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Innovation for forming aluminum alloy thin shells at ultra-low temperature by the dual enhancement effect 被引量:7
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作者 Fan Xiaobo Yuan Shijian 《International Journal of Extreme Manufacturing》 SCIE EI CAS 2022年第3期99-103,共5页
Integral thin shells made of high strength aluminum alloys are urgently needed in new generation transportation equipment. There are challenges to overcoming the co-existing problems of wrinkling and splitting by the ... Integral thin shells made of high strength aluminum alloys are urgently needed in new generation transportation equipment. There are challenges to overcoming the co-existing problems of wrinkling and splitting by the cold forming and hot forming processes. An innovative technology of ultra-low temperature forming has been invented for aluminum alloy thin shells by the new phenomenon of ‘dual enhancement effect’. That means plasticity and hardening are enhanced simultaneously at ultra-low temperatures. In this perspective, the dual enhancement effect is described, and the development, current state and prospects of this new forming method are introduced. This innovative method can provide a new approach for integral aluminum alloy components with large size, ultra-thin thickness, and high strength. An integral tank dome of rocket with 2 m in diameter was formed by using a blank sheet with the same thickness as the final component, breaking through the limit value of thickness-diameter ratio. 展开更多
关键词 aluminum alloy thin shell ultra-low temperature forming dual enhancement effect
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Optical Absorption Enhancement Effects of Silver Nanodisk Arrays in the Application of Silicon Solar Cell 被引量:1
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作者 Xiao-Ping Huang Zao-Jin Zeng Lei Zhong Dan Wu Fang-Chun Yan 《Journal of Electronic Science and Technology》 CAS 2011年第1期35-40,共6页
Surface plasmon resonance of noble metal nanoparticles leads to the optical absorption enhancement effects,which have great potential applications in solar cell.By using the general numerical method of discrete dipole... Surface plasmon resonance of noble metal nanoparticles leads to the optical absorption enhancement effects,which have great potential applications in solar cell.By using the general numerical method of discrete dipole approximation (DDA),we study the absorption and scattering properties of two-dimensional square silver nanodisks (2D SSN) arrays on the single crystal silicon solar cell.Based on the effective reflective index model of the single crystal silicon solar cell,we investigate the optical enhancement absorption of light energy by varying the light incident direction,particle size,aspect ratio,and interparticle spacing of the silver nanodisks.The peak values and position of the optical extinction spectra of the 2D square arrays of noble metal nanodisks are obtained with the different array structures. 展开更多
关键词 effective reflective index model optical absorption enhancement effects silicon solar cell two-dimensional square silver nanodisks arrays.
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An Evaluation of Artificial Fish Nest for Assessment Enhancement Effects of Fishery Resources of in Xiangjiang River 被引量:1
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作者 Ying Xia Qiang Hu Xiping Yuan 《Journal of Geoscience and Environment Protection》 2020年第6期15-19,共5页
Artificial fish nests are set in Lukou section and Hengyang section of Xiangjiang River from March 20 to May 10, 2019. The structure of artificial fish nest is bamboo frame, with the size of 2.5 m × 5.0 m × ... Artificial fish nests are set in Lukou section and Hengyang section of Xiangjiang River from March 20 to May 10, 2019. The structure of artificial fish nest is bamboo frame, with the size of 2.5 m × 5.0 m × 4 and a unit frame area of 60 m<sup>2</sup>. A total of 58,201 eggs were collected by 24 monitoring times, of which 30,441 were from Lukou and 27,760 from Hengyang. 3831 fish eggs identify 8 fish species using morphological or molecular biological methods. The results showed that the number of eggs peaked from the 8<sup>th</sup> day to the 24<sup>th</sup> day after the nest entered the water, and then decreased rapidly. There was significant negative correlation between egg number in per m<sup>2</sup> fish nest and days of fish nest (P < 0.01). The economic benefits of artificial fish nests were RMB 11.81 million. The artificial fish nest can not only increase the population of fish, but also has significant economic benefits. 展开更多
