A RP-HPLC method was used for the determination of eprinomectin concentration in sheep plasma following i.v. and s.c. administration at a single dose of 0.2 mg kg 1. Eprinomectin in plasma within 2.5200 ng ml 1 rang...A RP-HPLC method was used for the determination of eprinomectin concentration in sheep plasma following i.v. and s.c. administration at a single dose of 0.2 mg kg 1. Eprinomectin in plasma within 2.5200 ng ml 1 ranges had a good linear relationship(R=0.9968).The average recovery of the method was 99.65±3.84%.The RSD% of within-day and between-day assays were less than 10 and 12%, respectively. The extract of plasma samples were loaded onto a C 18 catridge. After solvent exchange, the methanol eluate was derivatized via the addition of 1-methylimidazole and trifluoroacetic anhydride in acetonitrile. The fluorescent derivative was analyzed.The main pharmacokinetic parameters were as follows, for i.v. administration: T 1/2β=12.66±2.05 h, AUC 0t= 1.02 ± 0.3 mg h L 1, f c=0.13±0.05; for s.c. administration: T 1/2Ka= 4.42 ±1.04 h, C max=0.02±0.01 μg ml 1, T max= 15.36 ± 2.91 h, t 1/2K=26.22±9.04 h, AUC 0t= 1.19±0.37 mg h L 1. The results showed that eprinomectin was distributed widely and taken long time to eliminate in sheep after i.v. adminstration. When given subcutaneously, eprinomectin had better absorption and longer residue time in sheep.Eprinomectin was eliminated much slowly after s.c. adminstration compared with i.v. administration.展开更多
Dual-mode electron paramagnetic resonance(EPR)spectroscopy was employed to analyze redox mechanisms in lithium cobalt oxide LiCoO_(2)(LCO)cathode material during delithiation and lithiation.It was found that the O_(3)...Dual-mode electron paramagnetic resonance(EPR)spectroscopy was employed to analyze redox mechanisms in lithium cobalt oxide LiCoO_(2)(LCO)cathode material during delithiation and lithiation.It was found that the O_(3)-II could not fully convert back to the pristine O_(3) -I phase while oxygen vacancies quickly generate and accumulate during the cycling.Our study paves the way for better understanding the doping effects of different elements on LiCoO_(2) in the future.展开更多
文摘A RP-HPLC method was used for the determination of eprinomectin concentration in sheep plasma following i.v. and s.c. administration at a single dose of 0.2 mg kg 1. Eprinomectin in plasma within 2.5200 ng ml 1 ranges had a good linear relationship(R=0.9968).The average recovery of the method was 99.65±3.84%.The RSD% of within-day and between-day assays were less than 10 and 12%, respectively. The extract of plasma samples were loaded onto a C 18 catridge. After solvent exchange, the methanol eluate was derivatized via the addition of 1-methylimidazole and trifluoroacetic anhydride in acetonitrile. The fluorescent derivative was analyzed.The main pharmacokinetic parameters were as follows, for i.v. administration: T 1/2β=12.66±2.05 h, AUC 0t= 1.02 ± 0.3 mg h L 1, f c=0.13±0.05; for s.c. administration: T 1/2Ka= 4.42 ±1.04 h, C max=0.02±0.01 μg ml 1, T max= 15.36 ± 2.91 h, t 1/2K=26.22±9.04 h, AUC 0t= 1.19±0.37 mg h L 1. The results showed that eprinomectin was distributed widely and taken long time to eliminate in sheep after i.v. adminstration. When given subcutaneously, eprinomectin had better absorption and longer residue time in sheep.Eprinomectin was eliminated much slowly after s.c. adminstration compared with i.v. administration.
基金the National Natural Science Foundation of China(Nos.21872055,22172049,21874045)Shanghai Science and technology innovation action plan(No.19142202900)+1 种基金BASF,Fundamental Research Funds for Central Universities and Open Foundation of ECNU(42125102)ECNU multifunctional platform for innovation(EPR).
文摘Dual-mode electron paramagnetic resonance(EPR)spectroscopy was employed to analyze redox mechanisms in lithium cobalt oxide LiCoO_(2)(LCO)cathode material during delithiation and lithiation.It was found that the O_(3)-II could not fully convert back to the pristine O_(3) -I phase while oxygen vacancies quickly generate and accumulate during the cycling.Our study paves the way for better understanding the doping effects of different elements on LiCoO_(2) in the future.
