Anti-infective therapy durations predict psychological stress and laparoscopic surgery quality in pelvic abscess patients

BACKGROUND The degree of psychological stress and the difficulty and efficacy of laparoscopic surgery differ in patients with pelvic abscesses after different durations of antiinfection treatment.AIM To compare and analyse the effects of different durations of anti-infective therapy on patients’preoperative psychological stress level and the clinical efficacy of laparoscopic surgery in patients with pelvic abscesses to offer a reference for the selection of therapy plans.METHODS A total of 100 patients with pelvic abscesses who were admitted to the Department of Gynecology of Suzhou Ninth Hospital affiliated to Soochow University(Suzhou Ninth People's Hospital)from January 2018 to December 2022 were retrospectively enrolled.According to the different durations of antiinfective therapy,they were divided into Group S(50 patients,received antiinfective therapy for 24-48 h)and Group L(50 patients,received anti-infective therapy for 48-96 h).Baseline data,state-trait anxiety score at admission and before surgery,self-rating anxiety scale(SAS)+self-rating depression scale(SDS)score,surgery time,adhesion grading score,intraoperative blood loss,presence or absence of intraoperative intestinal injury,ureteral injury or bladder injury,postoperative body temperature,length of hospital stay,and presence or absence of recurrence within 3 mo after surgery,chronic pelvic pain,incision infection,dysmenorrhea,menstrual disorder or intestinal obstruction were compared between the S group and the L group.RESULTS There was no significant difference in the background data between the S group and the L group(P<0.05).There was no significant difference in the state-trait anxiety score or SAS+SDS score between the S group and the L group on admission(P<0.05).The state-trait anxiety score and SAS+SDS score of the S group were lower than those of Group L after receiving different durations of anti-infective therapy(P<0.05).There was no significant difference in the incidence of intestinal,ureteral or bladder injury between the S group and the L group(P<0.05).The surgery time of Group S was shorter than that of Group L,and the adhesion score and intraoperative blood loss volume were lower than those of Group L(P<0.05).There was no significant difference in the incidence of incision infection,dysmenorrhea,menstrual disorder or intestinal obstruction between the S group and the L group(P<0.05).The postoperative body temperature of Group S was lower than that of Group L(P<0.05),and the hospital stay was shorter than that of Group L(P<0.05).The incidences of recurrence and chronic pelvic pain within 3 mo after surgery were lower than that of Group L(P<0.05).CONCLUSION Twenty-four to forty-eight hours of anti-infective therapy is better than 48-96 h of anti-infective therapy for patients with pelvic abscesses because the degree of psychological stress is lower,which is more conducive to achieving better outcomes after laparoscopic surgery.

Comprehensive Evaluation of Talent Training Model for Modern Rehabilitation Therapy Technology:A Case Study of School Y

The purpose of this study is to comprehensively evaluate the modern training model of rehabilitation therapy technology talents.Selecting the third-year students of the rehabilitation therapy technology program in School Y as the research subject,300 questionnaires were collected and the effective response rate was 92%.The strengths and weaknesses of the modern training model were analyzed through a mixed qualitative and quantitative research method.It was found that 68%of the students thought that the modern model had obvious advantages in practical teaching,but 42%of the students thought that it still needed to be improved in personalized teaching.This study provides an empirical basis and specific suggestions for optimizing the cultivation of rehabilitation therapy technology talents.

Efficacy and Safety Assessment of Antifungal Sequential Therapy from Micafungin to Liposomal Amphotericin B for Antibiotics-Refractory Febrile Neutropenia in Patients with Hematologic Malignancies

Invasive fungal infections are a major challenging problem in the management of febrile neutropenia (FN) in patients with hematologic malignancies. Liposomal amphotericin B (L-AmB) or micafungin (MCFG) has been widely used as a first-line empirical antifungal therapy for suspected fungal infection in such patients. However, there are several issues in patients receiving these agents: drug related toxicities for L-AmB and breakthrough fungal infections for MCFG. In order to make the best use of these 2 agents, we conducted a prospective study of sequential therapy from MCFG to L-AmB, and evaluated the efficacy and safety of this strategy in FN patients with hematologic malignancies. A total of 18 patients were enrolled, and 11 patients who fulfilled the protocol defined criteria were evaluated. Underlying diseases consisted of acute leukemia (n = 9), non-Hodgkin lymphoma (n = 1), and myelodysplastic syndrome (n = 1). Treatment success was achieved in 8 patients (72.7%). Drug-related adverse events occurred in 8 patients (72.7%). All of those adverse events except one case were below grade 2. Three patients required discontinuation of L-AmB. Although our empirical antifungal sequential therapy seems to be encouraging for antibiotics-refractory FN in patients with hematologic malignancies, further investigation in large-scale studies is warranted.