关键词 Artificial Fish Nest enhancement effects of Fishery Resources Xiangjiang River
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Conductive Polymer Composites Fabricated by Disposable Face Masks and Multi-Walled Carbon Nanotubes: Crystalline Structure and Enhancement Effect
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作者 Meng Xiang Zhou Yang +5 位作者 Jingjing Yang Tong Lu Danqi Wu Zhijun Liu Rongjie Xue Shuang Dong 《Journal of Renewable Materials》 SCIE EI 2022年第3期821-831,共11页
Influenced by recent COVID-19,wearing face masks to block the spread of the epidemic has become the simplest and most effective way.However,after the people wear masks,thousands of tons of medical waste by used dis-po... Influenced by recent COVID-19,wearing face masks to block the spread of the epidemic has become the simplest and most effective way.However,after the people wear masks,thousands of tons of medical waste by used dis-posable masks will be generated every day in the world,causing great pressure on the environment.Herein,con-ductive polymer composites are fabricated by simple melt blending of mask fragments(mask polypropylene,short for mPP)and multi-walled carbon nanotubes(MWNTs).MWNTs were used as modifiers for composites because of their high strength and high conductivity.The crystalline structure,mechanical,electrical and thermal enhancement effect of the composites were investigated.MWNTs with high thermal stability acted the role of promoting the crystallisation of mPP by expediting the crystalline nucleation,leading to the improvement of amount for crystalline nucleus.MWNTs fibers interpenetrate with each other in mPP matrix to form conducting network.With 2.0 wt% MWNTs loading,the tensile strength and electrical conductivity of the composites were increased by 809% and 7 orders of magnitude.MWNTs fibers interpenetrate with each other in mPP matrix to form conducting network.Thus,more conducting paths were constructed to transport carriers.The findings may open a way for high value utilization of the disposable masks. 展开更多
关键词 Disposable face masks multi-walled carbon nanotubes crystalline structure mechanical enhancement effect conducting network
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Structure and Luminescent Enhancement Effect of Na_5Eu(MoO_4)_4 by Doping(WO_4)^(2-)
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作者 郭常新 李碧琳 陈永清 《Journal of Rare Earths》 SCIE EI CAS CSCD 1993年第3期183-185,共3页
The luminescent enhancement effect of Na_5Eu(MoO_4)_4 by doping(WO_4)^(2-) has been studied. When the value x in Na_5Eu(Mo_(1-x)W_xO_4)_4 is in 0<x<0.21,its photoluminescent spectrum is near to that of Na_5Eu(Mo... The luminescent enhancement effect of Na_5Eu(MoO_4)_4 by doping(WO_4)^(2-) has been studied. When the value x in Na_5Eu(Mo_(1-x)W_xO_4)_4 is in 0<x<0.21,its photoluminescent spectrum is near to that of Na_5Eu(MoO_4)_4,but its luminescent intensity increases.When x=0.033,the intensity is increased by about 30%.According to the X-ray diffraction analysis,W ions get into the lattice and occupy the sites of the Mo ions.The change of crystal environment of Eu^(3+) may result in the luminescent enhancement. 展开更多
关键词 Eu^(3+)luminescence Na_5Eu(MoO_4)_4 Luminescent enhancement effect
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Study on Enhancement Effect of Cavitation Caused by HIFU Piezoelectricity Transducer
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作者 Xinnan Fan Changping Zhu +2 位作者 Shichuan He Minglei Shan Jiacai Chen 《稀有金属材料与工程》 SCIE EI CAS CSCD 北大核心 2006年第A03期527-529,共3页
An orthogonal ultrasonic irradiation system consisting of HIFU with frequency at 1.05 MHz combined with ultrasound with frequency at 28 kHz was applied in this paper.Effect of cavitation was detected by pH-value measu... An orthogonal ultrasonic irradiation system consisting of HIFU with frequency at 1.05 MHz combined with ultrasound with frequency at 28 kHz was applied in this paper.Effect of cavitation was detected by pH-value measurement and conductance measurement.The result shows that the effect of cavitation caused by ultrasound with frequency at 28 kHz is greatly enhanced by HIFU piezoelectricity transducer with frequency at 1.05 MHz. 展开更多
关键词 HIFU piezoelectricity transducer enhanced cavitation effect orthogonal ultrasonic irradiation
