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Partial Fusion (F) Gene Analysis of Newcastle Disease Virus Detected in Pakistan during 2021-2022
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作者 Muhammad Danish Mehmood Huma Anwar Ul-Haq +6 位作者 Rauf Khalid Yasir Amin Muhammad Usman Ghani Muhammad Ismail Rabia Habib Fareeha Arshed Abdul Rasheed Shaukat 《Journal of Biosciences and Medicines》 2024年第5期256-275,共20页
Newcastle disease (ND) virus is a leading threat to commercial and domestic poultry in Pakistan. The virus infects and constitutes irreversible impairment to the nervous system, damages the respiratory system, and mar... Newcastle disease (ND) virus is a leading threat to commercial and domestic poultry in Pakistan. The virus infects and constitutes irreversible impairment to the nervous system, damages the respiratory system, and marks severe gastrointestinal lesions leading to heavy mortality in short-living birds and substantial losses in layers and breeders. The continuous emergence and evolution of the virus made it inclined to evade the humoral response and indirectly the circumvention of artificial active immunization. Newcastle disease is caused by the orthoavula genus of the paramyxoviridae family and has shown high genetic diversity even in their genotypes while information regarding enzootic trends of the virus is scanty in Pakistan. A total of 40 tracheal samples of NDV were collected from different commercial broiler farms and 11 isolates of NDV were identified. In the current study, we determined the genetic diversity of the Newcastle disease virus based on the partial sequencing of the fusion protein gene available in the NCBI database. Genetic analysis showed that seven isolates belonged to class I genotype VII and four belonged to class II genotype II. Interestingly, two isolates had epidemiological connections with vaccine-like class II genotype II. Our findings, concerning the recent outbreaks of class I genotype VII and class II genotype II of NDV in vaccinated commercial flocks, suggest possible potential partial mutations in the fusion protein gene. Genetic diversity and formation of the new cleavage site in an important neutralizing protein of wild strain are linked with the potency of artificial active immunization and a major cause of vaccine failure. 展开更多
关键词 Newcastle Disease Virus Haemagglutination Inhibition Polymerase Chain Reaction Phylogenetic Tree Mutation analysis
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Investigation and Analysis of Main Diseases of Landscape Plants in the Main Urban Area of Lu'an City
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作者 Gao LIU Hao SONG Juanjuan HU 《Plant Diseases and Pests》 2024年第1期18-21,共4页
To figure out the disease occurrence of landscape plants in the main urban area of Lu'an City,the author investigated the disease occurrence of landscape plants in park green space,residential green space,unit att... To figure out the disease occurrence of landscape plants in the main urban area of Lu'an City,the author investigated the disease occurrence of landscape plants in park green space,residential green space,unit attached green space and main road in the area under administration.The survey results showed that there were 29 species of urban landscape plant diseases,mainly powdery mildew and spot diseases.According to the characteristics of the diseases,the causes and problems of the diseases were analyzed,and the corresponding prevention and control measures were put forward. 展开更多
关键词 Landscape plant Disease species INVESTIGATION Status analysis Lu'an City
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Correlation Analysis between Well-cellar Early Transplanting of Robust Seedlings and Diseases in Shiyan Tobacco-growing Area
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作者 Dingjun WANG Aihua LI +4 位作者 Liguang CHAI Dan LIU Yixia LIU Minggang LI Jingyang PENG 《Plant Diseases and Pests》 2024年第4期21-24,36,共5页
[Objectives]The paper was to investigate the relationship between the well-cellar early transplanting of robust seedlings and the prevalence of diseases in the Shiyan tobacco-growing area.[Methods]The relationship bet... [Objectives]The paper was to investigate the relationship between the well-cellar early transplanting of robust seedlings and the prevalence of diseases in the Shiyan tobacco-growing area.[Methods]The relationship between disease occurrence and meteorological factors during the field growth period was examined by analyzing the prevalence of flue-cured tobacco virus diseases,brown spot,and total disease in the Shiyan tobacco-growing area before(2013-2017)and after(2018-2022)the well-cellar early transplanting of robust tobacco seedlings.