急性上消化道出血规范化治疗与经验性治疗的对比研究

目的:对急性上消化道出血规范化治疗与经验性治疗进行对比研究,为临床实践提供一定指导。方法:选择2020年至2023年在吉林省四平市中心人民医院进行上消化道出血治疗的90名患者作为此次研究的样本对象,随机分为经验组与规范组,两组各45人,分别给予常规经验性治疗及规范化治疗,对比不同治疗方案下患者的临床指标。结果:对照实验结果可知,规范组的整体治疗效果较好,其治疗情况如止血时间、输血量等数据比经验组更优质,其中所有研究数据具有统计学意义(P﹤0.05)。结论:急性上消化道出血规范化治疗能让患者的治疗情况与恢复效果更好,值得大力推广和应用。

Retrospective study of the incidence, risk factors, treatment outcomes of bacterial infections at uncommon sites in cirrhotic patients

BACKGROUND Bacterial infections(BI)negatively affect the natural course of cirrhosis.The most frequent BI are urinary tract infections(UTI),pneumonia,and spontaneousbacterial peritonitis(SBP).AIM To assess the relevance of bacterial infections beyond the commonly recognized types in patients with cirrhosis and to investigate their relationship with other clinical variables.METHODS We retrospectively analyzed patients with cirrhosis and BI treated between 2015 and 2018 at our tertiary care center.BIs were classified as typical and atypical,and clinical as well as laboratory parameters were compared between the two groups.RESULTS In a cohort of 488 patients with cirrhosis,we identified 225 typical BI(95 UTI,73 SBP,72 pulmonary infections)and 74 atypical BIs,predominantly cholangitis and soft tissue infections(21 each),followed by intra-abdominal BIs(n=9),cholecystitis(n=6),head/throat BIs(n=6),osteoarticular BIs(n=5),and endocarditis(n=3).We did not observe differences concerning age,sex,or etiology of cirrhosis in patients with typical vs atypical BI.Atypical BIs were more common in patients with more advanced cirrhosis,as evidenced by Model of End Stage Liver Disease(15.1±7.4 vs 12.9±5.1;P=0.005)and Child-Pugh scores(8.6±2.5 vs 8.0±2;P=0.05).CONCLUSION Atypical BIs in cirrhosis patients exhibit a distinct spectrum and are associated with more advanced stages of the disease.Hence,the work-up of cirrhosis patients with suspected BI requires detailed work-up to elucidate whether typical BI can be identified.

郑日新经验方治疗痰瘀互结型耳眩晕临床观察

目的 探讨郑日新经验方治疗痰瘀互结型耳眩晕的临床效果。方法 从2020年6月—2022年6月江西省中西医结合医院收治的痰瘀互结型耳眩晕患者中抽取70例作为研究对象,采用随机数字表法分为对照组和观察组,各35例。对照组予甲磺酸倍他司汀片治疗,观察组予郑日新经验方治疗,对比两组临床疗效和治疗前后的眩晕障碍程度。结果 观察组临床总有效率为97.14%(34/35),高于对照组的77.14%(27/35)(P<0.05)。治疗后,观察组眩晕障碍量表(DHI)的躯体评分、情绪评分、功能评分及总分均低于对照组(P<0.05)。结论 痰瘀互结型耳眩晕患者采用郑日新经验方治疗,可以显著提高整体临床效果,减轻其眩晕障碍程度,值得临床进一步推广。

Recovery rates of combination antibiotic therapy using in vitro microdialysis simulating in vivo conditions

Microdialysis is a technique used to measure the unbound antibiotic concentration in the interstitial spaces, the target site of action. In vitro recovery studies are essential to calibrating the microdialysis system for in vivo studies. The effect of a combination of antibiotics on recovery into microdialysate requires investigation. In vitro microdialysis recovery studies were conducted on a combination of vancomycin and tobramycin, in a simulated in vivo model. Comparison was made between recoveries for three different concentrations and three different perfusate flow rates. The overall relative recovery for vancomycin was lower than that of tobramycin. For tobramycin, a concentration of 20μg/mL and flow rate of 1.0μL/min had the best recovery. A concentration of 5.0μg/mL and flow rate of 1.0μL/min yielded maximal recovery for vancomycin. Large molecular size and higher protein binding resulted in lower relative recoveries for vancomycin. Perfusate flow rates and drug concentrations affected the relative recovery when a combination of vancomycin and tobramycin was tested. Low perfusate flow rates were associated with higher recovery rates. For combination antibiotic measurement which includes agents that are highly protein bound, in vitro studies performed prior to in vivo studies may ensure the reliable measurement of unbound concentrations.

