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Insights into epigenetic patterns in mammalian early embryos 被引量:22
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作者 Ruimin Xu Chong Li +1 位作者 Xiaoyu Liu Shaorong Gao 《Protein & Cell》 SCIE CAS CSCD 2021年第1期7-28,共22页
Mammalian fertilization begins with the fusion of two specialized gametes,followed by major epigenetic remodeling leading to the formation of a totipotent embryo.During the development of the pre-implantation embryo,p... Mammalian fertilization begins with the fusion of two specialized gametes,followed by major epigenetic remodeling leading to the formation of a totipotent embryo.During the development of the pre-implantation embryo,precise reprogramming progress is a prerequisite for avoiding developmental defects or embryonic lethality,but the underlying molecular mechanisms remain elusive.For the past few years,unprecedented breakthroughs have been made in mapping the regulatory network of dynamic epigenomes during mammalian early embryo development,taking advantage of multiple advances and innovations in low-input genome-wide chromatin analysis technologies.The aim of this review is to highlight the most recent progress in understanding the mechanisms of epigenetic remodeling during early embryogenesis in mammals,including DNA methylation,histone modifications,chromatin accessibility and 3D chromatin organization. 展开更多
关键词 epigenetic reprogramming DNA methylation histone modifications early embryo development
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Epigenetic Modification in Oocyte and Preimplantation Embryonic Development
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作者 Yi-Xin Ren William Chang Jie Qiao 《Reproductive and Developmental Medicine》 CSCD 2017年第1期13-17,共5页
DNA methylation and histone modification are two of the most characterized epigenetic modifications.With advanced detecting techniques,particularly single-cell sequencing,we can dissect epigenomic patterns and their r... DNA methylation and histone modification are two of the most characterized epigenetic modifications.With advanced detecting techniques,particularly single-cell sequencing,we can dissect epigenomic patterns and their regulatory roles in the growth and differentiation of gametes and early embryos in animals and humans.Assisted reproductive technology(ART)procedures have been shown to influence the methylation of certain genes.Aberrant epigenetic regulation may cause several developmental disorders and clinical diseases.Here,we describe some concepts in epigenetics and review recent researches on DNA methylation and the histone modification profile and their regulatory roles during early embryo development.We also summarize the recent progress in understanding the imprinting disorders associated with ART procedures. 展开更多
关键词 Assisted Reproductive Technology DNA Methylation early embryo development Histone Modification
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