The primary objective of the present literature review is to provide a constructive and systematical discussion based on the relevant development,unsolved issues,gaps,and misconceptions in the literature regarding the...The primary objective of the present literature review is to provide a constructive and systematical discussion based on the relevant development,unsolved issues,gaps,and misconceptions in the literature regarding the fields of study that are building blocks of artificial intelligence-aided life extension assessment for offshore wind turbine support structures.The present review aims to set up the needed guidelines to develop a multi-disciplinary framework for life extension management and certification of the support structures for offshore wind turbines using artificial intelligence.The main focus of the literature review centres around the intelligent risk-based life extension management of offshore wind turbine support structures.In this regard,big data analytics,advanced signal processing techniques,supervised and unsupervised machine learning methods are discussed within the structural health monitoring and condition-based maintenance planning,the development of digital twins.Furthermore,the present review discusses the critical failure mechanisms affecting the structural condition,such as high-cycle fatigue,low-cycle fatigue,fracture,ultimate strength,and corrosion,considering deterministic and probabilistic approaches.展开更多
Four different topics for high-temperature components, namely the development of the assessment codes for the structural integrity of high-temperature components, the application of continuous damage mechanics and pro...Four different topics for high-temperature components, namely the development of the assessment codes for the structural integrity of high-temperature components, the application of continuous damage mechanics and probabilistic damage mode on the life assessment of high-temperature components, the life extension for high-temperature components and a proposed strategy for remanufacturing of high-temperature components were discussed in this paper. These topics should provide some important insights for the design and re-design of high- temperature components.展开更多
This paper focuses on how aging can affect performance of safety-related structures in nuclear power plant (NPP). Knowledge and assessment of impacts of aging on structures are essential to plant life extension analys...This paper focuses on how aging can affect performance of safety-related structures in nuclear power plant (NPP). Knowledge and assessment of impacts of aging on structures are essential to plant life extension analysis,especially performance to severe loadings such as loss-of-coolant-accidents or major seismic events. Plant life extension issues are of keen interest in countries (like the United States) which have a large,aging fleet of NPPs. This paper addresses the overlap and relationship of structure aging to severe loading performance,with particular emphasis on containment structures.展开更多
BACKGROUND Considering the limited effectiveness of clinical interventions for knee osteoarthritis(KOA),it is necessary to continue to explore appropriate and effective treatment strategies to improve the condition of...BACKGROUND Considering the limited effectiveness of clinical interventions for knee osteoarthritis(KOA),it is necessary to continue to explore appropriate and effective treatment strategies to improve the condition of KOA patients.AIM To clarify the influence of ankle flexion and extension exercises combined with a psychological intervention on the psychological status and activities of daily living(ADLs)of patients with KOA.METHODS The research participants were 116 KOA patients admitted to The First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine between May 2019 and May 2022,including 54 patients receiving routine treatment,care and psychological intervention(control group)and 62 patients additionally treated with ankle flexion and extension exercises(research group).The two groups were comparatively analyzed in terms of psychological status(Self-rating Anxiety/Depression Scale,SDS/SAS),ADLs,knee joint function(Lysholm Knee Scoring Scale),pain(Visual Analog Scale,VAS),fatigue(Multidimensional Fatigue Inventory,MFI),and quality of life(QoL;Short-Form 36 Item Health Survey,SF-36).RESULTS After evaluation,it was found that the postinterventional SDS,SAS,VAS,and MFI scores in the research group were significantly reduced compared with the baseline(before the intervention)values and those of the control group,while the postinterventional Lysholm,ADL and SF-36 scores were markedly elevated.CONCLUSION Therefore,ankle flexion and extension exercises are highly effective in easing negative psychological status,enhancing ADLs,daily living ability,knee joint function and QoL,and relieving pain and fatigue in KOA patients,thus warranting clinical promotion.展开更多
Antibodies are currently the fastest growing class of therapeutic proteins. When antibody fragments are included, there are over thirty-five antibody-based medicines approved for human therapy. Many more antibody and ...Antibodies are currently the fastest growing class of therapeutic proteins. When antibody fragments are included, there are over thirty-five antibody-based medicines approved for human therapy. Many more antibody and antibody-like fragments are being evaluated clinically. Production of antibody fragments can be efficient and their compact size can allows for better tissue extravasation into solid tumors than full antibodies. Unfortunately, a key limitation of antibody fragments for systemic use is their short half-life in circulation. Prolonging their circulation half-life can be accomplished clinically by the covalent conjugation of the antibody fragment to the water-soluble polymer, poly(ethylene glycol) (PEG). Many polymers and strategies are also being pursued to increase antibody fragment half-life.展开更多
Red and white guavas were treated with wax emulsion or irradiation (0.25-2.0 kGy) and kept for 12 days at room temperature. Initiation of rot attack occurred after 3 days which increased significantly during further s...Red and white guavas were treated with wax emulsion or irradiation (0.25-2.0 kGy) and kept for 12 days at room temperature. Initiation of rot attack occurred after 3 days which increased significantly during further storage. In the waxed fruits rottage, weight loss and vitamin loss were significantly less than controls and irradiated ones. Sensory scores decreased with storage time and they ranged 3.7-4.5, 2.1-3.9 and 2.3-2.7 in waxed, radiated and untreated controls respectively, after 12 days storage. Waxing was found to increase the. shelf life of this fruit for 3-4 d while irradiation exhibited no beneficial effects.展开更多
The s recent works on the improvement of the Strain Range Partitioning(SRP) method and its application to the life prediction of high temperature structural components are summarized. Examined components are divided ...The s recent works on the improvement of the Strain Range Partitioning(SRP) method and its application to the life prediction of high temperature structural components are summarized. Examined components are divided into three groups, that is, components in the steel production plants, in the automobile and in the fossil power plants. Based on the results of the inelastic analysis and the creepfatigue properties of the material, which were obtained by IJ(=PP,PC, CP, CC) tests, the effects of the material properties, operating conditions and configuration of components were quantitatively evaluated to select the most effective measures for the thermal fatigue life extension. The SRP has been successfully applied until now to the life prediction and extension of the actual structural components subjected to thermal cycling by the s.展开更多
文摘The primary objective of the present literature review is to provide a constructive and systematical discussion based on the relevant development,unsolved issues,gaps,and misconceptions in the literature regarding the fields of study that are building blocks of artificial intelligence-aided life extension assessment for offshore wind turbine support structures.The present review aims to set up the needed guidelines to develop a multi-disciplinary framework for life extension management and certification of the support structures for offshore wind turbines using artificial intelligence.The main focus of the literature review centres around the intelligent risk-based life extension management of offshore wind turbine support structures.In this regard,big data analytics,advanced signal processing techniques,supervised and unsupervised machine learning methods are discussed within the structural health monitoring and condition-based maintenance planning,the development of digital twins.Furthermore,the present review discusses the critical failure mechanisms affecting the structural condition,such as high-cycle fatigue,low-cycle fatigue,fracture,ultimate strength,and corrosion,considering deterministic and probabilistic approaches.
