Automatic crack detection of cement pavement chiefly benefits from the rapid development of deep learning,with convolutional neural networks(CNN)playing an important role in this field.However,as the performance of cr...Automatic crack detection of cement pavement chiefly benefits from the rapid development of deep learning,with convolutional neural networks(CNN)playing an important role in this field.However,as the performance of crack detection in cement pavement improves,the depth and width of the network structure are significantly increased,which necessitates more computing power and storage space.This limitation hampers the practical implementation of crack detection models on various platforms,particularly portable devices like small mobile devices.To solve these problems,we propose a dual-encoder-based network architecture that focuses on extracting more comprehensive fracture feature information and combines cross-fusion modules and coordinated attention mechanisms formore efficient feature fusion.Firstly,we use small channel convolution to construct shallow feature extractionmodule(SFEM)to extract low-level feature information of cracks in cement pavement images,in order to obtainmore information about cracks in the shallowfeatures of images.In addition,we construct large kernel atrous convolution(LKAC)to enhance crack information,which incorporates coordination attention mechanism for non-crack information filtering,and large kernel atrous convolution with different cores,using different receptive fields to extract more detailed edge and context information.Finally,the three-stage feature map outputs from the shallow feature extraction module is cross-fused with the two-stage feature map outputs from the large kernel atrous convolution module,and the shallow feature and detailed edge feature are fully fused to obtain the final crack prediction map.We evaluate our method on three public crack datasets:DeepCrack,CFD,and Crack500.Experimental results on theDeepCrack dataset demonstrate the effectiveness of our proposed method compared to state-of-the-art crack detection methods,which achieves Precision(P)87.2%,Recall(R)87.7%,and F-score(F1)87.4%.Thanks to our lightweight crack detectionmodel,the parameter count of the model in real-world detection scenarios has been significantly reduced to less than 2M.This advancement also facilitates technical support for portable scene detection.展开更多
In order to prevent possible casualties and economic loss, it is critical to accurate prediction of the Remaining Useful Life (RUL) in rail prognostics health management. However, the traditional neural networks is di...In order to prevent possible casualties and economic loss, it is critical to accurate prediction of the Remaining Useful Life (RUL) in rail prognostics health management. However, the traditional neural networks is difficult to capture the long-term dependency relationship of the time series in the modeling of the long time series of rail damage, due to the coupling relationship of multi-channel data from multiple sensors. Here, in this paper, a novel RUL prediction model with an enhanced pulse separable convolution is used to solve this issue. Firstly, a coding module based on the improved pulse separable convolutional network is established to effectively model the relationship between the data. To enhance the network, an alternate gradient back propagation method is implemented. And an efficient channel attention (ECA) mechanism is developed for better emphasizing the useful pulse characteristics. Secondly, an optimized Transformer encoder was designed to serve as the backbone of the model. It has the ability to efficiently understand relationship between the data itself and each other at each time step of long time series with a full life cycle. More importantly, the Transformer encoder is improved by integrating pulse maximum pooling to retain more pulse timing characteristics. Finally, based on the characteristics of the front layer, the final predicted RUL value was provided and served as the end-to-end solution. The empirical findings validate the efficacy of the suggested approach in forecasting the rail RUL, surpassing various existing data-driven prognostication techniques. Meanwhile, the proposed method also shows good generalization performance on PHM2012 bearing data set.展开更多
The detection of brain disease is an essential issue in medical and research areas.Deep learning techniques have shown promising results in detecting and diagnosing brain diseases using magnetic resonance imaging(MRI)...The detection of brain disease is an essential issue in medical and research areas.Deep learning techniques have shown promising results in detecting and diagnosing brain diseases using magnetic resonance imaging(MRI)images.These techniques involve training neural networks on large datasets of MRI images,allowing the networks to learn patterns and features indicative of different brain diseases.However,several challenges and limitations still need to be addressed further to improve the accuracy and effectiveness of these techniques.This paper implements a Feature Enhanced Stacked Auto Encoder(FESAE)model to detect brain diseases.The standard stack auto encoder’s results are trivial and not robust enough to boost the system’s accuracy.Therefore,the standard Stack Auto Encoder(SAE)is replaced with a Stacked Feature Enhanced Auto Encoder with a feature enhancement function to efficiently and effectively get non-trivial features with less activation energy froman image.The proposed model consists of four stages.First,pre-processing is performed to remove noise,and the greyscale image is converted to Red,Green,and Blue(RGB)to enhance feature details for discriminative feature extraction.Second,feature Extraction is performed to extract significant features for classification using DiscreteWavelet Transform(DWT)and Channelization.Third,classification is performed to classify MRI images into four major classes:Normal,Tumor,Brain Stroke,and Alzheimer’s.Finally,the FESAE model outperforms the state-of-theart,machine learning,and deep learning methods such as Artificial Neural Network(ANN),SAE,Random Forest(RF),and Logistic Regression(LR)by achieving a high accuracy of 98.61% on a dataset of 2000 MRI images.The proposed model has significant potential for assisting radiologists in diagnosing brain diseases more accurately and improving patient outcomes.展开更多
