An Experimental Analysis of Gas-Liquid Flow Breakdown in a T-Junction

When a gas-liquid two-phase flow(GLTPF)enters a parallel separator through a T-junction,it generally splits unevenly.This phenomenon can seriously affect the operation efficiency and safety of the equipment located downstream.In order to investigate these aspects and,more specifically,the so-called bias phenomenon(all gas and liquid flowing to one pipe,while the other pipe is a liquid column that fluctuates up and down),laboratory experiments were carried out by using a T-junction connected to two parallel vertical pipes.Moreover,a GLTPF prediction model based on the principle of minimum potential energy was introduced.The research results indicate that this model can accurately predict the GLTPF state in parallel risers.The boundary of the slug flow and the churn flow in the opposite pipe can be predicted.Overall,according to the results,the pressure drop curves of the two-phase flow in the parallel risers are basically the same when there is no bias phenomenon,but the pressure drop in the parallel riser displays a large deviation when there is a slug flow-churn flow.Only when the parallel riser is in a state of asymmetric flow and one of the risers produces churn flow,the two-phase flow is prone to produce the bias phenomenon.

Three-dimensional stability calculation method for high and large composite slopes formed by mining stope and inner dump in adjacent open pits

The 2D limit equilibrium method is widely used for slope stability analysis.However,with the advancement of dump engineering,composite slopes often exhibit significant 3D mechanical effects.Consequently,it is of significant importance to develop an effective 3D stability calculation method for composite slopes to enhance the design and stability control of open-pit slope engineering.Using the composite slope formed by the mining stope and inner dump in Baiyinhua No.1 and No.2 open-pit coal mine as a case study,this research investigates the failure mode of composite slopes and establishes spatial shape equations for the sliding mass.By integrating the shear resistance and sliding force of each row of microstrip columns onto the bottom surface of the strip corresponding to the main sliding surface,a novel 2D equivalent physical and mechanical parameters analysis method for the strips on the main sliding surface of 3D sliding masses is proposed.Subsequently,a comprehensive 3D stability calculation method for composite slopes is developed,and the quantitative relationship between the coordinated development distance and its 3D stability coefficients is examined.The analysis reveals that the failure mode of the composite slope is characterized by cutting-bedding sliding,with the arc serving as the side interface and the weak layer as the bottom interface,while the destabilization mechanism primarily involves shear failure.The spatial form equation of the sliding mass comprises an ellipsoid and weak plane equation.The analysis revealed that when the coordinated development distance is 1500 m,the error rate between the 3D stability calculation result and the 2D stability calculation result of the composite slope is less than 8%,thereby verifying the proposed analytical method of equivalent physical and mechanical parameters and the 3D stability calculation method for composite slopes.Furthermore,the3D stability coefficient of the composite slope exhibits an exponential correlation with the coordinated development distance,with the coefficient gradually decreasing as the coordinated development distance increases.These findings provide a theoretical guideline for designing similar slope shape parameters and conducting stability analysis.

Exploring the mechanism of active ingredients of Smilacis Glabrae Rhizoma in treating migraine headache through network pharmacology and animal experiments

Background:To explore the potential mechanism of action of the active ingredients of Smilacis Glabrae Rhizoma(SGR)in the treatment of migraine using network pharmacology and in vivo experiments.Methods:Through the search of Traditional Chinese Medicines Systems Pharmacology Database and Analysis Platform,Genecards,Drugbank and other databases,we obtained active ingredients,targets of SGR and related disease targets of migraine,and took the intersection for protein-protein interactions analysis.After constructing the network diagram,network topology analysis was performed to derive the core targets and key active ingredients,and Gene Ontology enrichment and Kyoto Encyclopedia of Genes and Genomes enrichment analyses were performed.Finally,molecular docking was performed and validated by in vivo experiments.In vivo experiments,18 male BALB/c mice were selected,and the SGR group was fed with SGR drinking tablet concentrate,and nitroglycerin injection was used to construct a mouse model of migraine.Enzyme-linked immunosorbent assay test was used to detect the levels of TNF-α,IL-1β,IL-6,and AKT1 in plasma.Results:The results showed that the core targets of SGR for the treatment of migraine were TNF-α,IL-1β,IL-6,and AKT1.These core targets and key active ingredients had better binding ability.Compared with the blank group,the number of head scratching in the model group increased.Compared with the model group,there was a significant reduction of the number of head scratching in the SGR group.In comparison with the blank group,the protein level in the plasma in the model group was markedly higher.Compared with the model group,the protein level in the SGR group was significantly lower.Conclusion:SGR has the characteristics of improving migraine based on multi-targets,multi-components and multi-pathways,and the mechanism of action may be related to the inhibition of the release of inflammatory factors,neuron protection,and interference with apoptosis and other processes.

