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In Situ Deposition of Drug and Gene Nanoparticles on a Patterned Supramolecular Hydrogel to Construct a Directionally Osteochondral Plug 被引量:1
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作者 Jiawei Kang Yaping Li +7 位作者 Yating Qin Zhongming Huang Yifan Wu Long Sun Cong Wang Wei Wang Gang Feng Yiying Qi 《Nano-Micro Letters》 SCIE EI CAS CSCD 2024年第1期341-359,共19页
The integrated repair of bone and cartilage boasts advantages for osteochondral restoration such as a long-term repair effect and less deterioration compared to repairing cartilage alone.Constructing multifactorial,sp... The integrated repair of bone and cartilage boasts advantages for osteochondral restoration such as a long-term repair effect and less deterioration compared to repairing cartilage alone.Constructing multifactorial,spatially oriented scaffolds to stimulate osteochondral regeneration,has immense significance.Herein,targeted drugs,namely kartogenin@polydopamine(KGN@PDA)nanoparticles for cartilage repair and miRNA@calcium phosphate(miRNA@CaP)NPs for bone regeneration,were in situ deposited on a patterned supramolecular-assembled 2-ureido-4[lH]-pyrimidinone(UPy)modified gelation hydrogel film,facilitated by the dynamic and responsive coordination and complexation of metal ions and their ligands.This hydrogel film can be rolled into a cylindrical plug,mimicking the Haversian canal structure of natural bone.The resultant hydrogel demonstrates stable mechanical properties,a self-healing ability,a high capability for reactive oxygen species capture,and controlled release of KGN and miR-26a.In vitro,KGN@PDA and miRNA@CaP promote chondrogenic and osteogenic differentiation of mesenchymal stem cells via the JNK/RUNX1 and GSK-3β/β-catenin pathways,respectively.In vivo,the osteochondral plug exhibits optimal subchondral bone and cartilage regeneration,evidenced by a significant increase in glycosaminoglycan and collagen accumulation in specific zones,along with the successful integration of neocartilage with subchondral bone.This biomaterial delivery approach represents a significant toward improved osteochondral repair. 展开更多
关键词 osteochondral regeneration Oriented hydrogel Kartogenin miRNA-26a
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High quality repair of osteochondral defects in rats using the extracellular matrix of antler stem cells 被引量:1
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作者 Yu-Su Wang Wen-Hui Chu +4 位作者 Jing-Jie Zhai Wen-Ying Wang Zhong-Mei He Quan-Min Zhao Chun-Yi Li 《World Journal of Stem Cells》 SCIE 2024年第2期176-190,共15页
BACKGROUND Cartilage defects are some of the most common causes of arthritis.Cartilage lesions caused by inflammation,trauma or degenerative disease normally result in osteochondral defects.Previous studies have shown... BACKGROUND Cartilage defects are some of the most common causes of arthritis.Cartilage lesions caused by inflammation,trauma or degenerative disease normally result in osteochondral defects.Previous studies have shown that decellularized extracellular matrix(ECM)derived from autologous,allogenic,or xenogeneic mesenchymal stromal cells(MSCs)can effectively restore osteochondral integrity.AIM To determine whether the decellularized ECM of antler reserve mesenchymal cells(RMCs),a xenogeneic material from antler stem cells,is superior to the currently available treatments for osteochondral defects.METHODS We isolated the RMCs from a 60-d-old sika deer antler and cultured them in vitro to 70%confluence;50 mg/mL L-ascorbic acid was then added to the medium to stimulate ECM deposition.Decellularized sheets of adipocyte-derived MSCs(aMSCs)and antlerogenic periosteal cells(another type of antler stem cells)were used as the controls.Three weeks after