The goal of street-to-aerial cross-view image geo-localization is to determine the location of the query street-view image by retrieving the aerial-view image from the same place.The drastic viewpoint and appearance g...The goal of street-to-aerial cross-view image geo-localization is to determine the location of the query street-view image by retrieving the aerial-view image from the same place.The drastic viewpoint and appearance gap between the aerial-view and the street-view images brings a huge challenge against this task.In this paper,we propose a novel multiscale attention encoder to capture the multiscale contextual information of the aerial/street-view images.To bridge the domain gap between these two view images,we first use an inverse polar transform to make the street-view images approximately aligned with the aerial-view images.Then,the explored multiscale attention encoder is applied to convert the image into feature representation with the guidance of the learnt multiscale information.Finally,we propose a novel global mining strategy to enable the network to pay more attention to hard negative exemplars.Experiments on standard benchmark datasets show that our approach obtains 81.39%top-1 recall rate on the CVUSA dataset and 71.52%on the CVACT dataset,achieving the state-of-the-art performance and outperforming most of the existing methods significantly.展开更多
The topological connectivity information derived from the brain functional network can bring new insights for diagnosing and analyzing dementia disorders.The brain functional network is suitable to bridge the correlat...The topological connectivity information derived from the brain functional network can bring new insights for diagnosing and analyzing dementia disorders.The brain functional network is suitable to bridge the correlation between abnormal connectivities and dementia disorders.However,it is challenging to access considerable amounts of brain functional network data,which hinders the widespread application of data-driven models in dementia diagnosis.In this study,a novel distribution-regularized adversarial graph auto-Encoder(DAGAE)with transformer is proposed to generate new fake brain functional networks to augment the brain functional network dataset,improving the dementia diagnosis accuracy of data-driven models.Specifically,the label distribution is estimated to regularize the latent space learned by the graph encoder,which canmake the learning process stable and the learned representation robust.Also,the transformer generator is devised to map the node representations into node-to-node connections by exploring the long-term dependence of highly-correlated distant brain regions.The typical topological properties and discriminative features can be preserved entirely.Furthermore,the generated brain functional networks improve the prediction performance using different classifiers,which can be applied to analyze other cognitive diseases.Attempts on the Alzheimer’s Disease Neuroimaging Initiative(ADNI)dataset demonstrate that the proposed model can generate good brain functional networks.The classification results show adding generated data can achieve the best accuracy value of 85.33%,sensitivity value of 84.00%,specificity value of 86.67%.The proposed model also achieves superior performance compared with other related augmentedmodels.Overall,the proposedmodel effectively improves cognitive disease diagnosis by generating diverse brain functional networks.展开更多
Latent information is difficult to get from the text in speech synthesis.Studies show that features from speech can get more information to help text encoding.In the field of speech encoding,a lot of work has been con...Latent information is difficult to get from the text in speech synthesis.Studies show that features from speech can get more information to help text encoding.In the field of speech encoding,a lot of work has been conducted on two aspects.The first aspect is to encode speech frame by frame.The second aspect is to encode the whole speech to a vector.But the scale in these aspects is fixed.So,encoding speech with an adjustable scale for more latent information is worthy of investigation.But current alignment approaches only support frame-by-frame encoding and speech-to-vector encoding.It remains a challenge to propose a new alignment approach to support adjustable scale speech encoding.This paper presents the dynamic speech encoder with a new alignment approach in conjunction with frame-by-frame encoding and speech-to-vector encoding.The speech feature fromourmodel achieves three functions.First,the speech feature can reconstruct the origin speech while the length of the speech feature is equal to the text length.Second,our model can get text embedding fromspeech,and the encoded speech feature is similar to the text embedding result.Finally,it can transfer the style of synthesis speech and make it more similar to the given reference speech.展开更多
