Strength criterion for crystalline rocks considering grain size effect and tensile-compressive strength ratio

The macroscopic mechanical properties of rocks are significantly influenced by their microstructure.As a material bonded by mineral grains,the grain morphology of crystalline rock is the primary factor influencing the strength.However,most strength criteria neglect the strength variations caused by different grain characteristics in rocks.Furthermore,the traditional linear criteria tend to overestimate tensile strength and exhibit apex singularity.To address these shortcomings,a piecewise strength criterion that considers the grain size effect has been proposed.A part of an ellipse was employed to construct the envelope of the tensive-shear region on the meridian plane,to accurately reproduce the low tensile-compressive strength ratio.Based on the analysis of experimental data,both linear and exponential modification functions that account for grain size effects were integrated into the proposed criterion.The corresponding finite element algorithm has been implemented.The accuracy and applicability of the proposed criterion were validated by comparing with the experimental data.

Three-Dimensional Direct Numerical Simulation of Flow past A Near-Wall Circular Cylinder:Combined Effects of Gap Ratio and Boundary Layer Thickness on Flow Profiles and Pressure Distribution

Three-dimensional direct numerical simulations of the wake flow downstream of a near-wall circular cylinder at different gap ratios and boundary layer thicknesses are carried out by using the iterative immersed boundary method.The non-dimensional gap between the cylinder and the wall,G/D=0.2,0.6 and 1.0,the non-dimensional boundary layer thickness,δ/D=0.0,0.7 and 1.6,the Reynolds number,Re=350,and the aspect ratio of the cylinder,L/D=25are adopted.High-resolution visualizations of the complex vortex structures at differentδ/D and G/D are presented.The transition of the streamwise vortex mode,the combined effects ofδ/D and G/D on the flow statistics,the pressure and shear stress distribution and the hydrodynamic forces are analyzed.Results show that with decreasing G/D and increasingδ/D,the gap flow and its vortex-shedding are significantly weakened,together with an elongated wake and an enlarged low-velocity area near the wall,leading to the wake mode transition from the two-sided to one-sided vortex-shedding.Different relative positions of the cylinder regarding the boundary layer alter the flow features of the shear layers.With an increase inδ/D,the front stagnation point shifts to the upper surface,and the distance between the flow divergence point and the maximum pressure position increases.The mean drag coefficient and r.m.s.values of drag and lift coefficients decrease with a decrease in G/D and an increase inδ/D,while the mean lift coefficient increases with decreasing G/D but decreases with increasingδ/D.

Tailoring-compensated ferrimagnetic state and anomalous Hall effect in quaternary Mn–Ru–V–Ga Heusler compounds

Cubic Mn_(2)Ru_(x)Ga Heusler compound is a typical example of compensated ferrimagnet with attractive potential for high-density,ultrafast,and low-power spintronic applications.In the form of epitaxial thin films,Mn_(2)Ru_(x)Ga exhibits high spin polarization and high tunability of compensation temperature by freely changing the Ru content x in a broad range(0.3<x<1.0).Herein Mn-Ru-Ga-based polycrystalline bulk buttons prepared by arc melting are systematically studied and it is found that in equilibrium bulk form,the cubic structure is unstable when x<0.75.To overcome this limitation,Mn-Ru-Ga is alloyed with a fourth element V.By adjusting the content of V in the By adjusting the content of V in the Mn_(2)Ru_(0.75)V_(y)Ga and Mn_(2.25-y)Ru_(0.75)V_(y)Ga quaternary systems the magnetic compensation temperature is tuned.Compensation is achieved near 300 K which is confirmed by both the magnetic measurement and anomalous Hall effect measurement.The analyses of the anomalous Hall effect scaling in quaternary Mn-Ru-V-Ga alloy reveal the dominant role of skew scattering,notably that contributed caused by the thermally excited phonons,in contrast to the dominant intrinsic mechanism found in many other 3d ferromagnets and Heusler compounds.It is further shown that the Ga antisites and V content can simultaneously control the residual resistivity ratio(RRR)as well as the relative contribution of phonon and defect to the anomalous Hall effect a"/a0'in Mn-Ru-V-Ga,resulting in a scaling relation a"/a0'∝RRR^(1.8).