ascorbic acid stimulation,the ECM sheets were harvested and applied to the osteochondral defects in rat knee joints.RESULTS The defects were successfully repaired by applying the ECM-sheets.The highest quality of repair was achieved in the RMC-ECM group both in vitro(including cell attachment and proliferation),and in vivo(including the simultaneous regeneration of well-vascularized subchondral bone and avascular articular hyaline cartilage integrated with surrounding native tissues).Notably,the antler-stem-cell-derived ECM(xenogeneic)performed better than the aMSC-ECM(allogenic),while the ECM of the active antler stem cells was superior to that of the quiescent antler stem cells.CONCLUSION Decellularized xenogeneic ECM derived from the antler stem cell,particularly the active form(RMC-ECM),can achieve high quality repair/reconstruction of osteochondral defects,suggesting that selection of decellularized ECM for such repair should be focused more on bioactivity rather than kinship. 展开更多
关键词 osteochondral defect repair Mesenchymal stem cells Extracellular matrix DECELLULARIZATION Antler stem cells Reserve mesenchymal cells Xenogeneic
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Bioceramic-mediated chondrocyte hypertrophy promotes calcified cartilage formation for rabbit osteochondral defect repair
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作者 Rachel H.Koh Junhee Kim +9 位作者 Jeong-Uk Kim Seunghyun L.Kim Arun Kumar Rajendran Seunghun SLee Heesoo Lee Joo Hyun Kim Ji Hoon Jeong Yongsung Hwang Jong Woo Bae Nathaniel S.Hwang 《Bioactive Materials》 SCIE CSCD 2024年第10期306-317,共12页
Osteochondral tissue is a highly specialized and complex tissue composed of articular cartilage and subchondral bone that are separated by a calcified cartilage interface.Multilayered or gradient scaffolds,often in co... Osteochondral tissue is a highly specialized and complex tissue composed of articular cartilage and subchondral bone that are separated by a calcified cartilage interface.Multilayered or gradient scaffolds,often in conjunction with stem cells and growth factors,have been developed to mimic the respective layers for osteochondral defect repair.In this study,we designed a hyaline cartilage-hypertrophic cartilage bilayer graft(RGD/RGDW)with chondrocytes.Previously,we demonstrated that RGD peptide-modified chondroitin sulfate cryogel(RGD group)is chondro-conductive and capable of hyaline cartilage formation.Here,we incorporated whitlockite(WH),a Mg2+-containing calcium phosphate,into RGD cryogel(RGDW group)to induce chondrocyte hypertrophy and form collagen X-rich hypertrophic cartilage.This is the first study to use WH to produce hypertrophic cartilage.Chondrocytes-laden RGDW cryogel exhibited significantly upregulated expression of hypertrophy markers in vitro and formed ectopic hypertrophic cartilage in vivo,which mineralized into calcified cartilage in bone microenvironment.Subsequently,RGD cryogel and RGDW cryogel were combined into bilayer(RGD/RGDW group)and implanted into rabbit osteochondral defect,where RGD layer supports hyaline cartilage regeneration and bioceramic-containing RGDW layer promotes calcified cartilage formation.While the RGD group(monolayer)formed hyaline-like neotissue that extends into the subchondral bone,the RGD/RGDW group(bilayer)regenerated hyaline cartilage tissue confined to its respective layer and promoted osseointegration for integrative defect repair. 展开更多
关键词 BIOCERAMIC Whitlockite Bilayer scaffold Chondrocyte hypertrophy osteochondral defect repair
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A bibliometric analysis and visualization of osteochondral lesions of talus (2004-2021)
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作者 Xiao-Jie Sun Shu-Long Wang +1 位作者 Zi-Dong Wang Zhao-Jun Chen 《Medical Data Mining》 2024年第3期17-25,共9页