Low eradication rate of Helicobacterpyloriwith triple 7-14 days and quadriple therapy in Turkey

AIM:The eradication rate of Helicobacter pylori (H pylori) shows variation among countries and regimens of treatment. We aimed to study the eradication rates of different regimens in our region and some factors affecting the rate of eradication. METHODS:One hundred and sixty-four H pylori positive patients (68 males,96 females;mean age:48±12 years) with duodenal or gastric ulcer without a smoking history were included in the study.The patients were divided into three groups according to the treatment regimens.Omeprazole 20mg,clarithromycin 500mg,amoxicillin 1g were given twice daily for 1 week (Group Ⅰ) and 2 weeks (Group Ⅱ). Patients in Group Ⅲ received bismuth subsitrate 300mg, tetracyline 500mg and metronidazole 500mg four times daily in addition to Omeprazole 20mg twice daily.Two biopsies each before and after treatment were obtained from antrum and corpus,and histopathologically evaluated. Eradication was assumed to be successful if no H pylorus was detected from four biopsy specimens taken after treatment.The effects of factors like age,sex,H pylori density on antrum and corpus before treatment,the total H pylori density,and the inflammation scores on the rate of H pylori eradication were evaluated. RESULTS:The overall eradication rate was 42%.The rates in groups Ⅱ and Ⅲ were statistically higher than that in group Ⅰ (P<0.05).The rates of eradication were 24.5%, 40.7% and 61.5% in groups Ⅰ,Ⅱ and Ⅲ,respectively.The eradication rate was negatively related to either corpus H pylori density or total H pylori density (P<0.05).The median age was older in the group in which the eradication failed in comparison to that with successful eradication (55 yr vs 39 yr,P<0.001).No correlation between sex and H pylori eradication was found. CONCLUSION:Our rates of eradication were significantly lower when compared to those reported in literature.We believe that advanced age and high H pylori density are negative predictive factors for the rate of H pylori eradication.

“互斥原则”提升孤独症谱系障碍儿童词语习得效果实证研究

目的比较孤独症谱系障碍(autism spectrum disorder,ASD)儿童在“互斥原则(mutual exclusivity)”和“直接重复”两种不同策略下词语习得的效果差异。方法招募37例ASD儿童,年龄45~83个月,平均年龄(60.83±9.87)个月。随机分为两组学习新词,一组(n=18)采用“互斥原则”策略,另一组(n=19)采用“直接重复”策略进行,干预后行5 min手指操任务,然后即时评估儿童词语习得的效果。结果干预前后,两组正确回忆的新词数量均有提升(P<0.001),互斥原则组习得新词(2.92±1.49)个,直接重复组习得新词(1.35±0.99)个,干预后互斥原则组习得的新词数量大于直接重复组(P<0.001)。结论与“直接重复”的干预策略相比,“互斥原则”策略下ASD儿童习得新词的数量更多,“互斥原则”策略能提升ASD儿童的词语习得效果。

面向戒毒人员的“七位一体”交互式阅读疗法干预模式实证研究

为拓展图书馆阅读推广维度及阅读疗法服务群体,本研究面向戒毒人员,深入剖析戒毒现状、吸毒成因、心理问题及成因、融入家庭和社会的困难与成因,构建“心理问题干预、毒瘾戒治辅助、道德良知唤醒、坚韧人格重建、自尊水平提升、自我效能提升、创伤经历疗愈”的“七位一体”干预模式;提出基于跨理论模型的干预策略;采用将认知预备、问题认知与施治、成因认知与施治和团体辅导、小组交流、个人感悟相结合的交互式阅读疗法施治手段。实证研究结果表明:提出的干预策略和施治手段确保了实验的有效开展;干预模式和书方体系可显著提升其心理健康水平和戒毒自我效能感,可助其实现找回自我、回归家庭和回归社会的目标。本研究为图书馆面向特殊群体的阅读疗法提供一般研究范式参考。

Self-enhanced photothermal-chemodynamic antibacterial agents for synergistic anti-infective therapy