Effect of Low pH on Forming Process of Desulfurization Gypsum Composite Boards Strengthened by Melamine-formaldehyde Resin

Through exploring the effects of low pH on the composite system of desulfurization gypsum(DG)enhanced by melamine-formaldehyde resin(MF),it is found that the inducing of sulfate-ion,in contrast to chloride and oxalate ions,favors the longitudinal growth of the crystalline form of the hydration product,which was relatively simple and had the highest length to width(L/D)ratio.At the same time,MF can also improve L/D ratio of gypsum hydration products,which favors the formation of hydrated whiskers.Finally,in a composite system composed of hemihydrate gypsum,MF,and glass fibers,when dilute sulfuric acid was used to regulate pH=3-4,the tight binding formed among the components of the composite system compared to pH=5-6.The hydration product of gypsum adheres tightly to glass fiber surface and produces a good cross-linking and binding effect with MF.The flexural strength,compressive strength,elastic modulus,and water absorption of the desulphurized gypsum composite board is 22.7 MPa,39.8 MPa,5608 MPa,and 1.8%,respectively.

Causal associations between intermediate very-low-density lipoprotein cholesterol-to-total lipids ratio and peptic ulcer:A bidirectional Mendelian randomization study

BACKGROUND Previous epidemiologic investigations have consistently demonstrated a strong association between the ratio of cholesterol to total lipids in medium very-lowdensity lipoprotein(VLDL)and the occurrence of peptic ulcers(PU).However,the precise causal relationship between these factors remains ambiguous.Consequently,this study aims to elucidate the potential correlation between the ratio of cholesterol to total lipids in medium VLDL and the incidence of peptic ulcer.AIM To investigate the ratio of cholesterol to total lipids in medium very-low-density lipoprotein(VLDL)association with PU via genetic methods,guiding future clinical research.METHODS Genome-wide association study(GWAS)datasets for the ratio of cholesterol to total lipids in intermediate VLDL and peptic ulcer were retrieved from the IEU OpenGWAS project(https://gwas.mrcieu.ac.uk).For the forward Mendelian randomization(MR)analysis,72 single nucleotide polymorphisms(SNPs)were identified as instrumental variables.These SNPs were selected based on their association with the ratio of cholesterol to total lipids in intermediate VLDL,with peptic ulcer as the outcome variable.Conversely,for the inverse MR analysis,no SNPs were identified with peptic ulcer as the exposure variable and the ratio of cholesterol to total lipids in intermediate VLDL as the outcome.All MR analyses utilized inverse variance weighted(IVW)as the primary analytical method.Additionally,weighted median and MR-Egger methods were employed as supplementary analytical approaches to assess causal effects.Egger regression was used as a supplementary method to evaluate potential directional pleiotropy.Heterogeneity and multiplicity tests were conducted using the leave-one-out method to evaluate result stability and mitigate biases associated with multiple testing.RESULTS The genetically predicted ratio of cholesterol to total lipids in medium VLDL was significantly associated with an elevated risk of peptic ulcer(IVW:OR=2.557,95%CI=1.274-5.132,P=0.008).However,no causal association of peptic ulcer with the ratio of cholesterol to total lipids in medium VLDL was observed in the inverse Mendelian randomization analysis.CONCLUSION In conclusion,our study reveals a significant association between the ratio of cholesterol to total lipids in medium VLDL and an elevated risk of peptic ulcers.However,further validation through laboratory investigations and larger-scale studies is warranted to strengthen the evidence and confirm the causal relationship between these factors.