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Tunnel elasticity enhancement effect of 3D submicron ceramics(A_(l)2O_(3),TiO_(2),ZrO_(2)) fiber on polydimethylsiloxane (PDMS) 被引量:1
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作者 Yuxiu HAO Junwei XIE +3 位作者 Bingqing XU Bingkun HU Yunpeng ZHENG Yang SHEN 《Journal of Advanced Ceramics》 SCIE CAS CSCD 2021年第3期502-508,共7页
Some polymers are flexible,foldable,and wearable.Structural-functional composite is fabricated by adding inorganic fillers with functional properties.Up to date,compared with the polymer matrix,the composite prepared ... Some polymers are flexible,foldable,and wearable.Structural-functional composite is fabricated by adding inorganic fillers with functional properties.Up to date,compared with the polymer matrix,the composite prepared by polymer-inorganic fillers has lower flexibility,higher brittleness,and higher modulus of elasticity.In this paper,three-dimensional (3D) net-shaped submicron α-Al_(2)O_(3),orthorhombic ZrO_(2),and rutile TiO_(2) fiber were fabricated by solution blowing spinning on a large scale.On the contrary,the elastic modulus (E) of the composite prepared by this 3D ceramic fiber was greatly reduced,and the flexibility of the composite was higher than that of the polymer matrix.When the strain was 75%,the E of the 3D net-shaped Al_(2)O_(3) fiber-polydimethylsiloxane(PDMS) composite was 20% lower than that of PDMS.When the strain was 78%,the E of the 3D net-shaped TiO_(2) fiber-PDMS and 3D net-shaped ZrO_(2) fiber-PDMS composites decreased by 20% and 25%,respectively.This abnormal effect,namely the tunnel elastic enhancement effect,has great practical significance.In all-solid-state lithium-ion batteries,the composite inhibits lithium dendrite growth and the 3D inorganic network contributes to lithium ion transport.It is possible to promote the industrial production of low-cost and large-scale flexible solid-state lithium-ion batteries and it can enhance the energy storage density of energy storage materials.This novel idea also has bright prospects in flexible electronic materials. 展开更多
关键词 ceramic fiber tunnel elasticity enhancement effect solution blowing spinning
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Parentage determination of black sea bream(Acanthopagrus schlegelii)for stock enhancement:effectiveness and loss of genetic variation
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作者 Binbin Shan Yan Liu +4 位作者 Na Song Changping Yang Shengnan Liu Tianxiang Gao Dianrong Sun 《Acta Oceanologica Sinica》 SCIE CAS CSCD 2021年第6期41-49,共9页
The stock enhancement programs for black sea bream Acanthopagrus schlegelii have been conducted in China for a fewyears.However,little information has been reported concerning the effectiveness and genetic effect of b... The stock enhancement programs for black sea bream Acanthopagrus schlegelii have been conducted in China for a fewyears.However,little information has been reported concerning the effectiveness and genetic effect of black sea bream stock enhancement.In order to detect the contribution of released individuals in Zhujiang River Estuary(ZRE)and Daya Bay(DB),six microsatellite markers were used to identify the hatchery-released individuals.In addition,this pedigree of hatchery populations(broodfish and hatchery-released offspring)was traced to detect the number of effective parents(N_(e)),the inbreeding coefficient and the decrease of genetic variability in the reproduction.The pedigree reconstruction showed that at least 69(out of 93)broodfish had offspring.The estimated N_(e) was 54.8,consequently the inbreeding coefficient was 0.91%.The genetic diversity of hatchery-released offspring was lower than that in that of broodfish(heterozygosity alleles,0.727-0.774),some alleles(number of alleles,61-69)and genetic variance were lost during reproduction.It was observed that wild samples had higher levels of genetic diversity compared with hatchery populations as well as recaptured samples in releasing area.A total of 128 hatchery-released black sea bream were identified among 487 recaptured samples in ZRE,while a total of 15 samples were identified among 96 samples in DB.In summary,there was a high survival of released fish.N_(e)vertheless,the results provided evidence to consider a loss of genetic variation in hatcheryreleased stock and a negative genetic effect of the stock enhancement. 展开更多
关键词 Acanthopagrus schlegelii stock enhancement effectiveness microsatellite maker genetic effect pedigree of hatchery populations