Cu_(2-x)S nanostructures have been intensively studied as outstanding chemodynamic therapy(CDT)and good photothermal therapy(PTT)antibacterial agents due to their highly efficient Cu(Ⅰ)-initiated Fenton-like catalytic activity and good photothermal conversion property.However,they still suffer from shortage of Cu(Ⅰ)supply in the long-term and comparatively low inherent photothermal conversion efficiency.Herein,we constructed a self-enhanced synergistic PTT/CDT nanoplatform(Cu_(1.94)S@MPN)by coating Cu_(1.94)S nanoparticles with Fe(Ⅲ)/tannic acid based metal-polyphenol networks(MPN).Activated by the acidic bacterial infection microenvironment,Cu_(1.94)S@MPN could be decomposed to continuously release Cu(Ⅱ),Fe(Ⅲ)ions and tannic acid.As the result of tannic acid-involved Cu and Fe redox cycling,Cu(Ⅰ)/Fe(Ⅱ)-rich CDT could be achieved through the highly accelerated catalytic Fenton/Fenton-like reactions.More importantly,experimental results demonstrated that Cu_(1.94)S@MPN exhibited both excellent photothermal antibacterial and photothermal-enhanced CDT properties to eradicate bacteria in vitro and in vivo.Overall,this novel nanotherapeutics has great potential to become a clinic candidate for anti-infective therapy in future.

Efficacy and safety of itraconazole as empirical antifungal therapy in febrile neutropenic patients with hematologic malignancies： an open-lable, multicenter, observational trial in a Chinese cohort

Background Invasive fungal infection （IFI） is a common and fatal complication in neutropenic patients with hematological malignancy. Empirical antifungal therapy is widely used in practice due to the difficulty of pathogens determination and illness of the hosts. The aim of this study was to evaluate the efficacy and safety of itraconazole as empirical antifungal therapy for persistent fever in neutropenic patients with hematologic malignancies. Methods Two hundred and seventy-four patients with hematologic malignancies who had suspected fungal infections were enrolled in 18 centers across China between April 2008 and April 2009. Empirical antifungal therapy with intravenous itraconazole 200 mg twice daily was given for the first two days, followed by 200 mg once daily for the next 12 days. Oral itraconazole solution was sequential for follow-up therapy if necessary. Five composite end points were evaluated for the response, which was more restrictive and adopted for the first time in such study in China. Results The intent-to-treat analysis included data from 274 patients （full analysis set, FAS）, of whom 248 were included as the per-protocol population （PPS）. As the composite end point of five indices was concerned, the overall response rate was 43.4%. Seperately, defervescence was achieved in 90% of patients in which 55.5% occured during neutropenia. The mean time to defervescence was 2.71 days. Absence of breakthrough IFI during drug administration or within the first 7 days after study completion was observed in 71.5% of patients. Fifty-five point five percent patients with IFI at baseline was successfully treated. Ninety point five percent patients survived for at least 7 days after completing the study. PPS analysis revealed that the duration of neutropenia 〉10 days was a statistically significant negative predictor for the response. The withdrawal rate due to drug-related toxicity or lack of efficacy was 11.0%. The incidence of adverse events was 22.6%, in which 11.6% was study drug related. The most frequent adverse events were mild to moderate liver toxicity. Conclusion Itraconazole shows desirable efficacy and safety as empirical antifungal therapy for febrile neutropenic patients with hematologic malignancies.

Epidemiology of methicillin-resistant Staphylococcus aureus infection and empirical antibiotic therapy for MRSA infection： multicenter investigation

Background The epidemiology of methicillin-resistant Staphylococcus aureus （MRSA） maybe changed by strict infection control measures,and the impact of empirical antibiotic therapy on the outcomes of MRSA infection was not clear.We aimed to investigate the present epidemiological status of MRSA infection and empirical antibiotic therapy for MRSA infection in university teaching hospitals in China's Mainland.Methods The present study was a multicenter prospective observational study conducted in five university teaching hospitals.Patients who were consecutively admitted to the intensive care unit and signed a consent form from March 3,2011 to May 31,2011 were included.Patients with age 〈18 years or with a length of hospital stay 〈48 hours were excluded from this study.The following variables were collected or recorded：demographic data,general status,APACHE Ⅱ score of the patient at the time of admission,infections,and the use of antibiotics during a stay.Primary outcomes and prognostic indicators included length of hospital stay and 28-day and 90-day mortality.The differences between the patients with appropriate empirical therapy and patients with inappropriate therapy were analyzed to detect the influences of antibiotic therapy on the prognosis of MRSA infection.Results A total of 682 cases were enrolled.Thirty （66.2%） of 88 MRSA cases were treated with effective antibiotics for MRSA infection; only 20% received appropriate empirical antibiotic treatment.The empirical therapy group compared with the target therapy group had a shorter length of stay,but there were no significant differences in mortality rates.There were no significant differences in the length of hospital stay,length of stay,and 28-day and 90-day mortality between MRSA-infected patients who received or not received effective antibiotics.Two hundred and eighteen cases received sensitive antibiotics for MRSA.Conclusions The MRSA infection rates are at relatively low levels in university teaching hospitals in China.The empirical use of sensitive antibiotics for MRSA infection was at relatively high rate,and there is a tendency of overusing in patients without MRSA infection.On the other hand,the rate of appropriate empirical antibiotic therapy for patients with MRSA infection is relatively low.