Degradation of effective carrier-power-to-noise densityratio based on code trackingspectral sensitivitycoefficient for GNSS radio frequencycompatibilityin C band

The frequency band between 5 010 MHz and 5 030 MHz allocated as C band has been used as a candidate in the global navigation satellite systems （GNSS） along with more and more naviga- tion services in L band. The potential benefits and technical requirements of C band for satellite navi- gation have been analyzed before. However the degradation of effective carrier-power-to-noise densi- ty ratio（ A （C/No ）eu） based on code tracking spectral sensitivity coefficient（ CT_SSC ） as a compati- bility assessment methodology for potential GNSS radio frequency compatibility in C-Band has not been discussed clearly. So the compatibility of the signals in the C band between BeiDou （BD） B1 C and GPS L1C, L1C/A, Galileo E1Os as the interoperability or classical signals in L band is analyzed. Simulation results reveal the interference degree between BD III B1C and GPS L1C/A, L1C, Galileo E1OS. The results can also reveal that the multiplexed binary offset carrier （MBOC） and binary phase shift keying （BPSK） modulation is not appropriate for C band.

Computational Film Cooling Effectiveness of Dual Trench Configuration on Flat Plate at Moderate Blowing Ratios

In the present work, computational simulations was made using ANSYS CFX to predict the improvements in film cooling performance with dual trench. Dual-trench confguradon consists of two trenches together, one wider trench and the other is narrow trench that extruded from the wider one. Several blowing ratios in the range （0.5：5） were investigated. The pitch-to-diameter ratio of 2.775 is used. By using the dual trench configuration, the coolant jet impacted the trench wall two times allowing increasing the spreading of coolant laterally in the trench, reducing jet velocity and jet completely covered on the surface. The results indicate that this configuration increased adiabatic effectiveness as blowing ratio increased. The spatially averaged adiabatic effectiveness reached 57.6% for at M= 2. No observed film blow-off at all blowing ratios. The adiabatic film effectiveness of dual trench case outperformed the narrow trench case, laidback fan-shaped hole, fan-shaped hole and cylinder hole at different blowing ratios.

Composting MSW and sewage sludge with effective complex microorganisms

The effects of complex microorganisms in composting process of the municipal solid waste (MSW) and sludge were examined through inspecting biomass, temperature, oxygen consumption, organic mater, and C/N (the ratio of carbon and nitrogen). The experimental results shows: complex microorganisms are effective to compose organic matter and speedup composting change into humus.

Estimating the site effects in Luoyang basin using horizontal-to-vertical spectral ratio method from a short-period dense array

The influence of local site effects on seismic ground motions is an important issue in seismic hazard assessment and earthquake resistant design. Determining site effects in densely populated cities built on basins can help to reduce the earthquake hazard. Site effects of Luoyang basin are estimated by the horizontal-to-vertical spectral ratio(HVSR) method using ambient noise records from a short-period dense array. The sites in Luoyang basin are sorted into three types according to the pattern of the HVSR curves. There are cases with a single clear peak, two clear peaks, and an unclear low frequency peak or multiple peaks, which correspond to there being one large impedance contrast interface, two large interfaces, and a moderate one beneath the sites, respectively. The site effects characterized by fundamental frequency from HVSR curves are affected by underlying sedimentary layers and depth of sedimentary basement. According to our results, the existence of thick sediment layer obviously lowers the fundamental frequency to the period range from 2 to 4 s in the downtown area of Luoyang city. The ground motion will amplify when through the sites and the buildings with height of 20–50 floors can resonate at the similar frequency domain. Site effects estimation using HVSR method from a short-period dense array is an effective technique in areas of moderate seismic risk where strong motion recordings are lacking, such as the Luoyang basin.

