α-Poly(_(L)-lysine)(α-PLL)is a water-soluble cationic biopolymer containing the monomeric unitα-_(L)-lysine,which not only possesses excellent intrinsic properties but also can be modified via facile reactions betw...α-Poly(_(L)-lysine)(α-PLL)is a water-soluble cationic biopolymer containing the monomeric unitα-_(L)-lysine,which not only possesses excellent intrinsic properties but also can be modified via facile reactions between the side amine groups and many other functional moieties.Ring-opening polymerization(ROP)is the most prevalently used technique for the synthesis of PL_(L)-based polypeptides,which involves initial conversion of theε-primary amine-protectedα-_(L)-lysine to the _(L)-lysine NCA monomer.However,obtaining N-carboxyanhydrides(NCAs)in high purity has been a formidable challenge for over 50 years,let alone the large-scale synthesis.Herein,we show an unprecedented scale-up synthesis of _(L)-Cbz-LysNCA monomer and its polymers,generating linearα-poly(_(L)-lysine)with molecular weight(MW)up to 13.4 kDa.This easy operated scale-up strategy will lay the foundations for the industrial preparation of _(L)-Cbz-LysNCA and its polymers,and further extend the realm of existing applications,offering a paradigm for scale-up synthesis of other polypeptides.展开更多
3-Aminopropyltriethoxysilane functionalized worm-like mesoporous silica monolithic（WMSM-NH2） was prepared and used as a new regenerable adsorbent for the removal of Cu2＋ ions. The analysis results show that the WMS...3-Aminopropyltriethoxysilane functionalized worm-like mesoporous silica monolithic（WMSM-NH2） was prepared and used as a new regenerable adsorbent for the removal of Cu2＋ ions. The analysis results show that the WMSM-NH2 monolithic had a high efficiency value of 99.3% for Cu2＋ remediation when the Cu2＋ solution was at an initial concentration of 10.32 mg/L. The regeneration study of the WMSM-NH2 monolithic presented that the adsorp- tion efficiency of 89.0% was remained and a mass of 92.0% was left after seven adsorption-desorption cycles were executed. The monolithic material with high resistance to the acid and good mechanical stability can facilitate the operations of adsorption and regeneration of the adsorbent.展开更多
基金supported by the National Natural Science Foundation of China(91856113 and U21A2089)the National Key Research and Development Program of China(2022YFE0130500).
文摘α-Poly(_(L)-lysine)(α-PLL)is a water-soluble cationic biopolymer containing the monomeric unitα-_(L)-lysine,which not only possesses excellent intrinsic properties but also can be modified via facile reactions between the side amine groups and many other functional moieties.Ring-opening polymerization(ROP)is the most prevalently used technique for the synthesis of PL_(L)-based polypeptides,which involves initial conversion of theε-primary amine-protectedα-_(L)-lysine to the _(L)-lysine NCA monomer.However,obtaining N-carboxyanhydrides(NCAs)in high purity has been a formidable challenge for over 50 years,let alone the large-scale synthesis.Herein,we show an unprecedented scale-up synthesis of _(L)-Cbz-LysNCA monomer and its polymers,generating linearα-poly(_(L)-lysine)with molecular weight(MW)up to 13.4 kDa.This easy operated scale-up strategy will lay the foundations for the industrial preparation of _(L)-Cbz-LysNCA and its polymers,and further extend the realm of existing applications,offering a paradigm for scale-up synthesis of other polypeptides.
基金Supported by the National Natural Science Foundation of China（Nos. 50573030 and 21171065）.
文摘3-Aminopropyltriethoxysilane functionalized worm-like mesoporous silica monolithic（WMSM-NH2） was prepared and used as a new regenerable adsorbent for the removal of Cu2＋ ions. The analysis results show that the WMSM-NH2 monolithic had a high efficiency value of 99.3% for Cu2＋ remediation when the Cu2＋ solution was at an initial concentration of 10.32 mg/L. The regeneration study of the WMSM-NH2 monolithic presented that the adsorp- tion efficiency of 89.0% was remained and a mass of 92.0% was left after seven adsorption-desorption cycles were executed. The monolithic material with high resistance to the acid and good mechanical stability can facilitate the operations of adsorption and regeneration of the adsorbent.