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Prediction of Enhancement Effect of Nitroimidazoles on Irradiation by Gene Expression Programming
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作者 LONG Wei ZHANG Xiao-dong +2 位作者 WANG Hao SHEN Xiu SI Hong-zong 《Chemical Research in Chinese Universities》 SCIE CAS CSCD 2013年第3期519-525,共7页
A novel machine learning method, gene expression programming(GEP), was employed to build quatitative structure-activity relationship(QSAR) models for predicting the enhancement effect of nitroimidazole compounds o... A novel machine learning method, gene expression programming(GEP), was employed to build quatitative structure-activity relationship(QSAR) models for predicting the enhancement effect of nitroimidazole compounds on irradiation. The models were based on descriptors which were calculated from the molecular structures. Four descriptors were selected from the pool of descriptors by best multiple linear regression(BMLR) method. After that, three regression methods, multiple linear regression(MLR), support vector machine(SVM) and GEP, were used to build QSAR models. Compared to MLR and SVM, GEP produced a better model with the square of correlation coefficient(R2), 0.9203 and 0.9014, and the root mean square error(RMSE), 0.6187 and 0.6875, for training set and test set, respectively. The results show that the GEP model has better predictive ability and more reliable than the MLR and SVM models. This indicates that GEP is a promising method on relevant researches in radiation area. 展开更多
关键词 NITROIMIDAZOLE Irradiation enhancement effect Gene expression programming
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1.3μm broadband swept sources with enhanced nonlinear effects
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作者 Panqiu Jiang Jiale Mu +2 位作者 Yuxing Liu Pinghe Wang Guohua Shi 《Journal of Innovative Optical Health Sciences》 SCIE EI CSCD 2023年第3期124-131,共8页
In this work,a new structure is used to enhance the nonlinear effect in the cavity,which improvesthe performance of the 1.3μm broadband swept source.The swept source adopts a semiconductoroptical amplifier(SOA),a cir... In this work,a new structure is used to enhance the nonlinear effect in the cavity,which improvesthe performance of the 1.3μm broadband swept source.The swept source adopts a semiconductoroptical amplifier(SOA),a circulator,a coupler,and a tunable filter.In the structure,the lightpasses through the nonlinear medium(SOA)twice in two opposite directions,which excites thenonlinear ffect and increases the performance of the swept source.The tunable filter is based on apolygon rotating mirror and gratings.Traditionally,multiple SOAs are adopted to improve thesweep range and the optical power,which increases the cost and complexity of the swept source.The method proposed in this paper can improve the spectral range and optical power of the sweptsources without additional accessories.For the short-cavity swept source,the power increasesfrom 6 mW to 7.7 mW,and the sweep range increases from 98 nm to 120 nm.The broadband swept sources could have wide applications in biomedical imaging,sensor system,measurementand so on. 展开更多
关键词 Optical coherence tomography swept source enhanced nonlinear effects
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Matrix Effects and Behaviors of Elements in Oxalic Acid Medium by Inductively Coupled Plasma Mass Spectrometry 被引量:4
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作者 Hua Lin XIE Yu Jie LI +1 位作者 Xi Du NIE Li Bo LI 《Chinese Chemical Letters》 SCIE CAS CSCD 2006年第7期945-948,共4页
The influence of different concentration of oxalic acid matrix on elemental inductively coupled plasma mass spectrometry (ICP-MS) has been investigated. It has been proved that the sensitivity of analytes can be sig... The influence of different concentration of oxalic acid matrix on elemental inductively coupled plasma mass spectrometry (ICP-MS) has been investigated. It has been proved that the sensitivity of analytes can be significantly enhanced by adding small amounts of oxalic acid medium with adjusted nebulizer flow-rate gas, especially for the elements with ionization potential between 9 and 11 eV. Oxalic acid, as an enhancement agent, can be used to compensate the signal depression caused by inorganic matrix and to improve the detection limits about two to eight times, for the hard-to-ionize elements in ICP-MS determination. 展开更多
关键词 ICP-MS oxalic acid enhancement effect.
