Enhanced motor cortex excitability after spinal cord injury

Transcranial magnetic stimulation（TMS）represents a useful non-invasive approach to studying cortical physiology,in addition to the descending motor pathways（Hallett,2000）,and may also be used to investigate the intracortical facilitatory and inhibitory mechanisms.

Enhanced population of excited single state strategy:Irradiation and ultrasound dual-response and host tumor-driven nanosensitizers construction in triple synergistic therapy

Phototheranostics is an emerging field in synergistic antitumor therapy in which irradiation and sensitizers are combined to produce reactive oxygen species(ROS),bio-images,and high temperatures.All of these are arrived from the energy of sensitizers,which located in excited single state(S_(1)).Undeniably,the decentralization of the S_(1)population indirectly decreases the effect of each individual treatment.In this study,a strategy was proposed for enhancing the S_(1)population,and a sensitizer with mitochondrial targeting property,1,4-indolyl iodinated pyrrolo[3,2-b]pyrrole derivative(2I-TPIS),was assembled into adenosine triphosphate(ATP)-responsive nanoparticles(DPA-2I NPs)to achieve dual responses to irradiation and ultrasonication(US)for application to photo-sonodynamic therapy(PSDT).Compared with monotherapies,2I-TPIS generated more ROS in PSDT,inducing mitochondrial autophagy and apoptosis,which in turn triggered immunogenic cell death(ICD).Subsequently,DPA-2I NPs were constructed and self-assembled with the chemotherapeutic agents DPA-Cd and 2I-TPIS to achieve a triple synergistic strategy involving chemotherapy(CT)and PSDT.DPA-2I NPs exhibited absolute sensitization,intra-tumoral overexpression of ATP,and disassembly.Importantly,the biosafety and potent antitumor efficiency of the DPA-2I NP-based“PSDT+CT”therapy were revealed using a 4T1 tumor model.The study results provide insights into the design of sensitizers possessing a sufficient S_(1)population and a highly efficient tumor ablation capacity derived from molecular structural modulation,further enabling triple synergistic antitumor therapies,and expanding the clinical application of sensitizers.

Enhanced 1.32 μm fluorescence and broadband amplifying for O-band optical amplifier in Nd^(3＋)-doped tellurite glass

WO_3 oxides with relatively high phonon energy and different concentrations were introduced into the Nd^(3+)-doped tellurite-based glasses of Te O_2-Zn O-Na_2 O to improve the 1.32 μm band fluorescence emission. The absorption spectra,Raman spectra,1.32 μm band fluorescence spectra and differential scanning calorimeter(DSC) curves were measured,together with the Judd-Ofelt intensity parameters,stimulated emission and gain parameters were calculated to evaluate the effects of WO_3 amount on the glass structure and spectroscopic properties of 1.32 μm band fluorescence. It is shown that the introduction of an appropriate amount of WO_3 oxide can effectively improve the 1.32 μm band fluorescence intensity through the enhanced multi-phonon relaxation(MPR) processes between the excited levels of Nd^(3+). The results indicate that the prepared Nd^(3+)-doped tellurite glass with an appropriate amount of WO_3 oxide is a potential gain medium applied for the O-band broad and high-gain fiber amplifier.