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A magic organic molecule assembled capping layer enables airprocessed α-FAPbI_(3) perovskite solar cell with state-of-the-art performances
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作者 Yulong Wang Xiuwen Xu +1 位作者 Shujuan Liu Qiang Zhao 《Journal of Semiconductors》 EI CAS CSCD 2024年第10期3-6,共4页
The black-phase formamidine-lead iodide(α-FAPbI_(3)),boasting an optimal bandgap of 1.5 eV,stands out as a premier choice for narrow-bandgap perovskite solar cells(PSCs),achieving a certified power conversion efficie... The black-phase formamidine-lead iodide(α-FAPbI_(3)),boasting an optimal bandgap of 1.5 eV,stands out as a premier choice for narrow-bandgap perovskite solar cells(PSCs),achieving a certified power conversion efficiency(PCE)of 26.1%[1−5].This impressive performance hinges on the orderly and homogeneous crystallization ofα-phase pure FAPbI_(3),facilitated by coordinating solvents such as dimethyl sulfoxide(DMSO)to form intermediates like PbI_(2)-DMSO complex(D-complex).The D-complex plays a pivotal role in crystallization thermodynamics,enabling the direct formation of α-FAPbI_(3) without the photoinactiveδ-phase[6−9].However,DMSO,a commonly used coordinating solvent,is highly hygroscopic and prone to hydration upon moisture exposure.This tendency leads to incomplete perovskite crystallization and accelerates the transformation of α-FAPbI_(3) into itsδ-phase[2,10].Consequently,the best-performing α-FAPbI_(3)PSCs must be processed in an inert atmosphere with strictly controlled relative humidity(RH)and suffers from relatively poor reproducibility.Given the hard-to-control atmosphere at industrial scale,it is challenging yet imperative to eliminate the negative effects stemming from hygroscopic coordinating solvents[11−13]. 展开更多
关键词 PEROVSKITE CRYSTALLIZATION enable
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Enabling Technologies for Autonomous Robotic Systems in Manufacturing
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作者 ERDŐS Gábor ABAI Kristóf +17 位作者 BEREGI Richárd CSEMPESZ János CSERTEG Tamás GODÓGábor HAJÓS Mátyás HÁY Borbála HORVÁTH Dániel HORVÁTH Gergely JUNIKIÁdám KEMÉNY Zsolt KOVÁCS András NACSA János PANITI Imre PEDONE Gianfranco TAKÁCS Emma TIPARY Bence ZAHORÁN László VÁNCZA József 《Transactions of Nanjing University of Aeronautics and Astronautics》 EI CSCD 2024年第4期403-431,共29页
Research of autonomous manufacturing systems is motivated both by the new technical possibilities of cyber-physical systems and by the practical needs of the industry.Autonomous operation in semi-structured industrial... Research of autonomous manufacturing systems is motivated both by the new technical possibilities of cyber-physical systems and by the practical needs of the industry.Autonomous operation in semi-structured industrial environments can now be supported by advanced sensor technologies,digital twins,artificial intelligence and novel communication techniques.These enable real-time monitoring of production processes,situation recognition and prediction,automated and adaptive(re)planning,teamwork and performance improvement by learning.This paper summarizes the main requirements towards autonomous industrial robotics and suggests a generic workflow for realizing such systems.Application case studies will be presented from recent practice at HUN-REN SZTAKI in a broad range of domains such as assembly,welding,grinding,picking and placing,and machining.The various solutions have in common that they use a generic digital twin concept as their core.After making general recommendations for realizing autonomous robotic solutions in the industry,open issues for future research will be discussed. 展开更多