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Construction of enhanced multi-polarization and high performance electromagnetic wave absorption by self-growing ZnFe_(2)O_(4)on Cu_(9)S_(5)
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作者 Wenxiong Chen Honglong Xing 《International Journal of Minerals,Metallurgy and Materials》 SCIE EI CAS CSCD 2024年第8期1922-1934,共13页
The development of 3D structural composites with electromagnetic(EM)wave absorption could attenuate EM waves.Herein,magnetized flower-like Cu_(9)S_(5)/ZnFe_(2)O_(4)composites were fabricated through a multistep hydrot... The development of 3D structural composites with electromagnetic(EM)wave absorption could attenuate EM waves.Herein,magnetized flower-like Cu_(9)S_(5)/ZnFe_(2)O_(4)composites were fabricated through a multistep hydrothermal method.The crystallographic and surface phase chemical information,morphological structure,and magnetic and EM parameters of the composites were analyzed.The prepared Cu_(9)S_(5)/ZnFe_(2)O_(4)composites have multiple loss paths for EM waves and present an overall 3D flower-like structure.The Cu_(9)S_(5)/ZnFe_(2)O_(4)composites exhibit a minimum reflection loss of-54.38 dB and a broad effective absorption bandwidth of 5.92 GHz.Through magnetization,ZnFe_(2)O_(4)particles are self-assembled and grown on the surfaces of Cu_(9)S_(5).Such a modification is conducive to the generation of additional cross-linking contact sites and the effective introduction of a large number of phase interfaces,crystalline defects,special three-dimensional flower-like structures,and magneto-electrical coupling loss effects.Moreover,the synergistic effect of multiple loss strategies effectively improves EM wave absorption by the material.This work can provide a strategy for the use of magnetizationmodified sulfide composite functional materials in EM wave absorption. 展开更多
关键词 self-assembled material electromagnetic wave absorption enhanced multi-polarization effect Cu_(9)S_(5)/ZnFe_(2)O_(4)composites radar cross-section
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Enhanced effect of plasma on catalytic reduction of CO2 to CO with hydrogen over Au/CeO2 at low temperature 被引量:2
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作者 Xiaobing Zhu Jian-Hao Liu +3 位作者 Xiao-Song Li Jing-Lin Liu Xin Qu Ai-Min Zhu 《Journal of Energy Chemistry》 SCIE EI CAS CSCD 2017年第3期488-493,共6页
In terms of the reaction of COreduction to CO with hydrogen, COconversion is very low at low temperature due to the limitation of thermodynamic equilibrium(TE). To overcome this limitation, plasma catalytic reductio... In terms of the reaction of COreduction to CO with hydrogen, COconversion is very low at low temperature due to the limitation of thermodynamic equilibrium(TE). To overcome this limitation, plasma catalytic reduction of COto CO in a catalyst-filled dielectric barrier discharge(DBD) reactor is studied. An enhanced effect of plasma on the reaction over Au/CeOcatalysts is observed. For both the conventionally catalytic(CC) and plasma catalytic(PC, Pin= 15 W) reactions under conditions of 400 °C, H/CO= 1,200 SCCM, GHSV = 12,000 mL·gcat·h, COconversions over Au/CeOreach 15.4% and 25.5% due to the presence of Au, respectively, however, those over CeOare extremely low and negligible. Moreover,COconversion over Au/CeOin the PC reaction exceeds 22.4% of the TE conversion. Surface intermediate species formed on the catalyst samples during the reactions are determined by in-situ temperatureprogrammed decomposition(TPD) technique. Interestingly, it disclosed that in the PC reaction, the formation of formate intermediate is enhanced by plasma, and the acceleration by plasma in the decomposition of formate species is much greater than that in the formation of formate species on Au/CeO. Enhancement factor is introduced to quantify the enhanced effect of plasma. Lower reactor temperature, higher gas hourly space velocity(GHSV), and lower molar ratio of H/COwould be associated with larger enhancement factor. 展开更多