Background:Osteochondral lesions of the talus(OLTs)are a significant challenge for foot and ankle specialists,which could cause pain and decrease patient function.Researchers can use the findings of this study to shap... Background:Osteochondral lesions of the talus(OLTs)are a significant challenge for foot and ankle specialists,which could cause pain and decrease patient function.Researchers can use the findings of this study to shape future directions for research by exploring global trends and hotspots in OLT.Methods:Web of Science Core Collection was used to retrieve literature related to OLT between 2004 and 2021.This report covers the current state of OLTs,such as publications,journals,trends,hotspots,and the performances of relevant countries,institutions and authors.The co-citation analysis,the coauthorship analysis,the cooccurrence analysis,and the bibliographic coupling analysis were conducted with the Bibliometrix R package,VOSviewer v1.6.10.0,and CiteSpace 5.8.R3.Results:During an 18-year review,717 articles and 76 review articles on OLT published from 2004 to 2021 were reviewed.The USA has made the largest contribution to the OLT-related literature,and a significant contribution has been made by Kennedy JG(48/6.05%)and van Dijk CN(30/3.78%).In terms of total link strength,Foot&Ankle International was the leading journal.Analysis showed that the global research hotspots of OLTs focused on the pathogenesis,diagnosis,clinical research,and surgical treatment of OLT.It would be significant to pay close attention to future research on osteochondral autograft transplantation and management,surgery,multidisciplinary integration and mechanisms of OLT,and its related diseases.Conclusions:The study provides information about the current status and hotspots of research in the domain of OLT over the past 18 years that will assist researchers in identifying potential perspectives on hot topics and research frontiers. 展开更多
关键词 bibliometric analysis HOTSPOTS osteochondral lesions of the talus TRENDS visualised analysis
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Osteochondritis dissecans剥脱性骨软骨炎
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作者 初建平 《影像诊断与介入放射学》 2014年第2期191-191,共1页
Sub-articular,post-traumatic necrosis Occurs only on convex surfaees of bone Medial condyle of femur Capitellum Proximal surface of talus Head of 1st metatarsal Most patients are athletic Direct blow is more common ca... Sub-articular,post-traumatic necrosis Occurs only on convex surfaees of bone Medial condyle of femur Capitellum Proximal surface of talus Head of 1st metatarsal Most patients are athletic Direct blow is more common cause than a rotational injury 医学词汇注释与简要讲解Medial condyle内侧髁Capitellum肱骨小头胫骨近端关节面 metatarsal 展开更多
关键词 BODY THAN osteochondritis dissecans
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Lumbar Disc Herniation with End-Plate Fracture and Secondary Ossification Mimicking an Epidural Tumor: A Case Report 被引量:2
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作者 Koun Yamauchi Akira Hioki +2 位作者 Kazunari Fushimi Kei Miyamoto Katsuji Shimizu 《Open Journal of Orthopedics》 2013年第2期102-105,共4页
We report a unique case of lumbar disc herniation, in particular, with end-plate and surrounded by extensive ossification, mimicking a tumor with calcification. A 69-year-old female suffered from right buttock and leg... We report a unique case of lumbar disc herniation, in particular, with end-plate and surrounded by extensive ossification, mimicking a tumor with calcification. A 69-year-old female suffered from right buttock and leg pain. Computed tomography (CT) showed an intracanalar mass with calcification or ossification, which most likely originated from the vertebral body at the L1/2 