Dynamic Energy Budget software aims to identify simple quantitative rules for the organization of metabolism of individual organisms. It is always used to delineate reserves, as separate from structure. The energy den...Dynamic Energy Budget software aims to identify simple quantitative rules for the organization of metabolism of individual organisms. It is always used to delineate reserves, as separate from structure. The energy density of Eriocheir sinensis was studied through DEB software in this paper. The results showed that Hepatopancreas energy density （32.17 ± 3.77 KJ/g） was higher than gonad （23.19 ± 2.86KJ/ g）, muscle （24.41± 1.41 K J/g） and carapace energy density （14.42 ±1.76 KJ/g）. The difference between gonad （23.19± 2.86KJ/g） and muscle energy density （4.41 ±1.41 K J/g） of females and males was significant （P 〈 0.01）, but not between muscle and carapace energy density （P 〉 0.05）, and no difference between female and male individual in total energy （P = 0.887） at the stable stage. The linear relation between volume and weight of Eriocheir sinensis was gained by using regression analysis, V=6.104＋ 1.117WW （R2=0.973, n=98）, and the linear relation between total energy and dry weight was also gained, E= 18.12DW-28.05 （R2=0.962 ,n=24）.展开更多
We propose a computational model to study the growth and spread of bacterial biofilms on interfaces,as well as the action of antibiotics on them.Bacterial membranes are represented by boundaries immersed in a fluid ...We propose a computational model to study the growth and spread of bacterial biofilms on interfaces,as well as the action of antibiotics on them.Bacterial membranes are represented by boundaries immersed in a fluid matrix and subject to interaction forces.Growth,division and death of bacterial cells follow dynamic energy budget rules,in response to variations in environmental concentrations of nutrients,toxicants and substances released by the cells.In this way,we create,destroy and enlarge boundaries,either spherical or rod-like.Appropriate forces represent details of the interaction between cells,and the interaction with the environment.We can investigate geometrical arrangements and the formation of porous structures.Numerical simulations illustrate the evolution of top views and diametral slices of small biofilm seeds,as well as the action of antibiotics.We show that cocktails of antibiotics targeting active and dormant cells can entirely eradicate a biofilm.展开更多
文摘Dynamic Energy Budget software aims to identify simple quantitative rules for the organization of metabolism of individual organisms. It is always used to delineate reserves, as separate from structure. The energy density of Eriocheir sinensis was studied through DEB software in this paper. The results showed that Hepatopancreas energy density （32.17 ± 3.77 KJ/g） was higher than gonad （23.19 ± 2.86KJ/ g）, muscle （24.41± 1.41 K J/g） and carapace energy density （14.42 ±1.76 KJ/g）. The difference between gonad （23.19± 2.86KJ/g） and muscle energy density （4.41 ±1.41 K J/g） of females and males was significant （P 〈 0.01）, but not between muscle and carapace energy density （P 〉 0.05）, and no difference between female and male individual in total energy （P = 0.887） at the stable stage. The linear relation between volume and weight of Eriocheir sinensis was gained by using regression analysis, V=6.104＋ 1.117WW （R2=0.973, n=98）, and the linear relation between total energy and dry weight was also gained, E= 18.12DW-28.05 （R2=0.962 ,n=24）.
基金This research has been partially supported by the FEDER/Ministerio de Ciencia,Innovaci´on y Universidades-Agencia Estatal de Investigacin grants MTM2017-84446-C2-1-R and PID2020-112796RB-C21(AC,RG),by fellowship PRE2018-083807(RG)by the Ministerio de Ciencia,Innovaci´on y Universidades”Salvador de Madariaga”grant PRX18/00112(AC)A.C.thanks R.E.Caflisch for hospitality during a sabbatical stay at the Courant Institute,NYU,and C.S.Peskin for nice discussions and useful suggestions.
文摘We propose a computational model to study the growth and spread of bacterial biofilms on interfaces,as well as the action of antibiotics on them.Bacterial membranes are represented by boundaries immersed in a fluid matrix and subject to interaction forces.Growth,division and death of bacterial cells follow dynamic energy budget rules,in response to variations in environmental concentrations of nutrients,toxicants and substances released by the cells.In this way,we create,destroy and enlarge boundaries,either spherical or rod-like.Appropriate forces represent details of the interaction between cells,and the interaction with the environment.We can investigate geometrical arrangements and the formation of porous structures.Numerical simulations illustrate the evolution of top views and diametral slices of small biofilm seeds,as well as the action of antibiotics.We show that cocktails of antibiotics targeting active and dormant cells can entirely eradicate a biofilm.