关键词 CO2 reduction Plasma catalysis Enhanced effect
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Enhanced Anti-tumor Effect of an IFN-γ-EGF Fusion Protein 被引量:2
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作者 CHEN WANG-QIU DING YAN-PING +1 位作者 ZHANG LI-LANG AND HOU YUN-DE(National Laboratory of Milecular Virology and GeneticEngineering, Institute of Virology, Chinese Academyof Preventive Mndicine, Beijing, 100052, China) 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 1997年第4期387-395,共9页
The novel fusion proteins harbering human or mouse interferon combined with epidermalgrowth factor receptor binding domain were constructed using methods of genetic and proteinengineering. The fusion proteins were ass... The novel fusion proteins harbering human or mouse interferon combined with epidermalgrowth factor receptor binding domain were constructed using methods of genetic and proteinengineering. The fusion proteins were assayed to retain complete antiviral activities. The EGFreceptor binding moiety of the fusion proteins exhibited competitive binding saainst 125 I-EGFfor EGF receptbrs on A431 cells. The fusion proteins were shown to be more potent in in-hibiting the growth of cultured target carcinoma cells than interferon-y alone. Experimentaldata derived from rnouse Bl6 malignant melanoma models indicates that the weight of tumorin mice treated with IFN fusion proteins was significantly smaller than that of mice treatedwith interferon-y alone. The work here is unprecedented in the world and provides a reliableevidence to supPOrt the upcoming clinical employment of a class of interferons that specificallytarget tumor cell 展开更多
关键词 EGF Fusion Protein WANG De cell Enhanced Anti-tumor effect of an IFN
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Effect of projectile parameters on opening behavior of PELE penetrating RC target 被引量:2
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作者 Li-zhi Xu Cheng-xin Du +4 位作者 Chun Cheng Xiao-dong Wang Jiang-bo Wang Zhong-hua Du Guang-fa Gao 《Defence Technology(防务技术)》 SCIE EI CAS CSCD 2021年第3期859-873,共15页
When a penetrator with enhanced lateral effect(PELE) impacts on a reinforced concrete(RC) target,the target is damaged with a large opening.An understanding of how PELE projectile parameters affect the opening dimensi... When a penetrator with enhanced lateral effect(PELE) impacts on a reinforced concrete(RC) target,the target is damaged with a large opening.An understanding of how PELE projectile parameters affect the opening dimension,is essential for effective design of the PELE projectile.In this study,under the condition that the impact velocity and target parameters(strength and thickness) were fixed values,the important influence factors of the PELE(jacket wall thickness B,jacket material strength Y1,filling material strength Y2 and angle of monolithic jacket θ) were determined by a dimensional analysis.Tests and simulations of the PELE penetrating the RC target were conducted to analyze the influence of these factors on opening diameter(D,an equivalent diameter under relative kinetic energy).Based on the test and simulation results,it is found that the influence of these factors B,Y1 and θ on the deformation mode of the jacket shows a similar trend:as values of the three factors decrease,the jacket deforms from small bending deformation to large one,and then to curling deformation.This causes the opening diameter to first increase with the decrease of these three factors,and then decreases.It is well known that the bending resistance of the jacket is related to these factors B,Y1 and θ.Therefore,a plastic limit bending