemia reperfusion,spreading depression and brain injury diseases.展开更多
The present study aimed to investigate the possibility of using dual-energy computed tomography (CT) before therapy to discriminate between normal breast tissue and tumor tissue in patients with breast cancer, without...The present study aimed to investigate the possibility of using dual-energy computed tomography (CT) before therapy to discriminate between normal breast tissue and tumor tissue in patients with breast cancer, without the need to use a contrast medium. The following patient data were extracted by interview and from the hospital’s radiology information system: height, weight, age, menstrual cycle, CT images of normal tissue and tumors with or without contrast medium, and the histopathological diagnosis of the aspiration biopsy. The median age of the 43 participants was 56 years (range, 30 - 80 years). The CT values were evaluated using a clinical analytical program based on the three-material decomposition technique. Breast cancer was classified into ductal carcinoma in situ, invasive ductal carcinoma, invasive lobular carcinoma, fibromatosis-like metaplastic carcinoma, and apocrine carcinoma. In all conditions, regardless of contrast medium, the CT values of tumor tissues were higher than those of normal breast tissue, indicating the effectiveness of dual-energy CT (DE-CT) in the diagnosis of breast cancer. By contrast, DE-CT showed limited potential for distinguishing ductal carcinoma in situ from invasive ductal carcinoma. There have only been a few reports regarding CT examination of breast cancer, and it is expected this study encourage the development of DE-CT imaging to improve tumor detection in patients with breast cancer.展开更多
基金Project supported by the National Natural Science Foundation of China(Grant No.11535015)the National Special Foundation of China for Major Science Instrument(Grant No.61227802)+3 种基金the National Natural Science Foundation of China(Grant Nos.61405120,61605119,61571305,and 11674232)the Natural Science Foundation of Shenzhen,China(Grant No.JCYJ20170302142617703)the Natural Science Foundation of Shenzhen University,China(Grant Nos.2017017 and 2018041)sponsored by the Post-doctoral International Exchange Program of China
文摘Grating-based x-ray phase contrast imaging has attracted increasing interest in recent decades as multimodal and laboratory source usable method.Specific efforts have been focused on establishing a new extraction method to perform practical applications.In this work,noise properties of multi-combination information of newly established information extraction method,so-called angular signal radiography method,are investigated to provide guidelines for targeted and specific applications.The results show that how multi-combination of images can be used in targeted practical applications to obtain a high-quality image in terms of signal-to-noise ratio.Our conclusions can also hold true for upcoming targeted practical applications such as biomedical imaging,non-destructive imaging,and materials science.
文摘目的探讨自主研发的16通道高分辨盆腔专用线圈(16C)在3.0 T盆腔MRI中的应用价值。材料和方法前瞻性招募35例行盆腔MRI的患者,分别用16C线圈和32通道的体部线圈(32C)采集相同的轴位和矢状位T2WI序列。比较相同序列图像中第三骶椎、子宫肌层、前列腺外周带、直肠壁和闭孔内肌的信噪比(signal to noise ratio,SNR)及对比噪声比(contrast to noise ratio,CNR)。由两位诊断医师各自对两组图像质量和直肠轴位图像直肠壁分层结构的显示度进行主观评分。结果两组线圈相同序列的T2WI矢状位第三骶椎、子宫肌层、前列腺外周带和轴位闭孔内肌的SNR差异具有统计学意义(P<0.05),矢状位第三骶椎、子宫肌层和轴位直肠壁对肌肉的CNR差异具有统计学意义(P<0.05),16C组高于32C组。两组线圈相同序列的T2WI图像质量主观评价差异具有统计学意义(P<0.05),16C组图像质量更优。在轴位T2WI直肠壁分层结构的显示度评价方面两组图像差异具有统计学意义(P<0.05),16C组更优。结论16C线圈在3.0 T磁共振设备上成像质量更好,更有利于盆腔疾病的诊断。
文摘目的探讨联合应用AIR-魔毯线圈磁共振成像(MRI)对胸椎结核扫描图像信噪比(signal to noise ratio,SNR)、对比噪声比(contrast to noise ratio,CNR)和脂肪抑制成像效果的价值。方法选取我院80例经手术病理证实为胸椎结核患者,按1:1随机分为两组,应用常规线圈(脊柱相控阵线圈,头颈联合线圈)、常规线圈联合AIR魔毯线圈对两组患者分别进行扫描。扫描序列包括胸椎矢状位T_(2)WI,T_(1)WI,T_(2)FLEX,进一步测量、比较SNR,CNR及脂肪抑制效果,分析MRI多序列诊断胸腰椎结核的准确率、特异度和灵敏度。结果常规线圈联合AIR-魔毯线圈扫描组,胸椎矢状位图像的SNR、CNR及压脂效果优于常规线圈组。结论联合应用AIR-魔毯线圈的图像SNR、CNR得到提高,脂肪抑制效果稳定良好。
基金This study was supported by National Major Scientific Instruments and Equipments Development Project Funded by National Natural Science Foundation of China(81827803,81727804)National Natural Science Foundation of China(61875085,81601532)+2 种基金Natural Science Foundation of Jiangsu Province(BK20160814)Jiangsu Science and Technology Support Plan(Social Development)(BE2016759)Jiangsu Innovation Program for Graduate Education(KYLX16339).