[Results]The implementation of a well-cellar early transplanting technique of robust seedlings resulted in a reduction in the average incidence of tobacco virus disease,brown spot,and total disease by 0.83%,8.85%,and 7.91%,respectively,in comparison to the incidence observed prior to early transplanting.These findings suggest that early transplanting can significantly reduce the incidence of flue-cured tobacco diseases.Prior to the well-cellar early transplanting of robust tobacco seedlings,there was a significant(including highly significant)positive correlation between the incidence of brown spot and total disease and precipitation in August and September.The incidence of brown spot and total disease in tobacco plants was found to be significantly positively correlated with May precipitation and significantly negatively correlated with May sunshine hours following the well-cellar early transplanting of robust seedlings.The advancement of the transplanting period by 20 d resulted in a reduction in the growing period of tobacco plants in the field under autumn rains(late August to November)in western China.This effectively circumvented the suitable conditions for disease occurrence and can reduce the incidence of disease.[Conclusions]This study offers a framework for enhancing the quality and efficiency of flue-cured tobacco production in the northwest tobacco-growing area of Hubei. 展开更多
关键词 Tobacco disease Well-cellar early transplanting of robust seedlings Meteorological factor Correlation analysis Shiyan tobacco-growing area
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Research status and prospects of the fractal analysis of metal material surfaces and interfaces
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作者 Qinjin Dai Xuefeng Liu +2 位作者 Xin Ma Shaojie Tian Qinghe Cui 《International Journal of Minerals,Metallurgy and Materials》 SCIE EI CAS 2025年第1期20-38,共19页
As a mathematical analysis method,fractal analysis can be used to quantitatively describe irregular shapes with self-similar or self-affine properties.Fractal analysis has been used to characterize the shapes of metal... As a mathematical analysis method,fractal analysis can be used to quantitatively describe irregular shapes with self-similar or self-affine properties.Fractal analysis has been used to characterize the shapes of metal materials at various scales and dimensions.Conventional methods make it difficult to quantitatively describe the relationship between the regular characteristics and properties of metal material surfaces and interfaces.However,fractal analysis can be used to quantitatively describe the shape characteristics of metal materials and to establish the quantitative relationships between the shape characteristics and various properties of metal materials.From the perspective of two-dimensional planes and three-dimensional curved surfaces,this paper reviews the current research status of the fractal analysis of metal precipitate interfaces,metal grain boundary interfaces,metal-deposited film surfaces,metal fracture surfaces,metal machined surfaces,and metal wear surfaces.The relationship between the fractal dimensions and properties of metal material surfaces and interfaces is summarized.Starting from three perspectives of fractal analysis,namely,research scope,image acquisition methods,and calculation methods,this paper identifies the direction of research on fractal analysis of metal material surfaces and interfaces that need to be developed.It is believed that revealing the deep influence mechanism between the fractal dimensions and properties of metal material surfaces and interfaces will be the key research direction of the fractal analysis of metal materials in the future. 展开更多
关键词 metal material surfaces and interfaces fractal analysis fractal dimension HOMOGENEITY
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Correlation Analysis Between Changes of D-Dimer Level and Rheumatoid Arthritis Complicated with Interstitial Lung Disease
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作者 Ying Li 《Journal of Clinical and Nursing Research》 2024年第6期393-397,共5页
Objective:To explore the correlation between the change of D-dimer level and rheumatoid arthritis complicated with interstitial lung disease.Methods:From January 2022 to February 2024,20 rheumatoid arthritis patients ... Objective:To explore the correlation between the change of D-dimer level and rheumatoid arthritis complicated with interstitial lung disease.Methods:From January 2022 to February 2024,20 rheumatoid arthritis patients complicated with interstitial lung disease(interstitial lung disease group),20 rheumatoid arthritis patients without interstitial lung disease(without interstitial lung disease group),and 20 healthy people(control group)in Xijing Hospital were selected for this study.The fasting venous blood of the three groups of subjects was collected and their D-dimer,C-reactive protein(CRP),rheumatoid factor(RF),and erythrocyte sedimentation rate(ESR)were detected.Subsequently,the correlation between each index and rheumatoid arthritis complicated with interstitial lung