moment(M0) of the jacket was quoted to characterize the influence of these factors on the bending deformation of the jacket and the opening diameter of the target.The influence factor Y2 causes D to first increase with the increase of Y2,and then decreases.A formula was developed to predict the opening diameter,whose influence parameters were considered in a dimensionless way.It has been shown that the dimensionless opening diameter D/d1 is dependent on two dimensionless parameters■ and■,where d1 and fc are the outer diameter of the projectile and the compressive strength of the target,respectively. 展开更多
关键词 Penetrator with enhanced lateral effect Opening behaviour Reinforced concrete target Dimensional analysis
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EPR Effect of Amphiphilic Copolymer Micelles Observed by Fluorescent Imaging 被引量:4
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作者 LIU Tong-jun LIU Shi +3 位作者 HU Xiu-li SHENG Shi-hou HUANG Yu-bin JING Xia-bin 《Chemical Research in Chinese Universities》 SCIE CAS CSCD 2011年第4期628-634,共7页
Enhanced permeation and retention(EPR) targeting effect of rhodamine B labeled PEG-b-P(LA-co-DHP) [PEG:poly(ethylene glycol);LA:L-lactide;DHP:2,2-dihydroxylmethyl-propylene carbonate] micelles(RhB-micelles)... Enhanced permeation and retention(EPR) targeting effect of rhodamine B labeled PEG-b-P(LA-co-DHP) [PEG:poly(ethylene glycol);LA:L-lactide;DHP:2,2-dihydroxylmethyl-propylene carbonate] micelles(RhB-micelles) was observed in H22 liver cancer bearing mice.The RhB-micelles were prepared by conjugating rhodamine B with the DHP units of amphiphilic block copolymer PEG-b-P(LA-co-DHP) followed by subsequent self-assembling of the conjugate.The parent copolymer PEG-b-P(LA-co-DHP) was synthesized by ring-opening copolymerization of LA and DHP with PEG as macroinitiator and diethyl zinc(ZnEt2) as catalyst.The micelles have a spherical shape and the average diameter is ca.50 nm by TEM(transmission electron microscope) or 80 nm by DLS(dynamic light scattering).Their in vitro cell uptake experiment by CLSM(confocal laser scanning microscopy) and flow cytometry showed preferential internalization of micelles by MCF-7 human breast cancer cells to free RhB.The in vivo tests by live animal imaging and ex vivo excised organ imaging showed that after vena tail injection,free RhB molecules were distributed in the whole body through the circulation system and then gradually metabolized and excreted and there was no preferential partition in tumor bed from the beginning to the end.But the RhB-micelles were preferentially distributed to the tumor bed so that their concentration(fluorescent intensity) in tumor bed got the level of the liver at a certain time point between 1 and 6 h and reached a maximum relative intensity at around 12 h,indicating an obvious EPR effect of RhB-micelles in H22 liver cancer. 展开更多
关键词 Enhanced permeability and retention(EPR) effect Fluorescent imaging MICELLE Passive targeting
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Valproic Acid Enhances the Anti-tumor Effect of(-)-gossypol to Burkitt Lymphoma Namalwa Cells 被引量:1
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作者 GONG Yi NI Zhen Hong +2 位作者 ZHANG Xi CHEN Xing Hua ZOU Zhong Min 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 2015年第10期773-777,共5页
Burkitt lymphoma is a highly aggressive B-cell neoplasm. New therapeutic methods are needed to overcome the adverse effect of intensive chemotherapy regimens. Valproic acid and (-)-gossypol are two kinds of chemical... Burkitt lymphoma is a highly aggressive B-cell neoplasm. New therapeutic methods are needed to overcome the adverse effect of intensive chemotherapy regimens. Valproic acid and (-)-gossypol are two kinds of chemical compounds used as new anti-tumor drugs in recent years. 展开更多