关键词 industrial robotics AUTONOMY digital twin enabling technology
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Effective extraction of polyribosomes from astrocytes enables future discoveries on translation regulation
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作者 Orna Elroy-Stein 《Neural Regeneration Research》 SCIE CAS 2025年第4期1083-1084,共2页
Translation regulation is an important layer of gene expression:Generation of genome-wide expression datasets at multi-omics levels in spatial,temporal,and cell-type resolution is essential for deciphering brain compl... Translation regulation is an important layer of gene expression:Generation of genome-wide expression datasets at multi-omics levels in spatial,temporal,and cell-type resolution is essential for deciphering brain complexity.Regulation of gene expression is a highly dynamic process aiming at the production of precise levels of gene products to guarantee optimal cellular function,in response to physiological cues.Speedy advances in next-generation sequencing enabled the understanding of epigenomic and transcriptomic dynamic landscapes of different brain regions along development,aging,and disease progression.However,the correlation of the“transcriptome”with protein levels is poor because numerous mRNAs are subjected to manipulation of their translation efficiency,to warrant a favorable result under certain conditions.Hence,it is widely accepted that regulation at the translation level is a vital layer of gene expression.Quantification of actively translated mRNA populations(i.e.,“translatome”)is a more reliable predictor of the“proteome”(Wang et al.,2020). 展开更多
关键词 TRANSLATION enable LANDSCAPE
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血清β-catenin、E-cadherin水平与糖尿病肾病患者钙磷代谢、颈动脉钙化的关系 被引量:1
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作者 高剑 梁铮 +2 位作者 赵飞 刘小静 马宁 《国际检验医学杂志》 CAS 2024年第12期1469-1473,共5页
目的探讨血清E-钙黏蛋白(E-cadherin)、β-连环蛋白(β-catenin)水平与糖尿病肾病患者钙磷代谢、颈动脉钙化的关系。方法选择2019年5月至2022年11月该院收治的112例糖尿病肾病患者作为研究组,并根据双侧颈动脉彩超检查结果分为颈动脉钙... 目的探讨血清E-钙黏蛋白(E-cadherin)、β-连环蛋白(β-catenin)水平与糖尿病肾病患者钙磷代谢、颈动脉钙化的关系。方法选择2019年5月至2022年11月该院收治的112例糖尿病肾病患者作为研究组,并根据双侧颈动脉彩超检查结果分为颈动脉钙化组(n=44)和非颈动脉钙化组(n=68),另选同期于该院接受体检的90例体检健康者为对照组。检测并比较各组血清E-cadherin、β-catenin及钙磷代谢水平,采用Pearson相关分析血清E-cadherin、β-catenin水平与糖尿病肾病患者钙磷代谢的关系,采用受试者工作特征(ROC)曲线评估血清E-cadherin、β-catenin对糖尿病肾病患者颈动脉钙化的预测价值,采用多因素Logistic回归分析糖尿病肾病患者颈动脉钙化的影响因素。结果研究组糖化血红蛋白、血磷、钙磷乘积、甲状旁腺激素(iPTH)、肌酐、碱性磷酸酶、β-catenin水平均高于对照组,E-cadherin水平低于对照组(P<0.05)。颈动脉钙化组血磷、血钙、钙磷乘积、iPTH、肌酐、碱性磷酸酶、β-catenin水平均高于非颈动脉钙化组,E-cadherin水平低于非颈动脉钙化组(P<0.001)。Pearson相关分析显示,糖尿病肾病患者血清E-cadherin与血磷、血钙、钙磷乘积、iPTH、肌酐、碱性磷酸酶均呈负相关(r=-0.453、-0.654、-0.365、-0.490、-0.411、-0.377,均P<0.05),血清β-catenin水平与血磷、血钙、钙磷乘积、iPTH、肌酐、碱性磷酸酶均呈正相关(r=0.444、0.345、0.421、0.398、0.651、0.622,均P<0.001)。ROC曲线分析显示,血清E-cadherin、β-catenin及二者联合预测糖尿病肾病颈动脉钙化的曲线下面积分别为0.844(95%CI 0.795~0.894)、0.853(95%CI 0.801~0.901)、0.901(95%CI 0.851~0.952)。多因素Logistic回归分析显示,血清E-cadherin(OR=3.789,95%CI 2.055~6.983)、β-catenin(OR=4.104,95%CI 1.795~9.385)、钙磷乘积(OR=2.998,95%CI 1.895~4.743)、iPTH(OR=2.713,95%CI 1.787~4.118)均是糖尿病肾病患者颈动脉钙化的影响因素(P<0.05)。结论糖尿病肾病患者β-catenin水平升高,E-cadherin水平降低,二者与患者钙磷代谢、颈动脉钙化密切相关,可作为评估糖尿病肾病患者颈动脉钙化的有效指标,同时二者联合对颈动脉钙化的预测价值更高。 展开更多