disease was analyzed.Results:The D-dimer level of the interstitial lung disease group was significantly higher than the other two groups(P<0.05).The D-dimer level of the group without interstitial lung disease was significantly higher than the control group(P<0.05).CRP levels in the interstitial lung disease group and the group without interstitial lung disease were significantly higher than those of the control group(P<0.05).The ESR and RF levels of the interstitial lung disease group were significantly higher than the other two groups(P<0.05).The levels of ESR and RF levels of the group without interstitial lung disease were significantly higher than the control group(P<0.05).Conclusion:D-dimer levels of rheumatoid arthritis patients are higher than those of healthy individuals,and those complicated with interstitial lung disease present even higher levels.This finding shows that there is a correlation between D-dimer levels and rheumatoid arthritis with interstitial lung disease,which may facilitate the evaluation and diagnosis of this disease. 展开更多
关键词 D-DIMER Rheumatoid arthritis complicated with interstitial lung disease ESR Rheumatoid factor Correlation analysis
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Multilevel analysis of the central-peripheral-target organ pathway:contributing to recovery after peripheral nerve injury
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作者 Xizi Song Ruixin Li +6 位作者 Xiaolei Chu Qi Li Ruihua Li Qingwen Li Kai-Yu Tong Xiaosong Gu Dong Ming 《Neural Regeneration Research》 SCIE CAS 2025年第10期2807-2822,共16页
Peripheral nerve injury is a common neurological condition that often leads to severe functional limitations and disabilities.Research on the pathogenesis of peripheral nerve injury has focused on pathological changes... Peripheral nerve injury is a common neurological condition that often leads to severe functional limitations and disabilities.Research on the pathogenesis of peripheral nerve injury has focused on pathological changes at individual injury sites,neglecting multilevel pathological analysis of the overall nervous system and target organs.This has led to restrictions on current therapeutic approaches.In this paper,we first summarize the potential mechanisms of peripheral nerve injury from a holistic perspective,covering the central nervous system,peripheral nervous system,and target organs.After peripheral nerve injury,the cortical plasticity of the brain is altered due to damage to and regeneration of peripheral nerves;changes such as neuronal apoptosis and axonal demyelination occur in the spinal cord.The nerve will undergo axonal regeneration,activation of Schwann cells,inflammatory response,and vascular system regeneration at the injury site.Corresponding damage to target organs can occur,including skeletal muscle atrophy and sensory receptor disruption.We then provide a brief review of the research advances in therapeutic approaches to peripheral nerve injury.The main current treatments are conducted passively and include physical factor rehabilitation,pharmacological treatments,cell-based therapies,and physical exercise.However,most treatments only partially address the problem and cannot complete the systematic recovery of the entire central nervous system-peripheral nervous system-target organ pathway.Therefore,we should further explore multilevel treatment options that produce effective,long-lasting results,perhaps requiring a combination of passive(traditional)and active(novel)treatment methods to stimulate rehabilitation at the central-peripheral-target organ levels to achieve better functional recovery. 展开更多
关键词 central nervous system central peripheral target organ multilevel pathological analysis nerve regeneration peripheral nerve injury peripheral nervous system target organs therapeutic approach
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Genetic Analysis of the VP2 Hypervariable Region of Thirty-six Infectious Bursal Disease Virus Isolates in China during 2009-2012 被引量:2
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作者 祁小乐 秦立廷 +10 位作者 高玉龙 高宏雷 李颖颖 高立 卢珍 王念 陈玉明 张礼洲 李凯 王永强 王笑梅 《Agricultural Science & Technology》 CAS 2015年第8期1565-1569,1602,共6页