人类基因组计划完成以来,科学家们一直在努力阐释基因组信息所代表的生物学意义。自2003年开始,美国国家人类基因组研究所(National Human Genome Research Institute,NHGRI)投资近3亿美元启动"DNA元件百科全书(Encyclopedia of DN...人类基因组计划完成以来,科学家们一直在努力阐释基因组信息所代表的生物学意义。自2003年开始,美国国家人类基因组研究所(National Human Genome Research Institute,NHGRI)投资近3亿美元启动"DNA元件百科全书(Encyclopedia of DNA Elements,ENCODE)"计划,集结了来自美国、中国、英国、日本、西班牙和新加坡等国家的32个实验室的440余名科学家,共同鉴定并分析人类基因组中所有的功能调控元件。高通量测序技术等实验手段的发展和生物信息学技术的不断完善使得ENCODE计划取得了丰硕的成果:确定了甲基化和组蛋白修饰等表观修饰区域及其对染色质结构的作用,进而确定染色质结构的改变影响基因表达;确定了转录因子及其结合位点的信息,并构建了转录因子调控网络;进一步修订更新了假基因和非编码RNA数据库;并确定了调控序列的单核苷酸多态性(Single nucleotide polymorphism,SNP)并与疾病相关联。这些发现一方面有助于系统解析基因和基因组信息、调控元件的调控作用以及非编码区转录调控等分子机制;同时也将为转化医学等生命科学研究领域提供丰富的数据来源。文章综述了高通量测序技术等实验手段的发展和生物信息学技术的不断完善对ENCODE计划的贡献、表观遗传学研究与ENCODE计划的关联性、ENCODE计划的主要科学成果等,同时展望了ENCODE计划对基础医学、临床医学和转化医学等生命科学研究领域的巨大推动作用。展开更多
在flash cs6的默认情况下,Flash cs6只支持flv和f4v格式的视频.如果不是这种格式的视频,我们可以使用Flash cs6自带的视频转换组件Adobe Media Encoder将其他视频格式转换成FLV和F4V格式.本文主要讲解如何使用flash自带的Adobe Media En...在flash cs6的默认情况下,Flash cs6只支持flv和f4v格式的视频.如果不是这种格式的视频,我们可以使用Flash cs6自带的视频转换组件Adobe Media Encoder将其他视频格式转换成FLV和F4V格式.本文主要讲解如何使用flash自带的Adobe Media Encoder组件进行视频文件的转换,导入和使用.展开更多
In a satellite laser ranging telescope system, well-aligned encoders of the elevation and azimuth axes are essential for tracking objects. However, it is very difficult and time-consuming to correct the bias between t...In a satellite laser ranging telescope system, well-aligned encoders of the elevation and azimuth axes are essential for tracking objects. However, it is very difficult and time-consuming to correct the bias between the absolute-position indices of the encoders and the astronomical coordinates, especially in the absence of a finder scope for our system. To solve this problem, a method is presented based on the phenomenon that all stars move anti-clockwise around Polaris in the northern hemisphere. Tests of the proposed adjustment procedure in a satellite laser ranging (SLR)system demonstrated the effectiveness and the time saved by using the approach, which greatly facilitates the optimization of a trackin~ svstem.展开更多
With the development of automation in smart grids,network reconfiguration is becoming a feasible approach for improving the operation of distribution systems.A novel reconfiguration strategy was presented to get the o...With the development of automation in smart grids,network reconfiguration is becoming a feasible approach for improving the operation of distribution systems.A novel reconfiguration strategy was presented to get the optimal configuration of improving economy of the system,and then identifying the important nodes.In this strategy,the objectives increase the node importance degree and decrease the active power loss subjected to operational constraints.A compound objective function with weight coefficients is formulated to balance the conflict of the objectives.Then a novel quantum particle swarm optimization based on loop switches hierarchical encoded was employed to address the compound objective reconfiguration problem.Its main contribution is the presentation of the hierarchical encoded scheme which is used to generate the population swarm particles of representing only radial connected solutions.Because the candidate solutions are feasible,the search efficiency would improve dramatically during the optimization process without tedious topology verification.To validate the proposed strategy,simulations are carried out on the test systems.The results are compared with other techniques in order to evaluate the performance of the proposed method.展开更多
Low cost and miniaturized rotary encoders are important in automatic and precise production. Presented here is a code called Single Track Cyclic Gray Code (STCGC) that is an image etched on a single circular track of ...Low cost and miniaturized rotary encoders are important in automatic and precise production. Presented here is a code called Single Track Cyclic Gray Code (STCGC) that is an image etched on a single circular track of a rotary encoder disk read by a group of even spread reading heads to provide a unique codeword for every angular position and features such that every two adjacent words differ in exactly one component, thus avoiding coarse error. The existing construction or combination methods are helpful but not sufficient in determining the period of the STCGC of large word length and the theoretical approach needs further development to extend the word length. Three principles, such as the seed combination, short code removal and ergodicity examination were put forward that suffice determination of the optimal period for such absolute rotary encoders using STCGC with even spread heads. The optimal periods of STCGC in 3 through 29 bit length were determined and listed.展开更多
Considerable studies have been carried out on fault diagnosis of gears, with most of them concentrated on conventional vibration analysis. However, besides the complexity of gear dynamics, the diagnosis results in ter...Considerable studies have been carried out on fault diagnosis of gears, with most of them concentrated on conventional vibration analysis. However, besides the complexity of gear dynamics, the diagnosis results in terms of vibration signal are easily misjudged owing to the interference of sensor position or other components. In this paper, an alternative gearbox fault detection method based on the instantaneous rotational speed is proposed because of its advantages over vibration analysis. Depending on the timer/counter-based method for the pulse signal of the optical encoder, the varying rotational speed can be obtained e ectively. Owing to the coupling and meshing of gears in transmission, the excitations are the same for the instantaneous rotational speed of the input and output shafts. Thus, the di erential signal of instantaneous rotational speeds can be adopted to eliminate the e ect of the interference excitations and extract the associated feature of the localized fault e ectively. With the experiments on multistage gearbox test system, the di erential signal of instantaneous speeds is compared with other signals. It is proved that localized faults in the gearbox generate small angular speed fluctuations, which are measurable with an optical encoder. Using the di erential signal of instantaneous speeds, the fault characteristics are extracted in the spectrum where the deterministic frequency component and its harmonics corresponding to crack fault characteristics are displayed clearly.展开更多