关键词 糖尿病肾病 e-钙黏蛋白 Β-连环蛋白 钙磷代谢 颈动脉钙化
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组织中MMP-9、E-cadherin与子宫内膜样癌伴MELF浸润方式及肿瘤侵袭程度的关系
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作者 李坤 王静 +2 位作者 金春亭 白睿 刘晓娟 《河北医科大学学报》 CAS 2024年第8期980-986,共7页
目的分析子宫内膜样癌组织中基质金属蛋白酶(matrix metalloproteinase,MMP)-9、E-钙黏蛋白(E-cadherin)与微囊性、伸长及碎片状(microcystic,elongation,and fragmentation,MELF)浸润方式及肿瘤侵袭程度之间的关系,探讨能够识别子宫内... 目的分析子宫内膜样癌组织中基质金属蛋白酶(matrix metalloproteinase,MMP)-9、E-钙黏蛋白(E-cadherin)与微囊性、伸长及碎片状(microcystic,elongation,and fragmentation,MELF)浸润方式及肿瘤侵袭程度之间的关系,探讨能够识别子宫内膜样癌伴MELF浸润的指标,抑制肿瘤侵袭能力。方法回顾性分析在河北北方学院附属第一医院接受手术治疗的112例子宫内膜样癌患者临床资料,全部患者均顺利完成改良根治性子宫切除术,并获得肿瘤标准,根据病理检查结果对112例患者进行分组,分为MELF组和N-MELF组。统计112例患者一般临床资料,血液检查项目包括肿瘤标志物,免疫组织化学检查项目包括组织中MMP-9、E-cadherin,根据检查结果,构建Logistic回归模型,分析组织中MMP-9、E-cadherin及相关指标与子宫内膜样癌MELF浸润方式及肿瘤侵袭程度的关系。结果研究中112例子宫内膜样癌患者,评估为MELF浸润患者21例(18.75%);MELF浸润患者病理等级低级别,国际妇产科联盟(International Federation of Gynecology and Obstetrics,FIGO)ⅣA期,淋巴脉管间隙浸润(lymphatic vascular space,LVSI)、组织中MMP-9阳性患者占比多于N-MELF浸润患者,E-cadherin阳性患者占比少于N-MELF浸润患者,人附睾蛋白(humanepididymisprotein 4,HE4),甲壳质酶蛋白(human cartilageglycopmtein,YKL-40)水平高于N-MELF患者,差异有统计学意义(P<0.05)。多元Logistic回归分析提示,组织中E-cadherin表达率低、MMP-9表达率高,MELF浸润与子宫内膜样癌FIGO分期进展有关(P<0.05)。结论子宫内膜样癌发生MELF浸润与组织中MMP-9、E-cadherin有关,MMP-9表达率高和E-cadherin表达率低能够通过导致MELF浸润发生,从而增强肿瘤侵袭能力。 展开更多
关键词 子宫内膜样癌 基质金属蛋白酶-9 e-钙黏蛋白
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血清ESM-1、E-cad对ACI-LAA溶栓后HT的预测价值
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作者 茹姗 邹婷 +2 位作者 杜磊 韩登峰 马建华 《脑与神经疾病杂志》 CAS 2024年第2期96-99,共4页
目的 探讨血清内皮细胞特异性分子-1 (ESM-1)、E-钙黏连蛋白(E-cad)对大动脉粥样硬化型脑梗死(ACI-LAA)溶栓后出血转化(HT)的预测价值。方法 选取2020年1月至2022年12月新疆医科大学第一附属医院收治的110例ACI-LAA患者,根据是否发生HT... 目的 探讨血清内皮细胞特异性分子-1 (ESM-1)、E-钙黏连蛋白(E-cad)对大动脉粥样硬化型脑梗死(ACI-LAA)溶栓后出血转化(HT)的预测价值。方法 选取2020年1月至2022年12月新疆医科大学第一附属医院收治的110例ACI-LAA患者,根据是否发生HT分为HT组和non-HT组。对比两组基础资料及血清ESM-1、E-cad水平。采用ROC曲线分析ESM-1、E-cad预测ACI-LAA患者发生HT的价值。结果 HT组患者NIHSS评分高于non-HT组,梗死面积大于non-HT组(P <0.05),HT组患者血清ESM-1、E-cad水平也高于non-HT组(P<0.05)。Logistic回归分析显示,梗死面积大、NIHSS评分高、血清ESM-1和E-cad水平升高是ACI-LAA患者发生HT的危险因素(P<0.05)。ESM-1联合E-cad预测ACI-LAA患者发生HT的曲线下面积为0.859,预测灵敏度为84.6%,特异度为72.6%。结论 血清ESM-1和E-cad水平与ACI-LAA患者HT密切相关,可作为早期预测发生HT的参考指标。 展开更多
关键词 动脉粥样硬化 脑梗死 出血转化 内皮细胞特异性分子-1 e-钙黏连蛋白
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MMP25和E-cadherin在类风湿关节炎中的诊断价值
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作者 方全钢 刘海芸 +1 位作者 万静 张水生 《江西医药》 CAS 2024年第2期143-147,154,共6页
目的探讨基质金属蛋白酶25(Matrix metalloproteinase 25,MMP25)和E-钙黏蛋白(E-cadherin)对类风湿关节炎的诊断意义。方法选取2020年1月至2023年10月我院67例类风湿关节炎患者为实验组,同期50例健康体检人群为对照组;采用酶联免疫吸附... 目的探讨基质金属蛋白酶25(Matrix metalloproteinase 25,MMP25)和E-钙黏蛋白(E-cadherin)对类风湿关节炎的诊断意义。方法选取2020年1月至2023年10月我院67例类风湿关节炎患者为实验组,同期50例健康体检人群为对照组;采用酶联免疫吸附试验(ELISA)检测二组血清中MMP25和E-cadherin蛋白水平。收集实验组患者ESR、CRP、CCP、RF、DAS28-ESR、DAS28-CRP指标,以及是否为初诊、是否合并并发症(贫血、间质性肺炎等)、病程、临床活动度等级,并与MMP25和E-cadherin水平进行相关性分析。结果实验组血清MMP25和E-cadherin水平均高于对照组,差异均有统计学意义(P<0.001)。与ESR、CRP、CCP和RF等指标进行散点图和简单线性回归性分析,结果显示:不同临床活动度患者表达MMP25水平差异有统计学意义(P<0.001),MMP25与病程(β=0.479,P<0.001),MMP25与CRP(β=0.271,P<0.05),MMP25与DAS28-ESR(β=0.660,P<0.001)和MMP25与DAS28-CRP(β=0.624,P<0.001)均有相关性。不同临床活动度患者表达E-cadherin水平差异有统计学意义(P<0.001),E-cadherin与ESR(β=0.425,P<0.001),E-cadherin与CRP(β=0.328,P<0.05),E-cadherin与DAS28-ESR(β=0.746,P<0.001),E-cadherin与DAS28-CRP(β=0.671,P<0.001)均有相关性。多重线性回归分析结果显示,MMP25表达水平与临床活动度正相关(β=1.032,P<0.001),E-cadherin表达水平与临床活动度正相关(β=0.407,P<0.05)、与病程长短正相关(β=0.497,P<0.001)。结论MMP25和E-cadherin表达水平可以作为类风湿关节炎评估临床活动度的标志物,此外,E-cadherin表达水平也可以衡量患者病程长短。 展开更多
