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Long-term prognosis and its associated predictive factors in patients with eosinophilic gastroenteritis 被引量:3
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作者 Kai-Wen Li Ge-Chong Ruan +8 位作者 Shuang Liu Tian-Ming Xu Ye Ma Wei-Xun Zhou Wei Liu Peng-Yu Zhao Zhi-Rong Du Ji Li Jing-Nan Li 《World Journal of Gastroenterology》 SCIE CAS 2024年第2期146-157,共12页
BACKGROUND Eosinophilic gastroenteritis(EGE)is a chronic recurrent disease with abnormal eosinophilic infiltration in the gastrointestinal tract.Glucocorticoids remain the most common treatment method.However,disease ... BACKGROUND Eosinophilic gastroenteritis(EGE)is a chronic recurrent disease with abnormal eosinophilic infiltration in the gastrointestinal tract.Glucocorticoids remain the most common treatment method.However,disease relapse and glucocorticoid dependence remain notable problems.To date,few studies have illuminated the prognosis of EGE and risk factors for disease relapse.AIM To describe the clinical characteristics of EGE and possible predictive factors for disease relapse based on long-term follow-up.METHODS This was a retrospective cohort study of 55 patients diagnosed with EGE admitted to one medical center between 2013 and 2022.Clinical records were collected and analyzed.Kaplan-Meier curves and log-rank tests were conducted to reveal the risk factors for long-term relapse-free survival(RFS).RESULTS EGE showed a median onset age of 38 years and a slight female predominance(56.4%).The main clinical symptoms were abdominal pain(89.1%),diarrhea(61.8%),nausea(52.7%),distension(49.1%)and vomiting(47.3%).Forty-three(78.2%)patients received glucocorticoid treatment,and compared with patients without glucocorticoid treatments,they were more likely to have elevated serum immunoglobin E(IgE)(86.8%vs 50.0%,P=0.022)and descending duodenal involvement(62.8%vs 27.3%,P=0.046)at diagnosis.With a median follow-up of 67 mo,all patients survived,and 56.4%had at least one relapse.Six variables at baseline might have been associated with the overall RFS rate,including age at diagnosis<40 years[hazard ratio(HR)2.0408,95%confidence interval(CI):1.0082–4.1312,P=0.044],body mass index(BMI)>24 kg/m^(2)(HR 0.3922,95%CI:0.1916-0.8027,P=0.014),disease duration from symptom onset to diagnosis>3.5 mo(HR 2.4725,95%CI:1.220-5.0110,P=0.011),vomiting(HR 3.1259,95%CI:1.5246-6.4093,P=0.001),total serum IgE>300 KU/L at diagnosis(HR 0.2773,95%CI:0.1204-0.6384,P=0.022)and glucocorticoid treatment(HR 6.1434,95%CI:2.8446-13.2676,P=0.003).CONCLUSION In patients with EGE,younger onset age,longer disease course,vomiting and glucocorticoid treatment were risk factors for disease relapse,whereas higher BMI and total IgE level at baseline were protective. 展开更多
关键词 eosinophilic gastroenteritis PROGNOSIS RELAPSE GLUCOCORTICOID Glucocorticoid dependence
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Acute Eosinophilic Pneumonia (AEP) Due to Daptomycin: Is Autoimmunity a Clinico-Pathophysiologic Bridge to AEP?
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作者 Shadee Tajik Sami Akram 《International Journal of Clinical Medicine》 CAS 2024年第8期365-374,共10页
Daptomycin induced acute eosinophilic pneumonia is a rare and potentially life threatening condition characterized by rapid respiratory failure, pulmonary infiltrates and eosinophilia. Risk factors for acute eosinophi... Daptomycin induced acute eosinophilic pneumonia is a rare and potentially life threatening condition characterized by rapid respiratory failure, pulmonary infiltrates and eosinophilia. Risk factors for acute eosinophilic pneumonia include smoking, environmental irritants or inhalants and certain medications such as Daptomycin [1]. In this review of literature, we aim to explore the potential triggers for developing acute eosinophilic pneumonia