Shape ratio effects on the mechanical characteristics of rectangular prism rocks and isolated pillars under uniaxial compression

Isolated pillars in underground mines are subjected to uniaxial stress,and the load bearing cross-section of pillars is commonly rectangularly shaped.In addition,the uniaxial compression test(UCT)is widely used for determining the basic mechanical properties of rocks and revealing the mechanism of isolated pillar disasters under unidimensional stress.The shape effects of rock mechanical properties under uniaxial compression are mainly quantitatively reflected in the specific shape ratios of rocks.Therefore,it is necessary to study the detailed shape ratio effects on the mechanical properties of rectangular prism rock specimens and isolated pillars under uniaxial compressive stress.In this study,granite,marble and sandstone rectangular prism specimens with various height to width ratios(r)and width to thickness ratios(u)were prepared and tested.The study results show that r and u have a great influence on the bearing ability of rocks,and thin or high rocks have lower uniaxial compressive strength.Reducing the level of r can enhance the u effect on the strength of rocks,and increasing the level of u can enhance the r effect on the strength of rocks.The lateral strain on the thickness side of the rock specimen is larger than that on the width side,which implies that crack growth occurs easily on the thickness side.Considering r and u,a novel strength prediction model of isolated pillars was proposed based on the testing results,and the prediction model was used for the safety assessment of 179 isolated pillars in the Xianglu Mountain Tungsten Mine.

P-Δ effect on inelastic displacement ratio spectra for inelastic structures

For the evaluation of structures with known ductility demands,the constant-ductility displacement ratio spectra(CDDRS) are particularly useful for providing inelastic displacement ratios to estimate maximum lateral inelastic displacement demands from maximum elastic displacement demands.The CDDRS are computed for single-degree-of-freedom systems(SDOF) by considering or ignoring P-Δ effect for different ductility levels when subjected to 344 earthquake ground motions recorded in four site classes.The modified expressions of CDDRS for P-Δ effect are proposed.It is concluded that the P-Δ effect on CDDRS is significant,and the effect increases with the increase of ductility level.In the long-period region,the CDDRS ignoring P-Δ effect almost conforms to the equal-displacement rule.But in the case of higher ductility level,the CDDRS considering P-Δ effect are much higher than 1.0,which do not conform to the equal-displacement rule.

Pile-soil stress ratio in bidirectionally reinforced composite ground by considering soil arching effect

To discuss the soil arching effect on the load transferring model and sharing ratios by the piles and inter-pile subsoil in the bidirectionally reinforced composite ground, the forming mechanism, mechanical behavior and its effect factors were discussed in detail. Then, the unified strength theory was introduced to set up the elastoplastic equilibrium differential equation of the subsoil under the limit equilibrium state. And from the equation, the solutions were derived with the corresponding formulas presented to calculate the earth pressure over and beneath the horizontal reinforced cushion or pillow, the stress of inter-pile subsoil and the pile-soil stress ratio. Based on the obtained solutions and measured data from an engineering project, the influence rules by the soil property parameters (i.e., the cohesion c and internal friction angle φ) and pile spacing on the pile-soil stress ratio n were discussed respectively. The results show that to improve the load sharing ratio by the piles, the more effective means for filling materials with a larger value of φ is to increase the ratio of pile cap size to spacing, while to reduce the pile spacing properly and increase the value of cohesion c is advisable for those filling materials with a smaller value of φ.

Influence of Chemical Effect on the Kβ/Kα Intensity Ratios and Kβ Energy Shift of Co, Ni, Cu, and Zn Complexes

Chemical effects on the Kβ/Kα intensity ratios and △E energy differences for Co, Ni, Cu, and Zn complexes were investigated. The samples were excited by 59.5 keV γ-rays from a ^241Am annular radioactive source. K X-rays emitted by samples were counted by an Ultra-LEGe detector with a resolution of 150 eV at 5.9 keV. We observed the effects of different ligands on the Kβ/Kα intensity ratios and △E energy differences for Co, Ni, Cu, and Zn complexes. We tried to investigate chemical effects on central atoms using the behaviors of different ligands in these complexes. The experimental values of Kβ/Kα were compared with the theoretical and other experimental values of pure Co, Ni, Cu, and Zn.