关键词 基质金属蛋白酶25 e-钙黏蛋白 类风湿关节炎 诊断价值
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miR-200c/ZEB1/E-cadherin轴在胆管癌转移侵袭中的作用及对胆管癌预后评估的价值
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作者 潘超 许蔚 +2 位作者 刘子君 陶平 杨士勇 《现代肿瘤医学》 CAS 2024年第7期1287-1294,共8页
目的:探讨微小RNA-200c(miR-200c)/锌指转录因子(ZEB1)/E-钙黏蛋白(E-cadherin)在胆管癌(HCCA)转移、侵袭中的作用及对HCCA预后评估的临床价值。方法:选取2020年08月至2022年12月间我院收治的胆管癌患者36例为研究对象,同时选取胆管良... 目的:探讨微小RNA-200c(miR-200c)/锌指转录因子(ZEB1)/E-钙黏蛋白(E-cadherin)在胆管癌(HCCA)转移、侵袭中的作用及对HCCA预后评估的临床价值。方法:选取2020年08月至2022年12月间我院收治的胆管癌患者36例为研究对象,同时选取胆管良性疾病患者(胆总管结石或胆管良性狭窄)20例作为对照。采用原位杂交、实时荧光定量PCR检测miR-200c在HCCA患者组织及血清中的表达;生存曲线分析miR-200c表达与总生存期的相关性;Transwell实验检测细胞的迁移及侵袭能力;免疫印迹检测ZEB1及E-cadherin蛋白的表达。体内研究构建裸鼠成瘤实验,采用免疫组化检测ZEB1及E-cadherin蛋白的表达;Tunel技术检测组织中的凋亡情况。受试者工作特征(ROC)曲线评估生物标志物对胆管癌预后的诊断效能。结果:miR-200c低表达于HCCA组织及血清中;生存曲线分析显示,miR-200c表达与患者的总生存期呈正相关性,TNM分期与患者的总生存期呈负相关性;miR-200c mimics抑制了胆管癌细胞的迁移和侵袭能力,并降低ZEB1表达而诱导E-cadherin表达;转染ZEB1逆转miR-200c的作用效应,促进胆管癌细胞的迁移和侵袭特性,抑制胆管癌细胞的凋亡。CA199、CEA和miR-200c联合检测诊断胆管癌预后的ROC曲线下面积为0.892,灵敏度0.8611,特异度0.8000。结论:miR-200c/ZEB1/Ecadherin轴参与胆管癌的转移侵袭;CA199、CEA和miR-200c联合检测对胆管癌预后的诊断效能良好,对临床胆管癌的治疗策略具有重要指导价值。 展开更多
关键词 胆管癌 微小RNA-200c(miR-200c) 锌指转录因子(ZEB1) e-钙黏蛋白(e-cadherin) 迁移 侵袭
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中药砒霜上调E-钙黏蛋白抑制宫颈癌Hela细胞生长、侵袭、迁移机制研究
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作者 李思瑾 李海盈 +3 位作者 何泽阳 李安 张亚文 李道成 《新中医》 CAS 2024年第14期145-152,共8页
目的:研究中药砒霜的主要成分三氧化二砷(As_(2)O_(3))抑制宫颈癌Hela细胞生长、侵袭、迁移的机制,观察As_(2)O_(3)对宫颈癌Hela细胞组蛋白脱乙酰基酶1(HDAC1)、E-钙黏蛋白表达的影响,以及联合HDAC1抑制剂伏立诺他(SAHA)的协同作用。方... 目的:研究中药砒霜的主要成分三氧化二砷(As_(2)O_(3))抑制宫颈癌Hela细胞生长、侵袭、迁移的机制,观察As_(2)O_(3)对宫颈癌Hela细胞组蛋白脱乙酰基酶1(HDAC1)、E-钙黏蛋白表达的影响,以及联合HDAC1抑制剂伏立诺他(SAHA)的协同作用。方法:以宫颈癌Hela细胞作为载体,随机分为空白对照组、As_(2)O_(3)组、SAHA组、As_(2)O_(3)+SAHA组4组,采用CCK-8法测定不同药物浓度对Hela细胞活性的抑制情况,并筛选后续实验药物浓度;采用Transwell法、划痕法检测各组药物对Hela细胞侵袭、迁移能力的影响;采用实时荧光定量聚合酶链式反应及蛋白免疫印迹法检测HDAC1和E-钙黏蛋白的mRNA表达情况与蛋白表达情况。结果:随着各组药物浓度增加,Hela细胞的活性逐渐降低。As_(2)O_(3)组、SAHA组、As_(2)O_(3)+SAHA组的Hela细胞活性均低于空白对照组(P<0.05)。As_(2)O_(3)组、SAHA组、As_(2)O_(3)+SAHA组穿越Transwell小室膜的细胞数量均少于空白对照组(P<0.05);As_(2)O_(3)+SAHA组的细胞数量少于As_(2)O_(3)组、SAHA组(P<0.05);As_(2)O_(3)组的细胞数量少于SAHA组(P<0.05)。As_(2)O_(3)组、SAHA组、As_(2)O_(3)+SAHA组的Hela细胞迁移百分比均低于空白对照组(P<0.05);As_(2)O_(3)+SAHA组的Hela细胞迁移百分比低于As_(2)O_(3)组、SAHA组(P<0.05);As_(2)O_(3)组的Hela细胞迁移百分比低于SAHA组(P<0.05)。As_(2)O_(3)组、SAHA组、As_(2)O_(3)+SAHA组的HDAC1 mRNA表达水平均低于空白对照组(P<0.05);As_(2)O_(3)组的HDAC1 mRNA表达水平高于SAHA组(P<0.05);As_(2)O_(3)+SAHA组的HDAC1 mRNA表达水平低于As_(2)O_(3)组、SAHA组(P<0.05)。As_(2)O_(3)组、SAHA组、As_(2)O_(3)+SAHA组的E-钙黏蛋白mRNA表达水平均高于空白对照组(P<0.05);As_(2)O_(3)+SAHA组的E-钙黏蛋白mRNA表达水平高于As_(2)O_(3)组、SAHA组(P<0.05)。As_(2)O_(3)组、SAHA组、As_(2)O_(3)+SAHA组的HDAC1蛋白表达水平均低于空白对照组(P<0.05);As_(2)O_(3)+SAHA组的HDAC1蛋白表达水平低于As_(2)O_(3)组、SAHA组(P<0.05)。As_(2)O_(3)组、SAHA组、As_(2)O_(3)+SAHA组E-钙黏蛋白的蛋白表达水平均高于空白对照组(P<0.05);As_(2)O_(3)+SAHA组E-钙黏蛋白的蛋白表达水平高于As_(2)O_(3)组、SAHA组(P<0.05)。结论:As_(2)O_(3)抑制Hela细胞的最佳浓度为8μmol/L,联合SAHA时,最佳抑制浓度为4μmol/L。As_(2)O_(3)可能通过抑制HDAC1的表达,同时促进升高E-钙黏蛋白的表达,与SAHA发挥协同作用抑制Hela细胞生长、侵袭、迁移。 展开更多
关键词 宫颈癌 HELA细胞 砒霜 三氧化二砷 伏立诺他 组蛋白脱乙酰基酶1 e-钙黏蛋白
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血清E-cadherin、VEGF、CYFRA21-1水平在甲状腺癌患者手术前后的变化及其对术后复发转移的预测价值
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作者 孙晓光 李彬 洪帅 《实用临床医学(江西)》 CAS 2024年第1期34-37,49,共5页