level epidural space. On a T1-weighted gadolinium magnetic resonance image, the capsule of the mass was enhanced and not only the content of the mass but also that of the L2 vertebral body were partially and slightly enhanced. The final pathological diagnosis was disc herniation with end-plate fracture and secondary ossification. A combination of these pathological conditions as accompanied by both end-plate fractures and extensive secondary ossifications has not been previously reported. This rare pathological condition needs to be recognized as a differential diagnosis. 展开更多
关键词 Disc HERNIATION EXTENSIVE Ossifications end-plate FRACTURES
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Osteochondritis dissecans of the capitellum in adolescents
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作者 Christiaan JA van Bergen Kimberly IM van den Ende +1 位作者 Bart ten Brinke Denise Eygendaal 《World Journal of Orthopedics》 2016年第2期102-108,共7页
Osteochondritis dissecans(OCD)is a disorder of articular cartilage and subchondral bone.In the elbow,an OCD is localized most commonly at the humeral capitellum.Teenagers engaged in sports that involve repetitive stre... Osteochondritis dissecans(OCD)is a disorder of articular cartilage and subchondral bone.In the elbow,an OCD is localized most commonly at the humeral capitellum.Teenagers engaged in sports that involve repetitive stress on the elbow are at risk.A high index of suspicion is warranted to prevent delay in the diagnosis.Plain radiographs may disclose the lesion but computed tomography and magnetic resonance imaging are more accurate in the detection of OCD.To determine the best treatment option it is important to differentiate between stable and unstable OCD lesions.Stable lesions can be initially treated nonoperatively with elbow rest or activity modification and physical therapy.Unstable lesions and stable lesions not responding to conservative therapy require a surgical approach.Arthroscopic debridement and microfracturing has become the standard initial procedure for treatment of capitellar OCD.Numerous other surgical options have been reported,including internal fixation of large fragments and osteochondral autograft transfer.The aim of this article is to provide a current concepts review of the etiology,clinical presentation,diagnosis,treatment,and outcomes of elbow OCD. 展开更多
关键词 osteochondritis dissecans CARTILAGE Elbow CAPITELLUM ATHLETES Overhead sports ARTHROSCOPY Bone MARROW stimulation ADOLESCENT Osteoarthritis
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Abnormal Femoral Origin of the Anterior Cruciate Ligament Associated with Osteochondritis Dissecans of the Medial Femoral Condyle
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作者 Massimiliano Salvi Francesco Caputo +2 位作者 Giuseppe Piu Marco Sanna Cristina Sanna 《Surgical Science》 2013年第10期474-476,共3页
We report a case of abnormal meniscal-like anterior cruciate ligament (ACL), inserting at the 9 o’clock position just beside the cartilage of the lateral femoral condyle, in a stable knee associated with osteochondri... We report a case of abnormal meniscal-like anterior cruciate ligament (ACL), inserting at the 9 o’clock position just beside the cartilage of the lateral femoral condyle, in a stable knee associated with osteochondritis dissecans (OCD) of the medial femoral condyle. 展开更多
关键词 CONGENITAL Anomaly ABNORMAL ANTERIOR CRUCIATE LIGAMENT FEMORAL Attachment osteochondritis Dissecans
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Treatment of knee osteochondritis dissecans with autologous tendon transplantation:Clinical and radiological results
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作者 Ahmet Ugur Turhan Sezgin Acil +3 位作者 Orkun Gul Kerim Oner Ahmet Emin Okutan Muhammet Salih Ayas 《World Journal of Orthopedics》 2021年第11期867-876,共10页