in patients exposed to Daptomycin. The exact immune mechanism for daptomycin induced AEP is unknown, however the current proposed mechanism describes a T helper 2 lymphocyte response to inactivated daptomycin in the pulmonary surfactant, which leads to eosinophilia. Disordered T regulatory cell function is seen in patients with certain cancers, allergies and autoimmune conditions. We propose that patients with these underlying risk factors may be at increased risk of developing AEP after becoming exposed to Daptomycin. Understanding potential risk factors is crucial for health care workers as it allows them to identify susceptible populations, explore preventative measures and treat accordingly. 展开更多
关键词 DAPTOMYCIN Acute eosinophilic Pneumonitis Daptomycin Induced Acute eosinophilic Pneumonia Drug Induced Pneumonia eosinophilic Pneumonia
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Animal models of eosinophilic esophagitis,review and perspectives
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作者 Dong Li Yujia Wei +1 位作者 Jing Wang Bo Wang 《Animal Models and Experimental Medicine》 CAS CSCD 2024年第2期127-135,共9页
Eosinophilic oesophagitis(EoE)is an allergen/immune-mediated chronic esophageal disease characterized by esophageal mucosal eosinophilic infiltration and esophageal dysfunction.Although the disease was originally attr... Eosinophilic oesophagitis(EoE)is an allergen/immune-mediated chronic esophageal disease characterized by esophageal mucosal eosinophilic infiltration and esophageal dysfunction.Although the disease was originally attributed to a delayed allergic reaction to allergens and a Th2-type immune response,the exact pathogenesis is complex,and the efficacy of existing treatments is unsatisfactory.Therefore,the study of the pathophysiological process of EOE has received increasing attention.Animal models have been used extensively to study the molecular mechanism of EOE pathogenesis and also provide a preclinical platform for human clinical intervention studies of novel therapeutic agents.To maximize the use of existing animal models of EOE,it is important to understand the advantages or limitations of each modeling approach.This paper systematically describes the selection of experimental animals,types of allergens,and methods of sensitization and excitation during the preparation of animal models of EoE.It also discusses the utility and shortcomings of each model with the aim of providing the latest perspectives on EoE models and leading to better choices of animal models. 展开更多
关键词 ANAPHYLAXIS disease models ANIMAL eosinophilic esophagitis METHODS
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Human Eosinophil Cell Manipulation by Optical Tweezers
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作者 Pavel Yale Jean Michel Edoukoua Konin +2 位作者 Abadê Ange-Boris N’guessan Michel Abaka Kouacou Jérémie T. Zoueu 《Open Journal of Biophysics》 2024年第3期330-338,共9页
In this work, lateral deformation of human eosinophil cell during the lateral indentation by an optically trapped microbead of diameter 4.5 µm is studied. The images were captured using a CCD camera and the Boltz... In this work, lateral deformation of human eosinophil cell during the lateral indentation by an optically trapped microbead of diameter 4.5 µm is studied. The images were captured using a CCD camera and the Boltzmann statistics method was used for force calibration. Using the Hertz model, we calculated and compared the elastic moduli resulting from the lateral force, showing that the differences are important and the force should be considered. Besides the lateral component, the setup also allows us to examine the lateral cell-bead interaction. The mean values of the properties obtained, in particular the elastic stiffness and the shear stiffness, were Eh = (37.76 ± 2.85) µN/m and Gh = (12.57 ± 0.32) µN/m. These results show that the lateral indentation can therefore be used as a routine method for cell study, because it enabled us to manipulate the cell without contact with the laser. 展开更多