目的探讨血清E-钙粘连蛋白(E-cadherin)、血管内皮生长因子(VEGF)、细胞角蛋白19片段抗原21-1(CYFRA21-1)水平在甲状腺癌患者手术前后的变化及其对术后复发转移的预测价值。方法选取118例行甲状腺癌根治术的分化型甲状腺癌(DTC)患者为... 目的探讨血清E-钙粘连蛋白(E-cadherin)、血管内皮生长因子(VEGF)、细胞角蛋白19片段抗原21-1(CYFRA21-1)水平在甲状腺癌患者手术前后的变化及其对术后复发转移的预测价值。方法选取118例行甲状腺癌根治术的分化型甲状腺癌(DTC)患者为研究组,118例健康体检者为对照组;根据术后6个月复发转移情况,将DTC患者分为复发转移组33例与未复发转移组85例。比较对照组与研究组(术前)、研究组手术前后、复发转移组与未复发转移组血清E-cadherin、VEGF、CYFRA21-1水平,采用ROC曲线分析上述各指标对术后复发转移的预测价值。结果研究组血清E-cadherin水平显著低于对照组,血清VEGF、CYFRA21-1水平显著高于对照组(P<0.05);研究组术后2周血清E-cadherin水平显著高于术前,血清VEGF、CYFRA21-1水平显著低于术前(P<0.05);未复发转移组术后2周血清E-cadherin水平显著高于术后复发转移组,血清VEGF、CYFRA21-1水平显著低于术后复发转移组(P<0.05)。术后2周上述各指标联合检测预测DTC患者术后复发转移的AUC为0.862,敏感度为90.91%,特异度为75.29%。结论DTC患者术后血清中E-cadherin表达上调,VEGF、CYFRA21-1表达下调,各指标联合检测对复发转移具有较高的预测效能,可作为临床评估DTC患者术后复发转移情况的辅助指标。 展开更多
关键词 e-钙粘连蛋白 血管内皮生长因子 细胞角蛋白19片段抗原21-1 甲状腺癌 复发转移
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血清人软骨糖蛋白-39、可溶性E-选择素与儿童湿疹及严重程度的相关性
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作者 张辉 杜凡 李燕妮 《安徽医药》 CAS 2024年第11期2197-2201,共5页
目的探究血清人软骨糖蛋白-39(YKL-40)、可溶性E-选择素(E-selectin)与儿童湿疹的相关性及与湿疹严重程度的关系。方法选取2019年3月至2020年3月延安大学附属医院收治的湿疹病儿120例为观察组,根据湿疹面积及严重程度指数(EASI)评分将... 目的探究血清人软骨糖蛋白-39(YKL-40)、可溶性E-选择素(E-selectin)与儿童湿疹的相关性及与湿疹严重程度的关系。方法选取2019年3月至2020年3月延安大学附属医院收治的湿疹病儿120例为观察组,根据湿疹面积及严重程度指数(EASI)评分将病儿分为轻度组(42例)、中度组(40例)和重度组(38例)。选取同期进行体检者50例作为对照组。检测血清YKL-40、E-selectin水平;比较临床资料;采用Pearson法分析观察组YKL-40、E-selectin水平的相关性;Spearman法分析血清YKL-40、E-selectin水平与病情严重程度的相关性;logistic分析发生重度湿疹的影响因素。结果观察组年龄和性别与对照组比较均差异无统计学意义(P>0.05),而观察组病儿在过敏性鼻炎[18.33%(32/120)]、过敏史[65.00%(78/120)]、糖尿病家族史[57.50%(69/120)]、YKL-40[(38.05±4.80)g/L]和E-selectin水平[(64.12±6.83)μg/L]上与对照组[10.00%(6/50)、28.00%(14/50)、38.00%(19/50)、(24.69±3.44)g/L、(56.38±6.18)μg/L]差异有统计学意义(t/χ^(2)=4.37、19.46、5.38、17.85、6.92,P<0.05);轻度组、中度组和重度组的YKL-40[(30.95±3.51)g/L、(38.28±4.69)g/L、(45.66±6.34)g/L]和E-selectin水平[(58.82±6.05)μg/L、(63.96±6.85)μg/L、(70.15±7.68)μg/L]均依次显著升高,差异有统计学意义(F=88.67、26.71,P<0.05);观察组血清YKL-40、E-selectin呈正相关(r=0.68,P=0.001);血清YKL-40、E-selectin与病情严重程度呈正相关(r=0.68、0.58,均P<0.001);过敏史、糖尿病家族史、YKL-40和E-selectin为患湿疹严重程度的独立危险因素(P<0.05)。结论血清YKL-40和E-selectin水平升高,湿疹病儿病情可能会加重,二者均为湿疹严重程度的独立危险因素。 展开更多
关键词 湿疹 人软骨蛋白-39 可溶性e-选择素 病情严重程度
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Artificial Intelligence: Enabling Technology to Empower Society 被引量:1
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作者 Yue-Guang Lyu 《Engineering》 SCIE EI 2020年第3期205-206,共2页
Artificial intelligence(AI)can be used to tackle problems that are difficult or impractical to solve using traditional methods.In general,the fundamental goals of AI are to enable machines to possess sensing(e.g.,spee... Artificial intelligence(AI)can be used to tackle problems that are difficult or impractical to solve using traditional methods.In general,the fundamental goals of AI are to enable machines to possess sensing(e.g.,speech recognition,natural language understanding,and/or computer vision),problem-solving/decision-making(e.g.,searching and/or planning),and acting(e.g.,robotics)capabilities that only humans or other intelligent creatures would naturally have. 展开更多
关键词 COMPUTER SEARCHING enable
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Instruction of Nominalization by Applying Enabling of POA 被引量:2
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作者 Hao CHEN 《Chinese Journal of Applied Linguistics》 2020年第3期342-358,389,共18页