[Objective] Infectious bursal disease (IBD) is a highly contagious immuno- suppressive disease caused by infectious bursal disease virus (IBDV). IBDV is ge- netically prone to mutation, which results in challenges... [Objective] Infectious bursal disease (IBD) is a highly contagious immuno- suppressive disease caused by infectious bursal disease virus (IBDV). IBDV is ge- netically prone to mutation, which results in challenges to the disease prevention and control. Thus, it is necessary to continuously monitor the prevalence of IBDV. [Method] 36 IBDVs were identified from ten provinces in China from 2009 to 2012. Partial fragments of VP2, including the hypervariable region (HVR), from new iso- lates were sequenced and analyzed through comparisons with published sequences of IBDV, including 18 strains isolated previously by our lab and 24 reference strains from China and around the world. [Result] Phylogenetic analysis showed a co-exis- tence of IBDV strains belonging to classic, variant, attenuated, and very virulent IB- DV (wlBDV) in China. wlBDVs remain the predominant strains in China and the new subgroup was emerging. Alignment analysis revealed several distinct amino acid mutations that might be involved in virulence or antigenicity variation. [Conclu- sion] The results offered evolutionary clues showing the emerging trend of obvious variations and diversity of IBDV in major poultry-producing regions of China particu- larly in recent years. These findings will contribute to a better understanding of the genetic evolution of IBDV. 展开更多
关键词 Genetic analysis VP2 Infectious bursal disease virus
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Construction of Midgut Tissue-Specific cDNA Library of Bombyx mandarina M. and Isolation and Sequence Analysis of Serine Protease Gene Fragment
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作者 王燕红 李兵 +4 位作者 王东 朱莎 赵华强 卫正国 沈卫德 《Agricultural Science & Technology》 CAS 2008年第3期35-38,共4页
[Objective] The aim of the study is to construct cDNA library of midgut tissue of wild silkworm and isolate the serine protease gene. [Method] The midgut tissue-specific cDNA library of wild silkworm was constructed v... [Objective] The aim of the study is to construct cDNA library of midgut tissue of wild silkworm and isolate the serine protease gene. [Method] The midgut tissue-specific cDNA library of wild silkworm was constructed via cDNA Library Construction Kit (TaKaRa), then the serine protease gene was cloned via sequencing of the yielded cDNA library. [Result] The titer of cDNA library reached 6.2×105 pfu/ml, average insert size was about 1.2 kb. The serine protease gene cDNA fragment was obtained from colony sequencing (Accession No: EU672968). The nucleotide sequence of the cloned 854 bp fragment encodes 284 amino acid residues. Homology analyses showed some homology between putative amino acid sequence of the cloned fragment and amino acid sequences of serine proteases from other ten insects. [Conclusion] The results may avail to reveal the resistance of silkworm and wild silkworm to exotic intrusion. 展开更多
关键词 Bombyx mandarina M. MIDGUT tissue cDNA LIBRARY SERINE PROTease gene Sequence analysis
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Genome Analysis in Wheat Breeding for Disease Resistance 被引量:2
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作者 刘大钧 《Acta Botanica Sinica》 CSCD 2002年第9期1096-1104,共9页
A brief review on the development of wheat germplasm with introduced powdery mildew and scab resistance from Haynaldia villosa Sch. and Leymus racemosus Lam., Roegneria ciliaris (Trin.) Nevski as well as R. kamoji C. ... A brief review on the development of wheat germplasm with introduced powdery mildew and scab resistance from Haynaldia villosa Sch. and Leymus racemosus Lam., Roegneria ciliaris (Trin.) Nevski as well as R. kamoji C. Koch respectively was made. In the course of germplasm development, genome analysis by means of chromosome banding, genomic in situ hybridization (GISH) or fluorescence in situ hybridization (FISH), molecular markers, particularly restriction fragment length polymorphism (RFLP) coupled with aneuploid analysis was employed for the purpose of improving breeding efficiency. Potential use of such germplasm in wheat breeding practice, basic studies and some related problems were also discussed. 展开更多
关键词 Triticum aestivum wheat relatives powdery mildew resistance scab resistance chromosome banding in situ hybridization molecular marker genome analysis
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Analysis on Resistance of Rice Cultivar Lianjing 7 to Rice Black-streaked Dwarf Disease
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作者 王宝祥 谭维娜 +2 位作者 卢百关 宋兆强 徐大勇 《Agricultural Science & Technology》 CAS 2015年第1期93-98,共6页
To analyze the resistance of Lianjing 7 against rice black-streaked dwarf disease and find the molecular markers closely linked with the resistance gene, an F2:3 population derived from an RBSDD-resistant cultivar Li... To analyze the resistance of Lianjing 7 against rice black-streaked dwarf disease and find the molecular markers closely linked with the resistance gene, an F2:3 population derived from an RBSDD-resistant cultivar Lianjing 7 and an RBSDD-susceptible cultivar Peiai 64, was evaluated using natural infection methods and artificial inoculation by scoring the disease severity rating. The results showed Lianjing 7 was resistant to RBSDD, with the incidence between 5.5% and 12.25% in all tests. For the parents of Lianjing 7, only Zhongjingchuan-2 was resistant to RBSDD. Besides this, Lianjing 7 assumed an antixenosis and antibiosis score similar with susceptible variety Wuyujing 3, which indicates that so RBSDD-resistance of Lianjing 7 is mainly caused by the resistance specifically to RBSDV. In the F2:3 population of Lianjing 7/Peiai 64, the disease severity rates showed a continuous distribution with transgressive segregation, it indicated the resistance of Lianjing 7 was controlled by multi-genes. The marker RM287 was determined closely linked with the resistance locus via BSA method. To conclude, Lianjing 7 has a high resistance to RBSDD, which is conferred with by Zhongjingchuan-2, and the marker RM287 should be useful for breeding novel RBSDD-resistant cultivars via marker-assisted selection (MAS). 展开更多