We developed a novel absolute multi-pole encoder structure to improve the resolution of the multi-pole encoder, realize absolute output and reduce the manufacturing cost of the encoder. The structure includes two ring...We developed a novel absolute multi-pole encoder structure to improve the resolution of the multi-pole encoder, realize absolute output and reduce the manufacturing cost of the encoder. The structure includes two ring alnicos defined as index track and sub-division track, respectively. The index track is magnetized based on the improved gray code, with linear halls placed around the track evenly. The outputs of linear halls show the region the rotor belongs to. The sub-division track is magnetized to N-S-N-S (north-south-north-south), and the number of N-S pole pairs is determined by the index track. Three linear hall sensors with an air-gap of 2 mm are used to translate the magnetic filed to voltage signals. The relative offset in a single N-S is obtained through look-up. The magnetic encoder is calibrated using a higher-resolution incremental optical encoder. The pulse output from the optical encoder and hall signals from the magnetic encoder are sampled at the same time and transmitted to a computer, and the relation between them is calculated, and stored in the FLASH of MCU (micro controller unit) for look-up. In the working state, the absolute angle is derived by looking-up with hall signals. The structure is simple and the manufacturing cost is very low and suitable for mass production.展开更多
A low density parity check(LDPC)encoder with the codes of(8176,7154)and encoding rate of 7/8 under CCSDS standard for near space communication is designed.Based on LDPC encoding theory,the FPGA-based coding algorithm ...A low density parity check(LDPC)encoder with the codes of(8176,7154)and encoding rate of 7/8 under CCSDS standard for near space communication is designed.Based on LDPC encoding theory,the FPGA-based coding algorithm is designed.Based on the characteristics of LDPC generating matrix,the cyclic shift register is introduced as the core of the encoding circuit,and the shift-register-Adder-Accumulator(SRAA)structure is adopted to realize the fast calculation of matrix multiplication,so as to construct the encoding module with partial parallel encoding circuit as the core.In addition,the serial port input and output module,RAM storage module and control module are also designed,which together constitute the encoder system.The design scheme is implemented by FPGA hardware and verified by simulation and experiment.The results show that the test results of the designed LDPC encoder are consistent with the theoretical results.Therefore,the coding system is practical,and the design method is simple and efficient.展开更多
Given the substantially increasing complexity of embedded systems, the use of relatively detailed clock cycle-accurate simulators for the design-space exploration is impractical in the early design stages. Raising the...Given the substantially increasing complexity of embedded systems, the use of relatively detailed clock cycle-accurate simulators for the design-space exploration is impractical in the early design stages. Raising the abstraction level is nowadays widely seen as a solution to bridge the gap between the increasing system complexity and the low design productivity. For this, several system-level design tools and methodologies have been introduced to efficiently explore the design space of heterogeneous signal processing systems. In this paper, we demonstrate the effectiveness and the flexibility of the Sesame/Artemis system-level modeling and simulation methodology for efficient peformance evaluation and rapid architectural exploration of the increasing complexity heterogeneous embedded media systems. For this purpose, we have selected a system level design of a very high complexity media application;a H.264/AVC (Advanced Video Codec) video encoder. The encoding performances will be evaluated using system-level simulations targeting multiple heterogeneous multiprocessors platforms.展开更多
Introduction Post-translational modifications of core histones have emerged as a critical player in dynamical regulation of gene expression and accurate chromatin structures<sup>[1-2]</sup>.In recent years...Introduction Post-translational modifications of core histones have emerged as a critical player in dynamical regulation of gene expression and accurate chromatin structures<sup>[1-2]</sup>.In recent years it has been demonstrated that,histone lysine methylation is particularly prominent as one of the most important epigenetic modifications during cell cycles,development and differentiation,and in response to external stimuli,e.g.exogenous growth factors and mechanical stimulation.This epigenetic modification may also be an early event that regulates the gene expression dur-展开更多
基金supported by the National Natural Science Foundation of China(No.62176034)the Science and Technology Research Program of Chongqing Municipal Education Commission(No.KJZD-M202300604)the Natural Science Foundation of Chongqing(Nos.cstc2021jcyj-msxmX0518,2023NSCQ-MSX1781).