It is noticeable that the academic papers written by Chinese English learners are lacking in academic features largely due to their poor ability to use nominalization.Therefore,the instruction of nominalization in an ... It is noticeable that the academic papers written by Chinese English learners are lacking in academic features largely due to their poor ability to use nominalization.Therefore,the instruction of nominalization in an academic English writing course is badly needed.The author conducted onesemester-long instruction of nominalization to 90 non-English majors under the guidance of the production-oriented approach(POA).This research demonstrated how to apply POA,specifically,the enabling procedure to the teaching of nominalization.By triangulating the data of students’interviews,learning journals and written output,and the data of 4 teachers’class observations and interviews,this study found that the accurate application of the three criteria of effective enabling contributed to the improvement of the quantity and quality of nominalization in academic writing. 展开更多
关键词 NOMINALIZATION INSTRUCTION academic English writing Production-Oriented Approach enabling
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Enabling in the Production-Oriented Approach:Theoretical Principles and Classroom Implementation 被引量:1
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作者 Lin QIU 《Chinese Journal of Applied Linguistics》 2020年第3期284-304,388,共22页
Enabling as the second phase of the Production-Oriented Approach(POA)instruction(Wen,2015),plays a vital role in determining the quality of productive performance of English language learners.To explore how to apply t... Enabling as the second phase of the Production-Oriented Approach(POA)instruction(Wen,2015),plays a vital role in determining the quality of productive performance of English language learners.To explore how to apply theoretical principles of enabling to practice,this paper interprets theoretical principles and reports the practice of the classroom implementation of enabling.The paper proposes a definition for enabling,clarifies the confusion between enabling and scaffolding,and clears up some misunderstandings about enabling.It explains three criteria for effective enabling,namely,alignment,gradualness,and variety,and elaborates on the relations among them.Based on the teaching material of Unit 7 of iEnglish,the paper demonstrates how to design and implement enabling activities under the guidance of these three criteria and evaluates the actual effectiveness of the enabling implemented in the classroom. 展开更多
关键词 POA instruction enabling ALIGNMENT gradualness VARIETY
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关于Enabling理想
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作者 雷震 《宁夏大学学报(自然科学版)》 CAS 2021年第2期134-136,共3页
环R的一个理想I称为enabling理想,是指对于任意a,e(e=e^(2))∈R,a-e∈I,存在一个幂等元f^(2)=f,使得a-f∈I,这里f∈aR(或者f∈Ra,或者f∈aRa).通过研究环R上的矩阵环及上三角矩阵环的理想,主要证明了理想I是enabling理想的一个充分必要... 环R的一个理想I称为enabling理想,是指对于任意a,e(e=e^(2))∈R,a-e∈I,存在一个幂等元f^(2)=f,使得a-f∈I,这里f∈aR(或者f∈Ra,或者f∈aRa).通过研究环R上的矩阵环及上三角矩阵环的理想,主要证明了理想I是enabling理想的一个充分必要条件,并证明了若M_(n)(I)是环R上的矩阵环M_(n)(R)的一个enabling理想,则理想I是环R的一个enabling理想. 展开更多
关键词 强提升理想 enabling理想 矩阵环
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监理质量E-旁站管理及应用研究
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作者 周亚平 余群舟 +2 位作者 骆汉宾 谢丹妮 杨传可 《工程管理学报》 2024年第2期142-147,共6页