BACKGROUND Defect treatment with tendon autograft in osteochondral lesions has been published in the literature with an experimental study in dogs.To demonstrate that it is possible to treat knee osteochondral lesions... BACKGROUND Defect treatment with tendon autograft in osteochondral lesions has been published in the literature with an experimental study in dogs.To demonstrate that it is possible to treat knee osteochondral lesions with the technique of autologous tendon transplantation.AIM To evaluate the clinical and radiological results of patients with knee osteochondral lesions who were treated with autologous tendon transplantation.METHODS Twenty patients(22 knees)with osteochondritis dissecans(OCD)lesions involving the knee were treated with autologous tendon transplantation between 2005-2018.All lesions were International Cartilage Repair Society grade IV.All patients were evaluated clinically at final follow-up with knee injury and osteoarthritis outcome score(KOOS);and radiologically with magnetic resonance observation and cartilage repair tissue(MOCART)and Kellgren-Lawrence(KL)classification.RESULTS A total of 20 patients(22 knees)with a mean age of 25.5±6.8 years were included.The average defect size was 4.2±2.1 cm^(2),and the average defect depth was 0.9±0.4 cm.Total KOOS score was preoperatively 29.4±5.5 and was later found to be 81.5±5.9 after an average of 68.7±37.7 mo follow-up.The mean MOCART score was 56.2±10.7.Preoperatively,all of the patients had KL grades of 0-1;during the follow-up period,80% of the patients showed no radiological progress of osteoarthritis.Patients with less than 4 cm^(2) lesion had statistically significantly better overall KOOS than patients whose more than 4 cm^(2) lesion,particularly in sport and quality of life subscales.CONCLUSION The autologous tendon transplantation is a single-step,safe,simple,cost-effective method for the treatment of knee OCD with satisfactory clinical and radiological outcomes,particularly in patients with less than 4 cm^(2) lesion. 展开更多
关键词 osteochondritis dissecans KNEE TENDON TRANSPLANTATION AUTOLOGOUS Peroneus
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Finite element analysis on temperature field and residual stress of welding assembly for I-beam and end-plate
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作者 贾栗 赵永生 +1 位作者 邹增大 邹勇料 《China Welding》 EI CAS 2013年第1期16-20,共5页
Based on full scale model of 1-beam and end-plate welding assembly with medium plate, welding temperature field and residual stress were simulated, infrared thermometers were employed to measure the real-time temperat... Based on full scale model of 1-beam and end-plate welding assembly with medium plate, welding temperature field and residual stress were simulated, infrared thermometers were employed to measure the real-time temperature Jbr verification purposes. Results show that the measured thermal cycle curves match well with the simulation result. Simulation results of welding residual stress indicate that the values of longitudinal and transverse stress on the upper surface of the plate are higher than the normal stress; higher tensile stresses exist at the end of the web weld toes and in the central area of the flange weld toes. The dangerous zones are located at the central areas of weld toes of the flange welds and near weld toes of the web welds. 展开更多
关键词 I-beam and end-plate welding assembly temperature field residual stress finite element analysis
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Subchondral bone as a novel target for regenerative therapy of osteochondritis dissecans:A case report
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作者 Sheng-Yang Zhang Hui-Hui Xu +4 位作者 Miao-Miao Xiao Jing-Jing Zhang Qiang Mao Bang-Jian He Pei-Jian Tong 《World Journal of Clinical Cases》 SCIE 2021年第15期3623-3630,共8页
