This paper describes the preparation of two new optically active aliphatic β-amino alcohols (R)-5,5-dimethyl-2-(dimethy-lamino)-1,1-diphenyl-1-hexanol (1a) and (S)-8,8-dimethyl-2-(dimethylamino)-1, 1-diphenyl-1-nonan...This paper describes the preparation of two new optically active aliphatic β-amino alcohols (R)-5,5-dimethyl-2-(dimethy-lamino)-1,1-diphenyl-1-hexanol (1a) and (S)-8,8-dimethyl-2-(dimethylamino)-1, 1-diphenyl-1-nonanol (1b). They were synthesized by methylation of the corresponding β-amino alcohols 2a and 2b. Compounds la and 1b catalyze the addition of diethylzinc to various aldehydes enantioselectively. The catalyst structure-enantioselectivity relationships were discussed.展开更多
Un der the catalysis of chiral Cu(ll)complex,C2 and C3 alkylati on of pyrrole and C3 alkylation of in dole were realized simulta neously.The chiral oxindole skeleton with an all-carb on quater nary stereogenic cen ter...Un der the catalysis of chiral Cu(ll)complex,C2 and C3 alkylati on of pyrrole and C3 alkylation of in dole were realized simulta neously.The chiral oxindole skeleton with an all-carb on quater nary stereogenic cen ter at the C3-position could be obtai ned exclusively with high yields(up to 95%)and excellent enantioselectivities(up to>99%).展开更多
A partially substituted β-cyclodextrin chiral stationary phase was prepared by the reaction of phenyl isocyanate. The enantiomers of a series of O,O-diethyl(p-methylbenzenesulfonamido)-aryl(or alkyl)-methylphos-. pho...A partially substituted β-cyclodextrin chiral stationary phase was prepared by the reaction of phenyl isocyanate. The enantiomers of a series of O,O-diethyl(p-methylbenzenesulfonamido)-aryl(or alkyl)-methylphos-. phonates were studied on the prepared phenyl carbamate derivative β-cyclodextrin bonded phase and a commercial ( S)-(.+ )-l-(l-naphthyl)ethylcarbamate derivative β-cyclodextrin bonded phase on normal phase chromato-graphic condition. Results show that the prepared phenyl carbamate derivative β-cyclodextrin bonded phase has better enantiomeric selectivity to the series of compounds. A chiral recognition mechanism was suggested for the separation of these novel organic phosphorus enantiomers.展开更多
文摘This paper describes the preparation of two new optically active aliphatic β-amino alcohols (R)-5,5-dimethyl-2-(dimethy-lamino)-1,1-diphenyl-1-hexanol (1a) and (S)-8,8-dimethyl-2-(dimethylamino)-1, 1-diphenyl-1-nonanol (1b). They were synthesized by methylation of the corresponding β-amino alcohols 2a and 2b. Compounds la and 1b catalyze the addition of diethylzinc to various aldehydes enantioselectively. The catalyst structure-enantioselectivity relationships were discussed.
文摘Un der the catalysis of chiral Cu(ll)complex,C2 and C3 alkylati on of pyrrole and C3 alkylation of in dole were realized simulta neously.The chiral oxindole skeleton with an all-carb on quater nary stereogenic cen ter at the C3-position could be obtai ned exclusively with high yields(up to 95%)and excellent enantioselectivities(up to>99%).
基金Project (No. 98010) supported by the 11th Foundation of State Key Laboratory of Elemento-Organic Chemistry,Nankai University.
文摘A partially substituted β-cyclodextrin chiral stationary phase was prepared by the reaction of phenyl isocyanate. The enantiomers of a series of O,O-diethyl(p-methylbenzenesulfonamido)-aryl(or alkyl)-methylphos-. phonates were studied on the prepared phenyl carbamate derivative β-cyclodextrin bonded phase and a commercial ( S)-(.+ )-l-(l-naphthyl)ethylcarbamate derivative β-cyclodextrin bonded phase on normal phase chromato-graphic condition. Results show that the prepared phenyl carbamate derivative β-cyclodextrin bonded phase has better enantiomeric selectivity to the series of compounds. A chiral recognition mechanism was suggested for the separation of these novel organic phosphorus enantiomers.