旁站是监理开展工作的重要方式之一,随着信息技术在土建行业的广泛应用,传统的监理旁站无论是在旁站内容的确定、旁站信息的采集与记录方式,还是在旁站信息的推送与反馈等方面都有提升和改进空间。在阐述监理质量E-旁站的概念与管理框... 旁站是监理开展工作的重要方式之一,随着信息技术在土建行业的广泛应用,传统的监理旁站无论是在旁站内容的确定、旁站信息的采集与记录方式,还是在旁站信息的推送与反馈等方面都有提升和改进空间。在阐述监理质量E-旁站的概念与管理框架的基础上,引入POP模型辅助确定E-旁站内容,并对监理质量E-旁站需要采集的信息进行分类,提出了E-旁站信息采集的要求。基于管理关系和职责,构建了E-旁站信息推送与反馈程序;设计了监理E-旁站管理APP并应用于实际工程。通过构建E-旁站管理模式,保证了监理旁站工作的及时性、有效性和可追溯性,进而提高监理旁站的工作效果。 展开更多
关键词 监理质量控制 e-旁站 POP模型 旁站信息
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Enabling Technologies for Agile Maritime Communication Networks
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《China Communications》 SCIE CSCD 2019年第10期I0001-I0001,共1页
With the rapid development of maritime activities, there has been a growing demand for high data rate and ultra-reliable maritime communications. Traditionally, this is provided by maritime satellites. Besides, shore ... With the rapid development of maritime activities, there has been a growing demand for high data rate and ultra-reliable maritime communications. Traditionally, this is provided by maritime satellites. Besides, shore and island-based base stations (BSs) can be built to extend the coverage of terrestrial networks providing the fourth-generation (4G) or even the fifth-generation (5G) services. Unmanned aerial vehicles (UAVs)-aided and ship-borne BSs can also be exploited to serve as relaying nodes in maritime mesh/ad-hoc networks. Despite all these approaches, there are still open issues towards the establishment of an agile maritime communication network (MCN). Different from terrestrial communications for urban or suburban coverage, the MCN faces several challenges due to the complicated electromagnetic propagation environment, the limited geometrically available BS sites, and rigorous service demands from mission-critical applications. To address all these challenges, conventional communications and networking theories and methods need to be tailored for maritime application scenarios or new ones should be explored. The goal of this feature topic is to present the state-of-the-art original research, and the latest advances and innovations in key theories, technologies, and innovative applications for agile MCNs, as well as identify emerging research topics and point out the future research directions. Extended versions of papers published in conferences, symposiums, or workshop proceedings are encouraged for consideration. 展开更多
关键词 MARITIME COMMUNICATION NETWORKS enabling TECHNOLOGIES
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Enabling Technologies for Agile Maritime Communication Networks
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《China Communications》 SCIE CSCD 2019年第8期I0001-I0001,共1页
With the rapid development of maritime activities, there has been a growing demand for high data rate and ultra-reliable maritime communications. Traditionally,this is provided by maritime satellites. Besides, shore a... With the rapid development of maritime activities, there has been a growing demand for high data rate and ultra-reliable maritime communications. Traditionally,this is provided by maritime satellites. Besides, shore and island-based base stations (BSs) can be built to extend the coverage of terrestrial networks providing the fourth-generation (4G) or even the fifth-generation (5G) services. 展开更多
关键词 MARITIME COMMUNICATION NETWORKS AGILE enabling TECHNOLOGIES
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圈与路的点被多重集可区别的E-全染色 被引量:1