BACKGROUND Osteochondritis dissecans(OCD)is a rare disease of unclear cause characterized by subchondral bone damage and overlying cartilage defects.The current report presents the results of subchondral bone as a nov... BACKGROUND Osteochondritis dissecans(OCD)is a rare disease of unclear cause characterized by subchondral bone damage and overlying cartilage defects.The current report presents the results of subchondral bone as a novel target for implantation of peripheral blood stem cells(PBSCs)in the treatment of OCD.CASE SUMMARY A 16-year-old patient diagnosed with OCD underwent subchondral bone implantation of PBSCs.Four months later,the patient's visual analog scale scores,Western Ontario and McMaster University osteoarthritis index,and whole-organ magnetic resonance imaging score improved significantly,and regeneration of cartilage and subchondral bone was observed on magnetic resonance imaging.CONCLUSION This is the first case of OCD treated with subchondral bone as an implantation target of PBSCs,which highlights the importance of subchondral bone for cartilage repair.This treatment could be a potential option for articular cartilage and subchondral bone recovery in OCD. 展开更多
关键词 osteochondritis dissecans Peripheral blood stem cells Subchondral bone CARTILAGE Case report
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Evaluation of Stiffened End-Plate Moment Connection through Optimized Artificial Neural Network
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作者 Mehdi Ghassemieh Mohsen Nasseri 《Journal of Software Engineering and Applications》 2012年第3期156-167,共12页
This study involves the development of an analytical model for understanding the behavior of the extended, stiffened end-plate moment connections with eight high strength bolts. Modeling of the connection as an assemb... This study involves the development of an analytical model for understanding the behavior of the extended, stiffened end-plate moment connections with eight high strength bolts. Modeling of the connection as an assemblage of finite elements (FE) used for load deformation analysis, with material, and contact nonlinearities are developed. Results from the FE mathematical model are verified with results from the ANSYS computer program as well as with the test results. Sensitivity and feasibility studies are carried out. Significant geometry and force related variables are introduced;and by varying the geometric variables of the connections within a practical range, a matrix of test cases is obtained. Maximum end-plate separation, maximum bending stresses in the end-plate, and the forces from the connection bolts for these test cases are obtained. From the FE analysis, a database is produced to collect results for the artificial neural network analysis. Finally, salient features of the optimized Artificial Neural Network (ANN) via Genetic Algorithm (GA) analysis are introduced and implemented with the aim of predicting the overall behavior of the connection. 展开更多
关键词 end-plate MOMENT CONNECTION Finite Element Method Artificial Neural Network SENSITIVITIES Analysis GENETIC Algorithm
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羟基磷灰石-聚乙烯醇/胶原-壳聚糖-明胶复合水凝胶修复兔骨软骨缺损 被引量:1
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作者 王武 樊晓磊 +2 位作者 谢杰 胡懿郃 曾敏 《中国组织工程研究》 CAS 北大核心 2024年第5期682-689,共8页