Effects of signal regulatory proteinα1 on proliferation of hepatocellular carcinoma: a preliminary study

BACKGROUND: Signal regulatory protein alpha1 (Sirpα1) is a negative regulatory factor, and inhibits receptor tyro- sine kinase-dependent cell proliferating signal. This study was undertaken to observe the effect of signal regulatory proteinα1 ( Sirpα1) on gankyrin, cyclin D1, CDK4 and Fas expression in Sk-hep1 mouse hepatoma carcinoma cell line. METHODS: BOSC 23 packed cells were respectively trans- fected by means of recombinated retrovirus including pLX- SN, pLXSN-Sirpα1 and pLXSN-Sirpα1Δ4Y2 with lipofec- tin, and various plasmid virus media (viral titer 2.1 × 106 CFU/ml) were collected and infected respectively in 80% confluent Sk-hepl cells. Transfected Sk-hep1 cells were se- lectively screened with G418 (1200 μg/ml), and Sk-hep1 cell lines transfected with various plasmids were obtained. The protein expressions of gankyrin, cyclin D1, CDK4 and Fas in various Sk-hep1 lines were determined by Western blotting. Various Sk-hep1 lines were recovered to culture with 10% fetal bovine serum at 12 hours and 24 hours after starving culture with free serum for 72 hours, and cells were collected to determine the percentage of S phase cells of proliferating cycle by flow cytometry. RESULTS: Sirpα1 transfection remarkably downregulated gankyrin and cyclin D1 expression. Sirpα1Δ4Y2 downregu- lation of gankyrin expression was greater than that of Sirpα1(P <0.05), but no significant effect of Sirpα1 and Sirpα1Δ4Y2 on CDK4 and Fas protein expression was ob- served in transfected Sk-hep1 lines (P >0.05). The per- centage of S phase cells significantly decreased in Sk-hep1 cells transfected with Sirpα1 and Sirpα1Δ4Y2 plasmids (vs pLXSN Sk-hep1, P <0.05). The percentage of S phase cells in various Sk-hep1 cells increased when recovering to culture with 10% fetal bovine serum at 12 hours, but the percentage of S phase cells in Sk-hep1 cells transfected with Sirpα1 was the lowest ( vs pLXSN and Sirpα1Δ4Y2 Sk- hepl, P<0.05). The percentage of S phase cells in trans- fected pLSXN Sk-hep1 cells was the largest (vs Sirpα1 and Sirpα1Δ4Y2 Sk-hepl, P <0. 05). There was no significant difference between the transfected Sirpα1 Sk-hepl cells and Sirpα1Δ4Y2 Sk-hep1 cells (P>0.05). CONCLUSIONS: Sirpα1 decreases gankyrin and cyclin D1 expression, and inhibits proliferation of liver carcinoma cells. It may be one of the forms for an Sirpα1 negative regulation of carcinogenesis and development of hepatocel- lular carcinoma.

Effect Mechanisms of Hygrothermal Environments on Failure of Single-Lap and Double-Lap CFRP-Aluminum Bolted Joints

The high demands for load-carrying capability and structural efficiency of composite-metal bolted joints trigger in-depth investigations on failure mechanisms of the joints in hygrothermal environments.However,few studies have been presented to exhaustively reveal hygrothermal effects on the failure of CFRP-metal bolted joints,which differ from CFRP-CFRP or metal-metal bolted joints because of the remarkably different material properties of CFRPs and metals.In this paper,hygrothermal effects on tensile failures of single-lap and double-lap CFRP-aluminum bolted joints were experimentally and numerically investigated.A novel numerical model,in which a hygrothermal-included progressive damage model of composites was established and elastic-plastic models of metals were built,was proposed to predict the failures of the CFRP-metal bolted joints in hygrothermal environments and validated by corresponding experiments.Different failure mechanisms of single-lap and double-lap CFRP-aluminum bolted joints,under 23°C/Dry and 70°C/Wet conditions,were revealed,respectively.It follows that both the collapse failures of the single-lap and double-lap bolted joints were dominated by the bearing failure of the CFRP hole laminate in the two conditions,indicating that the hygrothermal environment did not change the macro failure modes of the joints.However,the hygrothermal environment considerably shortened the damage propagation processes and reduced the strength of the joints.Besides,the hygrothermal environment weakened the load-transfer capability of the single-lap joint more severely than the double-lap joint because it aggravated the secondary bending effects of the single-lap joint obviously.