关键词 Rice (Oryza sativa L.) Lianjing 7 RBSDD Resistance analysis
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Epidemiological Analysis of Sexually Transmitted Disease Control and Prevention from 1998 to 2003 in Chongqing
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作者 丁贤彬 杨明芳 邝富国 《Chinese Journal of Sexually Transmitted Infections》 2005年第1期13-16,共4页
Objectives: To understand trends and epidemiology of STDs in Chongqing from 1998 to 2003 and to provide scientific evidence for developing preventive strategies and distributing government health resources effectivel... Objectives: To understand trends and epidemiology of STDs in Chongqing from 1998 to 2003 and to provide scientific evidence for developing preventive strategies and distributing government health resources effectively. Methods: STD case-reporting data collected from 43 counties and districts in Chongqing from 1998 to 2003 were analyzed with STD Data Management Software and Excel Software. Results: A total of 133,323 cases of eight different STDs were reported from 1998-2003. The annual incidence of all eight STDs combined was 71.89/10^5.Generally, reported cases and incidence have decreased since 2001. Although gonorrhoea diagnoses made up a significant proportion of the STD burden, this proportion decreased annually. The proportion of the STD burden attributed to Condyloma accuminatum (CA) was always above 30 percent. The proportions of non-gonoccocal urethritis, genital herpes and syphilis within the combinedSTD burden increased gradually from 1998 to 2003.Reported cases of HIV increased rapidly over this time. A total of 214 HIV cases were reported from 1998 to 2003,the majority of which were among men. For HIV, the maleto-female ratio was 1.17, but CA was found among more women than men. Incidence for all STDs was highest among 20-39 year olds, who accounted for 72.2% of reported infections. The majority of STDs were transmitted through extra-marital intercourse,accounting for 55.3%. Conclusion: The STD epidemic in Chongqing changed from 1998-2003. STD incidence declined, as a result of various factors. The epidemiology of STDs has changed.HIV incidence has increased rapidly. This indicates that the AIDS epidemic has reached a critical period. The results of this study suggest a need for readjusting control measures and redistributing health resources. 展开更多
关键词 Sexually Transmitted Disease (STD) EPIDEMIOLOGY analysis
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A bibliometric analysis of academic publication on diabetic retinopathy disease trends during 1980-2014:a global and medical view 被引量:7
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作者 Cagatay Caglar Emre Demir +1 位作者 Ferit Kerim Kucukler Mustafa Durmus 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2016年第11期1663-1668,共6页
AIM: To investigate diabetic retinopathy(DR) literature using the Institute for Scientific Information(ISI) Web of Science(Wo S) database and to analyse the correlation results between socio-economic developmen... AIM: To investigate diabetic retinopathy(DR) literature using the Institute for Scientific Information(ISI) Web of Science(Wo S) database and to analyse the correlation results between socio-economic development datas and number of DR publications.METHODS: The statistical analysis of the documents published during 1980-2014 was analysed. The data of this study were based on the database of Wo S. "Diabetic retinopathy" was used as the keywords to search the Wo S database.RESULTS: The United States ranked first in the DR research with 1840 publications and 24.38% of the world production followed by England and Japan. Besides, the most productive country was Iceland. A high correlation was found between number of publications and 2014 gross domestic product( GDP) values of 81 countries(r =0.800, P 〈0.001). We found a significant correlation between number of publications and Human Development Index(HDI)(r =0.645, P =0.001). There is a moderate correlation between people with diabetes and number of DR publications for 81 countries(r =0.514, P 〈0.01). It could be analysed that estimated publication number with DR title will be 445 according to the regression curve constituted with cubic model in 2015(R2=1.000).CONCLUSION: More DR studies have been published in developed countries, DR and other complications of diabetes have gradually increased in developing countries over recent decades. It can be expected that the number of DR studies will gradually increase in developing countries. 展开更多