关键词 Optical Tweezers Human eosinophil Cell INDENTATION Shear Stiffness
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Chest CT quantitative parameters in patients with acute exacerbation of chronic obstructive pulmonary disease:Correlations with blood eosinophil level
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作者 YANG Lu SHENG Yadan +7 位作者 YANG Kai HE Liyu GU Huihui SUN Guoqing CHEN Weiting ZHU Bingjie CHEN Yanrong JIN Chenwang 《中国医学影像技术》 CSCD 北大核心 2024年第8期1189-1193,共5页
Objective To observe the correlations of chest CT quantitative parameters in patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD)with blood eosinophil(EOS)level.Methods Chest CT data of 16... Objective To observe the correlations of chest CT quantitative parameters in patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD)with blood eosinophil(EOS)level.Methods Chest CT data of 162 AECOPD patients with elevated eosinophils were retrospectively analyzed.The patients were divided into low EOS group(n=105)and high EOS group(n=57)according to the absolute counting of blood EOS.The quantitative CT parameters,including the number of whole lung bronchi and the volume of blood vessels,low-attenuation area percentage(LAA%)of whole lung,of left/right lung and each lobe of lung,as well as the luminal diameter(LD),wall thickness(WT),wall area(WA)and WA percentage of total bronchial cross-section(WA%)of grade 3 to 8 bronchi were compared between groups.Spearman correlations were performed to analyze the correlations of quantitative CT parameters with blood EOS level.Results LAA%of the whole lung,of the left/right lung and each lobe of lung,as well as of the upper lobe of right lung LD grade 4,middle lobe of right lung WT grade 5,upper lobe of right lung WA grade 4,middle lobe of right lung WA grade 5 and lower lobe of left lung WA grade 3 in low EOS group were all higher than those in high EOS group(all P<0.05).Except for the upper lobe of right lung LD grade 4,the above quantitative CT indexes being significant different between groups were all weakly and negatively correlated with blood EOS level(r=-0.335 to-0.164,all P<0.05).Conclusion Chest CT quantitative parameters of AECOPD patients were correlated with blood EOS level,among which LAA%,a part of WT and WA were all weakly negatively correlated with blood EOS level. 展开更多
关键词 pulmonary disease chronic obstructive eosinophilS tomography X-ray computed
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Evolving strategies: Enhancements in managing eosinophilic esophagitis in pediatric patients
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作者 Ahmed Elghoudi Doaa Zourob +4 位作者 Eman Al Atrash Fatima Alshamsi Manal Alkatheeri Hassib Narchi Rana Bitar 《World Journal of Clinical Pediatrics》 2024年第1期14-22,共9页
Eosinophilic esophagitis is a newly recognized disease first described about 50 years ago.The definition,diagnosis,and management have evolved with new published consensus guidelines and newly approved treatment avail... Eosinophilic esophagitis is a newly recognized disease first described about 50 years ago.The definition,diagnosis,and management have evolved with new published consensus guidelines and newly approved treatment available to pediatricians,enabling a better understanding of this disease and more targeted treatment for patients.We describe the definition,presentation,and diagnosis of eosinophilic esophagitis including management,challenges,and future directions in children.The definition,diagnosis,and management of eosinophilic esophagitis have evolved over the last 50 years.Consensus guidelines and newly approved biologic treatment have enabled pediatricians to better understand this disease and allow for more targeted treatment for patients.We describe the definition,presentation,diagnosis,management,and treatment in addition to the challenges and future directions of eosinophilic esophagitis management in children. 展开更多