Protective Effects of Ginsenoside Rb1 on Septic Rats and Its Mechanism

This study aims to observe the protective effects of ginsenoside Rbl on liver and lung in rats with septic shock and reveal its mechanism. Rats were randomly divided into three groups： sham, cecal ligation and puncture （CLP）, and CLP with ginsenoside Rb1. Then, the survival rate, arterial blood pressure, TLR4 mRNA, and TNF-α levels were determined. The liver and lung tissues were stained with hematoxylin-eosin （HE）. The overall survival rate of the Rb1 group was significantly higher than that of the CLP group. Mean arterial blood pressure went down in both the CLP and Rb1 groups after CLP, and there was a significant difference both in the sham and Rb1 groups when compared with the CLP group. The Rb1 treatment group had markedly lower TLR4 mRNA expression and TNF-a levels than the CLP group. In the CLP group, pathology showed swelling, degeneration, necrosis, and neutrophii infiltration in the liver and alveolar epithelial cells. However, in the Rb1 group, there was mild degeneration and slight neutrophil infiltration, but no obvious necrosis. Rb1 may improve the survival rate, ameliorate arterial blood pressure, and protect the liver and lung in septic shock rats by downregulating the expression of TLR4 mRNA and inhibiting the production of TNF-α.

Effect of the Gut Microbiota on Obesity and Its Underlying Mechanisms: an Update

Obesity has become one of the most prevalent health issues of our time. According to a 2012 WHO report, around 3.4 million adults die each year as a result of being overweight or obese. Humans are in fact superorganisms composed of both human and microbial cells with 2 sets of genes, those encoded in our own genome and those encoded in our microbiota. All these cells and genes have the potential to influence our health.

Effects of Rare Earths on Properties and Microstructure of Automotive Friction Materials

Rare earth compounds as modifiers used widely in modern friction materials can enhance the interfacial binding of constituents of materials and improve the comprehensive properties of materials evidently. However, there are still few reports on application of rare earth in automotive friction materials. In order to study the effect mechanism of rare earths in friction materials, a rare earth compound was selected as additive and the effects of materials doped with or without rare earth on friction and wear properties of materials were studied. The microstructure and worn surface morphology were observed by scanning electron microscopy and the macro performance was discussed. Worn surface element constitution of materials was analyzed by energy dispersive spectroscopy. Effect mechanism of rare earths on friction and wear behaviors of friction materials were discussed. The results show that doping rare earths in friction materials can stabilize friction coefficient, lower the wear rate of materials and increase the impact strength of materials. The flexibility and fracture resistance of materials is greatly improved. Worn surface of materials doped with rare earth is compact and the surface adhesion is greatly enhanced.

Mechanical effects of light on the ■-type three-level atom in a high-finesse optical cavity

A theoretical study is carried out for the modification and implication of the effect on the type three level atom in a high-finesse optical cavity driven by light field including spontaneous emission and the cavity decay. Analytic expressions for the dipole force, the friction force, the optical potentials and the friction coefficient are obtained. Then the numerical and graphical methods are used to investigate the friction coefficient with the controlling parameters. It is shown that the friction coefficient is strongly dependent on the controlling parameters. The cooling rate can increase by one order of magnitude more than that of a two-level atomic system. The reason can be given using the dressed states and the Sisyphus cooling mechanism, which would stimulate further experimental investigations.