The Effect of Mass Ratio and Air Damper Characteristics on the Resonant Response of an Air Damped Dynamic Vibration Absorber

In this paper, it is shown that, a road vehicle 2DOF air damped quartercar suspension system can conveniently be transformed into a 2DOF air damped vibrating system representing an air damped dynamic vibration absorber (DVA) with an appropriate change in the ratio μ of the main mass and the absorber mass i.e. when mass ratio μ >> 1. Also the effect of variation of the mass ratio, air damping ratio and air spring rate ratio, on the motion transmissibility at the resonant frequency of the main mass of the DVA has been dis- cussed. It is shown that, as the air damping ratio in the absorber system increases, there is a substantial decrease in the motion transmissibility of the main mass system where the air damper has been modeled as a Maxwell type. Optimal value of the air damping ratio for the minimum motion transmissibility of the main mass of the system has been determined. An experimental setup has been designed and developed with a control system to vary air pressure in the damper in the absorber system. The motion transmissibility characteristics of the main mass system have been obtained, and the optimal value of the air damping ratio has been determined for minimum motion transmissibility of the main mass of the

Theoretical Insight into the Influence of Molecular Ratio on the Stability, Mechanical Property, Solvent Effect and Cooperativity Effect of HMX/DMI Cocrystal Explosive

Molecular dynamics method was employed to study the binding energies of the selected crystal planes of the 1,3,5,7-tetranitro-1,3,5,7-tetrazacyclooctane（HMX）/1,3-dimethyl-2-imidazolidinone（DMI） cocrystal in different molecular molar ratios. The mechanical properties were estimated in different molar ratios. Solvent effects were evaluated and the cooperativity effects were discussed in the HMX···HF···DMI ternary by using the M06-2x/6-311＋G（2df,2p） and MP2（full）/6-311＋G（2df,2p） methods. The results indicate that the substituted patterns（020） and（100） own the highest binding energies. The stabilities of cocrystals in the 1：1 and 2：1 ratios are the greatest, and thus the HMX/DMI cocrystals prefer cocrystallizing in the 1：1 and 2：1 molar ratios, which have good mechanical properties. The sensitivity change of cocrystal originates from not only the formation of intermolecular interaction but also the increment of bond dissociation energy of the N–NO2 bond. The cooperativity effect appears in the linear complex while the anti-cooperativity effect is found in the cyclic system. DMI binding to HMX is not energetically and structurally favored in the presence of HF. This is perhaps the reason that the solvent with large dielectric constant weakens the stability of the HMX/DMI cocrystals. Therefore, the solvents with low dielectric constants should be chosen in the preparation of HMX/DMI cocrystals.

Assessment of parental contribution and effective population size from a 3×3 diallel cross of clam Meretrix meretrix

Unbalanced parental contribution and small effective population size （Ne） are common issues during the artificial breeding of marine bivalves. The impact of hatchery-spawning practices on parental contribution, effective population size, the Ne/Nratio, and genetic diversity are largely unknown. To address this, we conducted a parentage analysis on a complete 3×3 diallel cross of clam Meretrix meretrix using eight microsatellite markers. The genetic diversity of the parents was higher than that of their respective offspring in most crosses （8/9）. Sires or dams from the same family contributed unequally to the pool of offspring from a particular cross, and the same parent clam exhibited large variation in parental contribution among different crosses. The variance in male contribution was higher than that of the female contribution in most crosses, suggesting that male contribution was more skewed than for females. The No/N ratio for nine crosses ranged from 0.58 to 0.86. There was no linear relationship between the sex ratio and the Ne/Nratio （P〉0.05）. Moreover, a sex ratio closer to one-to-one does not necessarily mean a larger effective population size. A solution to small effective population size in commercial breeding programs is increasing broodstoek numbers and attempting to maintain a balanced sex ratio.