关键词 eosinophilic esophagitis ESOPHAGITIS Gastroesophageal reflux disease Food allergy DYSPHAGIA
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Eosinophilic solid and cystic renal cell carcinoma with aggressive behavior:Two case reports
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作者 Hui-Hui Cao Hong Li +2 位作者 Xiao-Hong Guo Zhi-Xing Cao Bo-Hui Zhang 《World Journal of Clinical Cases》 SCIE 2024年第22期5124-5130,共7页
BACKGROUND Eosinophilic solid and cystic(ESC)renal cell carcinoma(RCC),a unique and emerging subtype of RCC,has an indolent nature;in some rare instances,it may exhibit metastatic potential.Current cases are inadequat... BACKGROUND Eosinophilic solid and cystic(ESC)renal cell carcinoma(RCC),a unique and emerging subtype of RCC,has an indolent nature;in some rare instances,it may exhibit metastatic potential.Current cases are inadequate to precisely predict the clinical outcome of ESC RCC and determine treatment choices.CASE SUMMARY Herein,we report two patients with ESC RCC.Patient 1 was a young woman with classical pathological characteristics.Patient 2 was a 52-year-old man with multifocal metastases,involving the pulmonary hilar and mediastinal lymph nodes,liver,brain,mesosternum,vertebra,rib,femur,and symphysis pubis.Awareness of ESC RCC,along with its characteristic architecture and immunophenotype,would contribute to making a definitive diagnosis,even on core biopsy samples.CONCLUSION The discovery of ESC RCC molecular signatures may provide new therapeutic strategies in the future. 展开更多
关键词 eosinophilic solid and cystic renal cell carcinoma Solid and cystic growth pattern CK20 TSC1 mutations TSC2 mutations Case report
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Clinical Research Progress of Peripheral Blood Eosinophils in Chronic Obstructive Pulmonary Disease
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作者 Chunxi Li 《Journal of Clinical and Nursing Research》 2024年第6期189-194,共6页
Chronic obstructive pulmonary disease(COPD)accounts for one of the major health and economic burdens worldwide.As a heterogeneous disease,the underlying inflammatory pattern of COPD differs from the previously thought... Chronic obstructive pulmonary disease(COPD)accounts for one of the major health and economic burdens worldwide.As a heterogeneous disease,the underlying inflammatory pattern of COPD differs from the previously thought neutrophil-dominated inflammation,with eosinophilic inflammation occupying approximately one third of stable COPD.Although the eosinophil(EOS)threshold associated with clinical relevance in patients with COPD is currently debated,eosinophil count can be used as a biomarker to guide treatment and to assess the risk of acute exacerbations of COPD,the efficacy of inhaled corticosteroids,and clinical outcomes.The purpose of this review is to describe the biological characteristics of eosinophils and the related research progress as clinical biomarkers. 展开更多
关键词 Chronic obstructive pulmonary disease eosinophilS Biomarkers
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外周血EOS、IL-21、CCL4与慢性鼻-鼻窦炎伴鼻息肉患者术后复发的相关性 被引量:1
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作者 徐蓉 刘甜甜 陈晓宇 《分子诊断与治疗杂志》 2024年第4期683-686,691,共5页