文摘Laser speckle contrast imaging(LSCI)is an optical imaging method,which can monitor microvascularflow variation directly without addition of any ectogenous dye.All the existing laser speckle contrast analysis(LASCA)methods are a combination of spatial and temporal statistics.In this study,we have proposed a new method,Gaussian kernel laser speckle contrast analysis(gLASCA),which processes the raw images primarily with the Gaussian kernel operator along the spatial direction of bloodflow.We explored the properties of gLASCA in the simulation and animal cerebral ischemia perfusion model.Compared with the other existing speckle processing methods based on spatial,temporal,spatial-temporal or anisotropic linear structure;the present gLASCA method has a high spatial-temporal resolution to respond the change of velocity especially in microvasculature.Besides,the gLASCA method obtains approximately 10.2%and 7.1%higher contrast-to-noise ratio(CNR)over the anisotropic linear method(aLASCA)in the simulation and experiment models.For these advantages,gLASCA could be a better method for local microvascular laser speckle imaging in terms of cerebral ischemia reperfusion,spreading depression and brain injury diseases.
文摘The present study aimed to investigate the possibility of using dual-energy computed tomography (CT) before therapy to discriminate between normal breast tissue and tumor tissue in patients with breast cancer, without the need to use a contrast medium. The following patient data were extracted by interview and from the hospital’s radiology information system: height, weight, age, menstrual cycle, CT images of normal tissue and tumors with or without contrast medium, and the histopathological diagnosis of the aspiration biopsy. The median age of the 43 participants was 56 years (range, 30 - 80 years). The CT values were evaluated using a clinical analytical program based on the three-material decomposition technique. Breast cancer was classified into ductal carcinoma in situ, invasive ductal carcinoma, invasive lobular carcinoma, fibromatosis-like metaplastic carcinoma, and apocrine carcinoma. In all conditions, regardless of contrast medium, the CT values of tumor tissues were higher than those of normal breast tissue, indicating the effectiveness of dual-energy CT (DE-CT) in the diagnosis of breast cancer. By contrast, DE-CT showed limited potential for distinguishing ductal carcinoma in situ from invasive ductal carcinoma. There have only been a few reports regarding CT examination of breast cancer, and it is expected this study encourage the development of DE-CT imaging to improve tumor detection in patients with breast cancer.
文摘目的 探讨深度学习重建(deep learning reconstruction, DLR)技术对膀胱癌MRI图像质量及扫描时间的影响。材料与方法 前瞻性纳入病理诊断为膀胱癌的初诊患者分别行膀胱MRI常规快速自旋回波(fast-spin echo, FSE)-T2WI和DLR快速FSE-T2WI扫描,并保存未使用DLR的原始快速FSE-T2WI。由2名放射科医师分别对三组T2WI(常规FSE-T2WI、快速FSE-T2WI和DLR快速FSE-T2WI)的整体图像质量和图像伪影进行图像质量主观评价(5分标准)。由1名放射科医师测量病变的信噪比(signal-to-noise ratio, SNR)和病变与髂腰肌的对比噪声比(contrast-to-noise ratio, CNR)。对正态分布和非正态分布的数据分别进行单因素方差分析和Friedman检验,比较分析三组T2WI的主观评分和客观指标的差异。采用Weighted-Kappa检验比较组间及组内主观评分一致性。结果 本研究共纳入32例膀胱癌患者,年龄39~93(65±11)岁。缩短扫描时间的快速FSE-T2WI的整体图像质量、伪影评分、SNR(63.2±25.5 vs. 94.7±40.8,P<0.05)、CNR(40.0±19.0vs. 59.6±29.8,P<0.05)均显著低于常规FSE-T2WI;应用DLR显著提高快速FSE-T2WI的整体图像质量、伪影评分、SNR(256.7±102.9 vs. 63.2±25.5,P<0.05)、CNR(168.0±77.3 vs. 40.0±19.0,P<0.05);DLR快速FSE-T2WI的整体图像质量评分及SNR(256.7±102.9 vs. 94.7±40.8,P<0.05)和CNR(168.0±77.3 vs. 59.6±29.8,P<0.05)显著高于常规FSE-T2WI。结论 DLR可以缩短图像扫描时间,并在定量和定性方面提高图像质量,使膀胱癌患者更快完成MRI检查成为可能。