文摘Automatic crack detection of cement pavement chiefly benefits from the rapid development of deep learning,with convolutional neural networks(CNN)playing an important role in this field.However,as the performance of crack detection in cement pavement improves,the depth and width of the network structure are significantly increased,which necessitates more computing power and storage space.This limitation hampers the practical implementation of crack detection models on various platforms,particularly portable devices like small mobile devices.To solve these problems,we propose a dual-encoder-based network architecture that focuses on extracting more comprehensive fracture feature information and combines cross-fusion modules and coordinated attention mechanisms formore efficient feature fusion.Firstly,we use small channel convolution to construct shallow feature extractionmodule(SFEM)to extract low-level feature information of cracks in cement pavement images,in order to obtainmore information about cracks in the shallowfeatures of images.In addition,we construct large kernel atrous convolution(LKAC)to enhance crack information,which incorporates coordination attention mechanism for non-crack information filtering,and large kernel atrous convolution with different cores,using different receptive fields to extract more detailed edge and context information.Finally,the three-stage feature map outputs from the shallow feature extraction module is cross-fused with the two-stage feature map outputs from the large kernel atrous convolution module,and the shallow feature and detailed edge feature are fully fused to obtain the final crack prediction map.We evaluate our method on three public crack datasets:DeepCrack,CFD,and Crack500.Experimental results on theDeepCrack dataset demonstrate the effectiveness of our proposed method compared to state-of-the-art crack detection methods,which achieves Precision(P)87.2%,Recall(R)87.7%,and F-score(F1)87.4%.Thanks to our lightweight crack detectionmodel,the parameter count of the model in real-world detection scenarios has been significantly reduced to less than 2M.This advancement also facilitates technical support for portable scene detection.
文摘In order to prevent possible casualties and economic loss, it is critical to accurate prediction of the Remaining Useful Life (RUL) in rail prognostics health management. However, the traditional neural networks is difficult to capture the long-term dependency relationship of the time series in the modeling of the long time series of rail damage, due to the coupling relationship of multi-channel data from multiple sensors. Here, in this paper, a novel RUL prediction model with an enhanced pulse separable convolution is used to solve this issue. Firstly, a coding module based on the improved pulse separable convolutional network is established to effectively model the relationship between the data. To enhance the network, an alternate gradient back propagation method is implemented. And an efficient channel attention (ECA) mechanism is developed for better emphasizing the useful pulse characteristics. Secondly, an optimized Transformer encoder was designed to serve as the backbone of the model. It has the ability to efficiently understand relationship between the data itself and each other at each time step of long time series with a full life cycle. More importantly, the Transformer encoder is improved by integrating pulse maximum pooling to retain more pulse timing characteristics. Finally, based on the characteristics of the front layer, the final predicted RUL value was provided and served as the end-to-end solution. The empirical findings validate the efficacy of the suggested approach in forecasting the rail RUL, surpassing various existing data-driven prognostication techniques. Meanwhile, the proposed method also shows good generalization performance on PHM2012 bearing data set.
基金supported by financial support from Universiti Sains Malaysia(USM)under FRGS Grant Number FRGS/1/2020/TK03/USM/02/1the School of Computer Sciences USM for their support.
文摘The detection of brain disease is an essential issue in medical and research areas.Deep learning techniques have shown promising results in detecting and diagnosing brain diseases using magnetic resonance imaging(MRI)images.These techniques involve training neural networks on large datasets of MRI images,allowing the networks to learn patterns and features indicative of different brain diseases.However,several challenges and limitations still need to be addressed further to improve the accuracy and effectiveness of these techniques.This paper implements a Feature Enhanced Stacked Auto Encoder(FESAE)model to detect brain diseases.The standard stack auto encoder’s results are trivial and not robust enough to boost the system’s accuracy.Therefore,the standard Stack Auto Encoder(SAE)is replaced with a Stacked Feature Enhanced Auto Encoder with a feature enhancement function to efficiently and effectively get non-trivial features with less activation energy froman image.The proposed model consists of four stages.First,pre-processing is performed to remove noise,and the greyscale image is converted to Red,Green,and Blue(RGB)to enhance feature details for discriminative feature extraction.Second,feature Extraction is performed to extract significant features for classification using DiscreteWavelet Transform(DWT)and Channelization.Third,classification is performed to classify MRI images into four major classes:Normal,Tumor,Brain Stroke,and Alzheimer’s.Finally,the FESAE model outperforms the state-of-theart,machine learning,and deep learning methods such as Artificial Neural Network(ANN),SAE,Random Forest(RF),and Logistic Regression(LR)by achieving a high accuracy of 98.61% on a dataset of 2000 MRI images.The proposed model has significant potential for assisting radiologists in diagnosing brain diseases more accurately and improving patient outcomes.