目的探究外周血嗜酸性粒细胞数(EOS)、白细胞介素-21(IL-21)、趋化因子4(CCL4)与慢性鼻-鼻窦炎伴鼻息肉(CRSwNP)患者术后复发的相关性。方法回顾性选取青岛市第八人民医院2020年1月至2022年6月收治的86例行慢性鼻-鼻窦炎伴鼻息肉切除术... 目的探究外周血嗜酸性粒细胞数(EOS)、白细胞介素-21(IL-21)、趋化因子4(CCL4)与慢性鼻-鼻窦炎伴鼻息肉(CRSwNP)患者术后复发的相关性。方法回顾性选取青岛市第八人民医院2020年1月至2022年6月收治的86例行慢性鼻-鼻窦炎伴鼻息肉切除术患者,收集所有患者的一般资料,对患者进行外周血EOS、IL-21、CCL4检测;并对患者进行随访1年,统计其复发情况,根据患者的术后复发情况将患者分为复发组(n=34)与正常组(n=52)。比较两组的临床资料和外周血EOS、IL-21、CCL4水平;采用Pearson相关性分析探讨外周血EOS、IL-21、CCL4与CRSwNP患者鼻窦CT Lund-Mackay评分的相关性;采用受试者工作特征(ROC)曲线评估CRSwNP患者术后复发的预测价值。结果随访期间共记录到术后复发患者34例,占比39.53%,未复发患者52例,占比60.47%。两组患者的嗜酸性粒细胞型鼻息肉例数、鼻窦CT Lund-Mackay评分、外周血EOS、IL-21、CCL4水平进行比较,差异有统计学意义(t=4.250、5.300、3.890、3.089、3.499,P<0.05)。多因素logistic回归分析结果显示外周血EOS、IL-21、CCL4水平均是CRSwNP患者术后复发的独立危险因素(P<0.05)。Pearson相关性分析结果显示,外周血EOS、IL-21、CCL4水平与CRSwNP患者鼻窦CT Lund-Mackay评分具有相关性(r=0.433、0.681、0.547,P<0.05)。ROC曲线结果显示,外周血EOS、IL-21、CCL4及三者联合对预测CRSwNP患者术后复发的AUC面积分别为:0.725、0.686、0.709、0.834,且联合预测的灵敏度和特异度最高,效果最好(P<0.05)。结论外周血EOS、IL-21、CCL4与CRSwNP患者病情程度具有相关性,通过外周血EOS、IL-21、CCL4预测慢性鼻-鼻窦炎伴鼻息肉患者术后复发具有一定的预测价值。 展开更多
关键词 嗜酸性粒细胞数 白细胞介素-21 趋化因子4 慢性鼻-鼻窦炎伴鼻息肉
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EOS双平面成像测量胫骨平台后倾角与前交叉韧带损伤的相关性研究
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作者 王杨雨凡 李剑 +1 位作者 王渭君 蒋青 《徐州医科大学学报》 CAS 2024年第4期261-265,共5页
目的探讨基于三维成像的EOS系统评估胫骨平台后倾角(PTS)对前交叉韧带(ACL)损伤患者的预测价值,并与3种传统X线片测量方法进行对比。方法回顾分析南京大学医学院附属鼓楼医院2018年10月—2021年12月收治的51例术中确诊为ACL损伤(ACL损伤... 目的探讨基于三维成像的EOS系统评估胫骨平台后倾角(PTS)对前交叉韧带(ACL)损伤患者的预测价值,并与3种传统X线片测量方法进行对比。方法回顾分析南京大学医学院附属鼓楼医院2018年10月—2021年12月收治的51例术中确诊为ACL损伤(ACL损伤组)及34例非ACL损伤(对照组)患者的临床资料。通过EOS法、全长法、近端法和后皮质法对患者的PTS进行评估,通过logistic回归分析等统计学方法,探讨不同PTS测量方法对ACL损伤的预测特异性。结果应用EOS法、全长法和近端法测量ACL损伤组患者的PTS,并与对照组相比,差异有统计学意义(P<0.05),采用logistic回归分析并构建受试者工作特征(ROC)曲线,曲线下面积(AUC)EOS法(0.955)和全长法(0.657)均优于近端法(0.558)和后皮质法(0.484)。对照组和ACL损伤组EOS法和全长法的测量结果均具有相关性(r=0.612,r=0.641)。结论采用EOS系统和基于下肢全长侧位X线片的全长法测量PTS预测ACL损伤的易发性优于近端法和后皮质法,在没有EOS条件的医院,可以使用全长法评估患者的PTS。 展开更多
关键词 前交叉韧带 胫骨平台后倾角 eos成像 膝关节 危险因素
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EOS^(TM)3D影像系统诊断复发性髌骨脱位的可靠性和稳定性
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作者 吕乐 白云召 +4 位作者 李鹏举 汤永刚 郑江 张宪 任博 《骨科》 CAS 2024年第2期104-108,共5页
目的 探讨EOS^(TM)3D影像系统诊断复发性髌骨脱位的可靠性和稳定性。方法 回顾性分析2022年3月至2023年3月西安交通大学附属红会医院运动医学中心收治的22例(26膝)复发性髌骨脱位病人的影像学资料,两位影像学医生同时使用EOS^(TM)系统... 目的 探讨EOS^(TM)3D影像系统诊断复发性髌骨脱位的可靠性和稳定性。方法 回顾性分析2022年3月至2023年3月西安交通大学附属红会医院运动医学中心收治的22例(26膝)复发性髌骨脱位病人的影像学资料,两位影像学医生同时使用EOS^(TM)系统测量病人下肢力线,使用sterEOS软件对影像图片进行3D模型重建,并在三维模型中测量胫骨结节-股骨滑车沟(tibial tubercle-trochlear groove,TTTG)间距,记录每次测量所需的时间和相关参数。所有病人同期进行常规膝关节CT扫描及三维重建。将EOS^(TM)3D影像和CT扫描测量的TT-TG数值进行比较,采用一致性检验研究和Bland-Altman分析图评价测量结果数据的可靠性和稳定性。结果 进行EOSTM下肢力线测量时,不同测量者间测量的股骨和胫骨长度、膝关节内外翻角度及股骨胫骨旋转角度之间差异无统计学意义(P>0.05)。病人常规下肢CT扫描及三维重建测量时间为(21.8±3.2)min(13~29 min),EOSTM3D测量时间为(6.3±1.8)min(4~11 min),差异有统计学意义(t=12.693,P<0.001)。两位医生使用EOS^(TM)3D测量TT-TG值的组内相关系数为0.791,使用常规CT测量的组内相关系数为0.843,两种测量方法组内一致性均较好。Bland-Altman分析结果显示两位测量者分别有96.2%(25/26)、92.3%(24/26)的点位于±1.96标准差范围内,显示使用常规CT三维重建和EOS^(TM)3D测量TT-TG值具备较好的一致性和稳定性。结论 使用EOS^(TM)3D影像系统测量复发性髌骨脱位病人的TT-TG值,具有良好的可靠性及可重复性,具有检查时间短、辐射低等优势,是评估此类病人下肢力线数据的一种快捷、可靠及稳定的方法。 展开更多
关键词 eos影像 电子计算机断层扫描 胫骨结节-股骨滑车沟间距 复发性髌骨脱位 3D建模 一致性检验
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143例儿童哮喘TSLP基因多态性与Eos、IgE及FeNO的关联性研究
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作者 李竹梅 吴静 +3 位作者 吴贵红 蒙文娟 张亚莉 朱晓萍 《免疫学杂志》 CAS CSCD 2024年第4期375-382,共8页
目的探讨胸腺基质淋巴细胞生成素(thymic stromal lymphopoietin,TSLP)基因rs1837253、rs3806933位点多态性与儿童哮喘易感性及Eos、IgE、FeNO水平的相关性。方法选取143例哮喘儿童作为研究组,选取同期健康体检儿童112例作为对照组。采... 目的探讨胸腺基质淋巴细胞生成素(thymic stromal lymphopoietin,TSLP)基因rs1837253、rs3806933位点多态性与儿童哮喘易感性及Eos、IgE、FeNO水平的相关性。方法选取143例哮喘儿童作为研究组,选取同期健康体检儿童112例作为对照组。采用MassARRAY SNP分型技术检测2个位点基因型,散射比浊法测定血清IgE水平,分析基因型及等位基因频率在2组间的分布差异,分析不同基因型对Eos、IgE及FeNO水平的影响。结果rs1837253等位基因及基因型频率、rs3806933等位基因频率在2组间分布无统计学差异(P>0.05);哮喘组rs3806933 CT基因型频率高于对照组,CC基因型频率低于对照组(P<0.05);与野生基因型相比,携带rs1837253 CT+CC和rs3806933 CT、CT+TT基因型的儿童患哮喘风险增高(CT+CC vs TT:OR=2.737,95%CI:1.514~4.945;CT vs CC:OR=2.058,95%CI:1.194~3.543:CT+TT vs CC:OR=1.843,95%CI:1.109~3.062)。哮喘组rs1837253位点3个基因型间Eos计数总体存在统计学差异(P<0.05,多重比较后矫正P>0.05),在对照组无统计学差异(P>0.05);2位点基因型间Eos%、IgE、FeNO及rs3806933基因型间Eos计数水平无统计学差异(P>0.05)。结论TSLP基因启动子区rs1837253、rs3806933位点多态性与儿童哮喘易感性有关,rs3806933CT基因型可能作为哮喘潜在的遗传标志物,rs1837253CT+CC、rs3806933CT+TT基因型是儿童患哮喘的风险因子;rs1837253位点多态性有影响血液Eos计数的趋势;2个SNPs与Eos%、血清IgE、FeNO水平无关。 展开更多