An empirical study on the green effects of new energy vehicle promotion in the context of global carbon neutrality

In the context of global carbon neutrality,new energy vehicle promotion(NEVP)has become an important means of reducing carbon emissions.This paper constructs a theoretical model and uses panel data on NEVP in 21 countries from 2012 to 2018 to empirically examine the green effect of NEVP.The results indicate the following:(1)NEVP significantly reduces greenhouse gases emissions,and the green effect can be transmitted and diffused through a direct path.(2)Replacing fuel-fired vehicles and accelerating the end-of-life vehicle scrapping process significantly conducted the green effect,and aggravating traffic congestion was not statistically significant.(3)The transmission mechanism of the green effect is regulated by regional economic heterogeneity.In regions with better development of fuel-fired vehicles,the transmission of the green effect is subject to the elimination of fuel-fired vehicles and traffic congestion governance,and the transmission efficiency is low.However,regions with a relatively weak fuel-fired automobile industry foundation show a strong“advantage of backwardness”,and the green effect is more prominent.This means that global NEVP should be further accelerated to achieve the green effect and the goal of global carbon neutrality.

MECHANISM FOR THE EFFECTS OF MONO-VALENT CATIONS ON ^(23)Na NMR

The effects of mono-valent cations, Li^+, K^+, Rb^+, Cs^+ and NH_4^+, on ^(23)Na NMR were investigated. It was found that the chemical shifts for Na^+ signal shifted downfield with the increase in the relative amounts of monovalent cations. It was suggested that mono-valent cations had competition coordination with Na^+ for Dy(PPP)_2^(7-).

MECHANISM OF PROMOTING EFFECTS OF RIBOFLAVIN DEFICIENCY ON CARCINOGENESIS OF NITROSAMINES (EFFECTS ON RAT LIVER GLUTATHIONE CONTENT)

The effects of riboflavin deficiency and simultaneously nitrosodimethylamine (NDMA) given by gastric intubation on the hepatic glutathione (GSH) content were examined in rats. On different days of the experiment, hepatic GSH content of the riboflavin deficient rats decreased to 55-61% of the control rats. When NDMA was given 6 mg kg by gastric intubation to riboflavin deficient rats, hepatic GSH content decreased markedly to 39-43% of the control rats. After supplying riboflavin, hepatie GSH content of the deficient rats recovered to the level of the control rats. These results suggest that alterations of rat hepatic GSH content during riboflavin deficiency may imply as one of the promoting effects of riboflavin deficiency on the carcinogenesis of nitrosamines.

Electromagnetic effects on the orbital motion of a charged spacecraft

This paper deals with the effects of electromagnetic forces on the orbital motion of a spacecraft. The electrostatic charge which a spacecraft generates on its surface in the Earth＇s magnetic field will be subject to a perturbative Lorentz force. A model incorporating all Lorentz forces as a function of orbital elements has been developed on the basis of magnetic and electric fields. This Lorentz force can be used to modify or perturb the spacecraft＇s orbits. Lagrange＇s planetary equations in the Gauss variational form are derived using the Lorentz force as a perturbation to a Keplerian orbit. Our approach incorporates orbital inclination and the true anomaly. The numer- ical results of Lagrange＇s planetary equations for some operational satellites show that the perturbation in the orbital elements of the spacecraft is a second order perturba- tion for a certain value of charge. The effect of the Lorentz force due to its magnetic component is three times that of the Lorentz force due to its electric component. In addition, the numerical results confirm that the strong effects are due to the Lorentz force in a polar orbit, which is consistent with realistic physical phenomena that occur in polar orbits. The results confirm that the magnitude of the Lorentz force depends on the amount of charge. This means that we can use artificial charging to create a force to control the attitude and orbital motion of a spacecraft.

Effects of A1 Additions on Microstructure and Mechanical Properties of MoSi_2

The effects of Al additions on the microstructure and mechanical properties of MoSi2 have been studied. With the A1 additions from 2.5 wt pct to 5 wt pct, the siliceous grain boundary phase in hot pressed samples was eliminated because of the formation of Al2O3 particles. It was shown that Al and SiO2 reacted at 860℃. During the reaction, A1 atoms were mainly transferred to Al2O3 particles, and to some extent, diffused into MoSi2 grains. Both the toughness and strength of Al containing composites exceeded those of pure MoSi2 material. Bending strength and fracture toughness reach the highest value of 350 MPa, 4.05 MPa.m1/2, respectively, at ambient temperature when Al addition was of 3.5 wt pct.