背景:关节骨软骨缺损是目前骨科医生面临的难题,传统修复方法难以取得满意疗效,以羟基磷灰石-聚乙烯醇为基础的复合水凝胶材料是目前研究的一个方向。目的:制备羟基磷灰石-聚乙烯醇/胶原-壳聚糖-明胶复合水凝胶,表征其物理学特征,验证... 背景:关节骨软骨缺损是目前骨科医生面临的难题,传统修复方法难以取得满意疗效,以羟基磷灰石-聚乙烯醇为基础的复合水凝胶材料是目前研究的一个方向。目的:制备羟基磷灰石-聚乙烯醇/胶原-壳聚糖-明胶复合水凝胶,表征其物理学特征,验证其植入体内后的组织相容性及细胞黏附增殖能力,探讨其对兔骨软骨缺损的修复效果。方法:利用3D打印技术制备圆柱状多孔聚乳酸支架(孔径分别为1.2,1.4,1.6,1.8 mm),再将聚乙烯醇及羟基磷灰石混合乳液灌入聚乳酸支架中,经过冻融及二氯甲烷溶解后制成羟基磷灰石-聚乙烯醇水凝胶。然后将胶原-壳聚糖-明胶混合液灌入羟基磷灰石-聚乙烯醇水凝胶中,利用京尼平进行交联,最后经乙醇清洗及冷冻干燥制成羟基磷灰石-聚乙烯醇/胶原-壳聚糖-明胶复合水凝胶,表征4组水凝胶的物理学特征,筛选性能最优的水凝胶进行后续实验。将羟基磷灰石-聚乙烯醇水凝胶、胶原-壳聚糖-明胶复合水凝胶分别植入SD大鼠皮下,苏木精-伊红与Masson染色观察材料表面的细胞黏附生长状况。在15只兔双侧膝关节股骨滑车制作骨软骨缺损(直径5 mm、深6 mm)模型,左侧植入复合水凝胶(实验组),右侧未植入任何材料(对照组),Micro-CT及组织学检测来评估其对骨软骨缺损的修复效果。结果与结论:①综合孔隙率、含水率、力学测试及扫描电镜结果,得出孔径1.2 mm的羟基磷灰石-聚乙烯醇/胶原-壳聚糖-明胶复合水凝胶更符合天然软骨的一般特性,用于后续实验;②苏木精-伊红与Masson三色染色显示,随着材料植入大鼠皮下时间的延长,两种材料周边黏附的细胞均明显增多,其中胶原-壳聚糖-明胶植入后的细胞增殖状况更好,可见大量细胞长入其形成的网状结构,且网状结构也逐渐降解;③在兔骨软骨缺损实验中,至术后8周时,Micro-CT检查显示实验组植入的材料和周围骨-软骨整合良好,其表面及内部均有部分骨长入,对照组软骨及软骨下层仍然存在明显的缺损,未形成有效修复;苏木精-伊红与甲苯胺蓝染色显示,实验组植入复合水凝胶4-8周后即与周围骨软骨发生整合,随着时间的延长材料表面逐渐有新生软骨形成,至12周时缺损处大部分被新生软骨覆盖,软骨下层也出现良好的骨长入;对照组至术后12周虽然深层骨缺损大部分修复、浅层的软骨及软骨下骨缺损也有一定程度修复,但主要被纤维组织及部分纤维软骨替代;④结果表明,羟基磷灰石-聚乙烯醇/胶原-壳聚糖-明胶复合水凝胶材料可仿生天然软骨的结构和功能,在动物实验中能有效修复骨软骨缺损。 展开更多
关键词 羟基磷灰石 聚乙烯醇 胶原 壳聚糖 水凝胶 骨软骨缺损
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关节镜下自体骨软骨移植对膝关节局限性软骨损伤的临床疗效评价 被引量:2
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作者 李杰峰 金艳南 +3 位作者 王庆东 康乐 徐向峰 李付彬 《组织工程与重建外科》 CAS 2024年第1期83-86,92,共5页
目的探讨关节镜下自体骨软骨移植术对膝关节局限性软骨损伤的临床疗效,并以磁共振成像(MRI)检查对疗效进行评价。方法选取2018年6月至2021年6月诊治的100例膝关节局限性软骨损伤患者,按随机数字表法分为研究组和对照组,每组各50例。研... 目的探讨关节镜下自体骨软骨移植术对膝关节局限性软骨损伤的临床疗效,并以磁共振成像(MRI)检查对疗效进行评价。方法选取2018年6月至2021年6月诊治的100例膝关节局限性软骨损伤患者,按随机数字表法分为研究组和对照组,每组各50例。研究组采取关节镜下自体骨软骨移植术,对照组采取微骨折术治疗。采用MRI评估其手术疗效,并记录其术后膝关节软骨愈合时间;采用Lysholm膝关节功能评分表、国际膝关节文献委员会(IKDC)膝关节评估表,评估患者治疗前后膝关节功能变化;统计患者术后并发症发生率。结果研究组关节软骨愈合优良率98.00%,高于对照组84.00%(P<0.05)。两组术前和术后3个月的Lysholm评分、IKDC评分比较差异无统计学意义(P>0.05);术后6、12、24个月,研究组Lysholm评分、IKDC评分均高于对照组(P<0.05)。两组患者术后均无严重并发症,且并发症发生率差异无统计学意义(P>0.05)。研究组术后膝关节软骨愈合时间短于对照组(P<0.05)。结论关节镜下自体骨软骨移植术对膝关节局限性软骨损伤的远期治疗效果显著,可有效改善患者术后膝关节功能,缩短膝关节软骨愈合时间,安全性高。 展开更多
关键词 关节镜 自体骨软骨移植术 膝关节局限性软骨损伤 磁共振成像 膝关节功能
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体外冲击波疗法联合自体骨软骨移植治疗Hepple-V期距骨骨软骨损伤的疗效
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作者 刘核达 刘林 +4 位作者 黄飞 李鹏伟 李明 刘胜 李森田 《检验医学与临床》 CAS 2024年第21期3229-3233,共5页
目的观察体外冲击波疗法(ESWT)联合自体骨软骨移植(OAT)治疗Hepple-V期距骨骨软骨损伤(OLT)的疗效。方法选择2021年1月至2023年1月该院收治的60例OLT患者,按随机数字表法分为对照组和研究组,每组30例。对照组实施OAT治疗,研究组实施ESW... 目的观察体外冲击波疗法(ESWT)联合自体骨软骨移植(OAT)治疗Hepple-V期距骨骨软骨损伤(OLT)的疗效。方法选择2021年1月至2023年1月该院收治的60例OLT患者,按随机数字表法分为对照组和研究组,每组30例。对照组实施OAT治疗,研究组实施ESWT联合OAT治疗。比较两组软骨下骨骨髓水肿(BME)体积、视觉模拟量表(VAS)评分、白细胞介素-8(IL-8)水平、降钙素原(PCT)水平、血小板衍生生长因子(PDGF)水平、转化生长因子-β1(TGF-β1)水平、踝关节活动度(ROM)、不良反应及足、踝关节功能。结果治疗后3个月,两组的软骨下骨BME体积、VAS评分及IL-8、PCT、TGF-β1水平均小于治疗前(P<0.05),且研究组小于对照组(P<0.05)。治疗后3个月,两组的PDGF水平、跖屈ROM、背伸ROM、足踝结局评分、美国足踝关节外科协会评分均大于治疗前(P<0.05),且研究组大于对照组(P<0.05)。研究组的不良反应总发生率低于对照组(P<0.05)。结论ESWT联合OAT可改善Hepple-V期OLT患者的足、踝关节功能及踝关节ROM,缓解BME,减轻疼痛,降低不良反应发生率,且能调节IL-8、PCT、PDGF、TGF-β1水平。 展开更多
关键词 体外冲击波疗法 自体骨软骨移植 Hepple-V期 距骨骨软骨损伤 疗效
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对齐软骨下骨的自体骨软骨移植治疗运动员距骨骨软骨损伤的疗效分析
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作者 申成春 黄雷 +3 位作者 张峰 俞嘉锫 朱彦昭 贺萍萍 《足踝外科电子杂志》 2024年第3期6-9,17,共5页
目的探讨运动员距骨骨软骨损伤的临床特点及对齐软骨下骨自体骨软骨移植治疗的临床效果。方法回顾性分析2019年6月至2022年6月在宁波市第六医院入院被诊断为距骨骨软骨损伤并接受对齐软骨下骨的自体骨软骨移植手术治疗的23例患者的临床... 目的探讨运动员距骨骨软骨损伤的临床特点及对齐软骨下骨自体骨软骨移植治疗的临床效果。方法回顾性分析2019年6月至2022年6月在宁波市第六医院入院被诊断为距骨骨软骨损伤并接受对齐软骨下骨的自体骨软骨移植手术治疗的23例患者的临床资料,比较本组病例手术前后的视觉模拟评分法(visual analogue scale,VAS)评分、美国足踝外科协会(American Orthopaedic Foot and Ankle Society,AOFAS)后足评分和健康调查简表(the MOS item short from health survey,SF-36)评分,并对距骨骨软骨损伤的临床特点进行分析。结果本组研究人群均成功行对齐软骨下骨的自体骨软骨移植术,平均随访时间为(39.2±8.4)个月,软骨损伤面积为(1.29±0.24)cm²。根据距骨软骨的分区,1区为3例,3区为1例,4区为17例,6区为2例。与术前比较,术后的VAS评分、AOFAS评分、SF-36评分和踝关节活动度均显著改善(P<0.01)。结论对齐软骨下骨的自体骨软骨移植手术可以帮助距骨骨软骨损伤运动员恢复到伤前竞技水平。二次关节镜检查提示对齐软骨下骨的自体软骨移植后软骨形态及弹性与自体距骨软骨一致。 展开更多
关键词 距骨骨软骨损伤 自体骨软骨移植 美国足踝外科协会评分
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壮筋养血汤对距骨骨软骨损伤的疗效研究
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作者 汤样华 史立萍 +2 位作者 母卓松 莫亚峰 熊振飞 《中国现代医生》 2024年第22期92-95,共4页