关键词 胸腺基质淋巴细胞生成素 单核苷酸多态性 嗜酸性粒细胞 免疫球蛋白E 呼出气一氧化氮 哮喘
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EOS风险计算器联合血清C反应蛋白、降钙素原对新生儿早发型败血症的预测价值
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作者 钟西鹤 郑俊虎 +2 位作者 胡丽文 陈一帆 余瑞伦 《中国现代医学杂志》 CAS 2024年第15期19-24,共6页
目的探讨EOS风险计算器(SRC)联合血清C反应蛋白(CRP)、降钙素原(PCT)在预测新生儿早发型败血症(EOS)中的价值。方法选取2021年1月—2021年12月在瑞安市人民医院分娩的胎龄≥34周的286例新生儿作为研究对象。新生儿按照1∶1的比例分为A组... 目的探讨EOS风险计算器(SRC)联合血清C反应蛋白(CRP)、降钙素原(PCT)在预测新生儿早发型败血症(EOS)中的价值。方法选取2021年1月—2021年12月在瑞安市人民医院分娩的胎龄≥34周的286例新生儿作为研究对象。新生儿按照1∶1的比例分为A组与B组。A组实施SRC评分辅助的抗菌药物管理;B组实施新生儿败血症治疗方案的抗菌药物治疗。比较两组入院时SRC评分、住院时间、抗生素使用率及并发症发生率。286例新生儿中,将95例确诊EOS的新生儿作为EOS组,191例未感染的新生儿作为对照组,均进行风险评分并检测血清CRP、PCT水平。绘制受试者工作特征(ROC)曲线分析EOS计算器联合血清CRP、PCT在新生儿EOS中的预测效能。结果A组入院时SRC评分较B组高(P<0.05),住院时间较B组短(P<0.05),抗生素使用率、并发症发生率均较B组低(P<0.05);EOS组的风险评分及CRP、PCT水平均高于对照组(P<0.05)。ROC曲线分析结果显示,SRC评分联合血清CRP、PCT在新生儿EOS中的预测效能最高,敏感性、特异性分别为97.0%(95%CI:0.871,0.981)、90.8%(95%CI:0.891,0.965),ROC曲线下面积为0.973(95%CI:0.949,0.997),高于单项检测。结论EOS计算器联合血清CRP、PCT在预测新生儿EOS中表现出高敏感性和特异性,能够有效提高EOS的诊断准确率,减少不必要的抗生素使用和并发症的发生,对早期识别及治疗新生儿EOS具有重要的临床应用价值。 展开更多
关键词 早发型败血症 新生儿 eos计算器 C-反应蛋白 降钙素原
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祛湿清热针刺疗法治疗急性湿疹患者的疗效及对其AhR、IFN-γ、EOS、IL-17水平的影响
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作者 夏恺 林夏 李峰 《世界中西医结合杂志》 2024年第10期2056-2060,2066,共6页
目的探讨祛湿清热针刺疗法对急性湿疹患者AhR、IFN-γ、EOS、IL-17水平的影响。方法选取2021年11月—2023年7月期间于马鞍山中医院收治的78例急性湿疹患者,采用随机数字表法分为对照组和治疗组,每组各39例。对照组给予常规治疗,治疗组... 目的探讨祛湿清热针刺疗法对急性湿疹患者AhR、IFN-γ、EOS、IL-17水平的影响。方法选取2021年11月—2023年7月期间于马鞍山中医院收治的78例急性湿疹患者,采用随机数字表法分为对照组和治疗组,每组各39例。对照组给予常规治疗,治疗组给予祛湿清热针刺疗法治疗。治疗2周后,观察比较两组患者临床疗效、不良反应情况,治疗前后中医证候评分、湿疹面积及严重度指数(Eczema area and severity index,EASI)评分、视觉模拟评分法(Visual pain scale,VAS)评分、实验室检查指标[嗜酸性粒细胞(Eosinophil,EOS)、白细胞介素-17(Interleukin-17,IL-17)、干扰素-γ(Interferon,IFN-γ)、芳香烃受体(Aromatic hydrocarbon receptor,AhR)]、皮肤生理功能指标。结果治疗后治疗组临床总有效率97.44%(38/39)明显高于对照组82.05%(32/39),差异有统计学意义(P<0.05)。治疗后两组患者发病急、病程短、渗出明显、皮损潮红、伴红疹、灼热瘙痒、自觉发热、口渴欲饮、心烦评分均较治疗前降低,差异有统计学意义(P<0.05);且治疗组患者发病急、病程短、渗出明显、皮损潮红、伴红疹、灼热瘙痒、自觉发热、口渴欲饮、心烦评分均明显低于对照组,差异有统计学意义(P<0.05)。治疗后两组患者EASI、VAS评分均较治疗前降低,差异有统计学意义(P<0.05);且治疗组EASI、VAS评分均较对照组明显降低,差异有统计学意义(P<0.05)。治疗后两组患者AhR、IL-17、IFN-γ、EOS水平均较治疗前降低,差异有统计学意义(P<0.05);且治疗组AhR、IL-17、IFN-γ、EOS水平均较对照组明显降低,差异有统计学意义(P<0.05)。治疗后两组患者皮肤生理功能指标较治疗前升高,差异有统计学意义(P<0.05);且治疗组皮肤生理功能指标较对照组明显升高,差异有统计学意义(P<0.05)。治疗期间,治疗组不良反应发生率7.69%(3/39)与对照组17.95%(7/39)比较,差异无统计学意义(P>0.05)。结论祛湿清热针刺疗法能够有效降低急性湿疹患者AhR、IFN-γ、EOS、IL-17水平,降低炎症反应,疗效明显。 展开更多
关键词 祛湿清热针刺疗法 急性湿疹 eos IL-17 IFN-Γ
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射干麻黄汤加味联合孟鲁司特钠治疗儿童咳嗽变异性哮喘的疗效观察及对EOS和血清ECP、IgE、LTC4的影响 被引量:1
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作者 李威 《中国中医药科技》 CAS 2024年第4期643-646,共4页
目的:观察射干麻黄汤加味联合孟鲁司特钠咀嚼片治疗儿童咳嗽变异性哮喘(CVA)的疗效及其对外周血EOS(嗜酸性粒细胞)和血清ECP(嗜酸性粒细胞阳离子蛋白)、IgE(免疫球蛋白E)、LTC4(白三烯C4)的影响。方法:78例CVA患儿随机分为孟鲁司特钠治... 目的:观察射干麻黄汤加味联合孟鲁司特钠咀嚼片治疗儿童咳嗽变异性哮喘(CVA)的疗效及其对外周血EOS(嗜酸性粒细胞)和血清ECP(嗜酸性粒细胞阳离子蛋白)、IgE(免疫球蛋白E)、LTC4(白三烯C4)的影响。方法:78例CVA患儿随机分为孟鲁司特钠治疗对照组和射干麻黄汤加味联合孟鲁司特钠治疗观察组,每组39例。2组患儿均治疗30 d评价疗效,对治疗前后主症、次症进行严重程度评分,检测外周血EOS计数和血清ECP、IgE、LTC4(ELISA)水平。结果:治疗30 d后,2组患儿主症(咳嗽)和次症(咯痰清稀、喷嚏、鼻塞、流清涕、咽痒)评分均降低(P<0.05),观察组治疗后主、次症评分低于对照组(P<0.05);观察组总有效率(92.3%)高于对照组(79.5%)(P<0.05)。治疗后2组患儿外周血EOS计数明显减少(P<0.05),血清ECP、IgE、LTC4水平显著下降(P<0.05或0.01);观察组上述指标减少或下降较对照组明显(P<0.05或0.01)。结论:射干麻黄汤加味可提高孟鲁司特钠治疗儿童咳嗽变异性哮喘的临床疗效,有助于减少EOS数量及其释放的毒性物质ECP,降低气道高反应性,抑制气道炎症。 展开更多
关键词 咳嗽变异性哮喘 儿童 风寒袭肺证 射干麻黄汤加味 孟鲁司特钠咀嚼片 eos ECP IGE LTC4
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FeNO和TIgE及外周血EOS计数联合检测对儿童2型气道炎症相关咳嗽变异性哮喘的诊断价值
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作者 赵苗苗 陈露萍 +4 位作者 杨轶童 马文娟 孙媛 孙珠君 石曌玲 《中国妇幼健康研究》 2024年第11期76-84,共9页