Cost-Effectiveness Analysis of Neoadjuvant Chemotherapy with Zoledronic Acid for HER2-Negative Breast Cancer in Japan: The JONIE1 Study

Objective: Zoledronic acid (ZOL) is a nitrogen-containing bisphosphonate that induces osteoclast apoptosis and inhibits bone resorption. Adding ZOL to neoadjuvant chemotherapy has been shown to have potential anticancer benefits in women with HER2-negative breast cancer. The objective of the present study was to investigate ZOL’s cost-effectiveness from the perspective of health care payers in Japan. Methods: A Markov model was developed to evaluate the costs and effectiveness associated with ZOL + chemotherapy (CTZ) and chemotherapy (CT) alone over a 10-year time horizon. Monthly transition probabilities were estimated according to JONIE1 (Japan Organization of Neoadjuvant Innovative Expert) Study data and an extrapolated Weibull model. Health outcomes were measured in quality-adjusted life years (QALYs). Costs were calculated using year-2018 Japanese yen (JPY) (1.00 US dollars (USD) = 110.4 JPY). Model robustness was addressed through one-way and probabilistic sensitivity analysis. The costs and QALYs were discounted at a rate of 2% per year. Results: In the base case, the use of CTZ was associated with a gain of 3.94 QALYs. The incremental cost per QALY of the CTZ gain was 681,056.1 JPY (6168.99 USD) per QALY. Conclusion: It is convincing that neoadjuvant CTZ for patients with breast cancer would be expected to have statistically significant clinical efficacy. Addition of ZOL to CT might be a cost-effective option compared with CT alone.

Coupling Effects of Depletion Interactions in Three-Sphere Systems with Different Size Ratio of Large- to Small-Sphere

The coupling effects of depletion interactions in three-sphere systems with different size ratio of large- to small-sphere are studied by Monte Carlosimulations in this paper. The numerical results show that this coupling effect is affected by the size ratio of large- to small-sphere: the larger the size ratio is, the larger the coupling effect will be.

THE EFFECTS OF VELOCITY RATIO ON THE LARGE SCALE COHERENT STRUCTURES IN FREE SHEAR LAYERS

The velocity ratio of a free shear layer has an important influence on the spatial development of the large scale coherent structures in the layer. In this study, numerical simulations are performed to get an insight into this problem. The obtained numerical results agree quite well with those of a linear inviscid stability theory and the available experimental data.

Time-Lag Effect of Dietary Fiber and Fat Intake Ratio on Japanese Colon Cancer Mortality

The daily intake of total dietary fiber (TDF) was evaluated from data of the National Nutrition Survey (NNS) in Japan for 41 years since 1947. An interrelationship between the nutrient intake, including TDF, and the mortality from colon cancer in Japanese people was calculated by a simple correlation coefficient and time-series correlation coeffcient.TDF intake per capita decreased rapidly from 27.4 g in 1947 to 15.8 g in 1963, and subsequently decreased by a lesser rate to 15.3 g in 1987. Fat intake increased rapidly from 18.0 g in 1950 to 56.6 g in 1987.The age-adjusted mortality from colon cancer shows a significant positive correlation with both the intakes of animal protein and of total fat, and the fat energy ratio. A time-series analysis indicates that the mortality from colon cancer was negatively correlated with TDF with a 15-27 year delay, the maximum correlation existing with a 23-year lag (r = -0.947). The TDF intake was less than 17.9 g in 1965. At the same time, the mortality from colon cancer increased rapidly. A fat/TDF ratio above 3.0 resulted in a rapid increase in colon cancer mortality.The non-adjusted mortality from colon cancer has much the same interrelationship with TDF and fat intake as the adjusted figures. It is suggested that the cause of the increased mortality from colon cancer in Japan is positively related to the increased intake of fat and protein. In addition, the decrease in TDF intake has accelerated the mortality of colon cancer after a delay of 23-24 years. The importance of fat/TDF as a nutritional criterion for the incidence of colon cancer needs to be better recognized