目的探讨壮筋养血汤对Hepple分型Ⅰ、Ⅱ型距骨骨软骨损伤(osteochondral lesion of the talus,OLT)的临床疗效。方法选取2021年2月至2022年12月在杭州市萧山区中医院就诊的62例OLT患者为研究对象,根据随机数字表法将患者分为观察组和对... 目的探讨壮筋养血汤对Hepple分型Ⅰ、Ⅱ型距骨骨软骨损伤(osteochondral lesion of the talus,OLT)的临床疗效。方法选取2021年2月至2022年12月在杭州市萧山区中医院就诊的62例OLT患者为研究对象,根据随机数字表法将患者分为观察组和对照组,每组各31例。对照组采用常规西药治疗,观察组在对照组基础上联合壮筋养血汤治疗。比较两组患者治疗前后的血清基质金属蛋白酶13(matrix metalloproteinase 13,MMP-13)、肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)、踝关节视觉模拟评分法(visual analogue scale,VAS)评分、美国足踝外科学会(American Orthopedic Foot and Ankle Society,AOFAS)踝-后足功能评分、中医证候积分及软骨修复组织磁共振观察(magnetic resonance observation of cartilage repair tissue,MOCART)评分。结果治疗后5周、3个月,两组患者的MMP-13、TNF-α、VAS评分、中医证候积分均显著低于本组治疗前,AOFAS踝-后足功能评分、MOCART评分均显著高于本组治疗前(P<0.05);观察组患者的MMP-13、TNF-α、中医证候积分均显著低于对照组,MOCART评分显著高于对照组(P<0.05)。治疗后5周,观察组患者的VAS评分显著低于对照组,AOFAS踝-后足功能评分显著高于对照组(P<0.05)。结论壮筋养血汤治疗Hepple分型Ⅰ、Ⅱ型OLT的近期疗效良好,其具有抗炎镇痛、改善关节功能和促进软骨修复的作用。 展开更多
关键词 距骨骨软骨损伤 壮筋养血汤 气滞血瘀证 关节功能 软骨修复
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“重灸消敏”枕下三角区治疗过敏性鼻炎经验
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作者 张婷 鲁熹 +5 位作者 高素金 陈薏凤 孙奕陶 孔生辉 杨运宽 罗玲 《成都中医药大学学报》 2024年第5期9-12,共4页
过敏性鼻炎是常见的过敏性疾病之一,可严重影响患者的工作及生活。现代临床已证实艾灸可以通过激活一系列信号通路和神经内分泌免疫活动来产生治疗效果。门诊观察艾灸治疗过敏性鼻炎1例,根据其特点属于中医学中肺气虚寒型鼻鼽,通过重灸... 过敏性鼻炎是常见的过敏性疾病之一,可严重影响患者的工作及生活。现代临床已证实艾灸可以通过激活一系列信号通路和神经内分泌免疫活动来产生治疗效果。门诊观察艾灸治疗过敏性鼻炎1例,根据其特点属于中医学中肺气虚寒型鼻鼽,通过重灸枕下三角区治疗后,患者鼻炎迅速缓解。本文试从过敏性鼻炎的中医认识、枕下三角区与过敏性鼻炎的关系、枕下三角区易受邪的原理以及艾灸消“敏”的治疗机理等各方面,分析本病案中重灸取效的影响因素,为临床治疗提供新的诊疗思路。 展开更多
关键词 枕下三角区 过敏性鼻炎 重灸 消“敏” 骨缝理论
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A-PRF促进兔膝关节骨软骨损伤愈合的观察
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作者 朱泽宇 吕成奇 +3 位作者 刘旭凌 陈昱璐 邹德荣 陆家瑜 《上海交通大学学报(医学版)》 CAS CSCD 北大核心 2024年第1期13-22,共10页
目的·探讨改良型富血小板纤维蛋白(advanced platelet-rich fibrin,A-PRF)在骨软骨再生中的作用。方法·获取新西兰兔骨髓间充质干细胞(bone-marrow mesenchymal stem cells,BMSCs)和膝关节软骨细胞;通过低速离心兔心脏血液获... 目的·探讨改良型富血小板纤维蛋白(advanced platelet-rich fibrin,A-PRF)在骨软骨再生中的作用。方法·获取新西兰兔骨髓间充质干细胞(bone-marrow mesenchymal stem cells,BMSCs)和膝关节软骨细胞;通过低速离心兔心脏血液获得A-PRF。采用光学显微镜观察A-PRF的组织学结构;ELISA法检测A-PRF中生长因子,包括血小板衍生生长因子、转化生长因子-β、胰岛素样生长因子、血管内皮生长因子、表皮生长因子和成纤维细胞生长因子的释放;采用活/死细胞双染法及MTT法检测A-PRF对兔BMSCs细胞毒性及增殖情况的影响;采用实时荧光定量聚合酶链反应(qRT-PCR)检测A-PRF对兔BMSCsⅡ型胶原蛋白、聚集蛋白聚糖、碱性磷酸酶(ALP)和骨钙素(OCN)基因表达的影响;使用transwell小室测定A-PRF对于兔BMSCs以及软骨细胞迁移能力的影响。建立兔膝关节骨软骨缺损模型,将18只兔随机分为3组:A-PRF组(n=6)在缺损处植入A-PRF;A-PRF+BMSCs组(n=6)植入接种兔BMSCs的A-PRF;对照组(n=6)不进行植入操作。术后12周处死兔,采用苏木精-伊红(H-E)、甲苯胺蓝和番红O-固绿染色进行膝关节标本的组织学观察,并根据膝关节的表面形态学与组织学情况,采用国际软骨修复协会(International Cartilage Repair Society,ICRS)评分系统进行宏观与组织学评分。结果·A-PRF具有松散的网络结构,可以缓慢释放生长因子。加入A-PRF后,未观察到其对兔BMSCs具有细胞毒性;在加入A-PRF后24、48和72 h,BMSCs的增殖能力均明显升高(均P<0.05),成软骨相关基因Ⅱ型胶原蛋白、聚集蛋白聚糖,以及成骨相关基因ALP和OCN均显著上调(均P<0.05)。加入A-PRF后,兔BMSCs与软骨细胞的迁移能力均显著增强(均P<0.05),且兔BMSCs的迁移能力显著高于软骨细胞(P=0.025)。在兔膝关节缺损模型中,观察关节表面形态,可见A-PRF组和A-PRF+BMSCs组缺损均基本恢复,而对照组仅有软组织覆盖。在ICRS宏观评分方面,A-PRF组与A-PRF+BMSCs组的差异无统计学意义,但2组评分均显著高于对照组(均P<0.05)。组织学观察显示,A-PRF组和A-PRF+BMSCs组均产生骨软骨修复,但A-PRF组软骨更加成熟,对照组则形成纤维修复。在ICRS组织学评分方面,A-PRF组与A-PRF+BMSCs组的差异无统计学意义,但2组评分均显著高于对照组(均P<0.05)。结论·自体A-PRF具有良好的生物相容性和促进BMSCs增殖的能力,在体外和体内均可促进软骨和软骨下骨的修复。 展开更多
关键词 骨软骨损伤 改良型富血小板纤维蛋白 生长因子 硬组织再生
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应用MRI观察金黄膏配合针灸治疗耻骨联合骨软骨炎的疗效研究
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作者 李文峰 邓秋云 +1 位作者 熊伟 丁志超 《罕少疾病杂志》 2024年第10期122-124,共3页
目的探讨应用磁共振成像(MRI)观察金黄膏配合针灸治疗耻骨联合骨软骨炎的疗效。方法选取2019年7月至2023年1月期间南昌市洪都中医院收治的40例耻骨联合骨软骨炎患者为研究对象进行回顾性分析,入院时均予行盆骨MRI检查,均给予金黄膏配合... 目的探讨应用磁共振成像(MRI)观察金黄膏配合针灸治疗耻骨联合骨软骨炎的疗效。方法选取2019年7月至2023年1月期间南昌市洪都中医院收治的40例耻骨联合骨软骨炎患者为研究对象进行回顾性分析,入院时均予行盆骨MRI检查,均给予金黄膏配合针灸进行治疗,治疗结束后均行MRI检查。比较不同疗效耻骨联合骨软骨炎患者的MRI影像表达,分析MRI对金黄膏配合针灸治疗耻骨联合骨软骨炎患者疗效的评估价值。结果耻骨联合骨软骨炎应用金黄膏配合针灸治疗后,疗效明显;不同疗效患者的MRI影像表达存在明显差异。MRI影像表达对金黄膏配合针灸治疗耻骨联合骨软骨炎疗效的敏感度为91.241%,特异性为87.29%,AUC为0.917,95%CI为0.702~0.928。结论MRI影像表达对金黄膏配合针灸治疗耻骨联合骨软骨炎的疗效有较高的评估价值,临床可根据患者实际情况采用MRI评估该类患者的疗效。 展开更多
关键词 耻骨联合骨软骨炎 MRI 金黄膏 针灸
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