基金National Natural Science Foundation of China,Grant/Award Number:62106177supported by the Central University Basic Research Fund of China(No.2042020KF0016)supported by the supercomputing system in the Supercomputing Center of Wuhan University.
文摘The goal of street-to-aerial cross-view image geo-localization is to determine the location of the query street-view image by retrieving the aerial-view image from the same place.The drastic viewpoint and appearance gap between the aerial-view and the street-view images brings a huge challenge against this task.In this paper,we propose a novel multiscale attention encoder to capture the multiscale contextual information of the aerial/street-view images.To bridge the domain gap between these two view images,we first use an inverse polar transform to make the street-view images approximately aligned with the aerial-view images.Then,the explored multiscale attention encoder is applied to convert the image into feature representation with the guidance of the learnt multiscale information.Finally,we propose a novel global mining strategy to enable the network to pay more attention to hard negative exemplars.Experiments on standard benchmark datasets show that our approach obtains 81.39%top-1 recall rate on the CVUSA dataset and 71.52%on the CVACT dataset,achieving the state-of-the-art performance and outperforming most of the existing methods significantly.
基金This paper is partially supported by the British Heart Foundation Accelerator Award,UK(AA\18\3\34220)Royal Society International Exchanges Cost Share Award,UK(RP202G0230)+9 种基金Hope Foundation for Cancer Research,UK(RM60G0680)Medical Research Council Confidence in Concept Award,UK(MC_PC_17171)Sino-UK Industrial Fund,UK(RP202G0289)Global Challenges Research Fund(GCRF),UK(P202PF11)LIAS Pioneering Partnerships Award,UK(P202ED10)Data Science Enhancement Fund,UK(P202RE237)Fight for Sight,UK(24NN201)Sino-UK Education Fund,UK(OP202006)Biotechnology and Biological Sciences Research Council,UK(RM32G0178B8)LIAS Seed Corn,UK(P202RE969).
文摘The topological connectivity information derived from the brain functional network can bring new insights for diagnosing and analyzing dementia disorders.The brain functional network is suitable to bridge the correlation between abnormal connectivities and dementia disorders.However,it is challenging to access considerable amounts of brain functional network data,which hinders the widespread application of data-driven models in dementia diagnosis.In this study,a novel distribution-regularized adversarial graph auto-Encoder(DAGAE)with transformer is proposed to generate new fake brain functional networks to augment the brain functional network dataset,improving the dementia diagnosis accuracy of data-driven models.Specifically,the label distribution is estimated to regularize the latent space learned by the graph encoder,which canmake the learning process stable and the learned representation robust.Also,the transformer generator is devised to map the node representations into node-to-node connections by exploring the long-term dependence of highly-correlated distant brain regions.The typical topological properties and discriminative features can be preserved entirely.Furthermore,the generated brain functional networks improve the prediction performance using different classifiers,which can be applied to analyze other cognitive diseases.Attempts on the Alzheimer’s Disease Neuroimaging Initiative(ADNI)dataset demonstrate that the proposed model can generate good brain functional networks.The classification results show adding generated data can achieve the best accuracy value of 85.33%,sensitivity value of 84.00%,specificity value of 86.67%.The proposed model also achieves superior performance compared with other related augmentedmodels.Overall,the proposedmodel effectively improves cognitive disease diagnosis by generating diverse brain functional networks.
基金supported by National Key R&D Program of China (2020AAA0107901).
文摘Latent information is difficult to get from the text in speech synthesis.Studies show that features from speech can get more information to help text encoding.In the field of speech encoding,a lot of work has been conducted on two aspects.The first aspect is to encode speech frame by frame.The second aspect is to encode the whole speech to a vector.But the scale in these aspects is fixed.So,encoding speech with an adjustable scale for more latent information is worthy of investigation.But current alignment approaches only support frame-by-frame encoding and speech-to-vector encoding.It remains a challenge to propose a new alignment approach to support adjustable scale speech encoding.This paper presents the dynamic speech encoder with a new alignment approach in conjunction with frame-by-frame encoding and speech-to-vector encoding.The speech feature fromourmodel achieves three functions.First,the speech feature can reconstruct the origin speech while the length of the speech feature is equal to the text length.Second,our model can get text embedding fromspeech,and the encoded speech feature is similar to the text embedding result.Finally,it can transfer the style of synthesis speech and make it more similar to the given reference speech.
