In order to explore the propagation law of gas explosion in U type laneways,the propagation law of flame and shock wave in U type duct were experimentally and theoret- ically investigated.It is shown that the shock wa...In order to explore the propagation law of gas explosion in U type laneways,the propagation law of flame and shock wave in U type duct were experimentally and theoret- ically investigated.It is shown that the shock wave takes on the complicated stress state and the flame takes on complicated change rules in the U type duct.The propagation process of gas explosion in bend duct is the mutual action of explosion wave,flame and complicate flow,the destruction in bend surface is especially serious.In the mine exploita- tion and laneway design,the bend laneway should be avoided,especially continuous bend laneway.展开更多
BACKGROUND The combination of immune checkpoint inhibitors and chemotherapy has shown promising results for the treatment of advanced biliary tract cancer(BTC).Based on the results of the TOPAZ-1 trial,a gemcitabine a...BACKGROUND The combination of immune checkpoint inhibitors and chemotherapy has shown promising results for the treatment of advanced biliary tract cancer(BTC).Based on the results of the TOPAZ-1 trial,a gemcitabine and cisplatin plus durvalumab(GCD)regimen was recently approved as first-line therapy for patients with advanced BTC.However,post-GCD conversion surgery has not been previously studied.Herein,we describe a case of advanced intrahepatic cholangiocarcinoma(ICC)successfully treated with radical surgery after GCD.CASE SUMMARY A 65-year-old female diagnosed with advanced ICC with periductal infiltration into the hepatic hilum underwent eight cycles of GCD,followed by durvalumab maintenance treatment,with mild adverse events.Partial response was obtained.Subsequently,a conversion surgery with extended left hepatectomy and bile duct resection was performed.The resection margins were negative,and the pathological diagnosis was compatible with small duct type ICC.The patient remained disease-free for 8 months without adjuvant chemotherapy.CONCLUSION We describe the case of a patient who received successful conversion surgery after GCD treatment for advanced ICC.展开更多
基金the National Natural Science Foundation of China(50674047,50534090,50574093)State Key Base Development Plan(2005CB221506)
文摘In order to explore the propagation law of gas explosion in U type laneways,the propagation law of flame and shock wave in U type duct were experimentally and theoret- ically investigated.It is shown that the shock wave takes on the complicated stress state and the flame takes on complicated change rules in the U type duct.The propagation process of gas explosion in bend duct is the mutual action of explosion wave,flame and complicate flow,the destruction in bend surface is especially serious.In the mine exploita- tion and laneway design,the bend laneway should be avoided,especially continuous bend laneway.
文摘BACKGROUND The combination of immune checkpoint inhibitors and chemotherapy has shown promising results for the treatment of advanced biliary tract cancer(BTC).Based on the results of the TOPAZ-1 trial,a gemcitabine and cisplatin plus durvalumab(GCD)regimen was recently approved as first-line therapy for patients with advanced BTC.However,post-GCD conversion surgery has not been previously studied.Herein,we describe a case of advanced intrahepatic cholangiocarcinoma(ICC)successfully treated with radical surgery after GCD.CASE SUMMARY A 65-year-old female diagnosed with advanced ICC with periductal infiltration into the hepatic hilum underwent eight cycles of GCD,followed by durvalumab maintenance treatment,with mild adverse events.Partial response was obtained.Subsequently,a conversion surgery with extended left hepatectomy and bile duct resection was performed.The resection margins were negative,and the pathological diagnosis was compatible with small duct type ICC.The patient remained disease-free for 8 months without adjuvant chemotherapy.CONCLUSION We describe the case of a patient who received successful conversion surgery after GCD treatment for advanced ICC.