幽门螺杆菌分子耐药检测指导的个体化治疗研究进展

幽门螺杆菌耐药率的日益增高使经验性治疗的根除率逐年下降,而分子生物学耐药检测技术因灵敏、准确可靠、快速简便等优点,其指导的个体化治疗越来越被认可和重视。本文系统回顾和综合分析了基于分子耐药检测指导的个体化治疗效果的研究进展。目前的分子生物学耐药检测技术大多以聚合酶链式反应(PCR)技术为基础,临床上以检测克拉霉素的耐药突变为主并且多应用于指导首次治疗。一般来说,分子耐药检测指导的个体化治疗优于经验三联疗法,但与经验铋剂四联疗法和伴同疗法的效果相当。然而,当个体化治疗采用铋剂四联疗法时,其效果可优于经验铋剂四联疗法。尽管目前的分子耐药检测技术存在覆盖的抗生素检测类型有限、有创取样、假阴性风险等不足,但其指导的个体化治疗仍可以提高幽门螺杆菌根除率和减少不必要的耐药抗生素的使用。

益气祛风化瘀清利法治疗肾病综合征验案撷菁

肾病综合征是多种病理损害所致的一组临床综合征,主要表现为大量蛋白尿、低白蛋白血症、水肿及/或高脂血症,是临床上治疗较为棘手的疾病之一。目前现代医学针对肾病综合征主要使用激素和免疫抑制剂治疗,往往面临感染风险高以及不良反应大等问题,且疗效欠佳。周恩超教授以中医药治疗肾脏病近30年,临床经验丰富。周恩超教授认为肾病综合征的基本病机总属本虚标实,本虚总不离肺、脾、肾三脏功能失调,气血阴阳虚损;标实不外乎风、瘀、湿等因素,提出运用益气祛风化瘀清利法治疗本病,在治疗上强调健脾益肾扶助正气,注重祛风通络兼顾化瘀,佐以淡渗清利畅通三焦;在用药方面,常以生黄芪、太子参、炒白术、酒萸肉等益气健脾补肾扶固正气,以全蝎、僵蚕、蝉蜕、雷公藤、青风藤等以祛风通络,配伍红花、川芎、土鳖虫以活血化瘀,取茯苓皮、车前子、石韦、益母草、玉米须等以淡渗清利,往往能够取得良好效果。文章结合临床案例阐述周恩超教授治疗肾病综合征相关学术观点及用药经验,以期为临床治疗肾病综合征提供参考。

经验性覆盖非典型病原菌治疗成人非重症社区获得性肺炎的队列研究

目的研究经验性覆盖非典型病原菌治疗成人非重症社区获得性肺炎(CAP)的有效性、安全性及经济性。方法本研究为回顾性研究。搜集2019年1月—12月于清华大学第一附属医院收治的348例成人非重症CAP患者的病例资料。按照治疗方法不同,分为覆盖组208例,采用喹诺酮类、大环内酯类及四环素类单药或联合治疗;对照组140例,采用β-内酰胺类单药治疗。单因素分析两组患者的基线资料,治疗有效性、安全性、经济性所涉及的各项指标。组间计数资料采用χ^(2)检验或Fisher精确检验;符合正态分布的计量资料采用t检验比较,非正态分布则采用Wilcoxon秩和检验比较。以是否覆盖非典型病原菌为自变量,有效性与安全性其余指标为协变量,构建Logistic回归模型进行多因素分析。其中经济性指标,首先通过容忍度和方差膨胀因子判断共线性,若不存在共线性,则采用多元线性回归模型进行分析。结果覆盖组年龄>65岁(P<0.001)、有意识障碍(P=0.014)、血压降低(P=0.002)的患者占比均明显低于对照组,差异均有统计学意义。覆盖组的治疗方案以喹诺酮类联合β-内酰胺类药物占比最多61.1%(127/208)。单因素分析结果显示:覆盖组治疗有效率96.6%(201/208)、对照组96.4%(135/140),覆盖组不良反应发生率6.7%(14/208)、对照组3.6%(5/140),两组治疗有效率、不良反应发生率差异均无统计学意义(P均>0.05);覆盖组住院药物总费用、住院抗菌药物费用均明显高于对照组,差异均有统计学意义(P均<0.01)。多因素Logistic回归分析结果显示,男性(P=0.025)、年龄>65岁(P=0.025)、肾功能不全(P=0.018)、合并高血压(P=0.025)及非肺部肿瘤(P=0.020)是影响治疗有效性的独立危险因素。结论经验性覆盖与不覆盖非典型病原菌两种方法治疗成人非重症CAP,在有效性和安全性上优势相当,前者在经济性方面劣于后者。