文摘人类基因组计划完成以来,科学家们一直在努力阐释基因组信息所代表的生物学意义。自2003年开始,美国国家人类基因组研究所(National Human Genome Research Institute,NHGRI)投资近3亿美元启动"DNA元件百科全书(Encyclopedia of DNA Elements,ENCODE)"计划,集结了来自美国、中国、英国、日本、西班牙和新加坡等国家的32个实验室的440余名科学家,共同鉴定并分析人类基因组中所有的功能调控元件。高通量测序技术等实验手段的发展和生物信息学技术的不断完善使得ENCODE计划取得了丰硕的成果:确定了甲基化和组蛋白修饰等表观修饰区域及其对染色质结构的作用,进而确定染色质结构的改变影响基因表达;确定了转录因子及其结合位点的信息,并构建了转录因子调控网络;进一步修订更新了假基因和非编码RNA数据库;并确定了调控序列的单核苷酸多态性(Single nucleotide polymorphism,SNP)并与疾病相关联。这些发现一方面有助于系统解析基因和基因组信息、调控元件的调控作用以及非编码区转录调控等分子机制;同时也将为转化医学等生命科学研究领域提供丰富的数据来源。文章综述了高通量测序技术等实验手段的发展和生物信息学技术的不断完善对ENCODE计划的贡献、表观遗传学研究与ENCODE计划的关联性、ENCODE计划的主要科学成果等,同时展望了ENCODE计划对基础医学、临床医学和转化医学等生命科学研究领域的巨大推动作用。
文摘在flash cs6的默认情况下,Flash cs6只支持flv和f4v格式的视频.如果不是这种格式的视频,我们可以使用Flash cs6自带的视频转换组件Adobe Media Encoder将其他视频格式转换成FLV和F4V格式.本文主要讲解如何使用flash自带的Adobe Media Encoder组件进行视频文件的转换,导入和使用.
基金supported by the National Natural Science Foundation of China(41274189)
文摘In a satellite laser ranging telescope system, well-aligned encoders of the elevation and azimuth axes are essential for tracking objects. However, it is very difficult and time-consuming to correct the bias between the absolute-position indices of the encoders and the astronomical coordinates, especially in the absence of a finder scope for our system. To solve this problem, a method is presented based on the phenomenon that all stars move anti-clockwise around Polaris in the northern hemisphere. Tests of the proposed adjustment procedure in a satellite laser ranging (SLR)system demonstrated the effectiveness and the time saved by using the approach, which greatly facilitates the optimization of a trackin~ svstem.
基金Project(61102039)supported by the National Natural Science Foundation of ChinaProject(2014AA052600)supported by National Hi-tech Research and Development Plan,China
文摘With the development of automation in smart grids,network reconfiguration is becoming a feasible approach for improving the operation of distribution systems.A novel reconfiguration strategy was presented to get the optimal configuration of improving economy of the system,and then identifying the important nodes.In this strategy,the objectives increase the node importance degree and decrease the active power loss subjected to operational constraints.A compound objective function with weight coefficients is formulated to balance the conflict of the objectives.Then a novel quantum particle swarm optimization based on loop switches hierarchical encoded was employed to address the compound objective reconfiguration problem.Its main contribution is the presentation of the hierarchical encoded scheme which is used to generate the population swarm particles of representing only radial connected solutions.Because the candidate solutions are feasible,the search efficiency would improve dramatically during the optimization process without tedious topology verification.To validate the proposed strategy,simulations are carried out on the test systems.The results are compared with other techniques in order to evaluate the performance of the proposed method.
基金Project(JX2004J0170) supported by the Foundation of Beijing Jiaotong University, China
文摘Low cost and miniaturized rotary encoders are important in automatic and precise production. Presented here is a code called Single Track Cyclic Gray Code (STCGC) that is an image etched on a single circular track of a rotary encoder disk read by a group of even spread reading heads to provide a unique codeword for every angular position and features such that every two adjacent words differ in exactly one component, thus avoiding coarse error. The existing construction or combination methods are helpful but not sufficient in determining the period of the STCGC of large word length and the theoretical approach needs further development to extend the word length. Three principles, such as the seed combination, short code removal and ergodicity examination were put forward that suffice determination of the optimal period for such absolute rotary encoders using STCGC with even spread heads. The optimal periods of STCGC in 3 through 29 bit length were determined and listed.