Effects of N on Electronic and Mechanical Properties of H-Type SiC

Structural, electronic and mechanical properties of the nH-SiC （n = 2, 4, 6, 8 and 10） polytypes are calculated by using the first-principles calculations based on the density-functional theory approach. The optimized lattice parameters of nH-SiC are in good agreement with the experimental data. The mechanical properties, including elastic constants, bulk modulus, Young＇s modulus, shear modulus and Poisson＇s ratio, are calculated. The analysis of elastic properties indicates that the effects of n on the mechanical properties of the five nil-SiC structures have no difference. The indirect band gap relationship for the live polytypes is Ebg2H 〉 Ebg4H 〉 Ebg6H 〉 Ebg10H 〉 EbgsH.

Quantum Boltzmann equation solved by Monte Carlo method for nano-scale semiconductor devices simulation

A two-dimensional （2D） full band self-consistent ensemble Monte Carlo （MC） method for solving the quantum Boltzmann equation, including collision broadening and quantum potential corrections, is developed to extend the MC method to the study of nano-scale semiconductor devices with obvious quantum mechanical （QM） effects. The quantum effects both in real space and momentum space in nano-scale semiconductor devices can be simulated. The effective mobility in the inversion layer of n and p channel MOSFET is simulated and compared with experimental data to verify this method. With this method 50nm ultra thin body silicon on insulator MOSFET are simulated. Results indicate that this method can be used to simulate the 2D QM effects in semiconductor devices including tunnelling effect.

Influence of air pressure on mechanical effect of laser plasma shock wave

The influence of air pressure on mechanical effect of laser plasma shock wave in a vacuum chamber produced by a Nd：YAG laser has been studied. The laser pulses with pulse width of 10ns and pulse energy of about 320mJ at 1.06μm wavelength is focused on the aluminium target mounted on a ballistic pendulum, and the air pressure in the chamber changes from 2.8 × 10^ 3 to 1.01 × 10^5pa. The experimental results show that the impulse coupling coefficient changes as the air pressure and the distance of the target from focus change. The mechanical effects of the plasma shock wave on the target are analysed at different distances from focus and the air pressure.

Characteristics and triggering mechanism of Xinmo landslide on 24 June 2017 in Sichuan, China

At 5: 39 AM on 24 June 2017, a huge landslide-debris avalanche occurred on Fugui Mountain at Xinmo village, Diexi town, Maoxian county, Sichuan province, China. The debris blocked the Songpinggou River for about 2 km, resulting in a heavy loss of both human lives and properties(10 deaths, 3 injuries, 73 missing, and 103 houses completely destroyed). The objectives of this paper are to understand the overall process and triggering factors of this landslide and to explore the affecting factors for its long term evolution before failure. Post event surveys were carried out the day after the landslide occurrence. Information was gathered from literature and on-site investigation and measurement. Topography, landforms, lithology, geological setting, earthquake history, meteorological and hydrological data of the area were analysed. Aerial photographs and other remote sensing information were used for evaluation and discussion. Eye witnesses also provided a lot of helpful information for us to understand the process of initiation, development and deposition. The depositional characteristics of the moving material as well as the traces of the movement,the structural features of the main scarp and the seismic waves induced by the slide are presented and discussed in detail in this paper. The results show that the mechanism of the landslide is a sudden rupture of the main block caused by the instability of a secondary block at a higher position. After the initiation, the failed rock mass at higher position overloaded the main block at the lower elevation and collapsed in tandem. Fragmentation of the rock mass occurred later, thus forming a debris avalanche with high mobility. This landslide case indicates that such seismic events could influence geological hazards for over 80 years and this study provides reference to the long term susceptibility and risk assessment of secondary geological hazards from earthquake.

Experimental Study on the Effect of Steel-fibre in Concrete Thick Cap

The effect of steel fibre used in concrete was systematically analyzed by model testing of 30 2-pile thick caps of steel-fibre reinforced concrete, in which the model scale was 1：5. The experiment system composed of a loading device, strain measurement system and a data-acquisition system was used, also an electromechanic centigrade scale, a lens and a Y J-25 static resistance strainometer were used.The experimental results show that the volumetric rate of steel fibre and draw ratio have an important influence on its load-bearing capacity. The incorporation of steel fibre can effectively improve the extension and reduce the thickness of the caps.