目的探讨呼出气一氧化氮(FeNO)、总免疫球蛋白E(TIgE)及外周血嗜酸性粒细胞(EOS)计数联合检测对儿童2型气道炎症相关咳嗽变异性哮喘(CVA)的诊断价值。方法收集2022年12月至2023年8月在陕西中医药大学第二附属医院行FeNO、过敏原及外周血... 目的探讨呼出气一氧化氮(FeNO)、总免疫球蛋白E(TIgE)及外周血嗜酸性粒细胞(EOS)计数联合检测对儿童2型气道炎症相关咳嗽变异性哮喘(CVA)的诊断价值。方法收集2022年12月至2023年8月在陕西中医药大学第二附属医院行FeNO、过敏原及外周血EOS计数检测的163例确诊为慢性咳嗽的4~12岁患儿为观察组,再将其分为CVA组(n=54)、上气道咳嗽综合征(UACS)组(n=52)、感染后咳嗽(PIC)组(n=57);收集同期67例正常体检儿童为对照组。回顾性比较分析四组儿童的FeNO、TIgE、特异性免疫球蛋白E(SIgE)及外周血EOS计数,并采用受试者工作特征(ROC)曲线预测FeNO、TIgE、外周血EOS计数对CVA的诊断价值。结果CVA组的FeNO、TIgE及外周血EOS计数均明显高于UACS组、PIC组、对照组,经比较差异均有统计学意义(F值分别为17.591、15.654、3.985,P<0.05)。两两组间比较显示,UACS组与CVA组、对照组FeNO比较,差异均有统计学意义(t值分别为10.167、14.565,P<0.05),CVA组与PIC组、对照组FeNO比较,差异均有统计学意义(t值分别为18.723、15.541,P<0.05);UACS组与CVA组、PIC组、对照组TIgE比较,差异均有统计学意义(t值分别为-21.400、26.051、20.639,P<0.05),CVA组与PIC组、对照组TIgE比较,差异均有统计学意义(t值分别为44.509、41.546,P<0.05);UACS组与CVA组、对照组外周血EOS计数比较,差异均有统计学意义(t值分别为-2.802、2.434,P<0.05),CVA组与对照组外周血EOS计数比较,差异有统计学意义(t=4.862,P<0.05)。慢性咳嗽患儿吸入性过敏原阳性率较高的前三位致敏原分别是交链孢霉(29.62%)、屋尘(25.00%)和粉尘螨(17.30%);食入性过敏原阳性率较高的前三位致敏原分别是鸡蛋(21.15%)、牛奶(21.15%)及虾(7.69%)。ROC曲线分析显示,FeNO、TIgE及外周血EOS计数联合诊断CVA的曲线下面积(AUC)为0.890,95%CI:0.837~0.942,灵敏度为85.19%、特异度为93.27%,联合诊断CVA的灵敏度和特异度均高于单一检测指标;FeNO诊断CVA的灵敏度为73.72%、特异度为81.48%,FeNO诊断CVA的最佳阈值是38.65ppb,诊断价值明显高于其他两项单一诊断指标。结论FeNO、TIgE及外周血EOS计数与儿童2型气道炎症相关CVA的发生联系密切,三者对于典型2型气道炎症相关CVA的鉴别诊断均有价值,联合诊断可以提高对CVA诊断的准确率;诱导2型气道炎症相关CVA发生的主要原因是吸入性过敏原,其中交链孢霉阳性率最高;FeNO为38.65ppb可作为诊断CVA的参考界值,可更好地协助鉴别CVA与其他慢性咳嗽的差别。 展开更多
关键词 儿童 一氧化氮 免疫球蛋白E 嗜酸性粒细胞 咳嗽变异性哮喘 2型气道炎症
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Eosinophilic fasciitis difficult to differentiate from scleroderma:A case report 被引量:1
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作者 Tian-Yi Lan Zi-Han Wang +6 位作者 Wei-Ping Kong Jin-Ping Wang Nan Zhang Di-Er Jin Jing Luo Qing-Wen Tao Ze-Ran Yan 《World Journal of Clinical Cases》 SCIE 2023年第13期3092-3098,共7页
BACKGROUND Eosinophilic fasciitis(EF)is a rare connective tissue disease that can cause swelling and sclerosis of the extremities,and special attention is needed to differentiate EF from systemic sclerosis.Misdiagnosi... BACKGROUND Eosinophilic fasciitis(EF)is a rare connective tissue disease that can cause swelling and sclerosis of the extremities,and special attention is needed to differentiate EF from systemic sclerosis.Misdiagnosis or omission markedly delays treatment of EF,and severe skin sclerosis in advanced stages can cause joint contracture and tendon retraction,worsening the patient's prognosis and quality of life.CASE SUMMARY We report a case of EF in a young woman diagnosed by tissue biopsy,confirming the difficulty of differential diagnosis with scleroderma.CONCLUSION Focusing on skin manifestations,completing tissue biopsy and radiography can help diagnose EF effectively.Clinicians should enhance their understanding of the differences between EF and scleroderma,and early diagnosis and standardized treatment can improve the prognosis of patients with EF. 展开更多
关键词 eosinophilic fasciitis SCLERODERMA BIOPSY DIAGNOSE Prognosis Case report
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鼻内针刺鼻丘穴、内迎香穴联合中药贴敷治疗过敏性鼻炎疗效及对鼻腔分泌物EOS%、血清总IgE、IL-4及SP水平的影响
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作者 王浩 刘成云 刘骞 《四川中医》 2024年第5期193-197,共5页
目的:探讨鼻内针刺鼻丘穴、内迎香穴联合中药贴敷治疗过敏性鼻炎疗效及对鼻腔分泌物嗜酸性粒细胞百分比(EOS%)、血清总免疫球蛋白E(IgE)、白细胞介素-4(IL-4)及P物质(SP)水平的影响。方法:选取2021年1月~2023年5月在本院门诊接受治疗的... 目的:探讨鼻内针刺鼻丘穴、内迎香穴联合中药贴敷治疗过敏性鼻炎疗效及对鼻腔分泌物嗜酸性粒细胞百分比(EOS%)、血清总免疫球蛋白E(IgE)、白细胞介素-4(IL-4)及P物质(SP)水平的影响。方法:选取2021年1月~2023年5月在本院门诊接受治疗的过敏性鼻炎患者60例,按治疗方法分为对照组和观察组,每组30例,对照组给予现代治疗方案(温生理盐水鼻腔+氯雷他定片口服+糠酸莫米松气雾剂喷鼻内),观察组基于以上治疗方案再行鼻内针刺联合穴位敷贴治疗,评估两组中医证候疗效,比较两组治疗前及治疗4周后的中医鼻部主要症状积分、鼻腔分泌物EOS%、嗜酸细胞活化趋化因子(eotaxin)含量和血清总IgE、IL-4及SP水平变化。结果:治疗4周后,观察组的中医症候疗效显著优于对照组(P<0.05),总有效率显著高于对照组(P<0.05);治疗4周后,两组喷嚏频发、清水样鼻涕、鼻痒、鼻塞共4项中医鼻部主要症状积分相较于治疗前有显著性降低(P<0.05),两组鼻腔分泌物EOS%、eotaxin含量和血清总IgE、IL-4及SP水平相较于治疗前有显著性降低(P<0.05),以上指标观察组均显著低于对照组(P<0.05)。结论:探讨鼻内针刺鼻丘穴、内迎香穴联合中药贴敷治疗过敏性鼻的中医证候疗效显著,能减轻鼻部症状,抑制鼻腔分泌物EOS%、eotaxin含量和血清总IgE、IL-4及SP水平。 展开更多
关键词 鼻内针刺鼻丘穴 内迎香穴 中药贴敷 过敏性鼻炎 鼻腔分泌物eos% 血清总IGE 血清IL-4 血清SP
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痰液中ECP和IL-8对不同EOS分型慢性阻塞性肺疾病急性加重期患者的预测价值