文摘Four different topics for high-temperature components, namely the development of the assessment codes for the structural integrity of high-temperature components, the application of continuous damage mechanics and probabilistic damage mode on the life assessment of high-temperature components, the life extension for high-temperature components and a proposed strategy for remanufacturing of high-temperature components were discussed in this paper. These topics should provide some important insights for the design and re-design of high- temperature components.
文摘This paper focuses on how aging can affect performance of safety-related structures in nuclear power plant (NPP). Knowledge and assessment of impacts of aging on structures are essential to plant life extension analysis,especially performance to severe loadings such as loss-of-coolant-accidents or major seismic events. Plant life extension issues are of keen interest in countries (like the United States) which have a large,aging fleet of NPPs. This paper addresses the overlap and relationship of structure aging to severe loading performance,with particular emphasis on containment structures.
文摘BACKGROUND Considering the limited effectiveness of clinical interventions for knee osteoarthritis(KOA),it is necessary to continue to explore appropriate and effective treatment strategies to improve the condition of KOA patients.AIM To clarify the influence of ankle flexion and extension exercises combined with a psychological intervention on the psychological status and activities of daily living(ADLs)of patients with KOA.METHODS The research participants were 116 KOA patients admitted to The First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine between May 2019 and May 2022,including 54 patients receiving routine treatment,care and psychological intervention(control group)and 62 patients additionally treated with ankle flexion and extension exercises(research group).The two groups were comparatively analyzed in terms of psychological status(Self-rating Anxiety/Depression Scale,SDS/SAS),ADLs,knee joint function(Lysholm Knee Scoring Scale),pain(Visual Analog Scale,VAS),fatigue(Multidimensional Fatigue Inventory,MFI),and quality of life(QoL;Short-Form 36 Item Health Survey,SF-36).RESULTS After evaluation,it was found that the postinterventional SDS,SAS,VAS,and MFI scores in the research group were significantly reduced compared with the baseline(before the intervention)values and those of the control group,while the postinterventional Lysholm,ADL and SF-36 scores were markedly elevated.CONCLUSION Therefore,ankle flexion and extension exercises are highly effective in easing negative psychological status,enhancing ADLs,daily living ability,knee joint function and QoL,and relieving pain and fatigue in KOA patients,thus warranting clinical promotion.
文摘Antibodies are currently the fastest growing class of therapeutic proteins. When antibody fragments are included, there are over thirty-five antibody-based medicines approved for human therapy. Many more antibody and antibody-like fragments are being evaluated clinically. Production of antibody fragments can be efficient and their compact size can allows for better tissue extravasation into solid tumors than full antibodies. Unfortunately, a key limitation of antibody fragments for systemic use is their short half-life in circulation. Prolonging their circulation half-life can be accomplished clinically by the covalent conjugation of the antibody fragment to the water-soluble polymer, poly(ethylene glycol) (PEG). Many polymers and strategies are also being pursued to increase antibody fragment half-life.
文摘Red and white guavas were treated with wax emulsion or irradiation (0.25-2.0 kGy) and kept for 12 days at room temperature. Initiation of rot attack occurred after 3 days which increased significantly during further storage. In the waxed fruits rottage, weight loss and vitamin loss were significantly less than controls and irradiated ones. Sensory scores decreased with storage time and they ranged 3.7-4.5, 2.1-3.9 and 2.3-2.7 in waxed, radiated and untreated controls respectively, after 12 days storage. Waxing was found to increase the. shelf life of this fruit for 3-4 d while irradiation exhibited no beneficial effects.
文摘The s recent works on the improvement of the Strain Range Partitioning(SRP) method and its application to the life prediction of high temperature structural components are summarized. Examined components are divided into three groups, that is, components in the steel production plants, in the automobile and in the fossil power plants. Based on the results of the inelastic analysis and the creepfatigue properties of the material, which were obtained by IJ(=PP,PC, CP, CC) tests, the effects of the material properties, operating conditions and configuration of components were quantitatively evaluated to select the most effective measures for the thermal fatigue life extension. The SRP has been successfully applied until now to the life prediction and extension of the actual structural components subjected to thermal cycling by the s.