关键词 BIBLIOMETRICS correlation analysis developingcountries diabetic retinopathy socio-economic development
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Clinical classification and gene mutation of Chinese probands with Charcot-Marie-Tooth disease Analysis of 57 cases 被引量:4
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作者 Ruxu Zhang Xiaobo Li +5 位作者 Xiaohong Zi Shunxiang Huang Fufeng Zhang Kun Xia Qian Pan Beisha Tang 《Neural Regeneration Research》 SCIE CAS CSCD 2011年第9期706-711,共6页
Charcot-Marie-Tooth (CMT) disease is the most common inherited peripheral neuropathic disorder. CMT is clinically and genetically heterogeneous. To date, 27 genes associated with the disease have been cloned. The pr... Charcot-Marie-Tooth (CMT) disease is the most common inherited peripheral neuropathic disorder. CMT is clinically and genetically heterogeneous. To date, 27 genes associated with the disease have been cloned. The present study carried out clinical classification according to clinical, electrophysiological and pathological features, conducted inheritance classification according to inheritance patterns, and performed mutation analysis of 13 CMT disease genes (PMP22, CX32, HSPB1, MNF2, MPZ, HSPB8, GDAP1, NFL, EGR2, SIMPLE, RAB7, LMNA, MTMR2) in 57 Chinese probands with CMT. Five cases of AD-CMT1 and 13 cases of sporadic CMT1 were diagnosed as CMT1A; five cases of X-CMT1, one case of X-CMT2 and one case of sporadic CMT1 were diagnosed as CMTXl; four cases of AD-CMT2 were diagnosed as CMT2F; one case of AD-CMT2 and one case of sporadic CMT2 were diagnosed as CMT2A2; one case of AD-CMT2 was diagnosed as CMT2L; one case of AD-CMT2 was diagnosed as CMT2J; one case of AR-CMT1 was diagnosed as CMT4A. Among the 57 CMT probands, seven genotypes were determined among 34 patients, with a detection rate of 59.6%. The results indicated that the clinical classification and inheritance classification are indispensable for selecting potential disease genes for mutation detection, and for efficient molecular diagnosis. 展开更多
关键词 Charcot-Marie-Tooth disease clinical classification GENE mutation analysis
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Spatial analysis increases efficiency of progeny testing of Chinese fir 被引量:4
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作者 Liming Bian Renhua Zheng +4 位作者 Shunde Su Huazhong Lin Hui Xiao Harry Xiaming Wu Jisen Shi 《Journal of Forestry Research》 SCIE CAS CSCD 2017年第3期445-452,共8页
We used spatial, global trend and post-blocking analysis to examine the effectiveness of a progeny trial in a tree breeding program for Chinese fir (Cunninghamia lanceolata (Lamb.) Hook) on a hilly site with an en... We used spatial, global trend and post-blocking analysis to examine the effectiveness of a progeny trial in a tree breeding program for Chinese fir (Cunninghamia lanceolata (Lamb.) Hook) on a hilly site with an environmental gradient from hill top to bottom. Diameter at breast height (DBH) and tree height data had significant spatial auto-correlations among rows and columns. Adding a firstorder separable autoregressive term more effectively modelled the spatial variation than did the incomplete block (IB) model used for the experimental design. The spatial model also accounted for effects of experimental design factors and greatly reduced residual variances. The spatial analysis rel- ative to the IB analysis improved estimation of genetic parameters with the residual variance reduced 13 and 19% for DBH and tree height, respectively; heritability increased 35 and 51% for DBH and tree height, respectively; and genetic gain improved 3-5%. Fitting global trend and postblocking did not improve the analyses under IB model. The use of a spatial model or combined with a design model is recommended for forest genetic trials, particularly with global trend and local spatial variation of hilly sites. 展开更多
关键词 Chinese fir Genetic variance HERITABILITIES Progeny testing Spatial analysis
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Weighted Markov chains for forecasting and analysis in Incidence of infectious diseases in jiangsu Province,China 被引量:10
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作者 Zhihang Peng Changjun Bao +5 位作者 Yang Zhao Honggang Yi Letian Xia Hao Yu Hongbing Shen Feng Chen 《The Journal of Biomedical Research》 CAS 2010年第3期207-214,共8页