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作者 犹红 胡系伟 +1 位作者 岳龙飞 佟玉峰 《贵州医科大学学报》 CAS 2024年第6期873-881,共9页
目的探讨痰嗜酸性粒细胞阳离子蛋白(ECP)及白细胞介素-8(IL-8)对嗜酸性粒细胞(EOS)增高型及非EOS增高型慢性阻塞性肺疾病急性加重期(AECOPD)患者的临床预测价值,分析以EOS百分比及绝对值分类AECOPD患者的临床特征、炎症指标的差异。方... 目的探讨痰嗜酸性粒细胞阳离子蛋白(ECP)及白细胞介素-8(IL-8)对嗜酸性粒细胞(EOS)增高型及非EOS增高型慢性阻塞性肺疾病急性加重期(AECOPD)患者的临床预测价值,分析以EOS百分比及绝对值分类AECOPD患者的临床特征、炎症指标的差异。方法72名AECOPD住院患者根据EOS百分比(EOS%)分为非增高型1组(EOS%<2%)和增高型1组(EOS%≥2%),根据EOS绝对值(|EOS|)分为非增高型2组(|EOS|<10^(5)个/L)和增高型2组(|EOS|≥10^(5)个/L),t检验、秩和检验及χ2检验比较不同EOS分型AECOPD患者的痰液中ECP、IL-8水平、临床特征及外周血炎症指标的差异,采用Spearman分析外周血EOS与炎症指标和痰液ECP、IL-8的相关性,采用ROC曲线评价痰ECP、IL-8及外周血炎症指标对不同EOS分型AECOPD的预测价值。结果同种分类下比较,EOS非增高型1组、2组患者的中性粒细胞(NEU)、中性粒细胞百分比(NEUR)、中性粒细胞/淋巴细胞(NLR)、血小板/淋巴细胞(PLR)、纤维蛋白原/白蛋白(FAR)、C反应蛋白(CRP)、纤维蛋白原(FIB)、痰IL-8、过去1年急性加重次数、改良英国研究理事会呼吸困难指数(mMRC评分)及慢阻肺评估测试(CAT评分)均高于EOS增高型1组、2组AECOPD患者(P<0.05),淋巴细胞计数(LYM)、淋巴细胞百分比(LYM%)及痰ECP低于EOS增高型1组、2组AECOPD患者;非EOS增高型1组患者中的白细胞(WBC)高于EOS增高型1组患者、差异有统计学意义(P<0.05),非EOS增高型2组与EOS增高型2组患者的WBC水平差异无统计学意义(P>0.05);外周血EOS与痰中ECP呈正相关、与痰中IL-8及外周血NLR、NEU、NEUR、CRP、PLR、FAR呈负相关(P<0.05);ROC曲线分析提示,痰ECP及IL-8、外周血NLR、CRP及FAR对于不同EOS分型AECOPD的预测价值具有统计学意义(P<0.05)。结论EOS非增高型AECOPD较EOS增高型AECOPD住院患者的临床症状、炎症反应更严重,更易发生细菌感染,痰中ECP、IL-8及外周血炎症指标对AECOPD患者分型有一定价值。 展开更多
关键词 肺疾病 慢性阻塞性 嗜酸性粒细胞 嗜酸性粒细胞阳离子蛋白 白细胞介素-8
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Eosinophilic enteritis requiring differentiation from chronic enteropathy associated with SLCO2A1 gene:A case report 被引量:1
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作者 Kantaro Kimura Keisuke Jimbo +5 位作者 Nobuyasu Arai Masamichi Sato Mitsuyoshi Suzuki Takahiro Kudo Tomonori Yano Toshiaki Shimizu 《World Journal of Gastroenterology》 SCIE CAS 2023年第11期1757-1764,共8页
BACKGROUND Eosinophilic gastrointestinal disease(EGID)is a disorder characterized by infiltration of eosinophils causing mucosal damage and dysfunction of the gastrointestinal tract.The endoscopic findings of eosinoph... BACKGROUND Eosinophilic gastrointestinal disease(EGID)is a disorder characterized by infiltration of eosinophils causing mucosal damage and dysfunction of the gastrointestinal tract.The endoscopic findings of eosinophilic enteritis(EoN),an EGID variant,are nonspecific and occasionally difficult to diagnose.In contrast,chronic enteropathy associated with SLCO2A1(CEAS)is a chronic persistent small intestinal disorder characterized by endoscopic findings such as multiple oblique and circular ulcers.CASE SUMMARY We report the case of a 10-year-old boy who had suffered abdominal pain and fatigue for the preceding 6 mo.He was referred to our institute for investigation of suspected gastrointestinal bleeding because of severe anemia with hypoproteinemia and positive fecal human hemoglobin.The upper and lower gastrointestinal endoscopic findings were normal;however,double-balloon small bowel endoscopy showed multiple oblique and circular ulcers with discrete margins and mild constriction of the intestinal lumen in the ileum.The findings were highly consistent with CEAS,but urine prostaglandin metabolites were within normal limits,and no previously reported mutations in the SLCO2A1 gene were identified.Histological evaluation demonstrated moderate to severe eosinophilic infiltration localized to the small intestine suggesting a diagnosis of EoN.Clinical remission was maintained with montelukast and a partial elemental diet,but emergent surgery for bowel obstruction due to small intestinal stenosis was performed two years after the initial treatment.CONCLUSION EoN should be considered in the differential diagnosis of CEAS-like small intestinal ulcerative lesions and normal urinary prostaglandin metabolite levels. 展开更多
关键词 Anemia Chronic enteropathy associated with SLCO2A1 Double-balloon endoscopy eosinophilic gastrointestinal disease HYPOPROTEINEMIA Case report
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