基金Supported by National Natural Science Foundation of China(Grant No.51575438)China Postdoctoral Science Foundation(Grant Nos.2017M623159,2018T111046)Shaanxi Provincial Postdoctoral Science Foundation of China(Grant No.2017BSHEDZZ68)
文摘Considerable studies have been carried out on fault diagnosis of gears, with most of them concentrated on conventional vibration analysis. However, besides the complexity of gear dynamics, the diagnosis results in terms of vibration signal are easily misjudged owing to the interference of sensor position or other components. In this paper, an alternative gearbox fault detection method based on the instantaneous rotational speed is proposed because of its advantages over vibration analysis. Depending on the timer/counter-based method for the pulse signal of the optical encoder, the varying rotational speed can be obtained e ectively. Owing to the coupling and meshing of gears in transmission, the excitations are the same for the instantaneous rotational speed of the input and output shafts. Thus, the di erential signal of instantaneous rotational speeds can be adopted to eliminate the e ect of the interference excitations and extract the associated feature of the localized fault e ectively. With the experiments on multistage gearbox test system, the di erential signal of instantaneous speeds is compared with other signals. It is proved that localized faults in the gearbox generate small angular speed fluctuations, which are measurable with an optical encoder. Using the di erential signal of instantaneous speeds, the fault characteristics are extracted in the spectrum where the deterministic frequency component and its harmonics corresponding to crack fault characteristics are displayed clearly.
基金Funded partly by Heilongjiang Province Financial Fund for Researchers Returning from Abroad
文摘We developed a novel absolute multi-pole encoder structure to improve the resolution of the multi-pole encoder, realize absolute output and reduce the manufacturing cost of the encoder. The structure includes two ring alnicos defined as index track and sub-division track, respectively. The index track is magnetized based on the improved gray code, with linear halls placed around the track evenly. The outputs of linear halls show the region the rotor belongs to. The sub-division track is magnetized to N-S-N-S (north-south-north-south), and the number of N-S pole pairs is determined by the index track. Three linear hall sensors with an air-gap of 2 mm are used to translate the magnetic filed to voltage signals. The relative offset in a single N-S is obtained through look-up. The magnetic encoder is calibrated using a higher-resolution incremental optical encoder. The pulse output from the optical encoder and hall signals from the magnetic encoder are sampled at the same time and transmitted to a computer, and the relation between them is calculated, and stored in the FLASH of MCU (micro controller unit) for look-up. In the working state, the absolute angle is derived by looking-up with hall signals. The structure is simple and the manufacturing cost is very low and suitable for mass production.
文摘A low density parity check(LDPC)encoder with the codes of(8176,7154)and encoding rate of 7/8 under CCSDS standard for near space communication is designed.Based on LDPC encoding theory,the FPGA-based coding algorithm is designed.Based on the characteristics of LDPC generating matrix,the cyclic shift register is introduced as the core of the encoding circuit,and the shift-register-Adder-Accumulator(SRAA)structure is adopted to realize the fast calculation of matrix multiplication,so as to construct the encoding module with partial parallel encoding circuit as the core.In addition,the serial port input and output module,RAM storage module and control module are also designed,which together constitute the encoder system.The design scheme is implemented by FPGA hardware and verified by simulation and experiment.The results show that the test results of the designed LDPC encoder are consistent with the theoretical results.Therefore,the coding system is practical,and the design method is simple and efficient.
文摘Given the substantially increasing complexity of embedded systems, the use of relatively detailed clock cycle-accurate simulators for the design-space exploration is impractical in the early design stages. Raising the abstraction level is nowadays widely seen as a solution to bridge the gap between the increasing system complexity and the low design productivity. For this, several system-level design tools and methodologies have been introduced to efficiently explore the design space of heterogeneous signal processing systems. In this paper, we demonstrate the effectiveness and the flexibility of the Sesame/Artemis system-level modeling and simulation methodology for efficient peformance evaluation and rapid architectural exploration of the increasing complexity heterogeneous embedded media systems. For this purpose, we have selected a system level design of a very high complexity media application;a H.264/AVC (Advanced Video Codec) video encoder. The encoding performances will be evaluated using system-level simulations targeting multiple heterogeneous multiprocessors platforms.
基金supported in part by NIH HL098472 and NSF CBET0846429supported by China Scholarship Council as well
文摘Introduction Post-translational modifications of core histones have emerged as a critical player in dynamical regulation of gene expression and accurate chromatin structures<sup>[1-2]</sup>.In recent years it has been demonstrated that,histone lysine methylation is particularly prominent as one of the most important epigenetic modifications during cell cycles,development and differentiation,and in response to external stimuli,e.g.exogenous growth factors and mechanical stimulation.This epigenetic modification may also be an early event that regulates the gene expression dur-