关键词 VPA CELL gossypol to Burkitt Lymphoma Namalwa Cells Valproic Acid Enhances the Anti-tumor effect of
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EFFECT OF SOLVENT ON SURFACE ENHANCED RAMAN SCATTERING SPECTRA OF COLLOIDAL SILVER 被引量:2
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《Chinese Chemical Letters》 SCIE CAS CSCD 1992年第2期127-128,共2页
The effect of solvent on surface enhanced Raman scattering [SERS) of colloidal silver has been studied. Experiments show that the intensity of SERS is related to the polarity and molecular constitution of the solvent.... The effect of solvent on surface enhanced Raman scattering [SERS) of colloidal silver has been studied. Experiments show that the intensity of SERS is related to the polarity and molecular constitution of the solvent. The influence of solvent is due to the change of the adsorption quantity and adsorption intensity. 展开更多
关键词 SERS In effect OF SOLVENT ON SURFACE ENHANCED RAMAN SCATTERING SPECTRA OF COLLOIDAL SILVER
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Enhanced permeability and retention effect based nanomedicine, a solution for cancer 被引量:1
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作者 Jun Fang 《World Journal of Pharmacology》 2015年第2期168-171,共4页
Tumor-targeting is becoming more and more important for cancer chemotherapy. Though many molecular-target drugs have been developed in the past two decades which shed some light on targeted tumor therapy,clinical resu... Tumor-targeting is becoming more and more important for cancer chemotherapy. Though many molecular-target drugs have been developed in the past two decades which shed some light on targeted tumor therapy,clinical results of those molecular-target drugs are not so encouraging especially for solid tumors, problems mostly relating to the heterogeneity and mutations of target molecules in human solid tumors. More general tumor-targeting strategy is thus anticipated. In this regard, the enhanced permeability and retention(EPR) effect which is a unique phenomenon of solid tumors based on the anatomical and pathophysiological nature of tumor blood vessels, is receiving more and more attentions. This EPR effect now served as a standard for tumor-targeted macromolecular anticancer therapy, namely nanomedicine. Many nanoplatforms have been developed as targeted drug delivery systems, including liposome, polymeric micelles, polymer conjugate, nanoparticles. Ample macromolecular drugs are now approved for clinical use or in clinical stage development, all of which by taking advantage of EPR effect, show superior in vivo pharmacokinetics and remarkable tumor selectivity, resulting in improved antitumor effects with less adverse effects. We thus believe EPR-based nanomedicine will be a solution for cancer in the future, whereas further consideration of factors involved in EPR effect and strategies to augment/improve EPR effect are warranted. 展开更多
关键词 Enhanced permeability and retention effect Tumor targeting NANOMEDICINE CANCER Chemotherapy Polymeric therapeutics Macromolecular drugs
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STUDIES ON FLUORESCENCE ENHANCING EFFECT AND ALKALINE DEGRADATION MECHANISM OF DOXYCYCLINE AND METHACYCLINE
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作者 Yi Bing ZHAO Department of Chemistry,Xiamen University,Xiamen 361005Wen Bao CHANG Yun Xiang CI Department of Chemistry,Peking University,Beijing 100871 《Chinese Chemical Letters》 SCIE CAS CSCD 1993年第9期791-792,共2页
Degradation reaction of doxycycline or methacycline was carried out in KOH solution and intense fluorescence was obtained.A degradation mechanism of doxycycline or methacycline was suggested.
关键词 HC DC STUDIES ON FLUORESCENCE ENHANCING effect AND ALKALINE DEGRADATION MECHANISM OF DOXYCYCLINE AND METHACYCLINE KOH
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