This paper first applies the sequential cluster method to set up the classification standard of infectious disease incidence state based on the fact that there are many uncertainty characteristics in the incidence cou... This paper first applies the sequential cluster method to set up the classification standard of infectious disease incidence state based on the fact that there are many uncertainty characteristics in the incidence course.Then the paper presents a weighted Markov chain,a method which is used to predict the future incidence state.This method assumes the standardized self-coefficients as weights based on the special characteristics of infectious disease incidence being a dependent stochastic variable.It also analyzes the characteristics of infectious diseases incidence via the Markov chain Monte Carlo method to make the long-term benefit of decision optimal.Our method is successfully validated using existing incidents data of infectious diseases in Jiangsu Province.In summation,this paper proposes ways to improve the accuracy of the weighted Markov chain,specifically in the field of infection epidemiology. 展开更多
关键词 weighted.Markov chains sequential cluster infectious diseases forecasting and analysis Markov chain Monte Carlo
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Characterization of increased cuticular wax mutant and analysis of genes involved in wax biosynthesis in Dianthus spiculifolius 被引量:5
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作者 Aimin Zhou Enhui Liu +3 位作者 Jiao Liu Shuang Feng Shufang Gong Jingang Wang 《Horticulture Research》 SCIE 2018年第1期384-392,共9页
Cuticular wax formation on the surface of plant leaves is associated with drought-stress tolerance.The identification of wax biosynthesis-related genes will contribute to the genetic improvement of drought resistance ... Cuticular wax formation on the surface of plant leaves is associated with drought-stress tolerance.The identification of wax biosynthesis-related genes will contribute to the genetic improvement of drought resistance in plants.In this study,we characterize a novel Dianthus spiculifolius mutant with increased cuticular wax.The mutant exhibited stronger drought resistance as indicated by less leaf wilting and death,higher leaf relative water content and water retention capacity,and slower water loss and chlorophyll extraction than did the wild type during drought treatment.In the mutant leaves,2730 upregulated and 2151 downregulated differentially expressed genes(DEGs)were identified by transcriptome sequencing.A wax biosynthesis pathway of the identified DEGs was significantly enriched.Finally,three key genes(DsCER1,DsMAH1,and DsWSD1)involved in wax biosynthesis were identified and verified by qPCR.These results suggest that differential expression of DEGs involved in wax biosynthesis may be associated with the increase in cuticular wax in the mutant.Taken together,our results help elucidate wax formation patterns in D.spiculifolius.Furthermore,the DEGs involved in wax biosynthesis identified here may be valuable genetic resources for improving plant stress tolerance through increased accumulation of cuticular wax. 展开更多
关键词 DROUGHT SLOWER analysis
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Pedicle Screw Fixation with Kyphoplasty Decreases the Fracture Risk of the Treated and Adjacent Non-treated Vertebral Bodies:a Finite Element Analysis 被引量:4
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作者 Pan YANG Ying ZHANG +7 位作者 Huan-wen DING Jian LIU Lin-qiang YE Jin XIAO Qiang TU Tao YANG Fei WANG Guo-gang SUN 《Journal of Huazhong University of Science and Technology(Medical Sciences)》 SCIE CAS 2016年第6期887-894,共8页
Adjacent vertebral fractures are common in patients with osteoporotic vertebral compression fractures(OVCFs) after kyphoplasty.This finite element study was to examine whether short segment pedicle screw fixation(... Adjacent vertebral fractures are common in patients with osteoporotic vertebral compression fractures(OVCFs) after kyphoplasty.This finite element study was to examine whether short segment pedicle screw fixation(PSF) with kyphoplasty may decrease the fracture risk of the treated and adjacent non-treated vertebrae after kyphoplasty for OVCFs.By simulating cement augmentation with or without short segment pedicle screw fixation(PSF),two tridimensional,anatomically detailed finite element models of the T10–L2 functional spinal junction were developed.The insertion of pedicle screws into the intact vertebra apparently decreased the stress distribution of the treated vertebra in vertical compression and other load situations.The stress distribution in the bone structures of the intact vertebra adjacent to the intact-screwed vertebra was much less than that in the one adjacent to the treated vertebra.The insertion of pedicle screws into the intact vertebra greatly decreased the maximum displacement of the cortical bones and cancellous bones of the vertebrae.Our results indicated that short segment PSF with kyphoplasty may decrease the fracture risk of the treated and adjacent non-treated vertebrae in the management of OVCFs. 展开更多
关键词 finite element analysis osteoporotic vertebral compression fractures KYPHOPLASTY BIOMECHANICS pedicle screw fixation