国内外阅读疗法实证研究成果与展望——基于Web of Science与CNKI数据库相关文献分析

文章对2005-2022年Web of Science与CNKI数据库阅读疗法实证研究的57篇相关文献从研究主题、研究对象、研究方法、研究成果四个方面进行了系统分析梳理。分析发现国内外学者均非常重视阅读疗法的实证研究,且国内外阅读疗法的实证研究过程具有一定的差异性。通过深度剖析国内外阅读疗法领域的相关文献,系统性梳理不同研究方法下阅读疗法的研究成果及其作用,提出深入该领域实证研究的相关建议。

侵蚀艾肯菌感染15例临床分析

目的 探讨侵蚀艾肯菌感染的临床特征,为临床诊断及经验治疗提供依据。方法 回顾性分析2015年1月至2021年10月该院诊断为侵蚀艾肯菌感染的15例患者临床特征。结果 15例患者患者主要临床表现为颌面颈部局部肿痛、腹腔脓肿及脑脓肿。15株侵蚀艾肯菌主要分离自引流液。侵蚀艾肯菌对青霉素、头孢曲松、左氧氟沙星耐药,敏感率分别为53.3%、93.3%、80.0%,对亚胺培南、美罗培南、氨苄西林、阿莫西林-克拉维酸、甲氧苄啶-磺胺甲噁唑的敏感率均为100.0%。结论 侵蚀艾肯菌主要引起急性化脓性感染,并形成局部脓肿。亚胺培南、美罗培南可作为治疗侵蚀艾肯菌感染的经验性用药,并及时且连续对患者采取清创冲洗术治疗,具有较好效果。

Graphene-based nanomaterials for cancer therapy and anti-infections

Graphene-based nanomaterials(GBNMs)has been thoroughly investigated and extensively used in many biomedical fields,especially cancer therapy and bacteria-induced infectious diseases treatment,which have attracted more and more attentions due to the improved therapeutic efficacy and reduced reverse effect.GBNMs,as classic two-dimensional(2D)nanomaterials,have unique structure and excellent physicochemical properties,exhibiting tremendous potential in cancer therapy and bacteria-induced infectious diseases treatment.In this review,we first introduced the recent advances in development of GBNMs and GBNMs-based treatment strategies for cancer,including photothermal therapy(PTT),photodynamic therapy(PDT)and multiple combination therapies.Then,we surveyed the research progress of applications of GBNMs in anti-infection such as antimicrobial resistance,wound healing and removal of biofilm.The mechanism of GBNMs was also expounded.Finally,we concluded and discussed the advantages,challenges/limitations and perspective about the development of GBNMs and GBNMs-based therapies.Collectively,we think that GBNMs could be potential in clinic to promote the improvement of cancer therapy and infections treatment.

验方止痒膏异病同治皮肤瘙痒症临床观察

目的评价验方制剂止痒膏异病同治皮肤瘙痒症的临床有效性和安全性。方法选择2020年7月—2021年4月在济宁市皮肤病防治院门诊确诊的144例患者作为研究对象,随机分为观察组和对照组各72例,观察组口服依巴斯汀片合并外用止痒膏,对照组口服依巴斯汀片合并外用维生素E乳。2组均连续治疗4周。结果观察组患者治疗后的瘙痒程度评分、瘙痒频率评分、继发皮损评分、生活质量评分、症状总积分及临床综合疗效优于对照组,差异均有统计学意义(P<0.05)。结论验方止痒膏异病同治皮肤瘙痒症的临床效果显著,是治疗皮肤瘙痒症安全有效的方法。