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作者 陈祥恩 曹静 《华东师范大学学报(自然科学版)》 CAS CSCD 北大核心 2024年第2期14-22,共9页
图G的E-全染色是指使得相邻顶点染以不同色,每条边与它的端点染以不同的颜色的全染色.设f是图G的E-全染色,图G的一个顶点x在f下的多重色集合C˜(x)是指点x的颜色以及与x关联的边的颜色构成的多重集.若图G的任意两个不同顶点在f下的多重... 图G的E-全染色是指使得相邻顶点染以不同色,每条边与它的端点染以不同的颜色的全染色.设f是图G的E-全染色,图G的一个顶点x在f下的多重色集合C˜(x)是指点x的颜色以及与x关联的边的颜色构成的多重集.若图G的任意两个不同顶点在f下的多重色集合不同,则f称为图G的点被多重集可区别的E-全染色.对图G进行点被多重集可区别的E-全染色所需用的最少的颜色的数目叫做G的点被多重集可区别的E-全色数.利用反证法和构造具体染色的方法,讨论了圈与路的点被多重集可区别的E-全染色问题,给出了圈与路的最优的点被多重集可区别的E-全染色方案,并确定了圈与路的点被多重集可区别的E-全色数. 展开更多
关键词 多重色集合 e-全染色 点被多重集可区别的e-全染色
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Enablers, Difficulties and Features to Implement E-Learning Technology in Conventional Higher Education: Case Study and Prototype Implication
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作者 Yimer Amedie Muhie Cheru Haile Tesfay Biniyam Wondie Tamirat 《Journal of Software Engineering and Applications》 2020年第10期219-244,共26页
<div style="text-align:justify;"> <span style="font-family:Verdana;">Supporting higher education with modern technologies like E-Learning is very important for one country to improve qu... <div style="text-align:justify;"> <span style="font-family:Verdana;">Supporting higher education with modern technologies like E-Learning is very important for one country to improve quality of education, to meet student’s expectations and to continue teaching-learning and training when face to face education is impossible. However, it is in its preliminary stage in developing countries like Ethiopia. This study examined the enabling factors, difficulties and opportunities of E-Learning implementation in Assosa University (ASU), Ethiopia. Its purpose is to find the enabling factors, difficulties and opportunities of E-Learning implementation in ASU and developing prototype of E-Learning system to show its practicality and to identify approaches of students’ and lecturers towards E-Learning. The study employed questionnaires, observation and interview to gather the required information. A sample of 309 students and 64 Lecturers randomly selected from 7 colleges and two schools as well as ICT workers and other concerned bodies in the university. Also prototyping as a methodology was used to implement and test the proposed system for proof of concept. This study investigating the possibility of implementing E-Learning in ASU and important enablers, difficulties and opportunities is identified. Also the E-Learning platform of the university is developed and introduced for students and lecturers to show its practicality. Most students and lecturers showed good motivation in E-Learning implementation and they assumed that it is useful for the university. The result shows that although there are difficulties to implement E-Learning in ASU, the possibility of fully implementing E-Learning in the University is relatively high with mixed method. With this, the approaches of students and lecturers are positively viewed and the opportunities are very noticeable in the University. So, conventional higher education can practically implement E-Learning with mixed approach to use as supportive tool for educational improvements and to reduce physical presence.</span> </div> 展开更多
关键词 e-LEARNING enablers of e-Learning Difficulties of e-Learning e-Learning Im-plementation PROTOTYPING
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