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Disagreement between symptom-reflux association analysis parameters in pediatric gastroesophageal reflux disease investigation 被引量:3
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作者 Samuel C Lüthold Mascha K Rochat Peter Bhler 《World Journal of Gastroenterology》 SCIE CAS CSCD 2010年第19期2401-2406,共6页
AIM: To assess the agreement within 3 commonly used symptom-reflux association analysis (SAA) parameters investigating gastroesophageal reflux disease (GERD) in infants. METHODS: Twenty three infants with suspected GE... AIM: To assess the agreement within 3 commonly used symptom-reflux association analysis (SAA) parameters investigating gastroesophageal reflux disease (GERD) in infants. METHODS: Twenty three infants with suspected GERD were included in this study. Symptom index (SI), Symptom sensitivity index (SSI) and symptom association probability (SAP) related to cough and irritability were calculated after 24 h combined pH/multiple intraluminal impedance (MII) monitoring. Through defined cutoff values, SI, SSI and SAP values are differentiated in normal and abnormal, whereas abnormal values point towards gastroesophageal reflux (GER) as the origin of symptoms. We analyzed the correlation and the concordance of the diagnostic classification of these 3 SAA parameters.RESULTS: Evaluating the GER-irritability association, SI, SSI and SAP showed non-identical classification of normal and abnormal cases in 39.2% of the infants. When irritability was taken as a symptom, there was only a poor inter-parameter association between SI and SSI, and between SI and SAP (Kendall’s tau b = 0.37, P < 0.05; Kendall’s tau b = 0.36, P < 0.05, respectively). Evaluating the GER-cough association, SI, SSI and SAP showed non-identical classification of normal and abnormal cases in 52.2% of the patients. When cough was taken as a symptom, only SI and SSI showed a poor inter-parameter association (Kendall’s tau b = 0.33, P < 0.05). CONCLUSION: In infants investigated for suspected GERD with pH/MII-monitoring, SI, SSI and SAP showed a poor inter-parameter association and important dis-agreements in diagnostic classification. These limitations must be taken into consideration when interpreting the results of SAA in infants. 展开更多
关键词 Gastroesophageal reflux disease INFANT Symptom-reflux association analysis Intraluminal impedance monitoring pH
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Controlled-Release Analysis of Potassium Permanganate Using PMMA Matrix 被引量:3
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作者 Jude O. Ighere Ramesh C. Chawla 《Journal of Minerals and Materials Characterization and Engineering》 2014年第6期539-544,共6页
Excess amount of potassium permanganate has often been used in-situ for chemical oxidation of contaminated sites. The consequences are not limited to secondary contamination and cost but also inefficient remediation. ... Excess amount of potassium permanganate has often been used in-situ for chemical oxidation of contaminated sites. The consequences are not limited to secondary contamination and cost but also inefficient remediation. Encapsulation of permanganate using PMMA enables controlled dissolution of the oxidant and aids long-term processes. This paper focuses on the oxidant release efficiency from polymer matrix and analysis of data using existing models for glassy polymers. The efficiency profile obtained using mass ratios of 2:1, 4:1, and 8:1 of PMMA to KMnO4 showed a decrease in the extent of release with increasing mass ratio with 79%, 55.35% and 33.59% respectively. Patches were noticed on the surfaces of PMMA after the release of KMnO4, these were attributed to crevices created by the non-fickian diffusion of the oxidant. 展开更多
关键词 PMMA CONTROLLED-RELease PERMANGANATE analysis ENCAPSULATION
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MATHEMATICAL ANALYSIS OF DRUG RELEASE FROM PLANAR MATRIX WHEN DRUG IS LOADED UNDER THE SOLUBILITY 被引量:1
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作者 徐铜文 何炳林 +2 位作者 张凤宝 张国亮 王绍亭 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 1996年第3期86-92,共7页
1 INTRODUCTIONThe release of a drug from a diffusional matrix has been investigated by variousresearchers for different conditions [1-4].The drug loading in the matrix may beabove or below its solubility limit.If it i... 1 INTRODUCTIONThe release of a drug from a diffusional matrix has been investigated by variousresearchers for different conditions [1-4].The drug loading in the matrix may beabove or below its solubility limit.If it is beyond,the release boundary is generated bythe dissolution of drug,and the concentration in the released region may be propor-tional to the distance and kept at saturation in the unreleased region.Otherwise。 展开更多
关键词 planar matrix controlled release diffusion MATHEMATICAL analysis
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